LOCUS       NM_001276266            3102 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dual oxidase maturation factor 1 (DUOXA1), transcript
            variant 4, mRNA.
ACCESSION   NM_001276266 XM_006720749
VERSION     NM_001276266.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3102)
  AUTHORS   Wu,J.X., Liu,R., Song,K. and Chen,L.
  TITLE     Structures of human dual oxidase 1 complex in low-calcium and
            high-calcium states
  JOURNAL   Nat Commun 12 (1), 155 (2021)
   PUBMED   33420071
  REMARK    GeneRIF: Structures of human dual oxidase 1 complex in low-calcium
            and high-calcium states.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3102)
  AUTHORS   Meng,Y., Chen,C.W., Yung,M.M.H., Sun,W., Sun,J., Li,Z., Li,J.,
            Li,Z., Zhou,W., Liu,S.S., Cheung,A.N.Y., Ngan,H.Y.S.,
            Braisted,J.C., Kai,Y., Peng,W., Tzatsos,A., Li,Y., Dai,Z.,
            Zheng,W., Chan,D.W. and Zhu,W.
  TITLE     DUOXA1-mediated ROS production promotes cisplatin resistance by
            activating ATR-Chk1 pathway in ovarian cancer
  JOURNAL   Cancer Lett 428, 104-116 (2018)
   PUBMED   29704517
  REMARK    GeneRIF: Study shows that DUOXA1 is overexpressed in
            platinum-resistant ovarian cancer (OC) cells, resulting in over
            production of reactive oxygen species (ROS). Elevated ROS level
            sustains the activation of ATR-Chk1 pathway, leading to resistance
            to cisplatin in OC cells. Clinical studies also confirm the
            activation of ATR and DOUXA1 in OC patients, and elevated DOUXA1 or
            ATR-Chk1 pathway correlates with poor prognosis.
REFERENCE   3  (bases 1 to 3102)
  AUTHORS   Sirokmany,G., Pato,A., Zana,M., Donko,A., Biro,A., Nagy,P. and
            Geiszt,M.
  TITLE     Epidermal growth factor-induced hydrogen peroxide production is
            mediated by dual oxidase 1
  JOURNAL   Free Radic Biol Med 97, 204-211 (2016)
   PUBMED   27262981
  REMARK    GeneRIF: We analyzed the expression of NADPH oxidase isoforms and
            found both A431 and HaCaT cells to express the calcium-sensitive
            NADPH oxidase, Dual oxidase 1 (Duox1) and its protein partner Duox
            activator 1 (DuoxA1).Our observations provide evidence for a new
            signaling paradigm in which changes of intracellular calcium
            concentration are transformed into redox signals through the
            calcium-dependent activation of Duox1.
REFERENCE   4  (bases 1 to 3102)
  AUTHORS   Ostrakhovitch,E.A. and Semenikhin,O.A.
  TITLE     p53-mediated regulation of neuronal differentiation via regulation
            of dual oxidase maturation factor 1
  JOURNAL   Neurosci Lett 494 (1), 80-85 (2011)
   PUBMED   21362455
REFERENCE   5  (bases 1 to 3102)
  AUTHORS   Christophe-Hobertus,C. and Christophe,D.
  TITLE     Delimitation and functional characterization of the bidirectional
            THOX-DUOXA promoter regions in thyrocytes
  JOURNAL   Mol Cell Endocrinol 317 (1-2), 161-167 (2010)
   PUBMED   20060878
REFERENCE   6  (bases 1 to 3102)
  AUTHORS   Ostrakhovitch,E.A. and Li,S.S.
  TITLE     NIP1/DUOXA1 expression in epithelial breast cancer cells:
            regulation of cell adhesion and actin dynamics
  JOURNAL   Breast Cancer Res Treat 119 (3), 773-786 (2010)
   PUBMED   19322654
  REMARK    GeneRIF: DUOXA1 transient overexpression affected the cell-cell
            adhesion by modulating the actin cytoskeleton
REFERENCE   7  (bases 1 to 3102)
  AUTHORS   Luxen,S., Noack,D., Frausto,M., Davanture,S., Torbett,B.E. and
            Knaus,U.G.
  TITLE     Heterodimerization controls localization of Duox-DuoxA NADPH
            oxidases in airway cells
  JOURNAL   J Cell Sci 122 (Pt 8), 1238-1247 (2009)
   PUBMED   19339556
  REMARK    GeneRIF: Heterodimerization controls localization of Duox-DuoxA
            NADPH oxidases in airway cells.
REFERENCE   8  (bases 1 to 3102)
  AUTHORS   Morand,S., Ueyama,T., Tsujibe,S., Saito,N., Korzeniowska,A. and
            Leto,T.L.
  TITLE     Duox maturation factors form cell surface complexes with Duox
            affecting the specificity of reactive oxygen species generation
  JOURNAL   FASEB J 23 (4), 1205-1218 (2009)
   PUBMED   19074510
REFERENCE   9  (bases 1 to 3102)
  AUTHORS   Grasberger,H. and Refetoff,S.
  TITLE     Identification of the maturation factor for dual oxidase. Evolution
            of an eukaryotic operon equivalent
  JOURNAL   J Biol Chem 281 (27), 18269-18272 (2006)
   PUBMED   16651268
REFERENCE   10 (bases 1 to 3102)
  AUTHORS   Qin,H., Percival-Smith,A., Li,C., Jia,C.Y., Gloor,G. and Li,S.S.
