LOCUS       NM_030640               6661 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens dual specificity phosphatase 16 (DUSP16), mRNA.
ACCESSION   NM_030640 XM_039106
VERSION     NM_030640.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6661)
  AUTHORS   Shillingford,S., Zhang,L., Surovtseva,Y., Dorry,S., Lolis,E. and
            Bennett,A.M.
  TITLE     A novel site on dual-specificity phosphatase MKP7/DUSP16 is
            required for catalysis and MAPK binding
  JOURNAL   J Biol Chem 298 (12), 102617 (2022)
   PUBMED   36272649
  REMARK    GeneRIF: A novel site on dual-specificity phosphatase MKP7/DUSP16
            is required for catalysis and MAPK binding.
REFERENCE   2  (bases 1 to 6661)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6661)
  AUTHORS   Low,H.B., Wong,Z.L., Wu,B., Kong,L.R., Png,C.W., Cho,Y.L., Li,C.W.,
            Xiao,F., Xin,X., Yang,H., Loo,J.M., Lee,F.Y.X., Tan,I.B.H.,
            DasGupta,R., Shen,H.M., Schwarz,H., Gascoigne,N.R.J., Goh,B.C.,
            Xu,X. and Zhang,Y.
  TITLE     DUSP16 promotes cancer chemoresistance through regulation of
            mitochondria-mediated cell death
  JOURNAL   Nat Commun 12 (1), 2284 (2021)
   PUBMED   33863904
  REMARK    GeneRIF: DUSP16 promotes cancer chemoresistance through regulation
            of mitochondria-mediated cell death.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6661)
  AUTHORS   Ma,L., Li,H., Lin,Y., Wang,G., Xu,Q., Chen,Y., Xiao,K. and Rao,X.
  TITLE     CircDUSP16 Contributes to Cell Development in Esophageal Squamous
            Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis
  JOURNAL   J Surg Res 260, 64-75 (2021)
   PUBMED   33326930
  REMARK    GeneRIF: CircDUSP16 Contributes to Cell Development in Esophageal
            Squamous Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis.
REFERENCE   5  (bases 1 to 6661)
  AUTHORS   Katagiri,C., Masuda,K., Urano,T., Yamashita,K., Araki,Y.,
            Kikuchi,K. and Shima,H.
  TITLE     Phosphorylation of Ser-446 determines stability of MKP-7
  JOURNAL   J Biol Chem 280 (15), 14716-14722 (2005)
   PUBMED   15689616
  REMARK    GeneRIF: activation of the ERK pathway strongly blocks JNK
            activation through stabilization of MKP-7 mediated by
            phosphorylation
REFERENCE   6  (bases 1 to 6661)
  AUTHORS   Hoornaert,I., Marynen,P., Goris,J., Sciot,R. and Baens,M.
  TITLE     MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for
            chromosome region 12p12-13, reduces BCR-ABL-induced transformation
  JOURNAL   Oncogene 22 (49), 7728-7736 (2003)
   PUBMED   14586399
  REMARK    GeneRIF: context-dependent role for DUSP16 on cell transformation
            and apoptosis.
REFERENCE   7  (bases 1 to 6661)
  AUTHORS   Masuda,K., Shima,H., Katagiri,C. and Kikuchi,K.
  TITLE     Activation of ERK induces phosphorylation of MAPK phosphatase-7, a
            JNK specific phosphatase, at Ser-446
  JOURNAL   J Biol Chem 278 (34), 32448-32456 (2003)
   PUBMED   12794087
REFERENCE   8  (bases 1 to 6661)
  AUTHORS   Willoughby,E.A., Perkins,G.R., Collins,M.K. and Whitmarsh,A.J.
  TITLE     The JNK-interacting protein-1 scaffold protein targets MAPK
            phosphatase-7 to dephosphorylate JNK
  JOURNAL   J Biol Chem 278 (12), 10731-10736 (2003)
   PUBMED   12524447
REFERENCE   9  (bases 1 to 6661)
  AUTHORS   Masuda,K., Shima,H., Watanabe,M. and Kikuchi,K.
