LOCUS       NM_022156               2233 bp    mRNA    linear   PRI 30-JAN-2025
DEFINITION  Homo sapiens dihydrouridine synthase 1 like (DUS1L), mRNA.
ACCESSION   NM_022156
VERSION     NM_022156.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Matsuura,J., Akichika,S., Wei,F.Y., Suzuki,T., Yamamoto,T.,
            Watanabe,Y., Valasek,L.S., Mukasa,A., Tomizawa,K. and Chujo,T.
  TITLE     Human DUS1L catalyzes dihydrouridine modification at tRNA positions
            16/17, and DUS1L overexpression perturbs translation
  JOURNAL   Commun Biol 7 (1), 1238 (2024)
   PUBMED   39354220
  REMARK    GeneRIF: Human DUS1L catalyzes dihydrouridine modification at tRNA
            positions 16/17, and DUS1L overexpression perturbs translation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2233)
  AUTHORS   Finet,O., Yague-Sanz,C., Kruger,L.K., Tran,P., Migeot,V.,
            Louski,M., Nevers,A., Rougemaille,M., Sun,J., Ernst,F.G.M.,
            Wacheul,L., Wery,M., Morillon,A., Dedon,P., Lafontaine,D.L.J. and
            Hermand,D.
  TITLE     Transcription-wide mapping of dihydrouridine reveals that mRNA
            dihydrouridylation is required for meiotic chromosome segregation
  JOURNAL   Mol Cell 82 (2), 404-419 (2022)
   PUBMED   34798057
REFERENCE   3  (bases 1 to 2233)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB481578.1, BC064918.1, BC062566.1 and AC135056.4.
            
            On May 17, 2019 this sequence version replaced NM_022156.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064918.1, SRR14038196.428742.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306796.10/ ENSP00000303515.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               DB481578.1         18-182
            166-1859            BC064918.1         1-1694
            1860-1867           BC062566.1         2077-2084
            1868-2233           AC135056.4         23869-24234         c
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2233
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /note="dihydrouridine synthase 1 like"
                     /db_xref="GeneID:64118"
                     /db_xref="HGNC:HGNC:30086"
                     /db_xref="MIM:621087"
     exon            1..192
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            193..439
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1624
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /EC_number="1.3.1.88"
                     /codon_start=1
                     /product="tRNA-dihydrouridine(16/17) synthase
                     [NAD(P)(+)]-like"
                     /protein_id="NP_071439.3"
                     /db_xref="CCDS:CCDS32775.1"
                     /db_xref="GeneID:64118"
                     /db_xref="HGNC:HGNC:30086"
                     /db_xref="MIM:621087"
                     /translation="MPKLQGFEFWSRTLRGARHVVAPMVDQSELAWRLLSRRHGAQLC
                     YTPMLHAQVFVRDANYRKENLYCEVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAI
                     DLNLGCPQMIAKRGHYGAFLQDEWDLLQRMILLAHEKLSVPVTCKIRVFPEIDKTVRY
                     AQMLEKAGCQLLTVHGRTKEQKGPLSGAASWEHIKAVRKAVAIPVFANGNIQCLQDVE
                     RCLRDTGVQGVMSAEGNLHNPALFEGRSPAVWELAEEYLDIVREHPCPLSYVRAHLFK
                     LWHHTLQVHQELREELAKVKTLEGIAAVSQELKLRCQEEISRQEGAKPTGDLPFHWIC
                     QPYIRPGPREGSKEKAGARSKRALEEEEGGTEVLSKNKQKKQLRNPHKTFDPSLKPKY
                     AKCDQCGNPKGNRCVFSLCRGCCKKRASKETADCPGHGLLFKTKLEKSLAWKEAQPEL
                     QEPQPAAPGTPGGFSEVMGSALA"
     exon            440..548
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            549..599
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            600..712
