LOCUS       NM_007240               1330 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens dual specificity phosphatase 12 (DUSP12), mRNA.
ACCESSION   NM_007240
VERSION     NM_007240.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1330)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1330)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1330)
  AUTHORS   Monteiro,L.F. and Forti,F.L.
  TITLE     Network analysis of DUSP12 partners in the nucleus under genotoxic
            stress
  JOURNAL   J Proteomics 197, 42-52 (2019)
   PUBMED   30779967
  REMARK    GeneRIF: Network analysis of DUSP12 partners in the nucleus under
            genotoxic stress.
REFERENCE   4  (bases 1 to 1330)
  AUTHORS   Geng,Q., Xhabija,B., Knuckle,C., Bonham,C.A. and Vacratsis,P.O.
  TITLE     The Atypical Dual Specificity Phosphatase hYVH1 Associates with
            Multiple Ribonucleoprotein Particles
  JOURNAL   J Biol Chem 292 (2), 539-550 (2017)
   PUBMED   27856639
  REMARK    GeneRIF: These results propagate a role for dual specificity
            phosphatases at RNP particles and suggest that hYVH1 may affect a
            variety of fundamental cellular processes by regulating messenger
            ribonucleoprotein (mRNP) dynamics.
REFERENCE   5  (bases 1 to 1330)
  AUTHORS   Li,W.M., Zhao,Y.F., Zhu,G.F., Peng,W.H., Zhu,M.Y., Yu,X.J.,
            Chen,W., Xu,D.C. and Xu,Y.W.
  TITLE     Dual specific phosphatase 12 ameliorates cardiac hypertrophy in
            response to pressure overload
  JOURNAL   Clin Sci (Lond) 131 (2), 141-154 (2017)
   PUBMED   27702885
  REMARK    GeneRIF: A significant decrease in DUSP12 expression in
            hypertrophic hearts and cardiomyocytes.
REFERENCE   6  (bases 1 to 1330)
  AUTHORS   Sharda,P.R., Bonham,C.A., Mucaki,E.J., Butt,Z. and Vacratsis,P.O.
  TITLE     The dual-specificity phosphatase hYVH1 interacts with Hsp70 and
            prevents heat-shock-induced cell death
  JOURNAL   Biochem J 418 (2), 391-401 (2009)
   PUBMED   18973475
  REMARK    GeneRIF: hYVH1 is a novel cell survival phosphatase that
            co-operates with Hsp70 to positively affect cell viability in
            response to cellular insults.
REFERENCE   7  (bases 1 to 1330)
  AUTHORS   Hasstedt,S.J., Chu,W.S., Das,S.K., Wang,H. and Elbein,S.C.
  TITLE     Type 2 diabetes susceptibility genes on chromosome 1q21-24
  JOURNAL   Ann Hum Genet 72 (Pt 2), 163-169 (2008)
   PUBMED   18269685
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 1330)
  AUTHORS   Das,S.K., Chu,W.S., Hale,T.C., Wang,X., Craig,R.L., Wang,H.,
            Shuldiner,A.R., Froguel,P., Deloukas,P., McCarthy,M.I., Zeggini,E.,
            Hasstedt,S.J. and Elbein,S.C.
  TITLE     Polymorphisms in the glucokinase-associated, dual-specificity
            phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are
            associated with type 2 diabetes
  JOURNAL   Diabetes 55 (9), 2631-2639 (2006)
   PUBMED   16936214
  REMARK    GeneRIF: Our data suggest that sequences in or upstream of DUSP12
            may contribute to type 2 diabetes susceptibility, but the lack of
            replication suggests a small effect size.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1330)
  AUTHORS   Muda,M., Manning,E.R., Orth,K. and Dixon,J.E.
  TITLE     Identification of the human YVH1 protein-tyrosine phosphatase
            orthologue reveals a novel zinc binding domain essential for in
            vivo function
  JOURNAL   J Biol Chem 274 (34), 23991-23995 (1999)
   PUBMED   10446167
REFERENCE   10 (bases 1 to 1330)
  AUTHORS   Groom,L.A., Sneddon,A.A., Alessi,D.R., Dowd,S. and Keyse,S.M.
  TITLE     Differential regulation of the MAP, SAP and RK/p38 kinases by
            Pyst1, a novel cytosolic dual-specificity phosphatase
  JOURNAL   EMBO J 15 (14), 3621-3632 (1996)
   PUBMED   8670865
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC006286.1, ES309317.1,
            AW511560.1 and AL359541.11.
            
            On May 17, 2019 this sequence version replaced NM_007240.2.
