LOCUS       NM_080611               1224 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens dual specificity phosphatase 15 (DUSP15), transcript
            variant 1, mRNA.
ACCESSION   NM_080611
VERSION     NM_080611.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1224)
  AUTHORS   Fang F, Ge M, Liu J, Zhang Z, Yu H, Zhu S, Xu L and Shao L.
  TITLE     Association between Genetic Variants in DUSP15, CNTNAP2, and PCDHA
            Genes and Risk of Childhood Autism Spectrum Disorder
  JOURNAL   Behav Neurol 2021, 4150926 (2021)
   PUBMED   34257739
  REMARK    GeneRIF: Association between Genetic Variants in DUSP15, CNTNAP2,
            and PCDHA Genes and Risk of Childhood Autism Spectrum Disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1224)
  AUTHORS   Bhore N, Wang BJ, Wu PF, Lee YL, Chen YW, Hsu WM, Lee H, Huang YS,
            Yang DI and Liao YF.
  TITLE     Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling
            by Enhancing the Stability of Notch Protein
  JOURNAL   Mol Neurobiol 58 (5), 2204-2214 (2021)
   PUBMED   33417224
  REMARK    GeneRIF: Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch
            Signaling by Enhancing the Stability of Notch Protein.
REFERENCE   3  (bases 1 to 1224)
  AUTHORS   Tian Y, Wang L, Jia M, Lu T, Ruan Y, Wu Z, Wang L, Liu J and Zhang
            D.
  TITLE     Association of oligodendrocytes differentiation regulator gene
            DUSP15 with autism
  JOURNAL   World J Biol Psychiatry 18 (2), 143-150 (2017)
   PUBMED   27223645
  REMARK    GeneRIF: The results showed that dual specificity phosphatase 15
            (DUSP15) rs3746599 was significantly associated with autism under
            allelic, additive and dominant models,The findings initially
            suggest that DUSP15 might be a susceptibility gene for autism in
            Chinese Han population.
REFERENCE   4  (bases 1 to 1224)
  AUTHORS   Jeong DG, Wei CH, Ku B, Jeon TJ, Chien PN, Kim JK, Park SY, Hwang
            HS, Ryu SY, Park H, Kim DS, Kim SJ and Ryu SE.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   5  (bases 1 to 1224)
  AUTHORS   Schmidt F, van den Eijnden M, Pescini Gobert R, Saborio GP, Carboni
            S, Alliod C, Pouly S, Staugaitis SM, Dutta R, Trapp B and Hooft van
            Huijsduijnen R.
  TITLE     Identification of VHY/Dusp15 as a regulator of oligodendrocyte
            differentiation through a systematic genomics approach
  JOURNAL   PLoS One 7 (7), e40457 (2012)
   PUBMED   22792334
  REMARK    GeneRIF: Dusp15/VHY is a key regulator of oligodendrocyte
            differentiation, and PDGFR-beta and SNX6 are novel and specific
            Dusp15 substrates.
REFERENCE   6  (bases 1 to 1224)
  AUTHORS   Friedberg I, Nika K, Tautz L, Saito K, Cerignoli F, Friedberg I,
            Godzik A and Mustelin T.
  TITLE     Identification and characterization of DUSP27, a novel
            dual-specific protein phosphatase
  JOURNAL   FEBS Lett 581 (13), 2527-2533 (2007)
   PUBMED   17498703
REFERENCE   7  (bases 1 to 1224)
  AUTHORS   Yoon TS, Jeong DG, Kim JH, Cho YH, Son JH, Lee JW, Ryu SE and Kim
            SJ.
  TITLE     Crystal structure of the catalytic domain of human VHY, a
            dual-specificity protein phosphatase
  JOURNAL   Proteins 61 (3), 694-697 (2005)
   PUBMED   16170801
  REMARK    GeneRIF: crystal structure of catalytic domain
REFERENCE   8  (bases 1 to 1224)
  AUTHORS   Alonso A, Narisawa S, Bogetz J, Tautz L, Hadzic R, Huynh H,
            Williams S, Gjorloff-Wingren A, Bremer MC, Holsinger LJ, Millan JL
            and Mustelin T.
  TITLE     VHY, a novel myristoylated testis-restricted dual specificity
            protein phosphatase related to VHX
  JOURNAL   J Biol Chem 279 (31), 32586-32591 (2004)
   PUBMED   15138252
  REMARK    GeneRIF: VHY is a new member of a subgroup of myristoylated
            VH1-like small dual specificity phosphatases
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL160175.5.
            
            On Sep 25, 2020 this sequence version replaced NM_080611.4.
