LOCUS       NM_007026               1474 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens dual specificity phosphatase 14 (DUSP14), mRNA.
ACCESSION   NM_007026
VERSION     NM_007026.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Kia,V., Paryan,M., Mortazavi,Y., Biglari,A. and
            Mohammadi-Yeganeh,S.
  TITLE     Evaluation of exosomal miR-9 and miR-155 targeting PTEN and DUSP14
            in highly metastatic breast cancer and their effect on low
            metastatic cells
  JOURNAL   J Cell Biochem 120 (4), 5666-5676 (2019)
   PUBMED   30335891
  REMARK    GeneRIF: Bioinformatic studies showed that these two miRNAs target
            PTEN and DUSP14 tumor suppressor genes. Quantitative Real-time PCR
            confirmed the overexpression of the miRNAs and downregulation of
            their targets. Luciferase assay confirmed that the miRNAs target
            PTEN and DUSP14.
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Wang,S., Yan,Z.Z., Yang,X., An,S., Zhang,K., Qi,Y., Zheng,J.,
            Ji,Y.X., Wang,P.X., Fang,C., Zhu,X.Y., Shen,L.J., Yan,F.J., Bao,R.,
            Tian,S., She,Z.G. and Tang,Y.D.
  TITLE     Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses
            inflammation in the liver
  JOURNAL   Hepatology 67 (4), 1320-1338 (2018)
   PUBMED   29077210
  REMARK    GeneRIF: Hepatocyte DUSP14 is required for maintaining hepatic
            metabolic homeostasis and for suppressing inflammation, a novel
            function that relies on constraining TAK1 hyperactivation
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Hijikata,M., Matsushita,I., Le Hang,N.T., Thuong,P.H., Tam,D.B.,
            Maeda,S., Sakurada,S., Cuong,V.C., Lien,L.T. and Keicho,N.
  TITLE     Influence of the polymorphism of the DUSP14 gene on the expression
            of immune-related genes and development of pulmonary tuberculosis
  JOURNAL   Genes Immun 17 (4), 207-212 (2016)
   PUBMED   26938665
  REMARK    GeneRIF: The AA genotype was associated with protection against
            active TB.  Among disease-free individuals, T-helper type-1 related
            genes, IFNGR2 and STAT1 mRNA levels significantly increased as the
            number of A alleles of rs1051838 increased.
REFERENCE   4  (bases 1 to 1474)
  AUTHORS   Li,C.Y., Zhou,Q., Yang,L.C., Chen,Y.H., Hou,J.W., Guo,K., Wang,Y.P.
            and Li,Y.G.
  TITLE     Dual-specificity phosphatase 14 protects the heart from aortic
            banding-induced cardiac hypertrophy and dysfunction through
            inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway
  JOURNAL   Basic Res Cardiol 111 (2), 19 (2016)
   PUBMED   26891723
  REMARK    GeneRIF: levels significantly decreased in failing hearts
REFERENCE   5  (bases 1 to 1474)
  AUTHORS   Yang,C.Y., Chiu,L.L. and Tan,T.H.
  TITLE     TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is
            essential for its phosphatase activity
  JOURNAL   Cell Signal 28 (1), 145-151 (2016)
   PUBMED   26521044
  REMARK    GeneRIF: these findings reveal a novel mechanism by which TRAF2
            mediates Lys63-linked ubiquitination of DUSP14, leading to DUSP14
            activation in T cells
REFERENCE   6  (bases 1 to 1474)
  AUTHORS   Lountos,G.T., Tropea,J.E., Cherry,S. and Waugh,D.S.
  TITLE     Overproduction, purification and structure determination of human
            dual-specificity phosphatase 14
  JOURNAL   Acta Crystallogr D Biol Crystallogr 65 (Pt 10), 1013-1020 (2009)
   PUBMED   19770498
  REMARK    GeneRIF: The overproduction, purification and crystal structure at
            1.88 A resolution of human dual-specificity phosphatase 14, DUSP14
            (MKP6), are reported.
