LOCUS       NM_001371364            6828 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens DUS4L-BCAP29 readthrough (DUS4L-BCAP29), transcript
            variant 1, mRNA.
ACCESSION   NM_001371364
VERSION     NM_001371364.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6828)
  AUTHORS   Tang Y, Qin F, Liu A and Li H.
  TITLE     Recurrent fusion RNA DUS4L-BCAP29 in non-cancer human tissues and
            cells
  JOURNAL   Oncotarget 8 (19), 31415-31423 (2017)
   PUBMED   28415823
  REMARK    GeneRIF: we believe that in contrast to traditional gene fusions,
            DUS4L-BCAP29 cannot be used as a cancer biomarker. Instead, it is a
            fusion transcript that exists in normal physiology and that its
            pro-growth effect is not unique to cancer cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002381.1, AC004839.1 and AC078937.1.
            
            On Jul 18, 2019 this sequence version replaced NM_001371364.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring DUS4L (dihydrouridine
            synthase 4 like) and BCAP29 (B cell receptor associated protein 29)
            genes on chromosome 7. The readthrough transcript encodes a fusion
            protein that shares sequence identity with each individual gene
            product. [provided by RefSeq, Jul 2019].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968189,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC002381.1         169469-169707
            240-328             AC002381.1         170086-170174
            329-465             AC004839.1         215-351
            466-587             AC004839.1         4310-4431
            588-705             AC004839.1         6869-6986
            706-828             AC004839.1         8353-8475
            829-1055            AC004839.1         9531-9757
            1056-1161           AC004839.1         13924-14029
            1162-1262           AC004839.1         17047-17147
            1263-1413           AC004839.1         27120-27270
            1414-1549           AC004839.1         29032-29167
            1550-1658           AC004839.1         33562-33670
            1659-1759           AC004839.1         46497-46597
            1760-1838           AC004839.1         46819-46897
            1839-6123           AC004839.1         51493-55777
            6124-6828           AC078937.1         1-705
FEATURES             Location/Qualifiers
     source          1..6828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..6828
                     /gene="DUS4L-BCAP29"
                     /note="DUS4L-BCAP29 readthrough"
                     /db_xref="GeneID:115253422"
                     /db_xref="HGNC:HGNC:54422"
     exon            1..239
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            240..328
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            329..465
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..2116
                     /gene="DUS4L-BCAP29"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="DUS4L-BCAP29 protein isoform a"
                     /protein_id="NP_001358293.1"
                     /db_xref="GeneID:115253422"
                     /db_xref="HGNC:HGNC:54422"
                     /translation="MKSDCMQTTICQERKKDPIEMFHSGQLVKVCAPMVRYSKLAFRT
                     LVRKYSCDLCYTPMIVAADFVKSIKARDSEFTTNQGDCPLIVQFAANDARLLSDAARI
                     VCPYANGIDINCGCPQRWAMAEGYGACLINKPELVQDMVKQVRNQVETPGFSVSIKIR
