LOCUS       NM_001007271             567 bp    mRNA    linear   PRI 14-JUN-2024
DEFINITION  Homo sapiens dual specificity phosphatase 13A (DUSP13A), mRNA.
ACCESSION   NM_001007271
VERSION     NM_001007271.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 567)
  AUTHORS   Wei,C.H., Min,H.G., Kim,M., Kim,G.H., Chun,H.J. and Ryu,S.E.
  TITLE     Two intermediate states of the conformational switch in dual
            specificity phosphatase 13a
  JOURNAL   Pharmacol Res 128, 211-219 (2018)
   PUBMED   29106959
REFERENCE   2  (bases 1 to 567)
  AUTHORS   Jeong,D.G., Wei,C.H., Ku,B., Jeon,T.J., Chien,P.N., Kim,J.K.,
            Park,S.Y., Hwang,H.S., Ryu,S.Y., Park,H., Kim,D.S., Kim,S.J. and
            Ryu,S.E.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   3  (bases 1 to 567)
  AUTHORS   Park,J.E., Park,B.C., Kim,H.A., Song,M., Park,S.G., Lee,D.H.,
            Kim,H.J., Choi,H.K., Kim,J.T. and Cho,S.
  TITLE     Positive regulation of apoptosis signal-regulating kinase 1 by
            dual-specificity phosphatase 13A
  JOURNAL   Cell Mol Life Sci 67 (15), 2619-2629 (2010)
   PUBMED   20358250
REFERENCE   4  (bases 1 to 567)
  AUTHORS   Chen,H.H., Luche,R., Wei,B. and Tonks,N.K.
  TITLE     Characterization of two distinct dual specificity phosphatases
            encoded in alternative open reading frames of a single gene located
            on human chromosome 10q22.2
  JOURNAL   J Biol Chem 279 (40), 41404-41413 (2004)
   PUBMED   15252030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL392111.12.
            
            On Mar 7, 2023 this sequence version replaced NM_001007271.2.
            
            Summary: Members of the protein-tyrosine phosphatase superfamily
            cooperate with protein kinases to regulate cell proliferation and
            differentiation. This gene encodes a dual specificity phosphatase
            that acts on both phosphotyrosine and phosphoserine/threonine
            residues. The encoded protein is expressed in skeletal muscle.
            [provided by RefSeq, Mar 2023].
            
            CCDS Note: This CCDS representation is supported by the mRNAs
            AY674051.1 and AY040091.1. The transcript is a candidate for
            nonsense-mediated mRNA decay (NMD); however, the protein is
            represented based on demonstration of the endogenous protein in
            mouse tissues in PMID:15252030, and because there are no non-NMD
            transcripts that can encode this protein in either human and mouse.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000713560.1/ ENSP00000518853.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AL392111.12        39894-40042         c
            150-367             AL392111.12        38877-39094         c
            368-567             AL392111.12        36554-36753         c
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..567
                     /gene="DUSP13A"
                     /gene_synonym="BEDP; DUSP13; MDSP"
                     /note="dual specificity phosphatase 13A"
                     /db_xref="GeneID:128854680"
                     /db_xref="HGNC:HGNC:56772"
     CDS             1..567
                     /gene="DUSP13A"
                     /gene_synonym="BEDP; DUSP13; MDSP"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="muscle-restricted DSP; branching-enzyme interacting
                     DSP; dual specificity protein phosphatase 13;
                     branching-enzyme interacting dual specificity phosphatase;
                     muscle-restricted dual specificity phosphatase"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 13A"
                     /protein_id="NP_001007272.1"
                     /db_xref="CCDS:CCDS53542.1"
                     /db_xref="GeneID:128854680"
                     /db_xref="HGNC:HGNC:56772"
                     /translation="MAETSLPELGGEDKATPCPSILELEELLRAGKSSCSRVDEVWPN
                     LFIGDAATANNRFELWKLGITHVLNAAHKGLYCQGGPDFYGSSVSYLGVPAHDLPDFD
                     ISAYFSSAADFIHRALNTPGAKVLVHCVVGVSRSATLVLAYLMLHQRLSLRQAVITVR
                     QHRWVFPNRGFLHQLCRLDQQLRGAGQS"
     exon            1..149
                     /gene="DUSP13A"
                     /gene_synonym="BEDP; DUSP13; MDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            150..367
                     /gene="DUSP13A"
                     /gene_synonym="BEDP; DUSP13; MDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            368..567
                     /gene="DUSP13A"
                     /gene_synonym="BEDP; DUSP13; MDSP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctgaga cctctctccc agagctgggg ggagaggaca aagccacgcc ttgccccagc
       61 atcctggagc tggaggagct cctgcgggca gggaagtctt cttgcagccg tgtggacgaa
      121 gtttggccca accttttcat aggagatgcg gccacggcaa acaaccgctt tgagctgtgg
      181 aagctgggca tcacccacgt gctgaacgcc gcccacaagg gcctctactg tcagggcggc
      241 cctgacttct acggcagcag tgtgagctac ctgggggtgc cagcccacga cctccctgat
      301 tttgacatca gtgcctactt ctcctctgcg gctgacttca tccaccgtgc cctcaacacg
      361 cctggggcca aggtcctggt gcactgtgtg gtgggcgtga gccgctctgc cacgctggtc
      421 ctggcctacc tcatgctgca ccagcggctg tccctgcgcc aggcggtgat caccgtgagg
      481 cagcaccgat gggtcttccc caaccgaggc ttcctgcacc agctctgcag gctggaccag
      541 caactgcggg gtgccggcca gagctga
//