  TITLE     MKP-7, a novel mitogen-activated protein kinase phosphatase,
            functions as a shuttle protein
  JOURNAL   J Biol Chem 276 (42), 39002-39011 (2001)
   PUBMED   11489891
REFERENCE   10 (bases 1 to 6661)
  AUTHORS   Tanoue,T., Yamamoto,T., Maeda,R. and Nishida,E.
  TITLE     A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and
            p38 alpha and beta MAPKs
  JOURNAL   J Biol Chem 276 (28), 26629-26639 (2001)
   PUBMED   11359773
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092824.13, DB094627.1,
            AF506796.1 and AC007619.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_030640.2.
            
            Summary: This gene encodes a mitogen-activated protein kinase
            phosphatase that is a member of the dual specificity protein
            phosphatase subfamily. These phosphatases inactivate their target
            kinases by dephosphorylating both the phosphoserine/threonine and
            phosphotyrosine residues. The encoded protein specifically
            regulates the c-Jun amino-terminal kinase (JNK) and extracellular
            signal-regulated kinase (ERK) pathways.[provided by RefSeq, May
            2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2222091.1,
                                           SRR1803614.86187.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298573.9/ ENSP00000298573.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AC092824.13        9173-9521
            350-480             DB094627.1         1-131
            481-4046            AF506796.1         1-3566
            4047-6661           AC007619.23        57962-60576
FEATURES             Location/Qualifiers
     source          1..6661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..6661
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /note="dual specificity phosphatase 16"
                     /db_xref="GeneID:80824"
                     /db_xref="HGNC:HGNC:17909"
                     /db_xref="MIM:607175"
     exon            1..747
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1340
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             1113..3110
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MAPK phosphatase-7; MAP kinase phosphatase 7;
                     mitogen-activated protein kinase phosphatase 7"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 16"
                     /protein_id="NP_085143.1"
                     /db_xref="CCDS:CCDS8650.1"
                     /db_xref="GeneID:80824"
                     /db_xref="HGNC:HGNC:17909"
                     /db_xref="MIM:607175"
                     /translation="MAHEMIGTQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILE
                     AININCSKLMKRRLQQDKVLITELIQHSAKHKVDIDCSQKVVVYDQSSQDVASLSSDC
                     FLTVLLGKLEKSFNSVHLLAGGFAEFSRCFPGLCEGKSTLVPTCISQPCLPVANIGPT
                     RILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEK
                     ILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKE
                     KRPTISPNFNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPAVSEGGQKSE
                     TPLSPPCADSATSEAAGQRPVHPASVPSVPSVQPSLLEDSPLVQALSGLHLSADRLED