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            713..795
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            796..899
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1044
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1141
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1224
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1370
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1408
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1484
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..2233
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1840..1845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /note="hexamer: AATAAA"
     polyA_site      1859
                     /gene="DUS1L"
                     /gene_synonym="DUS1; PP3111"
                     /note="major polyA site"
ORIGIN      
        1 ggtggcggcg cggagccttg ggcccggctg cggcccggcg gcggccccgg cgcggtgcgg
       61 gcgttcgcgg cgccccggga gctgcagggg ccccgggcgg cggcgaggcc ggagaggggc
      121 gggcccggga caccggcacc cggcgccctc ggagccaaag gcgcgcggcg gacacggcgg
      181 ggccctcgcg cgcctggaga cgatgccaaa gctgcagggc ttcgagttct ggagccgcac
      241 cctgcgaggg gcccgccacg tcgtggcccc catggtggac cagagcgagc tggcctggag
      301 gctgctgagc cggcgccacg gggcacagct ctgctacacg cccatgctgc atgcccaggt
      361 ctttgtccgc gacgccaact accggaagga gaacctgtac tgcgaggtgt gccccgagga
      421 ccggcccctc atcgtgcagt tctgtgccaa tgacccggag gtgtttgttc aggcggctct
      481 cctggctcag gattactgtg acgccattga cctgaacttg ggctgcccac agatgatagc
      541 caagagaggt cactatggcg cctttctgca ggacgagtgg gacctgctcc aaagaatgat
      601 tttgctggcc cacgagaaac tctctgttcc tgtcacgtgc aaaatccgtg tcttcccgga
      661 gattgacaag accgtgaggt acgcccagat gctggagaag gccggctgcc agttgctgac
      721 ggtgcacgga cgcaccaagg agcagaaggg gcccctgtcg ggtgcagcgt cctgggagca
      781 tatcaaggct gtgcggaagg ctgtggccat ccctgtgttt gctaacggga acatccagtg
      841 cctgcaggac gtggagcgct gcctccggga cacgggtgtg cagggcgtca tgagcgcaga
      901 gggcaacctg cacaaccccg ccctgttcga gggccggagc cctgccgtgt gggagctggc
      961 cgaggagtat ctggacatcg tgcgggagca cccctgcccc ctgtcctacg tccgggccca
     1021 cctcttcaag ctgtggcacc acacgctgca ggtgcaccag gagctgcgag aggagctggc
     1081 caaggtgaag accctggagg gcatcgctgc tgtgagccag gagctgaagc tgcggtgtca
     1141 ggaggagata tccaggcagg agggagcgaa gcccaccggc gacttgccct tccactggat
     1201 ctgccagccc tacatccggc cggggcccag ggaggggagc aaggagaagg caggtgcgcg
     1261 cagcaagcgg gccctggagg aagaggaggg tggcacggag gtcctgtcca agaacaagca
     1321 aaagaagcag ctgaggaacc cccacaagac cttcgacccc tctctgaagc caaaatatgc
     1381 aaagtgtgac cagtgtggaa acccaaaggg caacagatgt gtgttcagcc tgtgccgcgg
     1441 ctgctgcaag aagcgagcct ccaaagagac tgcagactgc ccaggtcacg gattgctttt
     1501 taaaaccaaa ttggagaagt ctctggcctg gaaagaggcc cagcctgagc tgcaggagcc
     1561 tcagccagca gcacctggaa caccaggtgg cttctccgaa gtcatgggca gtgccctggc
     1621 ctgaaggccc acaaccccca cccccaggac tgctgctgga gcctggacac gtcctactta
     1681 agaaaatgcc ttttactcag ggaatctcct gctacttaat gtggaaagac acgcccatgt
     1741 cccccttcgg cccactctgg gggcctggaa atgctgcagt ggggagcagg ccccaggctg
     1801 gacctgccct gtcctcagca cgcgtgtgca aaagtgaaca ataaatcatt tcaaagatgc
     1861 gagagcccac agcctgtgac cactgccctc tcagacccag ggaggcatga gccggggcag
     1921 gtgcggttgg ggccagtggg ggcttctgaa caacaggata catctaaatg aaggcagcat
     1981 ctgggtagac aaaagtgggg gcttaggtcc cctccccacc tcccctaggc gcctccatag
     2041 gcaagtggcc aaagcctccg ggagcttcgt gatgcctcac agccttggaa gcaccgcctg
     2101 cgaggccaca gtggctgctg ctgggggctg ttgaatctga gggccaggct tctcatttct
     2161 ctcaccaggc cctgcctcca agcctagtcc cagggagaca gccctcagga acccaaggcc
     2221 acccaggggt gac
//