            
            Summary: The protein encoded by this gene has both protein-tyrosine
            phophatase activity and serine/threonine-specific phosphatase
            activity, and therefore is known as a dual specificity phosphatase.
            This protein may function in the differentiation of
            oligodendrocytes. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056911.1, AL527716.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339738.10/ ENSP00000341658.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AL160175.5         165103-165313       c
            212-245             AL160175.5         164350-164383       c
            246-328             AL160175.5         161857-161939       c
            329-378             AL160175.5         159739-159788       c
            379-453             AL160175.5         158693-158767       c
            454-625             AL160175.5         157357-157528       c
            626-1224            AL160175.5         155863-156461       c
FEATURES             Location/Qualifiers
     source          1..1224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1224
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /note="dual specificity phosphatase 15"
                     /db_xref="GeneID:128853"
                     /db_xref="HGNC:HGNC:16236"
                     /db_xref="MIM:616776"
     exon            1..211
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..898
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1;
                     VH1-related member Y; dual specificity phosphatase-like
                     15; dual specificity protein phosphatase 15; vaccinia
                     virus VH1-related dual-specific protein phosphatase Y"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 15 isoform
                     a"
                     /protein_id="NP_542178.2"
                     /db_xref="CCDS:CCDS13193.1"
                     /db_xref="GeneID:128853"
                     /db_xref="HGNC:HGNC:16236"
                     /db_xref="MIM:616776"
                     /translation="MGNGMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPL
                     LQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAY
                     VMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKLRRQLEERFGESPFR
                     DEEELRALLPLCKRCRQGSATSASSAGPHSAASEGTVQRLVPRTPREAHRPLPLLARV
                     KQTFSCLPRCLSRKGGK"
     exon            212..245
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /inference="alignment:Splign:2.1.0"
     exon            246..328
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /inference="alignment:Splign:2.1.0"
     exon            329..378
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /inference="alignment:Splign:2.1.0"
     exon            379..453
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /inference="alignment:Splign:2.1.0"
     exon            454..625
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /inference="alignment:Splign:2.1.0"
     exon            626..1224
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1205..1210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /note="hexamer: ATTAAA"
     polyA_site      1224
                     /gene="DUSP15"
                     /gene_synonym="C20orf57; VHY"
                     /note="major polyA site"
ORIGIN      
        1 atttccctcc cgggccgggg gtcggcgggc ggtggcggtg gctgggcagg gctgggcagg
       61 gccgcggacg ccaggccccc cgttccccgc caggctgcag gcgtcgggcc tgggccgtca
      121 gggcagctgt gaccggatcg cttcccgggc ggcgagctgg gggtgcaccc ggaccgccgc
      181 ccccgggatc atgggcaatg gcatgaccaa ggtacttcct ggactctacc tcggaaactt
      241 cattgatgcc aaagacctgg atcagctggg ccgaaataag atcacacaca tcatctctat
      301 ccatgagtca ccccagcctc tgctgcagga tatcacctac cttcgcatcc cggtcgctga
      361 tacccctgag gtacccatca aaaagcactt caaagaatgt atcaacttca tccactgctg
      421 ccgccttaat ggggggaact gccttgtgca ctgctttgca ggcatctctc gcagcaccac
      481 gattgtgaca gcgtatgtga tgactgtgac ggggctaggc tggcgggacg tgcttgaagc
      541 catcaaggcc accaggccca tcgccaaccc caacccaggc tttaggcagc agcttgaaga
      601 gtttggctgg gccagttccc agaagcttcg ccggcagctg gaggagcgct tcggcgagag
      661 ccccttccgc gacgaggagg agttgcgcgc gctgctgccg ctgtgcaagc gctgccggca
      721 gggctccgcg acctcggcct cctccgccgg gccgcactca gcagcctccg agggaaccgt
      781 gcagcgcctg gtgccgcgca cgccccggga agcccaccgg ccgctgccgc tgctggcgcg
      841 cgtcaagcag actttctctt gcctcccccg gtgtctgtcc cgcaagggcg gcaagtgagg
      901 atgcagtcca gccgtggctc cccacttccg actggctccc ttcgggggct gtctgcgcct
      961 tccacgcccc ccaggacggg cccagaggct gggggagccc cgcggcggcc tgaaccctgc
     1021 ctcccgcgcc cgccctgctc gtccgcgtct gcagtcagcg tccccaacct gtgcgtctct
     1081 gtgtccgggc cggcctgctg cagccacctg gtgccttagt ccttgggctg ggggaggggg
     1141 cccaccctta aaggcggcgg gaggggaggg agggagagtg gagggtttga cgggcctgga
     1201 gggtattaaa gagacacaga agaa
//