                     SNKLKRSFSLDIKSVSYSASMAASLHGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQE
                     LSEQTPETSPDKEEASIPKKLQTARPSDSQSKRLHSVRTSSSGTAQRSLLSPLHRSGS
                     VEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQTSTPSLTSSWYFATESSHF
                     YSASAIYGGSASYSAYSCSQLPTCGDQVYSVRRRQKPSDRADSRRSWHEESPFEKQFK
                     RRSCQMEFGESIMSENRSREELGKVGSQSSFSGSMEIIEVS"
     exon            1341..1479
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1643
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1803
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1927
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..6661
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4026..4031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /note="hexamer: AATAAA"
     polyA_site      4048
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /note="major polyA site"
     regulatory      5689..5694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /note="hexamer: AATAAA"
     polyA_site      5723
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /note="major polyA site"
     regulatory      5842..5847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
                     /note="hexamer: AATAAA"
     polyA_site      5868
                     /gene="DUSP16"
                     /gene_synonym="MKP-7; MKP7"
ORIGIN      
        1 agagtcgccg gactctggaa gggaacatga cctgacccct ccccgagcgg ccggaacgag
       61 gcgcggagcc gcgctccggg ctcgggcggc cgcgggatgg gcgagcgcgc ggccccgccc
      121 ggcgcccacc gccctgccct cgcctgtctc ctcctttccc cggggctccg ctgagttcat
      181 tcactgggat tggtttcaag tgacgccatc tctttatttt taaaccaatg acctcatccg
      241 cgcttgaagt ttcctgacca gcgactcttt ctctttcccc caacccccca ccccaccccc
      301 ccgcctttcc ccctctttct atgtatcagt gtttgggggg ctttaatcag tttttaaacg
      361 attattacca cctctctctc ccccccaacc cccactttca caacgcggcc ccccaccttt
      421 acctccctaa gttcttcatc tctttcgaca ttttttttga aggctgatgg gggggagggt
      481 ggaagagaaa gagtgaagaa aagttgcgag cgtctcctct cttcctaagc ctcccgcccc
      541 aacccacccc tcagagaagg agaagataat atactgaaaa gaagaggagg aggagagcga
      601 cgggacggga cgcgagcggg agcgcagccg ccctctcggc tccgcggcgg cgcctcgcaa
      661 gtccgggagg cgaggggggc ccgaggggag acgccgtgac aactttcgtt tccctctgag
      721 ggaattggga ggtcggcggc cccaaaagct ttcagtccag tgtaaagctg ttggagcgcg
      781 ggagcaaagg taaagaatga tgtaatgcgc tggctgctcc aaagcatctt ttgttgtgga
      841 atggttattc cagtcatctc tttatgaatc aaatgtgagg ggctgctttg tggacggagt
      901 cctttgcaag agcacatcaa cgggaaagag aaagagacat tcacttggag ggctcttgct
      961 gaaaatgggt ttaactctcc ttttgccagt caccaccagc ctgacctcat acacttttag
     1021 tacaatggag tggctgagcc tttgagcaca ccaccattac atcatcgtgg caaattaaag
     1081 aaggaggtgg gaaaagagga cttattgttg tcatggccca tgagatgatt ggaactcaaa
     1141 ttgttactga gaggttggtg gctctgctgg aaagtggaac ggaaaaagtg ctgctaattg
     1201 atagccggcc atttgtggaa tacaatacat cccacatttt ggaagccatt aatatcaact
     1261 gctccaagct tatgaagcga aggttgcaac aggacaaagt gttaattaca gagctcatcc
     1321 agcattcagc gaaacataag gttgacattg attgcagtca gaaggttgta gtttacgatc
     1381 aaagctccca agatgttgcc tctctctctt cagactgttt tctcactgta cttctgggta
     1441 aactggagaa gagcttcaac tctgttcacc tgcttgcagg tgggtttgct gagttctctc
