LOCUS       NM_001270419            2116 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens dihydrouridine synthase 4 like (DUS4L), transcript
            variant 2, mRNA.
ACCESSION   NM_001270419
VERSION     NM_001270419.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2116)
  AUTHORS   Li,Z., Zhao,P.L., Gao,X., Li,X., Meng,Y.Q., Li,Z.Q., Zhai,K.R.,
            Wei,S.L., Feng,H.M., Huang,H.R. and Li,B.
  TITLE     DUS4L suppresses invasion and metastasis in LUAD via modulation of
            PI3K/AKT and ERK/MAPK signaling through GRB2
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113043 (2024)
   PUBMED   39216120
  REMARK    GeneRIF: DUS4L suppresses invasion and metastasis in LUAD via
            modulation of PI3K/AKT and ERK/MAPK signaling through GRB2.
REFERENCE   2  (bases 1 to 2116)
  AUTHORS   Finet,O., Yague-Sanz,C., Kruger,L.K., Tran,P., Migeot,V.,
            Louski,M., Nevers,A., Rougemaille,M., Sun,J., Ernst,F.G.M.,
            Wacheul,L., Wery,M., Morillon,A., Dedon,P., Lafontaine,D.L.J. and
            Hermand,D.
  TITLE     Transcription-wide mapping of dihydrouridine reveals that mRNA
            dihydrouridylation is required for meiotic chromosome segregation
  JOURNAL   Mol Cell 82 (2), 404-419 (2022)
   PUBMED   34798057
REFERENCE   3  (bases 1 to 2116)
  AUTHORS   Tang,Y., Qin,F., Liu,A. and Li,H.
  TITLE     Recurrent fusion RNA DUS4L-BCAP29 in non-cancer human tissues and
            cells
  JOURNAL   Oncotarget 8 (19), 31415-31423 (2017)
   PUBMED   28415823
  REMARK    GeneRIF: we believe that in contrast to traditional gene fusions,
            DUS4L-BCAP29 cannot be used as a cancer biomarker. Instead, it is a
            fusion transcript that exists in normal physiology and that its
            pro-growth effect is not unique to cancer cells.
REFERENCE   4  (bases 1 to 2116)
  AUTHORS   Evangelou,E., Valdes,A.M., Kerkhof,H.J., Styrkarsdottir,U., Zhu,Y.,
            Meulenbelt,I., Lories,R.J., Karassa,F.B., Tylzanowski,P., Bos,S.D.,
            Akune,T., Arden,N.K., Carr,A., Chapman,K., Cupples,L.A., Dai,J.,
            Deloukas,P., Doherty,M., Doherty,S., Engstrom,G., Gonzalez,A.,
            Halldorsson,B.V., Hammond,C.L., Hart,D.J., Helgadottir,H.,
            Hofman,A., Ikegawa,S., Ingvarsson,T., Jiang,Q., Jonsson,H.,
            Kaprio,J., Kawaguchi,H., Kisand,K., Kloppenburg,M., Kujala,U.M.,
            Lohmander,L.S., Loughlin,J., Luyten,F.P., Mabuchi,A., McCaskie,A.,
            Nakajima,M., Nilsson,P.M., Nishida,N., Ollier,W.E.,
            Panoutsopoulou,K., van de Putte,T., Ralston,S.H., Rivadeneira,F.,
            Saarela,J., Schulte-Merker,S., Shi,D., Slagboom,P.E., Sudo,A.,
            Tamm,A., Tamm,A., Thorleifsson,G., Thorsteinsdottir,U., Tsezou,A.,
            Wallis,G.A., Wilkinson,J.M., Yoshimura,N., Zeggini,E., Zhai,G.,
            Zhang,F., Jonsdottir,I., Uitterlinden,A.G., Felson,D.T., van
            Meurs,J.B., Stefansson,K., Ioannidis,J.P. and Spector,T.D.
