LOCUS       NM_152511               3050 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens dual specificity phosphatase 18 (DUSP18), transcript
            variant 2, mRNA.
ACCESSION   NM_152511 XR_017891
VERSION     NM_152511.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3050)
  AUTHORS   Pu,J., Qin,Z., Fang,Q., Huang,Y., Lu,Y., Li,W., Wang,J., Tang,Q.,
            Zeng,D. and Wei,H.
  TITLE     Hypoxia-induced HIF1A activates DUSP18-mediated MAPK14
            dephosphorylation to promote hepatocellular carcinoma cell
            migration and invasion
  JOURNAL   Pathol Res Pract 237, 153955 (2022)
   PUBMED   35841693
  REMARK    GeneRIF: Hypoxia-induced HIF1A activates DUSP18-mediated MAPK14
            dephosphorylation to promote hepatocellular carcinoma cell
            migration and invasion.
REFERENCE   2  (bases 1 to 3050)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3050)
  AUTHORS   Ryu,J. and Lee,D.H.
  TITLE     Dual-specificity phosphatase 18 modulates the SUMOylation and
            aggregation of Ataxin-1
  JOURNAL   Biochem Biophys Res Commun 502 (3), 389-396 (2018)
   PUBMED   29852174
  REMARK    GeneRIF: JNK and DUSP18 reciprocally modulate the SUMOylation,
            which plays a regulatory role in the aggregation of ataxin-1.
REFERENCE   4  (bases 1 to 3050)
  AUTHORS   Yao,Z., Darowski,K., St-Denis,N., Wong,V., Offensperger,F.,
            Villedieu,A., Amin,S., Malty,R., Aoki,H., Guo,H., Xu,Y., Iorio,C.,
            Kotlyar,M., Emili,A., Jurisica,I., Neel,B.G., Babu,M., Gingras,A.C.
            and Stagljar,I.
  TITLE     A Global Analysis of the Receptor Tyrosine Kinase-Protein
            Phosphatase Interactome
  JOURNAL   Mol Cell 65 (2), 347-360 (2017)
   PUBMED   28065597
REFERENCE   5  (bases 1 to 3050)
  AUTHORS   Jeong,D.G., Wei,C.H., Ku,B., Jeon,T.J., Chien,P.N., Kim,J.K.,
            Park,S.Y., Hwang,H.S., Ryu,S.Y., Park,H., Kim,D.S., Kim,S.J. and
            Ryu,S.E.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   6  (bases 1 to 3050)
  AUTHORS   Patterson,K.I., Brummer,T., O'Brien,P.M. and Daly,R.J.
  TITLE     Dual-specificity phosphatases: critical regulators with diverse
            cellular targets
  JOURNAL   Biochem J 418 (3), 475-489 (2009)
   PUBMED   19228121
  REMARK    Review article
REFERENCE   7  (bases 1 to 3050)
  AUTHORS   Wu,Q., Huang,S., Sun,Y., Gu,S., Lu,F., Dai,J., Yin,G., Sun,L.,
            Zheng,D., Dou,C., Feng,C., Ji,C., Xie,Y. and Mao,Y.
  TITLE     Dual specificity phosphotase 18, interacting with SAPK,
            dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo
  JOURNAL   Front Biosci 11, 2714-2724 (2006)
   PUBMED   16720344
  REMARK    GeneRIF: DUSP18 appears to serve an important role by regulation of
            SAPK/JNK pathway
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3050)
  AUTHORS   Jeong,D.G., Cho,Y.H., Yoon,T.S., Kim,J.H., Son,J.H., Ryu,S.E. and
            Kim,S.J.
  TITLE     Structure of human DSP18, a member of the dual-specificity protein
            tyrosine phosphatase family
  JOURNAL   Acta Crystallogr D Biol Crystallogr 62 (Pt 6), 582-588 (2006)
   PUBMED   16699184
  REMARK    GeneRIF: The crystal structure of human DSP18 (official symbol
            DUSP18) has been determined at 2.0 A resolution.
REFERENCE   9  (bases 1 to 3050)
  AUTHORS   Wu,Q., Gu,S., Dai,J., Dai,J., Wang,L., Li,Y., Zeng,L., Xu,J.,
            Ye,X., Zhao,W., Ji,C., Xie,Y. and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel dual-specificity
            phosphatase18 gene from human fetal brain
  JOURNAL   Biochim Biophys Acta 1625 (3), 296-304 (2003)
   PUBMED   12591617
  REMARK    GeneRIF: molecular cloning, base sequence and amino acid sequence
REFERENCE   10 (bases 1 to 3050)
  AUTHORS   Hood,K.L., Tobin,J.F. and Yoon,C.