                     IHDDLKRTVDLCQKAEATGVSWITVHGRTAEERHQPVHYDSIKIIKENMSIPVIANGD
                     IRSLKEAENVWRITGTDGVKKKMTLQWAAVATFLYAEIGLILIFCLPFIPPQRWQKIF
                     SFNVWGKIATFWNKAFLTIIILLIVLFLDAVREVRKYSSVHTIEKSSTSRPDAYEHTQ
                     MKLFRSQRNLYISGFSLFFWLVLRRLVTLITQLAKELSNKGVLKTQAENTNKAAKKFM
                     EENEKLKRILKSHGKDEECVLEAENKKLVEDQEKLKTELRKTSDALSKAQNDVMEMKM
                     QSERLSKEYDQLLKEHSELQHSSFGEFLSKRSHKNGSIGKQTGSRKGSFRKRQQEKTV
                     NFIKDTCNILCQNDNFVMLASRKFKFRKMHYDRFVIFLMPHIGCIVMALSKYLMMFQI
                     YCKVCIPALKKNISMLNTIFTY"
     exon            466..587
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            588..705
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            706..828
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1055
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1161
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1262
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1413
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1549
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1658
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1759
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1838
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..6828
                     /gene="DUS4L-BCAP29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5359..5364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUS4L-BCAP29"
                     /note="hexamer: AATAAA"
     polyA_site      5381
                     /gene="DUS4L-BCAP29"
                     /note="major polyA site"
     regulatory      6804..6809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUS4L-BCAP29"
                     /note="hexamer: ATTAAA"
     polyA_site      6828
                     /gene="DUS4L-BCAP29"
ORIGIN      
        1 gcccgcccac ccagcccatg gctccaggcc cacctggcga actgactctc agcccgcgcc
       61 tgggctaagc ctggctagga gccgcgcagg tactcgagca gtgggcgccc agggtccgag
      121 tgctctgcgc ccagcgcacc gagggagcca aggccgtcgg gccggcgctt tcagctgtct
      181 ctcgcagcag ctcagggccg cgccccctgg gctggcgtcg tgccctagcc aaggagaagt
      241 ttcagtcacg tgccagactt tttcttaatt acaaactgat agatggtcca catctcaact
      301 aacagtattg acgctgtaag agcatcagat ttgaaacata tctgtattaa tgaagagtga
      361 ctgcatgcaa acgacaatat gtcaggaaag aaaaaaagat cccatagaaa tgtttcattc
      421 tggacagctg gtaaaagtct gtgccccaat ggttcgatat tcaaagttgg cttttaggac
      481 actagtaaga aaatatagtt gtgatctgtg ttacacacca atgattgttg ccgctgattt
      541 tgtcaaatct ataaaagcca gagacagcga atttaccaca aatcaaggtg attgcccatt
      601 gattgttcag tttgctgcta acgatgcaag acttttatct gatgctgctc gtatagtctg
      661 tccttatgcg aatggaatag acattaactg tggttgccct cagaggtggg caatggcaga
      721 aggttatggg gcttgcttaa taaacaagcc agagcttgtt caagacatgg tgaaacaagt
      781 aagaaatcaa gtggaaaccc ctggattttc agtttctatt aaaataagga tccatgatga
      841 ccttaaaaga actgtagatc tttgtcaaaa ggctgaagca acaggagttt catggattac
      901 agtccatgga agaactgctg aagaaagaca tcagccagtg cactatgatt ccattaaaat
      961 aattaaggaa aatatgtcta tacctgtaat tgctaatgga gacatcagaa gcttaaagga
     1021 agcagaaaat gtgtggcgga ttactgggac agatggtgtg aagaaaaaaa tgacactcca
     1081 atgggctgca gtggcaacct ttctttatgc cgaaatagga ctcattttaa tcttctgcct
     1141 accttttatt cctcctcaga gatggcagaa gattttttca tttaatgtct ggggtaaaat
     1201 tgcaactttt tggaacaagg ctttccttac cattatcatc ctattgattg ttctatttct
     1261 agatgctgtg agagaagtaa ggaaatattc ctcagttcat accattgaga agagctccac