  CONSRTM   arcOGEN Consortium; Translation Research in Europe Applied
            Technologies for Osteoarthritis (TreatOA)
  TITLE     Meta-analysis of genome-wide association studies confirms a
            susceptibility locus for knee osteoarthritis on chromosome 7q22
  JOURNAL   Ann Rheum Dis 70 (2), 349-355 (2011)
   PUBMED   21068099
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   5  (bases 1 to 2116)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB196544.1, BX395100.2, CX787147.1, BC111774.1, BU621752.1 and
            AA157330.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001270419.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.749101.1,
                                           SRR14243140.5860889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                DB196544.1         15-97
            84-412              BX395100.2         57-385
            413-1033            CX787147.1         146-766
            1034-1898           BC111774.1         1416-2280
            1899-2013           BU621752.1         16-130              c
            2014-2116           AA157330.1         65-167
FEATURES             Location/Qualifiers
     source          1..2116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..2116
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="dihydrouridine synthase 4 like"
                     /db_xref="GeneID:11062"
                     /db_xref="HGNC:HGNC:21517"
     exon            1..89
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            90..178
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            179..315
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1153
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /EC_number="1.3.1.90"
                     /note="protein similar to E.coli yhdg and R. capsulatus
                     nifR3"
                     /codon_start=1
                     /product="tRNA-dihydrouridine(20a/20b) synthase
                     [NAD(P)+]-like"
                     /protein_id="NP_001257348.1"
                     /db_xref="CCDS:CCDS5745.1"
                     /db_xref="GeneID:11062"
                     /db_xref="HGNC:HGNC:21517"
                     /translation="MKSDCMQTTICQERKKDPIEMFHSGQLVKVCAPMVRYSKLAFRT
                     LVRKYSCDLCYTPMIVAADFVKSIKARDSEFTTNQGDCPLIVQFAANDARLLSDAARI
                     VCPYANGIDINCGCPQRWAMAEGYGACLINKPELVQDMVKQVRNQVETPGFSVSIKIR
                     IHDDLKRTVDLCQKAEATGVSWITVHGRTAEERHQPVHYDSIKIIKENMSIPVIANGD
                     IRSLKEAENVWRITGTDGVMVARGLLANPAMFAGYEETPLKCIWDWVDIALELGTPYM
                     CFHQHLMYMMEKITSRQEKRVFNALSSTSAIIDYLTDHYGI"
     exon            316..437
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            438..555
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            556..678
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            679..905
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     exon            906..2116
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1496..1501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="hexamer: AATAAA"
     polyA_site      1517
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="major polyA site"
     regulatory      1992..1997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="hexamer: AATAAA"
     polyA_site      2013
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="major polyA site"
     regulatory      2096..2101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
                     /note="hexamer: AATGAA"
     polyA_site      2116
                     /gene="DUS4L"
                     /gene_synonym="DUS4; PP35"
ORIGIN      
        1 gcccgcccac ccagcccatg gctccaggcc cacctggcga actgactctc agcccgcgcc
       61 tgggctaagc ctggctagga gccgcgcagt ttcagtcacg tgccagactt tttcttaatt
      121 acaaactgat agatggtcca catctcaact aacagtattg acgctgtaag agcatcagat
      181 ttgaaacata tctgtattaa tgaagagtga ctgcatgcaa acgacaatat gtcaggaaag
      241 aaaaaaagat cccatagaaa tgtttcattc tggacagctg gtaaaagtct gtgccccaat
      301 ggttcgatat tcaaagttgg cttttaggac actagtaaga aaatatagtt gtgatctgtg
      361 ttacacacca atgattgttg ccgctgattt tgtcaaatct ataaaagcca gagacagcga
      421 atttaccaca aatcaaggtg attgcccatt gattgttcag tttgctgcta acgatgcaag
      481 acttttatct gatgctgctc gtatagtctg tccttatgcg aatggaatag acattaactg
      541 tggttgccct cagaggtggg caatggcaga aggttatggg gcttgcttaa taaacaagcc
      601 agagcttgtt caagacatgg tgaaacaagt aagaaatcaa gtggaaaccc ctggattttc
      661 agtttctatt aaaataagga tccatgatga ccttaaaaga actgtagatc tttgtcaaaa
      721 ggctgaagca acaggagttt catggattac agtccatgga agaactgctg aagaaagaca
      781 tcagccagtg cactatgatt ccattaaaat aattaaggaa aatatgtcta tacctgtaat
      841 tgctaatgga gacatcagaa gcttaaagga agcagaaaat gtgtggcgga ttactgggac
      901 agatggtgtg atggttgcaa gaggactctt agcaaacccg gccatgtttg ctggatatga
      961 ggaaacccca ctgaaatgca tctgggactg ggttgacatt gctcttgaac tcgggactcc
     1021 ttacatgtgt ttccatcaac atttaatgta catgatggaa aagataactt caaggcagga
     1081 aaaaagggta tttaatgctc tgtcaagcac atcagcaatc atagattacc ttacagacca
     1141 ttatggcatt tgactagact tcccaaataa ttttaatata tacttttaga cccacagtga
     1201 aaccacagaa ggtcatattt tgtaccttaa accagtagct ctcaaatttt agtataaaaa
     1261 caattcctgg gagcgttttt taaaaatcag ttgtagacac caccctcaga gattctgatt
     1321 aggtagatct ggagtagacc cagaaataca cagtttaaag aaaactccca gtggttcaaa
     1381 catcctgatc atcctaggca aacattgaca aatactgctc tgaatcctgt tctatagata
     1441 ttggggggat gggtagagtg ggaatttttt cctaatcatg tttttaacat tttaaaataa
     1501 aatttaatac taagaaatta tggcttatag tatctataaa ttaacaagaa gtatgcaggt
     1561 gcaaaaaagt ggtggaacaa ataccaacat ccatccaaaa tgaaaaagaa caggaaattc
     1621 tgaatagaat tgcactcaga acttatatta aaaattccat ttggttaatg acattaaatt
     1681 tggtacattt caaaacttct aggtcctcca aagattgaaa gcttaataat ctcctaccta
     1741 aaaagataaa attaattgca atctaccata tcttaagtat aggaaatttg gtgtccaacc
     1801 tggagatgat tatatatttg aaatatttcc tagagaatag taaccaggtt ttgtttttaa
     1861 ctttaaaacc taattacttt tgtgcctctc agccgttgat tgtaacttta aagtcccatg
     1921 gttttggagt gttattaata gattttgtta tcggtgggca tgcactgcaa gaattaagta
     1981 tctcagactg aaataaaacc gttcataatt aaagtattat tttgttttgc caacatgaaa
     2041 actgttataa ggaaacaatt atgtaaaact gtttaattca cgtttgggaa tattgaatga
     2101 atccatttta acataa
//