  TITLE     Identification and characterization of two novel
            low-molecular-weight dual specificity phosphatases
  JOURNAL   Biochem Biophys Res Commun 298 (4), 545-551 (2002)
   PUBMED   12408986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK056074.1 and AC003072.1.
            
            On Jun 2, 2019 this sequence version replaced NM_152511.4.
            
            Summary: Dual-specificity phosphatases (DUSPs) constitute a large
            heterogeneous subgroup of the type I cysteine-based
            protein-tyrosine phosphatase superfamily. DUSPs are characterized
            by their ability to dephosphorylate both tyrosine and
            serine/threonine residues. They have been implicated as major
            modulators of critical signaling pathways. DUSP18 contains the
            consensus DUSP C-terminal catalytic domain but lacks the N-terminal
            CH2 domain found in the MKP (mitogen-activated protein kinase
            phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson
            et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR
            compared to variant 1. Variants 1, 2, and 3 encode the same isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.196371.1,
                                           SRR1660805.54512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000334679.4/
                                                  ENSP00000333917.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1231              AK056074.1         11-1241
            1232-3050           AC003072.1         9207-11025          c
FEATURES             Location/Qualifiers
     source          1..3050
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..3050
                     /gene="DUSP18"
                     /gene_synonym="DSP18; DUSP20; LMWDSP20"
                     /note="dual specificity phosphatase 18"
                     /db_xref="GeneID:150290"
                     /db_xref="HGNC:HGNC:18484"
                     /db_xref="MIM:611446"
     exon            1..414
                     /gene="DUSP18"
                     /gene_synonym="DSP18; DUSP20; LMWDSP20"
                     /inference="alignment:Splign:2.1.0"
     exon            415..3050
                     /gene="DUSP18"
                     /gene_synonym="DSP18; DUSP20; LMWDSP20"
                     /inference="alignment:Splign:2.1.0"
     CDS             492..1058
                     /gene="DUSP18"
                     /gene_synonym="DSP18; DUSP20; LMWDSP20"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 2; low
                     molecular weight dual specificity phosphatase 20; dual
                     specificity protein phosphatase 18"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 18 isoform
                     a"
                     /protein_id="NP_689724.3"
                     /db_xref="CCDS:CCDS13883.1"
                     /db_xref="GeneID:150290"
                     /db_xref="HGNC:HGNC:18484"
                     /db_xref="MIM:611446"
                     /translation="MTAPSCAFPVQFRQPSVSGLSQITKSLYISNGVAANNKLMLSSN
                     QITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLL
                     HCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFG
                     KNTVHMVSSPVGMIPDIYEKEVRLMIPL"
     regulatory      1235..1240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP18"
                     /gene_synonym="DSP18; DUSP20; LMWDSP20"
                     /note="hexamer: ATTAAA"
     polyA_site      1265
                     /gene="DUSP18"
                     /gene_synonym="DSP18; DUSP20; LMWDSP20"
                     /note="major polyA site"
     regulatory      1627..1632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP18"
                     /gene_synonym="DSP18; DUSP20; LMWDSP20"
                     /note="hexamer: AAGAAA"
     polyA_site      1649
                     /gene="DUSP18"