     1321 cagcagacct gatgcctatg aacacacaca gatgaaactt tttaggtctc aaagaaatct
     1381 ttacatttct ggattttccc tatttttttg gctagttttg agacgtctgg ttacgcttat
     1441 tactcaactg gcaaaagaac tgtcaaacaa aggtgtactt aaaactcaag cagaaaatac
     1501 taacaaggct gccaaaaaat ttatggaaga aaacgaaaaa ctaaaaagga ttttgaaaag
     1561 ccatggtaaa gatgaagaat gtgttttgga agcagaaaat aaaaaactag tagaagacca
     1621 ggagaaactg aaaactgaat taaggaagac ttcagatgcc ctttctaagg cacaaaatga
     1681 tgtgatggaa atgaagatgc agtcagagag actttcgaaa gaatatgatc aactcctgaa
     1741 agaacactct gaacttcagc attccagttt tggtgaattt ttaagcaaaa gaagccacaa
     1801 aaatggcagc attggaaaac agactggttc tagaaaagga tcgtttagaa agaggcaaca
     1861 agaaaagact gtgaacttta taaaagacac ttgcaatata ctgtgtcaaa atgataattt
     1921 tgttatgtta gcctctagaa aatttaagtt cagaaaaatg cactatgacc ggttcgtaat
     1981 ttttttaatg ccacacatag gttgtattgt aatggcatta tcaaaatatt tgatgatgtt
     2041 tcagatatat tgcaaagtct gtattccagc tcttaagaaa aatataagca tgttaaatac
     2101 catatttaca tattgataat gtcattggta tatggtggct gtttaccaat aaaaggaaaa
     2161 aattcattaa ccggttgctt ccaaaattag aagttttaag ttgcatgaaa ccattaatag
     2221 ccttgaaagc tttgataagt tttcagtaat aataacctat ttaatcagat gatgatgtgt
     2281 ttgaaaatag tgttcaatat cagcaaattt gtacacaggg aatgtaaata aggataactg
     2341 atcagagtta tccactgtat ttataaggaa gagtcggaaa aaacaatgac cttagttttt
     2401 tttaagcctg atgatactat ggtttactct aataagatag ctatattgat aattatattt
     2461 ttgttactgt gcccttgcac attttggtct ttttgttaat atttttatta ataacacata
     2521 attagtaacc actctactgt ttcaagttaa tctagtaata gagcttacat atatttgtat
     2581 aactgctata ccactgaact gaatttattt tacaacagtg tagaattctt gaaaagttaa
     2641 cgtagaaaat atccaaaaag cagtatttct agaaagtgtc caaaaagcag tatttctttc
     2701 ccttggttgt gagagtaact aattatataa atattacctc aaaaatacat acactggtat
     2761 cacacagtct ttctacaatg tttctgtatt ctgaaagcta aatattaagt actatttttc
     2821 cattcaaata ttcatttaga atttccttta gaagatggca gtgattataa tattaatatg
     2881 atttcatttg ttccagtgtt tagacatgaa atcatcttcc ttgtctcatg aaaacctaaa
     2941 tataaaaaaa aggaaaatac tggagttttt atttctcttg tctttgttac atcctctgtt
     3001 tattataatt ttagcaccaa cttcacacct agctaatttt tttcatcata aagtggatga
     3061 aatgagcaag tacctaaaaa ttttatttca gataaaagtc aggagttact gctaaaaaac
     3121 agacatgtag gagacattca acaggagtat gaaatgagag ttagaccata tgggctgaca
     3181 acaccataaa taacaagaaa agggagtgct gaaataggag agaacagagc aaatgttagc
     3241 tcaaagtata gacttagaaa tatcaaagta agagctatct ggataaatat atagatattg
     3301 agtgcttgga atcctagcct actatgtgaa aattaagtct aatgtcagaa taacttacag
     3361 aaaaatagaa aatgcacagc tttaaaatgg gcagagttaa aatctattcc cagctttatc
     3421 acttatttag ccatgctagc ctaggcctct atttccttgt ctccaaaatg agaataataa
     3481 aatttaggtc aggattacta tataaactaa gataatacag tgattctcaa agttgttcag
     3541 actgtatagt aaggagaaag tctggttgca ctttgaagag cttgaagatt tgaaagattc
     3601 ccaaaaaagc attttaaagt ttacatttaa gggaccttgg acctcaaccc tctcaagttt
     3661 acaagtctga aactttagac atcaaaagtt tgagcagttt ttccaaggca acattgatag
     3721 ttagattcag ggccaggctg taagtctaga atttagatat cctgatcccc cagataccgc
     3781 tcttctggtt atacacagac cagctataat ttgctaaaca taaaatattg cagtgtatta
     3841 gccggctgtg gctccagagt ctgtgccctt taccaccgtg cccaactgtt tcacatgctg
     3901 tgtttggtag tttttcctag tactctcctt aataatggtg gtgtttagca aattgtatta
     3961 cataaataaa tatttatttc atggattgag ttatgttgca tattaaatta ctttccttcc
     4021 cattgtcaat aatgacttct ttatgtctta ggctgtatta taaattcaaa cacaggaatg
