LOCUS       NM_181581               2266 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens dihydrouridine synthase 4 like (DUS4L), transcript
            variant 1, mRNA.
ACCESSION   NM_181581 NM_007016
VERSION     NM_181581.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2266)
  AUTHORS   Li,Z., Zhao,P.L., Gao,X., Li,X., Meng,Y.Q., Li,Z.Q., Zhai,K.R.,
            Wei,S.L., Feng,H.M., Huang,H.R. and Li,B.
  TITLE     DUS4L suppresses invasion and metastasis in LUAD via modulation of
            PI3K/AKT and ERK/MAPK signaling through GRB2
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113043 (2024)
   PUBMED   39216120
  REMARK    GeneRIF: DUS4L suppresses invasion and metastasis in LUAD via
            modulation of PI3K/AKT and ERK/MAPK signaling through GRB2.
REFERENCE   2  (bases 1 to 2266)
  AUTHORS   Finet,O., Yague-Sanz,C., Kruger,L.K., Tran,P., Migeot,V.,
            Louski,M., Nevers,A., Rougemaille,M., Sun,J., Ernst,F.G.M.,
            Wacheul,L., Wery,M., Morillon,A., Dedon,P., Lafontaine,D.L.J. and
            Hermand,D.
  TITLE     Transcription-wide mapping of dihydrouridine reveals that mRNA
            dihydrouridylation is required for meiotic chromosome segregation
  JOURNAL   Mol Cell 82 (2), 404-419 (2022)
   PUBMED   34798057
REFERENCE   3  (bases 1 to 2266)
  AUTHORS   Tang,Y., Qin,F., Liu,A. and Li,H.
  TITLE     Recurrent fusion RNA DUS4L-BCAP29 in non-cancer human tissues and
            cells
  JOURNAL   Oncotarget 8 (19), 31415-31423 (2017)
   PUBMED   28415823
  REMARK    GeneRIF: we believe that in contrast to traditional gene fusions,
            DUS4L-BCAP29 cannot be used as a cancer biomarker. Instead, it is a
            fusion transcript that exists in normal physiology and that its
            pro-growth effect is not unique to cancer cells.
REFERENCE   4  (bases 1 to 2266)
  AUTHORS   Evangelou,E., Valdes,A.M., Kerkhof,H.J., Styrkarsdottir,U., Zhu,Y.,
            Meulenbelt,I., Lories,R.J., Karassa,F.B., Tylzanowski,P., Bos,S.D.,
            Akune,T., Arden,N.K., Carr,A., Chapman,K., Cupples,L.A., Dai,J.,
            Deloukas,P., Doherty,M., Doherty,S., Engstrom,G., Gonzalez,A.,
            Halldorsson,B.V., Hammond,C.L., Hart,D.J., Helgadottir,H.,
            Hofman,A., Ikegawa,S., Ingvarsson,T., Jiang,Q., Jonsson,H.,
            Kaprio,J., Kawaguchi,H., Kisand,K., Kloppenburg,M., Kujala,U.M.,
            Lohmander,L.S., Loughlin,J., Luyten,F.P., Mabuchi,A., McCaskie,A.,
            Nakajima,M., Nilsson,P.M., Nishida,N., Ollier,W.E.,
            Panoutsopoulou,K., van de Putte,T., Ralston,S.H., Rivadeneira,F.,
            Saarela,J., Schulte-Merker,S., Shi,D., Slagboom,P.E., Sudo,A.,
            Tamm,A., Tamm,A., Thorleifsson,G., Thorsteinsdottir,U., Tsezou,A.,
            Wallis,G.A., Wilkinson,J.M., Yoshimura,N., Zeggini,E., Zhai,G.,
            Zhang,F., Jonsdottir,I., Uitterlinden,A.G., Felson,D.T., van
            Meurs,J.B., Stefansson,K., Ioannidis,J.P. and Spector,T.D.
  CONSRTM   arcOGEN Consortium; Translation Research in Europe Applied
            Technologies for Osteoarthritis (TreatOA)
  TITLE     Meta-analysis of genome-wide association studies confirms a
            susceptibility locus for knee osteoarthritis on chromosome 7q22
  JOURNAL   Ann Rheum Dis 70 (2), 349-355 (2011)
   PUBMED   21068099
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   5  (bases 1 to 2266)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA133130.1, U62767.1, BX357552.2, BU621752.1 and AA157330.1.
            
            On Nov 22, 2018 this sequence version replaced NM_181581.2.