            
            Summary: The protein encoded by this gene is a member of the dual
            specificity protein phosphatase subfamily. These phosphatases
            inactivate their target kinases by dephosphorylating both the
            phosphoserine/threonine and phosphotyrosine residues. They
            negatively regulate members of the mitogen-activated protein (MAP)
            kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated
            with cellular proliferation and differentiation. Different members
            of the family of dual specificity phosphatases show distinct
            substrate specificities for various MAP kinases, different tissue
            distribution and subcellular localization, and different modes of
            inducibility of their expression by extracellular stimuli. This
            gene product is the human ortholog of the Saccharomyces cerevisiae
            YVH1 protein tyrosine phosphatase. It is localized predominantly in
            the nucleus, and is novel in that it contains, and is regulated by
            a zinc finger domain. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.260539.1,
                                           DRR138512.99368.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367943.5/ ENSP00000356920.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               BC006286.1         17-541
            526-526             ES309317.1         560-560
            527-1254            BC006286.1         543-1270
            1255-1256           AW511560.1         10-11               c
            1257-1330           AL359541.11        34926-34999         c
FEATURES             Location/Qualifiers
     source          1..1330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1330
                     /gene="DUSP12"
                     /gene_synonym="DUSP1; YVH1"
                     /note="dual specificity phosphatase 12"
                     /db_xref="GeneID:11266"
                     /db_xref="HGNC:HGNC:3067"
                     /db_xref="MIM:604835"
     exon            1..360
                     /gene="DUSP12"
                     /gene_synonym="DUSP1; YVH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1039
                     /gene="DUSP12"
                     /gene_synonym="DUSP1; YVH1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="serine/threonine specific protein phosphatase; YVH1
                     protein-tyrosine phosphatase ortholog; dual specificity
                     tyrosine phosphatase YVH1"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 12"
                     /protein_id="NP_009171.1"
                     /db_xref="CCDS:CCDS1234.1"
                     /db_xref="GeneID:11266"
                     /db_xref="HGNC:HGNC:3067"
                     /db_xref="MIM:604835"
                     /translation="MLEAPGPSDGCELSNPSASRVSCAGQMLEVQPGLYFGGAAAVAE
                     PDHLREAGITAVLTVDSEEPSFKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIG
                     QARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEW
                     QLKLYQAMGYEVDTSSAIYKQYRLQKVTEKYPELQNLPQELFAVDPTTVSQGLKDEVL
                     YKCRKCRRSLFRSSSILDHREGSGPIAFAHKRMTPSSMLTTGRQAQCTSYFIEPVQWM
                     ESALLGVMDGQLLCPKCSAKLGSFNWYGEQCSCGRWITPAFQIHKNRVDEMKILPVLG
                     SQTGKI"
     exon            361..474
                     /gene="DUSP12"
                     /gene_synonym="DUSP1; YVH1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..593
                     /gene="DUSP12"
                     /gene_synonym="DUSP1; YVH1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..690
                     /gene="DUSP12"
                     /gene_synonym="DUSP1; YVH1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..877
                     /gene="DUSP12"
                     /gene_synonym="DUSP1; YVH1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1330
                     /gene="DUSP12"
                     /gene_synonym="DUSP1; YVH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1233..1238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP12"
                     /gene_synonym="DUSP1; YVH1"
                     /note="hexamer: ATTAAA"
     polyA_site      1254
                     /gene="DUSP12"
                     /gene_synonym="DUSP1; YVH1"
                     /note="major polyA site"
ORIGIN      
        1 gtctctgggc gcggccatgt tggaggctcc gggcccgagt gatggctgcg agctcagcaa
       61 ccccagcgcc agcagagtca gctgtgccgg gcagatgctg gaagtgcagc caggattgta
      121 tttcggtggg gccgcggccg tcgcggagcc agatcacctg agggaagcgg gcatcacggc
      181 cgtgctaaca gtggactcgg aggagcccag cttcaaggcg gggcctgggg tcgaggatct
      241 atggcgcctc ttcgtgccag cgctggacaa acccgagacg gacctactca gccatctgga
      301 ccggtgcgtg gccttcatcg gtcaggcccg cgctgagggc cgtgcggtgt tggtgcactg
      361 tcatgcagga gtcagtcgaa gtgtggccat aataactgct tttctcatga agactgacca
      421 acttcccttt gaaaaagcct atgaaaagct ccagattctc aaaccagagg ctaagatgaa
      481 tgaggggttt gagtggcaac tgaaattata ccaggcaatg ggatacgaag tggatacctc
      541 tagtgcaatt tataagcaat atcgtttaca aaaggttaca gagaagtatc cagaattgca
      601 gaatttacct caagaactct ttgctgttga cccaactacc gtttcacaag gattgaaaga
      661 tgaggttctc tacaagtgta gaaagtgcag gcgatcatta tttcgaagtt ctagtattct
      721 ggatcaccgt gaaggaagtg gacctatagc ctttgcccac aagagaatga caccatcttc
      781 catgcttacc acagggaggc aagctcaatg tacatcttat ttcattgaac ctgtacagtg
      841 gatggaatct gctttgttgg gagtgatgga tggacagctt ctttgcccaa aatgcagtgc
      901 caagttgggt tccttcaact ggtatggtga acagtgctct tgtggtaggt ggataacacc
      961 tgcttttcaa atacataaga atagagtgga tgaaatgaaa atattgcctg ttttgggatc
     1021 acaaacagga aaaatatgaa catgatattt tatagcttgg gaagaaactt gcagatgata
     1081 tgtgctgcct ttgcttctta tcattcatgg cagattgttt gtgctttcaa catttcattt
     1141 gaaatgggag aagataaaat cacttgatgt aacctggaaa ctatgcttta catggcaatc
     1201 aaagcctttt gatcatgtac attttatttg atattaaaat cttttataac cagatactgt
     1261 ctgtgtttca tatattttta aaagttttga ttgttggaat gttatatgat cttaaggtct
     1321 gtatagacaa
//