                     /gene_synonym="DSP18; DUSP20; LMWDSP20"
ORIGIN      
        1 agagcccggg cggctacgga agcggtgaga ctgtctctcg gctgcagccc tggtgcgacc
       61 cggcccgttg ccgtagagat gggcagggct ggatggagtg gggtgcggtg agctgagctg
      121 accctgcttc gccacgggga ctgcagtgac cccggcttgc cggcagggcg ggtaacaggt
      181 tgagccaggg tggggctgct caggggcgtg gagccgaggc caggatttct ctgaagaccc
      241 ggcacaggct attcctttct gcgacgagcc cattgctatg gaaaccaaag cgttaggcca
      301 gcggggattg aggctgcggg atcatgacgg gtctctctcc cgaagaacct tgcctaaggc
      361 ttccccaagc ggctacttcc tgagcgaacc cgcccacccg cctgaaggag agagttttcc
      421 atggacacag cctagcagaa agacgcagcc ttcgtgcttc gctgactgct gaccactgac
      481 ccaccgcctt gatgacagca ccctcgtgtg ccttcccagt tcagttccgg cagccctcag
      541 tcagcggcct ctcgcagata accaaaagcc tgtatatcag caatggtgtg gccgccaaca
      601 acaagctcat gctgtctagc aaccagatca ccatggtcat caatgtctca gtggaggtag
      661 tgaacacctt gtatgaggat atccagtaca tgcaggtacc tgtggctgac tcccctaact
      721 cacgtctctg tgacttcttt gaccctattg ctgaccatat ccacagcgtg gagatgaagc
      781 agggccgtac tttgctgcac tgtgctgctg gtgtgagccg ctcagctgcc ctgtgcctcg
      841 cctacctcat gaagtaccac gccatgtccc tgctggacgc ccacacgtgg accaagtcat
      901 gccggcccat catccgaccc aacagcggct tttgggagca gctcatccac tatgagttcc
      961 aattgtttgg caagaacact gtgcacatgg tcagttcccc agtgggaatg atccctgaca
     1021 tctatgagaa ggaagtccgt ttgatgattc cactgtgagc catcccacga gcccctgcat
     1081 tggagtcaga ggtacagatc tattgttgat cttacaccaa gatccaaact tgaacattct
     1141 acttttgttg atacagaaaa aaacagatga tgccttttat gagcacaaaa aagagttgct
     1201 gtagctttta actttataat ccattttttt taagattaaa ctaattgtga gatggtgaag
     1261 ataaattttc tgccctgtga gtgacactgg ccaggggata ggttgaggca gatggtgccc
     1321 agaagaaaga gggcagcacc cattgcacat ggcaggcctg gaatcctgca gccctcccca
     1381 aaaacagatt gacccaggaa tgaatctgct acaattccac ctcattcttt cacacccaga
     1441 gccagagcct taagcatcat ggtacctctt gcgcttctta cagtgagtgc caatctacta
     1501 gataaatggc cttcaggcag tgctccagga atcctggggg gtcccaggcc acctctgctt
     1561 ccaccttcac tataagtggc ccagttctgg ttttctagat tgtacttatg cataagatag
     1621 tttttaaaga aagcattcca ctgtgtaaat ttttttttgt ctttttttga aactgtcctg
     1681 ctctgtcacc catcctagag tgcagtagtg tgatcatggc tcactgtagc cacaacctct
     1741 caggctcaag tgatcctctt accttagcct cctgcgtggc tgggactaca gatgtttgcc
     1801 accatgcccg cctcattttt tttctttttt tatagagatg agattttact atgtcgccca
     1861 gactggtctc aaactcctgg cctcaagcaa tcctcacgcc tcagcctccc aaagtgttga
     1921 tgagccactg taccccgata ccactgtata aaaaatttaa aaaaaattgt gagtgctatt
     1981 gtacatggca aagtttcaaa gagctcttgg ccatccctca ccaaactttg gcaaaagatg
     2041 gtgttagtcc ccttctccag ggcacatgag aaaaacaggc ctaacatcag gtctcagcgg
     2101 ttcctctcac aggccttggc ttggaaggct ggagcttcgg accaaggccc agccctgtca
     2161 cctcctcttc atgtgatgtg gacccctggg agcatcagtg tcctcatctg tccaatgaca
     2221 gcccttttct cacagagtta ttgtgaagat tcaacaattt cttggcatag tgcctggcac
     2281 atggtgtgtg cttagcgcaa atggcagctc tcatcatgaa tgatagactc tttcaccctg
     2341 ctggtcccag gtcggcacac acatccccat aatggcattt ctcctttctg tgcacagcac
     2401 tttattgtta caaagtactc ttccaaaaag ttaccctgtg tgtaaaaaaa aaaaaaaaaa
     2461 aaaatggttt aagtcctttc agaccctacc tcacaggagg cctagactta gagccttttg
     2521 agagcttccg tcttgtttaa tctaggtgca atctagaggt cctgaaacaa ggagcacagt
     2581 tccagcttcc cccaatcact tctaaacagt gactgcagcc ttgtttagaa tcactatgaa
     2641 aacctgcacc ccggctgact actgggatcc ataagggggc cgtgtcaaag ggactaacta
     2701 gtggactcca tcagtaggcc ctggaattca ggattgttca catcctcttg gtgccaagga
     2761 cctggctgaa gaccagctct tctgatccag aggttttcag caaacagcat ttgaaacaaa
     2821 agcacagctg ctctgtttga caccaaactg tggctccaga ttccagtaga agccaaatgc
     2881 tttttctttt aacagctggg tgcctgtaat cccagttact tgggaggctg aggcaggaga
     2941 attgcttgaa cccaggaggc ggaggttgca gtgagccgag cttgcaccat tgcactccag
     3001 cctgggcaac aagagtgaga ctccatctca aaaagaaaaa aaaaaaaaaa
//
