LOCUS       NM_001363514            1320 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens dual specificity phosphatase 13B (DUSP13B), transcript
            variant 9, mRNA.
ACCESSION   NM_001363514 XM_005269884
VERSION     NM_001363514.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Su,R., Zhang,H., Zhang,L., Khan,A.R., Zhang,X., Wang,R., Shao,C.,
            Wei,X. and Xu,X.
  TITLE     Systemic analysis identifying PVT1/DUSP13 axis for microvascular
            invasion in hepatocellular carcinoma
  JOURNAL   Cancer Med 12 (7), 8937-8955 (2023)
   PUBMED   36524545
  REMARK    GeneRIF: Systemic analysis identifying PVT1/DUSP13 axis for
            microvascular invasion in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Guler,S., Altunok,T.H., Sarioglu,A., Zik,B., Asmaz,D.,
            Kayapunar,N., Sonmez,O., Tepedelen,B.E. and Yalcin,A.
  TITLE     Overexpression of dual-specificity phosphatases 4 and 13 attenuates
            transforming growth factor beta1-induced migration and drug
            resistance in A549 cells in vitro
  JOURNAL   Biochem Biophys Res Commun 606, 35-41 (2022)
   PUBMED   35338857
  REMARK    GeneRIF: Overexpression of dual-specificity phosphatases 4 and 13
            attenuates transforming growth factor beta1-induced migration and
            drug resistance in A549 cells in vitro.
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   Jeong,D.G., Wei,C.H., Ku,B., Jeon,T.J., Chien,P.N., Kim,J.K.,
            Park,S.Y., Hwang,H.S., Ryu,S.Y., Park,H., Kim,D.S., Kim,S.J. and
            Ryu,S.E.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Katagiri,C., Masuda,K., Nomura,M., Tanoue,K., Fujita,S.,
            Yamashita,Y., Katakura,R., Shiiba,K., Nomura,E., Sato,M., Tanuma,N.
            and Shima,H.
  TITLE     DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses
            AP-1-dependent gene expression
  JOURNAL   Mol Cell Biochem 352 (1-2), 155-162 (2011)
   PUBMED   21360282
  REMARK    GeneRIF: data suggest an important role for DUSP13B in protection
            from external stress during spermatogenesis
REFERENCE   7  (bases 1 to 1320)
  AUTHORS   Kim,S.J., Jeong,D.G., Yoon,T.S., Son,J.H., Cho,S.K., Ryu,S.E. and
            Kim,J.H.
  TITLE     Crystal structure of human TMDP, a testis-specific dual specificity
            protein phosphatase: implications for substrate specificity
  JOURNAL   Proteins 66 (1), 239-245 (2007)
   PUBMED   17044055
  REMARK    GeneRIF: Here, we report the crystal structure of human TMDP at a
            resolution of 2.4 A. In spite of high sequence similarity with
            other DSPs, the crystal structure of TMDP shows distinct structural
            motifs and surface propertie
REFERENCE   8  (bases 1 to 1320)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1320)
  AUTHORS   Chen,H.H., Luche,R., Wei,B. and Tonks,N.K.
  TITLE     Characterization of two distinct dual specificity phosphatases
            encoded in alternative open reading frames of a single gene located
            on human chromosome 10q22.2
  JOURNAL   J Biol Chem 279 (40), 41404-41413 (2004)
   PUBMED   15252030
  REMARK    GeneRIF: identified a gene on chromosome 10q22.2 using alternative
            ORFs to encode two distinct DSPs: the testis and skeletal
            muscle-specific TMDP and a novel muscle-restricted DSP(MDSP)
REFERENCE   10 (bases 1 to 1320)
  AUTHORS   Nakamura,K., Shima,H., Watanabe,M., Haneji,T. and Kikuchi,K.
  TITLE     Molecular cloning and characterization of a novel dual-specificity
            protein phosphatase possibly involved in spermatogenesis
  JOURNAL   Biochem J 344 Pt 3 (Pt 3), 819-825 (1999)
   PUBMED   10585869
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL392111.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 11, 2020 this sequence version replaced NM_001363514.1.
            
            Summary: Members of the protein-tyrosine phosphatase superfamily
            cooperate with protein kinases to regulate cell proliferation and
            differentiation. This gene encodes a dual specificity phosphatase
            that acts on both phosphotyrosine and phosphoserine/threonine
            residues. The encoded protein is expressed in testis. [provided by
            RefSeq, Mar 2023].
