LOCUS       NM_007207               2589 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript
            variant 1, mRNA.
ACCESSION   NM_007207 XM_005273025
VERSION     NM_007207.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2589)
  AUTHORS   Xiao,F., Zhu,H., Guo,Y., Zhang,Z., Sun,G., Huang,K., Guo,H. and
            Hu,G.
  TITLE     DUSP10 is a novel immune-related biomarker connected with survival
            and cellular proliferation in lower-grade glioma
  JOURNAL   Aging (Albany NY) 15 (12), 5673-5697 (2023)
   PUBMED   37387540
  REMARK    GeneRIF: DUSP10 is a novel immune-related biomarker connected with
            survival and cellular proliferation in lower-grade glioma.
REFERENCE   2  (bases 1 to 2589)
  AUTHORS   Zhou,W., Xu,Y., Zhang,J., Zhang,P., Yao,Z., Yan,Z., Wang,H.,
            Chu,J., Yao,S., Zhao,S., Yang,S., Guo,Y., Miao,J., Liu,K.,
            Chan,W.C., Xia,Q. and Liu,Y.
  TITLE     MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing
            DNA damage repair in diffuse large B-cell lymphoma
  JOURNAL   Leukemia 36 (7), 1861-1869 (2022)
   PUBMED   35488020
  REMARK    GeneRIF: MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by
            enhancing DNA damage repair in diffuse large B-cell lymphoma.
REFERENCE   3  (bases 1 to 2589)
  AUTHORS   Foray,A.P., Candon,S., Hildebrand,S., Marquet,C., Valette,F.,
            Pecquet,C., Lemoine,S., Langa-Vives,F., Dumas,M., Hu,P.,
            Santamaria,P., You,S., Lyon,S., Scott,L., Bu,C.H., Wang,T., Xu,D.,
            Moresco,E.M.Y., Scazzocchio,C., Bach,J.F., Beutler,B. and
            Chatenoud,L.
  TITLE     De novo germline mutation in the dual specificity phosphatase 10
            gene accelerates autoimmune diabetes
  JOURNAL   Proc Natl Acad Sci U S A 118 (47) (2021)
   PUBMED   34782469
  REMARK    GeneRIF: De novo germline mutation in the dual specificity
            phosphatase 10 gene accelerates autoimmune diabetes.
REFERENCE   4  (bases 1 to 2589)
  AUTHORS   Liu,M., Qin,Y., Hu,Q., Liu,W., Ji,S., Xu,W., Fan,G., Ye,Z.,
            Zhang,Z., Xu,X., Yu,X. and Zhuo,Q.
  TITLE     SETD8 potentiates constitutive ERK1/2 activation via epigenetically
            silencing DUSP10 expression in pancreatic cancer
  JOURNAL   Cancer Lett 499, 265-278 (2021)
   PUBMED   33232789
  REMARK    GeneRIF: SETD8 potentiates constitutive ERK1/2 activation via
            epigenetically silencing DUSP10 expression in pancreatic cancer.
REFERENCE   5  (bases 1 to 2589)
  AUTHORS   Gannam,Z.T.K., Min,K., Shillingford,S.R., Zhang,L., Herrington,J.,
            Abriola,L., Gareiss,P.C., Pantouris,G., Tzouvelekis,A.,
            Kaminski,N., Zhang,X., Yu,J., Jamali,H., Ellman,J.A., Lolis,E.,
            Anderson,K.S. and Bennett,A.M.
  TITLE     An allosteric site on MKP5 reveals a strategy for small-molecule
            inhibition
  JOURNAL   Sci Signal 13 (646) (2020)
   PUBMED   32843541
  REMARK    GeneRIF: An allosteric site on MKP5 reveals a strategy for
            small-molecule inhibition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2589)
  AUTHORS   Masuda,K., Shima,H., Kikuchi,K., Watanabe,Y. and Matsuda,Y.
  TITLE     Expression and comparative chromosomal mapping of MKP-5 genes
            DUSP10/Dusp10
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 71-74 (2000)
   PUBMED   11060451
REFERENCE   7  (bases 1 to 2589)
  AUTHORS   Theodosiou,A., Smith,A., Gillieron,C., Arkinstall,S. and
            Ashworth,A.
  TITLE     MKP5, a new member of the MAP kinase phosphatase family, which
            selectively dephosphorylates stress-activated kinases
  JOURNAL   Oncogene 18 (50), 6981-6988 (1999)
   PUBMED   10597297
REFERENCE   8  (bases 1 to 2589)
  AUTHORS   Tanoue,T., Moriguchi,T. and Nishida,E.