     1501 gttgtttccc tggcctctgt gaaggaaaat ccactctagt ccctacctgc atttctcagc
     1561 cttgcttacc tgttgccaac attgggccaa cccgaattct tcccaatctt tatcttggct
     1621 gccagcgaga tgtcctcaac aaggagctga tgcagcagaa tgggattggt tatgtgttaa
     1681 atgccagcaa tacctgtcca aagcctgact ttatccccga gtctcatttc ctgcgtgtgc
     1741 ctgtgaatga cagcttttgt gagaaaattt tgccgtggtt ggacaaatca gtagatttca
     1801 ttgagaaagc aaaagcctcc aatggatgtg ttctagtgca ctgtttagct gggatctccc
     1861 gctccgccac catcgctatc gcctacatca tgaagaggat ggacatgtct ttagatgaag
     1921 cttacagatt tgtgaaagaa aaaagaccta ctatatctcc aaacttcaat tttctgggcc
     1981 aactcctgga ctatgagaag aagattaaga accagactgg agcatcaggg ccaaagagca
     2041 aactcaagct gctgcacctg gagaagccaa atgaacctgt ccctgctgtc tcagagggtg
     2101 gacagaaaag cgagacgccc ctcagtccac cctgtgccga ctctgctacc tcagaggcag
     2161 caggacaaag gcccgtgcat cccgccagcg tgcccagcgt gcccagcgtg cagccgtcgc
     2221 tgttagagga cagcccgctg gtacaggcgc tcagtgggct gcacctgtcc gcagacaggc
     2281 tggaagacag caataagctc aagcgttcct tctctctgga tatcaaatca gtttcatatt
     2341 cagccagcat ggcagcatcc ttacatggct tctcctcatc agaagatgct ttggaatact
     2401 acaaaccttc cactactctg gatgggacca acaagctatg ccagttctcc cctgttcagg
     2461 aactatcgga gcagactccc gaaaccagtc ctgataagga ggaagccagc atccccaaga
     2521 agctgcagac cgccaggcct tcagacagcc agagcaagcg attgcattcg gtcagaacca
     2581 gcagcagtgg caccgcccag aggtcccttt tatctccact gcatcgaagt gggagcgtgg
     2641 aggacaatta ccacaccagc ttccttttcg gcctttccac cagccagcag cacctcacga
     2701 agtctgctgg cctgggcctt aagggctggc actcggatat cttggccccc cagacctcta
     2761 ccccttccct gaccagcagc tggtattttg ccacagagtc ctcacacttc tactctgcct
     2821 cagccatcta cggaggcagt gccagttact ctgcctacag ctgcagccag ctgcccactt
     2881 gcggagacca agtctattct gtgcgcaggc ggcagaagcc aagtgacaga gctgactcgc
     2941 ggcggagctg gcatgaagag agcccctttg aaaagcagtt taaacgcaga agctgccaaa
     3001 tggaatttgg agagagcatc atgtcagaga acaggtcacg ggaagagctg gggaaagtgg
     3061 gcagtcagtc tagcttttcg ggcagcatgg aaatcattga ggtctcctga gaagaaagac
     3121 acttgtgact tctatagaca attttttttt cttgttcaca aaaaaattcc ctgtaaatct
     3181 gaaatatata tatgtacata catatatatt tttggaaaat ggagctatgg tgtaaaagca
     3241 acaggtggat caacccagtt gttactctct taacatctgc atttgagaga tcagctaata
     3301 cttctctcaa caaaaatgga agggcagatg ctagaatccc ccctagacgg aggaaaacca
     3361 ttttattcag tgaattacac atcctcttgt tcttaaaaaa gcaagtgtct ttggtgttgg
     3421 aggacaaaat cccctaccat tttcacgttg tgctactaag agatctcaaa tattagtctt
     3481 tgtccggacc cttccatagt acaccttagc gctgagactg agccagcttg ggggtcaggt
     3541 aggtagaccc tgttagggac agagcctagt ggtaaatcca agagaaatga tcctatccaa
     3601 agctgattca caaacccacg ctcacctgac agccgaggga cacgagcatc actctgctgg
     3661 acggaccatt aggggccttg ccaaggtcta ccttagagca aacccagtac ctcagacagg
     3721 aaagtcgggg ctttgaccac taccatatct ggtagcccat tttctaggca ttgtgaatag
     3781 gtaggtagct agtcacactt ttcagaccaa ttcaaactgt ctatgcacaa aattcccgtg
     3841 ggcctagatg gagataattt ttttttcttc tcagctttat gaagagaagg gaaactgtct
     3901 aggattcagc tgaaccacca ggaacctggc aacatcacga tttaagctaa ggttgggagg
     3961 ctaacgagtc tacctccctc tttgtaaatc aaagaattgt ttaaaatggg attgtcaatc
     4021 ctttaaataa agatgaactt ggtttcaagc caaatgtgaa tttatttggg ttggtagcag