            
            Transcript Variant: This variant (1) is protein-coding. Variants 1
            and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.158718.1,
                                           SRR1660805.134938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265720.8/ ENSP00000265720.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               DA133130.1         14-410
            398-832             U62767.1           210-644
            833-1551            BX357552.2         162-880
            1552-2163           BU621752.1         16-627              c
            2164-2266           AA157330.1         65-167
FEATURES             Location/Qualifiers
     source          1..2266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..2266
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="dihydrouridine synthase 4 like"
                     /db_xref="GeneID:11062"
                     /db_xref="HGNC:HGNC:21517"
     exon            1..239
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            240..328
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            329..465
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..1303
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /EC_number="1.3.1.90"
                     /note="protein similar to E.coli yhdg and R. capsulatus
                     nifR3"
                     /codon_start=1
                     /product="tRNA-dihydrouridine(20a/20b) synthase
                     [NAD(P)+]-like"
                     /protein_id="NP_853559.1"
                     /db_xref="CCDS:CCDS5745.1"
                     /db_xref="GeneID:11062"
                     /db_xref="HGNC:HGNC:21517"
                     /translation="MKSDCMQTTICQERKKDPIEMFHSGQLVKVCAPMVRYSKLAFRT
                     LVRKYSCDLCYTPMIVAADFVKSIKARDSEFTTNQGDCPLIVQFAANDARLLSDAARI
                     VCPYANGIDINCGCPQRWAMAEGYGACLINKPELVQDMVKQVRNQVETPGFSVSIKIR
                     IHDDLKRTVDLCQKAEATGVSWITVHGRTAEERHQPVHYDSIKIIKENMSIPVIANGD
                     IRSLKEAENVWRITGTDGVMVARGLLANPAMFAGYEETPLKCIWDWVDIALELGTPYM
                     CFHQHLMYMMEKITSRQEKRVFNALSSTSAIIDYLTDHYGI"
     exon            466..587
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            588..705
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            706..828
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1055
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..2266
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1646..1651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="hexamer: AATAAA"
     polyA_site      1667
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="major polyA site"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="hexamer: AATAAA"
     polyA_site      2163
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="major polyA site"
     regulatory      2246..2251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="hexamer: AATGAA"
     polyA_site      2266
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
ORIGIN      
        1 gcccgcccac ccagcccatg gctccaggcc cacctggcga actgactctc agcccgcgcc
       61 tgggctaagc ctggctagga gccgcgcagg tactcgagca gtgggcgccc agggtccgag
      121 tgctctgcgc ccagcgcacc gagggagcca aggccgtcgg gccggcgctt tcagctgtct
      181 ctcgcagcag ctcagggccg cgccccctgg gctggcgtcg tgccctagcc aaggagaagt
      241 ttcagtcacg tgccagactt tttcttaatt acaaactgat agatggtcca catctcaact
      301 aacagtattg acgctgtaag agcatcagat ttgaaacata tctgtattaa tgaagagtga
      361 ctgcatgcaa acgacaatat gtcaggaaag aaaaaaagat cccatagaaa tgtttcattc
      421 tggacagctg gtaaaagtct gtgccccaat ggttcgatat tcaaagttgg cttttaggac
      481 actagtaaga aaatatagtt gtgatctgtg ttacacacca atgattgttg ccgctgattt
      541 tgtcaaatct ataaaagcca gagacagcga atttaccaca aatcaaggtg attgcccatt
      601 gattgttcag tttgctgcta acgatgcaag acttttatct gatgctgctc gtatagtctg
      661 tccttatgcg aatggaatag acattaactg tggttgccct cagaggtggg caatggcaga
      721 aggttatggg gcttgcttaa taaacaagcc agagcttgtt caagacatgg tgaaacaagt
      781 aagaaatcaa gtggaaaccc ctggattttc agtttctatt aaaataagga tccatgatga
      841 ccttaaaaga actgtagatc tttgtcaaaa ggctgaagca acaggagttt catggattac
      901 agtccatgga agaactgctg aagaaagaca tcagccagtg cactatgatt ccattaaaat
      961 aattaaggaa aatatgtcta tacctgtaat tgctaatgga gacatcagaa gcttaaagga
     1021 agcagaaaat gtgtggcgga ttactgggac agatggtgtg atggttgcaa gaggactctt
     1081 agcaaacccg gccatgtttg ctggatatga ggaaacccca ctgaaatgca tctgggactg
     1141 ggttgacatt gctcttgaac tcgggactcc ttacatgtgt ttccatcaac atttaatgta
     1201 catgatggaa aagataactt caaggcagga aaaaagggta tttaatgctc tgtcaagcac
     1261 atcagcaatc atagattacc ttacagacca ttatggcatt tgactagact tcccaaataa
     1321 ttttaatata tacttttaga cccacagtga aaccacagaa ggtcatattt tgtaccttaa
     1381 accagtagct ctcaaatttt agtataaaaa caattcctgg gagcgttttt taaaaatcag
     1441 ttgtagacac caccctcaga gattctgatt aggtagatct ggagtagacc cagaaataca
     1501 cagtttaaag aaaactccca gtggttcaaa catcctgatc atcctaggca aacattgaca
     1561 aatactgctc tgaatcctgt tctatagata ttggggggat gggtagagtg ggaatttttt
     1621 cctaatcatg tttttaacat tttaaaataa aatttaatac taagaaatta tggcttatag
     1681 tatctataaa ttaacaagaa gtatgcaggt gcaaaaaagt ggtggaacaa ataccaacat
     1741 ccatccaaaa tgaaaaagaa caggaaattc tgaatagaat tgcactcaga acttatatta
     1801 aaaattccat ttggttaatg acattaaatt tggtacattt caaaacttct aggtcctcca
     1861 aagattgaaa gcttaataat ctcctaccta aaaagataaa attaattgca atctaccata
     1921 tcttaagtat aggaaatttg gtgtccaacc tggagatgat tatatatttg aaatatttcc
     1981 tagagaatag taaccaggtt ttgtttttaa ctttaaaacc taattacttt tgtgcctctc
     2041 agccgttgat tgtaacttta aagtcccatg gttttggagt gttattaata gattttgtta
     2101 tcggtgggca tgcactgcaa gaattaagta tctcagactg aaataaaacc gttcataatt
     2161 aaagtattat tttgttttgc caacatgaaa actgttataa ggaaacaatt atgtaaaact
     2221 gtttaattca cgtttgggaa tattgaatga atccatttta acataa
//