  TITLE     Molecular cloning and characterization of a novel dual specificity
            phosphatase, MKP-5
  JOURNAL   J Biol Chem 274 (28), 19949-19956 (1999)
   PUBMED   10391943
REFERENCE   9  (bases 1 to 2589)
  AUTHORS   Claudio,J.O., Liew,C.C., Dempsey,A.A., Cukerman,E., Stewart,A.K.,
            Na,E., Atkins,H.L., Iscove,N.N. and Hawley,R.G.
  TITLE     Identification of sequence-tagged transcripts differentially
            expressed within the human hematopoietic hierarchy
  JOURNAL   Genomics 50 (1), 44-52 (1998)
   PUBMED   9628821
REFERENCE   10 (bases 1 to 2589)
  AUTHORS   Martell,K.J., Angelotti,T. and Ullrich,A.
  TITLE     The 'VH1-like' dual-specificity protein tyrosine phosphatases
  JOURNAL   Mol Cells 8 (1), 2-11 (1998)
   PUBMED   9571625
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG720911.1, BC031405.1,
            BC063826.1 and AI261880.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007207.5.
            
            Summary: Dual specificity protein phosphatases inactivate their
            target kinases by dephosphorylating both the
            phosphoserine/threonine and phosphotyrosine residues. They
            negatively regulate members of the MAP kinase superfamily, which is
            associated with cellular proliferation and differentiation.
            Different members of this family of dual specificity phosphatases
            show distinct substrate specificities for MAP kinases, different
            tissue distribution and subcellular localization, and different
            modes of expression induction by extracellular stimuli. This gene
            product binds to and inactivates p38 and SAPK/JNK. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031405.1, BC063826.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366899.4/ ENSP00000355866.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BG720911.1         93-106
            15-2198             BC031405.1         1-2184
            2199-2530           BC063826.1         2180-2511
            2531-2589           AI261880.1         5-63                c
FEATURES             Location/Qualifiers
     source          1..2589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2589
                     /gene="DUSP10"
                     /gene_synonym="MKP-5; MKP5"
                     /note="dual specificity phosphatase 10"
                     /db_xref="GeneID:11221"
                     /db_xref="HGNC:HGNC:3065"
                     /db_xref="MIM:608867"
     exon            1..109
                     /gene="DUSP10"
                     /gene_synonym="MKP-5; MKP5"
                     /inference="alignment:Splign:2.1.0"
     exon            110..963
                     /gene="DUSP10"
                     /gene_synonym="MKP-5; MKP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1601
                     /gene="DUSP10"
                     /gene_synonym="MKP-5; MKP5"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="dual specificity phosphatase MKP-5;
                     serine/threonine specific protein phosphatase; map kinase
                     phosphatase 5; mitogen-activated protein kinase
                     phosphatase 5"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 10"
                     /protein_id="NP_009138.1"
                     /db_xref="CCDS:CCDS1528.1"
                     /db_xref="GeneID:11221"
                     /db_xref="HGNC:HGNC:3065"
                     /db_xref="MIM:608867"
                     /translation="MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPP
                     VIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTT
                     TTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMT
                     KCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISC
                     REGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSF
                     KQNHENLCDNSLQLQECREVGGGASAASSLLPQPIPTTPDIENAELTPILPFLFLGNE
                     QDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFE
                     FIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLN
                     FMGQLLEFEEDLNNGVTPRILTPKLMGVETVV"