REFERENCE   7  (bases 1 to 1474)
  AUTHORS   Patterson,K.I., Brummer,T., O'Brien,P.M. and Daly,R.J.
  TITLE     Dual-specificity phosphatases: critical regulators with diverse
            cellular targets
  JOURNAL   Biochem J 418 (3), 475-489 (2009)
   PUBMED   19228121
  REMARK    Review article
REFERENCE   8  (bases 1 to 1474)
  AUTHORS   Elass,E., Coddeville,B., Kremer,L., Mortuaire,M., Mazurier,J. and
            Guerardel,Y.
  TITLE     Mycobacterial lipomannan induces MAP kinase phosphatase-1
            expression in macrophages
  JOURNAL   FEBS Lett 582 (3), 445-450 (2008)
   PUBMED   18201568
  REMARK    GeneRIF: The binding of Lipomannan to TLR2 triggers MAPK
            activation, followed by an up-regulation of MKP-1 expression, which
            in turn may act as a negative regulator of MAPK activation.
REFERENCE   9  (bases 1 to 1474)
  AUTHORS   Nyati,M.K., Feng,F.Y., Maheshwari,D., Varambally,S., Zielske,S.P.,
            Ahsan,A., Chun,P.Y., Arora,V.A., Davis,M.A., Jung,M., Ljungman,M.,
            Canman,C.E., Chinnaiyan,A.M. and Lawrence,T.S.
  TITLE     Ataxia telangiectasia mutated down-regulates phospho-extracellular
            signal-regulated kinase 1/2 via activation of MKP-1 in response to
            radiation
  JOURNAL   Cancer Res 66 (24), 11554-11559 (2006)
   PUBMED   17178844
  REMARK    GeneRIF: Activation of ATM by radiation down-regulates
            phospho-ERK1/2 and its downstream signaling via increased
            expression of mitogen-activated protein kinase phosphatase MKP-1.
REFERENCE   10 (bases 1 to 1474)
  AUTHORS   Marti,F., Krause,A., Post,N.H., Lyddane,C., Dupont,B., Sadelain,M.
            and King,P.D.
  TITLE     Negative-feedback regulation of CD28 costimulation by a novel
            mitogen-activated protein kinase phosphatase, MKP6
  JOURNAL   J Immunol 166 (1), 197-206 (2001)
   PUBMED   11123293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC243654.3 and AC243585.2.
            
            On Nov 22, 2018 this sequence version replaced NM_007026.3.
            
            Summary: Dual-specificity phosphatases (DUSPs) constitute a large
            heterogeneous subgroup of the type I cysteine-based
            protein-tyrosine phosphatase superfamily. DUSPs are characterized
            by their ability to dephosphorylate both tyrosine and
            serine/threonine residues. They have been implicated as major
            modulators of critical signaling pathways. DUSP14 contains the
            consensus DUSP C-terminal catalytic domain but lacks the N-terminal
            CH2 domain found in the MKP (mitogen-activated protein kinase
            phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson
            et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.682731.1,
                                           SRR1660803.61384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617516.5/ ENSP00000478595.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC243654.3         206365-206432
            69-156              AC243585.2         42367-42454
            157-1474            AC243585.2         43871-45188
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1474
                     /gene="DUSP14"
                     /gene_synonym="MKP-L; MKP6"
                     /note="dual specificity phosphatase 14"
                     /db_xref="GeneID:11072"
                     /db_xref="HGNC:HGNC:17007"
                     /db_xref="MIM:606618"
     exon            1..68
                     /gene="DUSP14"