     4081 agcagcagca ccttcaaatt ctcagccaaa gcagatgttt ttgccctttc tgcttcactg
     4141 catggataca gttggtaaaa tgtaataata tggcagaatt ttataggaaa cttcctaggg
     4201 aggtaaatta tgggaagatt aagaaaggta caaattgctg aggagaagca ggaaacctgt
     4261 ttccttagtg gcttttatcc cctcggcatg cgatggggct gatgtttcta tgattgcctc
     4321 agactttcac atttactagt agggctgaga gaggctttag tgaggaagga atattcagaa
     4381 taaaacggtt gagaaagctg agaagaccat tgagttttga tcagttgtga atagagtgca
     4441 aagccatggc caagctgttt ttggaaacgc tggccggcgt gtcttcagtg gaaaaagcaa
     4501 atcaaaatgg agcgagagca aaggggcgtc ctcagtcctc aacctacaat cactgtatgg
     4561 aatcggtcct ggcagctgaa cataggaggt cactggaaca agtgatagtg cagattggct
     4621 ttcaaacatc ctcctggctt gagttttatc agctacaatg tgggtcctct tttgaagcct
     4681 taattcacaa cagcagcttt ttgggggtgg ggctgggcgg gtgttgtcat tgttctttcc
     4741 cttcctgtaa gtgtcgctag ttgctgcctc gtatctcagg tttttctctg tttttgagaa
     4801 atggacagtt ttttgaccag gatgtgactt catgtttcct atggtgactt ctaaaaccag
     4861 cacagaatga tatgactcaa cacagaccga cttggttatg gggatgatga gccgcacaga
     4921 cctcactagt tgtgcacaaa taatgtgcta tgatggggtg taaagtgaag gcagaagagg
     4981 gtcagccgca ttgttatgat actgggaaag tgctggtcaa cgatttgagt tagtttttag
     5041 atatacattg aaatctttaa tcagacattc tcaagtttca cacagtagtt tttgatgtta
     5101 tgtacacaca caccaaatgt gtaacagttc accacttcca gagtgtggtc atgcccaaaa
     5161 catgtttaag aaaggaaagc agtagctcct tgctaacgat gtttcaggag gtttggggga
     5221 cttggtttta atgagcttct gtcatttagg gcttctcttg gccatggtcc cccttccttc
     5281 tggaactgtg atgtagtcac atcctacagc ctttagtgct ggttcactag tgtcagataa
     5341 tcagttcttg gaatcgagac tgccgtggcg aaggggtggc ctcggaggca ggctctggag
     5401 ctgcttggat gtctttaggt ggggtggtgg ctggctctct tcagcatgta attggggaaa
     5461 ccctcgcgtc tactaggggt gatacagatg gtgattttaa agagcaaaac tagacttcta
     5521 tgtgagaagt gctggaaaat gatttaggac atgtgtaaag ttagatggaa agactgtaaa
     5581 tgtttaatat gaatatagtg ttcttttgaa gtaaggccag ctgttgaacg gttaaactgt
     5641 gcatttctca ttttgatgtg tcatgtatgt taatgtatga aatgattaaa taaaatcaaa
     5701 actggtacct gtttatacat aaatacgaga aaagacctat ctttgcagcc ataaactcgg
     5761 tgggaacacc accactcaag ttgccaaagg aggcagtggt gaaacctgtc ctgttctcac
     5821 ttaaatgagg atttagctca aaataaagtg gtggtgtcat caggtttatt ccgtgttctg
     5881 tcattcacat ggaacaccgg atgattagct aacagtttag tgccagcctt cattctttac
     5941 tgtgtacgtt aaatgcacac tacagtgaaa aagcctaaga cacttggtaa atattttcta
     6001 gctgactgat tccagaacac acaagtacat ggtaggaaaa aaaaggccag ctacacacac
     6061 atggcccatt tcgatataac atgtaaatga tgttacgatt cctacaggaa aaacaggaag
     6121 ggcaattgtt gaagagctgt cctttgtcct tgccacatac atctcaacaa cctctctgct
     6181 catgacacta gatttgatga cttatgagac tagaaactta gtctcatcag tttcataaaa
     6241 attaggcatt gaaggaataa agcttcagtg caaacagatg gaatattgac tacagaaaga
     6301 atcacaggtg accttgaagt tggttgagtt gaagttacat ttaagaaaat ttataagaaa
     6361 gattgggccg ggtgagctag actagaagag ctatcttggc caggaccctg cagaaaaaga
     6421 ggtggaagtg agatagagga ataaagggaa ttagaataaa tcagcctcca gagatagagg
     6481 gtaacaggag gaacagttgt ttcagtgaga ggcttccaat gagaagatgc agatcttggg
     6541 agagcctgaa gttcaggcca gttgctgaca gtgctcggag ccccttcatg accagcctca
     6601 gcaggctatt gttggaggac tggtttggat gtgacaacta caattagacc aggaattaaa
     6661 c
//
