LOCUS       NM_004417               2013 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens dual specificity phosphatase 1 (DUSP1), mRNA.
ACCESSION   NM_004417
VERSION     NM_004417.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Wang,J., Jia,Q., Sun,J., Wu,S., Wei,L. and Yao,W.
  TITLE     Arntl-induced upregulation of DUSP1 inhibits tumor progression in
            esophageal squamous cell carcinoma by inactivating ERK signaling
  JOURNAL   Cancer Biol Ther 25 (1), 2408042 (2024)
   PUBMED   39341782
  REMARK    GeneRIF: Arntl-induced upregulation of DUSP1 inhibits tumor
            progression in esophageal squamous cell carcinoma by inactivating
            ERK signaling.
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Gao,J., Wang,Z., Lin,S., Tian,Y., Wu,H., Li,Z. and Liu,F.
  TITLE     CCR7/DUSP1 signaling Axis mediates iCAF to regulates head and neck
            squamous cell carcinoma growth
  JOURNAL   Cell Signal 122, 111305 (2024)
   PUBMED   39067836
  REMARK    GeneRIF: CCR7/DUSP1 signaling Axis mediates iCAF to regulates head
            and neck squamous cell carcinoma growth.
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Liang,Z.Q., Zhang,W., Zeng,D.T., Chen,J.H., Luo,J.Y., Shi,L.,
            Wei,K.L. and Chen,G.
  TITLE     Upregulation of hsa-miR-141-3p promotes uterine cervical carcinoma
            progression via targeting dual-specificity protein phosphatase 1
  JOURNAL   Funct Integr Genomics 24 (4), 137 (2024)
   PUBMED   39138666
  REMARK    GeneRIF: Upregulation of hsa-miR-141-3p promotes uterine cervical
            carcinoma progression via targeting dual-specificity protein
            phosphatase 1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2013)
  AUTHORS   Acero-Riaguas,L., Griso-Acevedo,A.B., SanLorenzo-Vaquero,A.,
            Ibanez-Herrera,B., Fernandez-Diaz,S.M., Mascaraque,M.,
            Sanchez-Siles,R., Lopez-Garcia,I., Benitez-Buelga,C.,
            Bravo-Burguillos,E.R., Castelo,B., Cebrian-Carretero,J.L.,
            Perona,R., Sastre,L. and Sastre-Perona,A.
  TITLE     DUSP1 and SOX2 expression determine squamous cell carcinoma of the
            salivary gland progression
  JOURNAL   Sci Rep 14 (1), 15007 (2024)
   PUBMED   38951654
  REMARK    GeneRIF: DUSP1 and SOX2 expression determine squamous cell
            carcinoma of the salivary gland progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2013)
  AUTHORS   Kesarwani,M., Kincaid,Z., Azhar,M. and Azam,M.
  TITLE     Enhanced MAPK signaling induced by CSF3R mutants confers dependence
            to DUSP1 for leukemic transformation
  JOURNAL   Blood Adv 8 (11), 2765-2776 (2024)
   PUBMED   38531054
  REMARK    GeneRIF: Enhanced MAPK signaling induced by CSF3R mutants confers
            dependence to DUSP1 for leukemic transformation.
REFERENCE   6  (bases 1 to 2013)
  AUTHORS   Lewis,T., Groom,L.A., Sneddon,A.A., Smythe,C. and Keyse,S.M.
  TITLE     XCL100, an inducible nuclear MAP kinase phosphatase from Xenopus
            laevis: its role in MAP kinase inactivation in differentiated cells
            and its expression during early development
  JOURNAL   J Cell Sci 108 (Pt 8), 2885-2896 (1995)
   PUBMED   7593328
REFERENCE   7  (bases 1 to 2013)
  AUTHORS   Raingeaud,J., Gupta,S., Rogers,J.S., Dickens,M., Han,J.,
            Ulevitch,R.J. and Davis,R.J.