                     /gene_synonym="MKP-L; MKP6"
                     /inference="alignment:Splign:2.1.0"
     exon            69..156
                     /gene="DUSP14"
                     /gene_synonym="MKP-L; MKP6"
                     /inference="alignment:Splign:2.1.0"
     exon            157..1474
                     /gene="DUSP14"
                     /gene_synonym="MKP-L; MKP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..845
                     /gene="DUSP14"
                     /gene_synonym="MKP-L; MKP6"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MKP-6; MAP kinase phosphatase 6; MKP-1-like protein
                     tyrosine phosphatase; mitogen-activated protein kinase
                     phosphatase 6"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 14"
                     /protein_id="NP_008957.1"
                     /db_xref="CCDS:CCDS11320.1"
                     /db_xref="GeneID:11072"
                     /db_xref="HGNC:HGNC:17007"
                     /db_xref="MIM:606618"
                     /translation="MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASN
                     RHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSR
                     KHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLID
                     YERQLFGKSTVKMVQTPYGIVPDVYEKESRHLMPYWGI"
     regulatory      1452..1457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP14"
                     /gene_synonym="MKP-L; MKP6"
                     /note="hexamer: AATAAA"
     polyA_site      1474
                     /gene="DUSP14"
                     /gene_synonym="MKP-L; MKP6"
                     /note="major polyA site"
ORIGIN      
        1 gcagaagccg gtggccgcgc aggaggacgg agccctaacc gcaacccgct ccgcgccgcg
       61 ccgcgccgat ttgatttgta tccactgtca ccagcactgc tcacttagga ctttctggat
      121 ccggacccag gcagcgcaca ctggactctt gaggaagaag gagactctaa ttttggattc
      181 cttggtggag gaaaataaaa cactctggtc ttgccgccaa cgatgcaagt gtgactgctg
      241 gcgtcttcat gagctccaga ggtcacagca cgctaccaag gactctcatg gcccctcgga
      301 tgatttccga gggagacata ggaggcattg ctcaaatcac ctcctctcta ttcctgggca
      361 gaggcagtgt ggcctccaat cggcacctcc tccaggctcg tggcatcacc tgcattgtta
      421 atgctaccat tgagatccct aatttcaact ggccccaatt tgagtatgtt aaagtgcctc
      481 tggctgacat gccgcatgcc cccattggac tgtactttga caccgtggct gacaagatcc
      541 acagtgtgag caggaagcac ggggccacct tggtgcactg tgctgcaggg gtgagccgct
      601 cagccacgct gtgtatcgcg tacctgatga aattccacaa cgtgtgcctg ctggaggcgt
      661 acaactgggt gaaagcccgg cgacctgtca tcaggcccaa cgtaggcttc tggaggcaac
      721 tgatagacta cgagcgccag ctctttggga agtcgacagt taaaatggta cagacacctt
      781 atggcatagt tcccgacgtc tatgagaagg agtcccgaca cctgatgcct tactggggga
      841 tttagtgcca ctgaagcctg cgtcagcagc ccgagcgggg ccggcatctg ctccccgccg
      901 tctgctccct ctccactctc ttctcaaatg gctgacttct ggttctccct caagtgtttt
      961 ttacactggg tgttcaaatt tattttaaga gatagggagg gaggggacat aaagggaatg
     1021 catacattgc tagtcacatt tttaaaatta acattttgga atagtgttta tggaaatctt
     1081 tagcttttaa tcatttttac caatttgaac agtttaataa actggttctg ctctcttctg
     1141 aatctcatgc ctttggcacc ttggtaggtg caggaggagc tcagtgcaaa aatcactttg
     1201 gggcctcatt aaccctttag agacaagctt tgccccaggc tgcggaccag acagatgctt
     1261 agggaaggtt gataaccagc ttcagtctct actggattag ccctactctt tcctttcccc
     1321 tccattattt agtgactctg taagtaagtt aaatacaccc ttattattta gctgttaagt
     1381 aactataatg aaatctgctg caaaatctct cttggaatcc atgtgcccag gattatatta
     1441 gcattatttt taataaatct atatgcttaa cata
//