     4081 ttattcttgc ctttttccat cagaattacc taaagtttta ttagactttc cccctacttg
     4141 caaatctgcc tggaggttct ggtctttagg aagtagcact tagcaagttc tggataagca
     4201 ctccagaatt tgggatgagt tatccttgtt gtttgtccag ctctatcttg gaccccagtg
     4261 ctgctaatta gattcatgcc ttgttcttta gggcataagt tcctctcttg gctatttttc
     4321 ctagtatgct gagaactagg attccctttc agtgacagag tcctgccctg gaaccccaat
     4381 caagagccta aagtttaact actctctgag atattagcct gatgccagca gcctgcctgg
     4441 atctctaaat attacccatt ctgggagttg ttagtggtct ctgctttcct gcagtgtcac
     4501 tcctgcttcc tcattgggcc tgctagccac agctacttgg atgtacccga acctgttgcc
     4561 ttgccctacc tctgtgggct ggttcagttc tgcattccca ttccagtgtc cactgccttc
     4621 tcgctatccc tcccatctgt gcgccaccac cagcttatcc ccagccctgc taacatgaca
     4681 aactattgtg catttgagtg cccactatac aatgtgtgaa tataaccgtg cttttaagca
     4741 ttgactttaa tgtctgggat gatccgtcta gagtccatgg aaccctcctg tgttttttca
     4801 tccctttctt agtaatcttg gaaatccact tatgaaattc tttttctaac atttctttgc
     4861 tgaacggcat ttttaaaatt actttcacgg tgtttctttc cagtttgatc tctacacaaa
     4921 cacaacttta ttacttgcac cagaaatgat ttcaaacact ttaggaactg tggtaggctt
     4981 aattatgact tcccaaaaga tatccctata ccaatccctg gaacctggaa atgttctctt
     5041 ctatagcaaa agatatgatt aagttaaagt cttgagatgg agagattatt ctgggtaatc
     5101 tgggagtgcc ctaaatgcag ctacatctat gcttatatag aagcaaaggg agatattacc
     5161 acacagaaga ggagaaagca cagtgaccac agaggcagag attggagtga tggagccgca
     5221 gcaaaggaat gctgacagcc accagaagct ggaggaggca aagaacagat tcttccccag
     5281 agcctcttcc agcaggagca tggccctaca gataccgata aaactgatat tggacttcct
     5341 ggcctccaga actatgggaa taaatttatt gtttcaagct atcaagtttg tgattatttg
     5401 ttactgctgc catagtaaat taatacagga gcatgcagga cagatctgta atggcctgaa
     5461 ctgaatttca aggggtgtgg aaaacagtta ctctttaaca ccactccgtc ttccccatta
     5521 gccatttgga taagtcaaag atagccttag ccatctccta tcttagttac ttttctcctt
     5581 caactgtatt ttgccattgt cgttgccatt gcctctgcct aactgcaagc catcatcatc
     5641 tctcacatgg actatgacga cctcctcatc tccctgtatc ttctctaatg cttctctcat
     5701 atacatgctc tcagcagcca cctggtttaa aacaaaaaca aaaaaaacac taatcatgtc
     5761 attccctgct tgtcttcccg ttctttccaa ctgtcattcc ctgcttgtct tccaattctt
     5821 tccaactgca gttaagatca aaccaccaag acctcaccag gctcccatct acttttcagc
     5881 ctcaactcag tccacctgct ctgccaatca cacctgtttc tttttgttgt tctttcccta
     5941 ggatatagat cctggcatac ctgcattctg attcttcttg gaacaagcca aattctttcc
     6001 cctgtcagta cgtttgcatg tgtagtacat gttgcatccc aggcctgtct gccttcttac
     6061 cctattttat tttcatcata gcacttacta ccatctgaaa tgatctcatt tatggtttgt
     6121 ctcctcagtg attaacacag ttcctgcaca cagtaaatca gtagttctca acaggaagtg
     6181 aagaggtcat cctgagggga acatttagca atacctagag acatttctgg ttgtcataac
     6241 caggggaatg ctcctagtgg atagaagtca gggaggctgt taaacccatt ccacaatgca
     6301 caggactgga acaaagaatg atctctcact cagaatgtca gtgttgccaa ggtggagaca
     6361 tcctgcagta gatgcttgtg gcagagggta ctggttgtac cccagtatcc attctttcat
     6421 tcacctgtgt taatacatgc tccagttttg tatttttttt tataaacagc tgtcaagcat
     6481 aaagataaca ttttccatct ccttgtatgt aagtggaaat aggactgtca tgtggggcca
     6541 gtttcttttt tttcttcctc tgtcctgctg cttgaaacat atgctgctat cttagatcat
     6601 gaggtcgagg ccatgcaaag tggagcaaca aggagctgtg tccctgacgc cataagcacc
     6661 acacctgtcc tgaattgctg tgaatgacac cagctaacta caatgcattg tctcaacatc
     6721 ctagacataa taaaaagcca taaatatgtt tgtcctatgc agcacaaaac ctttgtatct
     6781 ttgcctttta tgttgggatc ttaattaaaa attacatcct ctactgtc
//