  TITLE     Pro-inflammatory cytokines and environmental stress cause p38
            mitogen-activated protein kinase activation by dual phosphorylation
            on tyrosine and threonine
  JOURNAL   J Biol Chem 270 (13), 7420-7426 (1995)
   PUBMED   7535770
REFERENCE   8  (bases 1 to 2013)
  AUTHORS   Martell,K.J., Kwak,S., Hakes,D.J., Dixon,J.E. and Trent,J.M.
  TITLE     Chromosomal localization of four human VH1-like protein-tyrosine
            phosphatases
  JOURNAL   Genomics 22 (2), 462-464 (1994)
   PUBMED   7806236
REFERENCE   9  (bases 1 to 2013)
  AUTHORS   Kwak,S.P., Hakes,D.J., Martell,K.J. and Dixon,J.E.
  TITLE     Isolation and characterization of a human dual specificity
            protein-tyrosine phosphatase gene
  JOURNAL   J Biol Chem 269 (5), 3596-3604 (1994)
   PUBMED   8106404
REFERENCE   10 (bases 1 to 2013)
  AUTHORS   Keyse,S.M. and Emslie,E.A.
  TITLE     Oxidative stress and heat shock induce a human gene encoding a
            protein-tyrosine phosphatase
  JOURNAL   Nature 359 (6396), 644-647 (1992)
   PUBMED   1406996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022463.1 and AK300487.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004417.3.
            
            Summary: The protein encoded by this gene is a phosphatase with
            dual specificity for tyrosine and threonine. The encoded protein
            can dephosphorylate MAP kinase MAPK1/ERK2, which results in its
            involvement in several cellular processes. This protein appears to
            play an important role in the human cellular response to
            environmental stress as well as in the negative regulation of
            cellular proliferation. Finally, the encoded protein can make some
            solid tumors resistant to both chemotherapy and radiotherapy,
            making it a target for cancer therapy. [provided by RefSeq, Aug
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022463.1, X68277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239223.4/ ENSP00000239223.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-842               BC022463.1         1-842
            843-1881            AK300487.1         762-1800
            1882-2013           BC022463.1         1882-2013
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..2013
                     /gene="DUSP1"
                     /gene_synonym="CL100; HVH1; MKP-1; MKP1; PTPN10"
                     /note="dual specificity phosphatase 1"
                     /db_xref="GeneID:1843"
                     /db_xref="HGNC:HGNC:3064"
                     /db_xref="MIM:600714"
     exon            1..610
                     /gene="DUSP1"
                     /gene_synonym="CL100; HVH1; MKP-1; MKP1; PTPN10"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1347
                     /gene="DUSP1"
                     /gene_synonym="CL100; HVH1; MKP-1; MKP1; PTPN10"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="serine/threonine specific protein phosphatase; MAP
                     kinase phosphatase 1; protein-tyrosine phosphatase CL100;
                     dual specificity protein phosphatase hVH1;
                     mitogen-activated protein kinase phosphatase 1; CL 100"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 1"
                     /protein_id="NP_004408.1"
                     /db_xref="CCDS:CCDS4380.1"
                     /db_xref="GeneID:1843"
                     /db_xref="HGNC:HGNC:3064"
                     /db_xref="MIM:600714"
                     /translation="MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSV
                     NVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTL
                     ALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESG
                     CSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHY
                     QYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRT
                     NRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTS
                     TTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC"
     exon            611..756
                     /gene="DUSP1"
                     /gene_synonym="CL100; HVH1; MKP-1; MKP1; PTPN10"
                     /inference="alignment:Splign:2.1.0"
     exon            757..976
                     /gene="DUSP1"
                     /gene_synonym="CL100; HVH1; MKP-1; MKP1; PTPN10"
                     /inference="alignment:Splign:2.1.0"
     exon            977..2013
                     /gene="DUSP1"
                     /gene_synonym="CL100; HVH1; MKP-1; MKP1; PTPN10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1988..1993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP1"
                     /gene_synonym="CL100; HVH1; MKP-1; MKP1; PTPN10"
                     /note="hexamer: AATAAA"
     polyA_site      2013
                     /gene="DUSP1"
                     /gene_synonym="CL100; HVH1; MKP-1; MKP1; PTPN10"
                     /note="major polyA site"
ORIGIN      
        1 gcgaaggaca tttgggctgt gtgtgcgacg cgggtcggag gggcagtcgg gggaaccgcg
       61 aagaagccga ggagcccgga gccccgcgtg acgctcctct ctcagtccaa aagcggcttt
      121 tggttcggcg cagagagacc cgggggtcta gcttttcctc gaaaagcgcc gccctgccct
      181 tggccccgag aacagacaaa gagcaccgca gggccgatca cgctgggggc gctgaggccg
      241 gccatggtca tggaagtggg caccctggac gctggaggcc tgcgggcgct gctgggggag
      301 cgagcggcgc aatgcctgct gctggactgc cgctccttct tcgctttcaa cgccggccac
      361 atcgccggct ctgtcaacgt gcgcttcagc accatcgtgc ggcgccgggc caagggcgcc
      421 atgggcctgg agcacatcgt gcccaacgcc gagctccgcg gccgcctgct ggccggcgcc
      481 taccacgccg tggtgttgct ggacgagcgc agcgccgccc tggacggcgc caagcgcgac
      541 ggcaccctgg ccctggcggc cggcgcgctc tgccgcgagg cgcgcgccgc gcaagtcttc
      601 ttcctcaaag gaggatacga agcgttttcg gcttcctgcc cggagctgtg cagcaaacag
      661 tcgaccccca tggggctcag ccttcccctg agtactagcg tccctgacag cgcggaatct
      721 gggtgcagtt cctgcagtac cccactctac gatcagggtg gcccggtgga aatcctgccc
      781 tttctgtacc tgggcagtgc gtatcacgct tcccgcaagg acatgctgga tgccttgggc
      841 atcactgcct tgatcaacgt ctcagccaat tgtcccaacc attttgaggg tcactaccag
      901 tacaagagca tccctgtgga ggacaaccac aaggcagaca tcagctcctg gttcaacgag
      961 gccattgact tcatagactc catcaagaat gctggaggaa gggtgtttgt ccactgccag
     1021 gcaggcattt cccggtcagc caccatctgc cttgcttacc ttatgaggac taatcgagtc
     1081 aagctggacg aggcctttga gtttgtgaag cagaggcgaa gcatcatctc tcccaacttc
     1141 agcttcatgg gccagctgct gcagtttgag tcccaggtgc tggctccgca ctgttcggca
     1201 gaggctggga gccccgccat ggctgtgctc gaccgaggca cctccaccac caccgtgttc
     1261 aacttccccg tctccatccc tgtccactcc acgaacagtg cgctgagcta ccttcagagc
     1321 cccattacga cctctcccag ctgctgaaag gccacgggag gtgaggctct tcacatccca
     1381 ttgggactcc atgctccttg agaggagaaa tgcaataact ctgggagggg ctcgagaggg
     1441 ctggtcctta tttatttaac ttcacccgag ttcctctggg tttctaagca gttatggtga
     1501 tgacttagcg tcaagacatt tgctgaactc agcacattcg ggaccaatat atagtgggta
     1561 catcaagtcc atctgacaaa atggggcaga agagaaagga ctcagtgtgt gatccggttt
     1621 ctttttgctc gcccctgttt tttgtagaat ctcttcatgc ttgacatacc taccagtatt
     1681 attcccgacg acacatatac atatgagaat ataccttatt tatttttgtg taggtgtctg
     1741 ccttcacaaa tgtcattgtc tactcctaga agaaccaaat acctcaattt ttgtttttga
     1801 gtactgtact atcctgtaaa tatatcttaa gcaggtttgt tttcagcact gatggaaaat
     1861 accagtgttg ggtttttttt tagttgccaa cagttgtatg tttgctgatt atttatgacc
     1921 tgaaataata tatttcttct tctaagaaga cattttgtta cataaggatg acttttttat
     1981 acaatggaat aaattatggc atttctattg aaa
//