            
            Transcript Variant: This variant (9) represents the allele encoded
            by the GRCh38 reference genome and encodes isoform 9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.123218.1,
                                           SRR14038194.4051624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000478873.7/ ENSP00000475626.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               AL392111.12        29916-30397         c
            483-656             AL392111.12        28597-28770         c
            657-877             AL392111.12        26460-26680         c
            878-1320            AL392111.12        25321-25763         c
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..1320
                     /gene="DUSP13B"
                     /gene_synonym="DUSP13; MDSP; SKRP4; TMDP"
                     /note="dual specificity phosphatase 13B"
                     /db_xref="GeneID:51207"
                     /db_xref="HGNC:HGNC:19681"
                     /db_xref="MIM:613191"
     exon            1..482
                     /gene="DUSP13B"
                     /gene_synonym="DUSP13; MDSP; SKRP4; TMDP"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1080
                     /gene="DUSP13B"
                     /gene_synonym="DUSP13; MDSP; SKRP4; TMDP"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 9 is encoded by transcript variant 9; dual
                     specificity phosphatase 13; Testis- and skeletal
                     muscle-specific DUSP; testis- and skeletal-muscle-specific
                     DSP; dual specificity protein phosphatase 13B"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 13B isoform
                     9"
                     /protein_id="NP_001350443.1"
                     /db_xref="CCDS:CCDS86105.1"
                     /db_xref="GeneID:51207"
                     /db_xref="HGNC:HGNC:19681"
                     /db_xref="MIM:613191"
                     /translation="MPQVGGRPLSHLERSQWGMRRTAWSSLPPCPTASHWVSLAKPAA
                     SWVPVSFSGPGTAYQREKMFFPVCTFPSHWSRGSGAVSKDRTPSPTRHQAHILVPLKI
                     QLRRVPDSFSQQMPETSYLTRVGPDIQCWPESWGMDSLQKQDLRRPKIHGAVQASPYQ
                     PPTLASLQRLLWVRQAATLNHIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGK
                     FQVDTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPQGRVLVHCAM
                     GVSRSATLVLAFLMICENMTLVEAIQTVQAHRNICPNSGFLRQLQVLDNRLGRETGRF
                     "
     exon            483..656
                     /gene="DUSP13B"
                     /gene_synonym="DUSP13; MDSP; SKRP4; TMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            657..877
                     /gene="DUSP13B"
                     /gene_synonym="DUSP13; MDSP; SKRP4; TMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1320
                     /gene="DUSP13B"
                     /gene_synonym="DUSP13; MDSP; SKRP4; TMDP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1298..1303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP13B"
                     /gene_synonym="DUSP13; MDSP; SKRP4; TMDP"
                     /note="hexamer: AATAAA"
     polyA_site      1320
                     /gene="DUSP13B"
                     /gene_synonym="DUSP13; MDSP; SKRP4; TMDP"
                     /note="major polyA site"
ORIGIN      
        1 agaacctgcc cagccctgtt ccgctcaggc agagtcctgc ccctgcaccc actcccccat
       61 tcccggcccc aggccatgcc ccaggtaggt ggcaggccac tcagccacct ggagaggtca
      121 cagtggggga tgaggaggac agcttggtct tcacttccgc cttgcccgac agcctcccac
      181 tgggtgagcc tggccaagcc ggcagcctcc tgggtgcctg tttctttttc tggtcctggc
      241 actgcctacc aaagggaaaa gatgttcttc ccagtatgca ccttccctag tcactggtcc
      301 aggggatcag gggcagttag caaagacagg accccctctc caacacggca ccaggcccat
      361 attctggtgc cgctgaaaat ccagctccgc agggtccctg actccttcag ccagcagatg
      421 cctgaaacaa gctacctgac ccgggtgggg cctgacatcc agtgctggcc tgagtcgtgg
      481 gggatggact cactgcagaa gcaggacctc cggaggccca agatccatgg ggcagtccag
      541 gcatctccct accagccgcc cacattggct tcgctgcagc gcttgctgtg ggtccgtcag
      601 gctgccacac tgaaccatat cgatgaggtc tggcccagcc tcttcctggg agatgcgtac
      661 gcagcccggg acaagagcaa gctgatccag ctgggaatca cccacgttgt gaatgccgct
      721 gcaggcaagt tccaggtgga cacaggtgcc aaattctacc gtggaatgtc cctggagtac
      781 tatggcatcg aggcggacga caaccccttc ttcgacctca gtgtctactt tctgcctgtt
      841 gctcgataca tccgagctgc cctcagtgtt ccccaaggcc gcgtgctggt acactgtgcc
      901 atgggggtaa gccgctctgc cacacttgtc ctggccttcc tcatgatctg tgagaacatg
      961 acgctggtag aggccatcca gacggtgcag gcccaccgca atatctgccc taactcaggc
     1021 ttcctccggc agctccaggt tctggacaac cgactggggc gggagacggg gcggttctga
     1081 tctggcaggc agccaggatc cctgaccctt ggcccaaccc caccagcctg gccctgggaa
     1141 cagcaggctc tgctgtttct agtgaccctg agatgtaaac agcaagtggg ggctgaggca
     1201 gaggcaggga tagctgggtg gtgacctctt agcgggtgga tttccctgac ccaattcaga
     1261 gattctttat gcaaaagtga gttcagtcca tctctataat aaaatattca tcgtcataaa
//