     exon            964..1335
                     /gene="DUSP10"
                     /gene_synonym="MKP-5; MKP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..2589
                     /gene="DUSP10"
                     /gene_synonym="MKP-5; MKP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1848..1853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP10"
                     /gene_synonym="MKP-5; MKP5"
                     /note="hexamer: AATAAA"
     polyA_site      1865
                     /gene="DUSP10"
                     /gene_synonym="MKP-5; MKP5"
                     /note="major polyA site"
     regulatory      2579..2584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP10"
                     /gene_synonym="MKP-5; MKP5"
                     /note="hexamer: AATGAA"
     polyA_site      2589
                     /gene="DUSP10"
                     /gene_synonym="MKP-5; MKP5"
ORIGIN      
        1 aactatgttg ctgctggaga tcaatgaagc cgagtgaatg ggggctgaat gtgcgagtcc
       61 atagctgaag aggagcgcca gatggtggag gaatacactt atttatgaaa ctgtcttgag
      121 ttcttcttga attgccagtt ttcagcctcc tcatgcctcc gtctccttta gacgacaggg
      181 tagtagtggc actatctagg cccgtccgac ctcaggatct caacctttgt ttagactcta
      241 gttaccttgg ctctgccaac ccaggcagta acagccaccc tcctgtcatc gccaccaccg
      301 ttgtgtccct caaggctgcg aatctgacgt atatgccctc atccagcggc tctgcccgct
      361 cgctgaattg tggatgcagc agtgccagct gctgcactgt ggcaacctac gacaaggaca
      421 atcaggccca aacccaagcc attgccgctg gcaccaccac cactgccatc ggaacctcta
      481 ccacctgccc tgctaaccag atggtcaaca ataatgagaa tacaggctct ctaagtccat
      541 caagtggggt gggcagccct gtgtcaggga cccccaagca gctagccagc atcaaaataa
      601 tctaccccaa tgacttggca aagaagatga ccaaatgcag caagagtcac ctgccgagtc
      661 agggccctgt catcattgac tgcaggccct tcatggagta caacaagagt cacatccaag
      721 gagctgtcca cattaactgt gccgataaga tcagccggcg gagactgcag cagggcaaga
      781 tcactgtcct agacttgatt tcctgtaggg aaggcaagga ctctttcaag aggatctttt
      841 ccaaagaaat tatagtttat gatgagaata ccaatgaacc aagccgagtg atgccctccc
      901 agccacttca catagtcctc gagtccctga agagagaagg caaagaacct ctggtgttga
      961 aaggtggact tagtagtttt aagcagaacc atgaaaacct ctgtgacaac tccctccagc
     1021 tccaagagtg ccgggaggtg gggggcggcg catccgcggc ctcgagcttg ctacctcagc
     1081 ccatccccac cacccctgac atcgagaacg ctgagctcac ccccatcttg cccttcctgt
     1141 tccttggcaa tgagcaggat gctcaggacc tggacaccat gcagcggctg aacatcggct
     1201 acgtcatcaa cgtcaccact catcttcccc tctaccacta tgagaaaggc ctgttcaact
     1261 acaagcggct gccagccact gacagcaaca agcagaacct gcggcagtac tttgaagagg
     1321 cttttgagtt cattgaggaa gctcaccagt gtgggaaggg gcttctcatc cactgccagg
     1381 ctggggtgtc ccgctccgcc accatcgtca tcgcttactt gatgaagcac actcggatga
     1441 ccatgactga tgcttataaa tttgtcaaag gcaaacgacc aattatctcc ccaaacctta
     1501 acttcatggg gcagttgcta gagttcgagg aagacctaaa caacggtgtg acaccgagaa
     1561 tccttacacc aaagctgatg ggcgtggaga cggttgtgtg acaatggtct ggatggaaag
     1621 gattgctgct ctccattagg agacaatgag gaaggaggat ggattctggt tttttttctt
     1681 tctttttttt tttgtagttg ggagtaagtt tgtgaatgga aacaaacttg tttaaacact
     1741 ttatttttaa caagtgtaag aagactataa cttttgatgc cattgagatt cacctcccac
     1801 aaactgacaa attaaggagg ttaaagaagt aattttttta agccaacaat aaaaatataa
     1861 tacaacttgt ttctccccct tttcctttta agctatttgt agagtttatg actaaatagt
     1921 ctgtgcaggt tcatagaccg aagatactac acactttaaa ccaattaaaa agaaccaaaa
     1981 gtaaatagaa aagacattga atcaccaagg cctgggatca acctgggctg tccacacaga
     2041 aaacaaaaac ccaaccaaac caagccctgt tgtgctcact ggtgcaaaga gaagatcagg
     2101 gcagcttaag tggtctaaga atccttcagg cattctttaa ggagaaaaag gatacctttg
     2161 attttgtgtg tttcatgctc tggatttttt ttttttttcc ttctctgggt ttaagagatt
     2221 ttttttgaaa tagtgaggaa ctgaccatta tatgccttca ctggcttctt gtgcaataat
     2281 atgatgtttt aagtgtgcaa acaagttaga gctggcagct gaatgataga caaatagtgc
     2341 aaatttgcca gcttggagat agaaaggaat tcaacaatat atcaaatact ttccttccca
     2401 cctttttcct tttttttttt tttttctgat ttgattctgg ttacagtgcc ataaaccttg
     2461 ttacatatgt atatcagaat gtaagaaaaa aaaatttatt taaaaatatt tttcgcaaaa
     2521 aaaaaaaaaa tcttggtgtg tttctgttga ttgtgtaaaa atttattttc attatataaa
     2581 tgaaactgg
//