  TITLE     A novel transmembrane protein recruits numb to the plasma membrane
            during asymmetric cell division
  JOURNAL   J Biol Chem 279 (12), 11304-11312 (2004)
   PUBMED   14670962
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091117.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jun 16, 2020 this sequence version replaced
            XM_006720749.1, NM_001276266.1.
            
            Summary: Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are
            involved in hydrogen peroxide production necessary for thyroid
            hormonogenesis. They form a heterodimer with specific maturation
            factors DUOXA1 and DUOXA2, respectively, which is essential for the
            maturation and function of the DUOX enzyme complexes. This gene
            encodes the DUOX1 activator or maturation factor DUOXA1. Rat
            studies identified a bidirectional promoter which controls the
            transcription of the DUOX1 and DUOXA1 genes. This protein is
            cotransported to the cell surface when coexpressed with DUOX1 and
            is retained in the endoplasmic reticulum when expressed without
            DUOX1 protein. The expression of this gene or the DUOX1 gene is not
            suppressed by thyroglobulin (Tg), a macromolecular precursor in
            thyroid hormone synthesis, while the expression of the DUOX2 and
            DUOXA2 are significantly suppressed by the Tg. This protein is also
            a p53-regulated neurogenic factor involved in p53 dependent
            neuronal differentiation. Multiple alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (4) lacks two exons and its
            transcription extends past a splice site that is used in variant 1,
            resulting in a novel 3' coding region and 3' UTR compared to
            variant 1. The resulting isoform (3, also known as alpha) is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3285439.1,
                                           DRR138524.1065413.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000560572.6/ ENSP00000454084.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC091117.5         180520-180547       c
            29-184              AC091117.5         180128-180283       c
            185-301             AC091117.5         179686-179802       c
            302-477             AC091117.5         173536-173711       c
            478-535             AC091117.5         172853-172910       c
            536-670             AC091117.5         171755-171889       c
            671-884             AC091117.5         171260-171473       c
            885-1102            AC091117.5         170771-170988       c
            1103-3102           AC091117.5         168034-170033       c
FEATURES             Location/Qualifiers
     source          1..3102
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..3102
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /note="dual oxidase maturation factor 1"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
     exon            1..28
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            29..184
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            185..301
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            302..477
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1362
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /note="isoform 3 is encoded by transcript variant 4;
                     homolog of Drosophila Numb-interacting protein; dual
                     oxidase activator 1; dual oxidase maturation factor 1
                     gamma; dual oxidase maturation factor 1 delta; dual
                     oxidase maturation factor 1 alpha; dual oxidase maturation
                     factor 1 beta"
                     /codon_start=1
                     /product="dual oxidase maturation factor 1 isoform 3"
                     /protein_id="NP_001263195.1"
                     /db_xref="CCDS:CCDS61621.1"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
                     /translation="MATLGHTFPFYAGPKPTFPMDTTLASIIMIFLTALATFIVILPG
                     IRGKTRLFWLLRVVTSLFIGAAILAVNFSSEWSVGQVSTNTSYKAFSSEWISADIGLQ
                     VGLGGVNITLTGTPVQQLNETINYNEEFTWRLGENYAEEYAKALEKGLPDPVLYLAEK
                     FTPRSPCGLYRQYRLAGHYTSAMLWVAFLCWLLANVMLSMPVLVYGGYMLLATGIFQL
                     LALLFFSMATSLTSPCPLHLGASVLHTHHGPAFWITLTTGLLCVLLGLAMAVAHRMQP
                     HRLKAFFNQSVDEDPMLEWSPEEGGLLSPRYRSMADSPKSQDIPLSEASSTKAYCKEA
                     HPKDPDCAL"
     exon            478..535
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            536..670
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            671..884
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1102
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..3102
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2954..2959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /note="hexamer: ATTACA"
     polyA_site      2981
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /note="major polyA site"
     regulatory      3066..3071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /note="hexamer: AATAGA"
     polyA_site      3102
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /note="major polyA site"
ORIGIN      
        1 gtgcttccag cggacggcag cgcgcgagac caggccaggc gtcaaagcaa gtcacccatc
       61 cgacctaaac ccctctaaga ccccggagtc acgtctccct ccggggatcc tcgtgaggtc
      121 ttgggggtcc caccgccctg cgagccgcgc ccgcgccccg ccagacccgg aactgcgtcg
      181 ctagaacgtc gggacctggt tccctcttta atcacacccc cgggggcgct tcgtgtgagg
      241 ttccacgggg gaaggcgaga ggcgcaggct gccacacacg cactgtttgg aagaggggaa
      301 gcattgcccc ccctgcacca cctcaccaag atggctactt tgggacacac attccccttc
      361 tatgctggcc ccaagccaac cttcccgatg gacaccactt tggccagcat catcatgatc
      421 tttctgactg cactggccac gttcatcgtc atcctgcctg gcattcgggg aaagacgagg
      481 ctgttctggc tgcttcgggt ggtgaccagc ttattcatcg gggctgcaat cctggctgtg
      541 aatttcagtt ctgagtggtc tgtgggccag gtcagcacca acacatcata caaggccttc
      601 agttctgagt ggatcagcgc tgatattggg ctgcaggtcg ggctgggtgg agtcaacatc
      661 acactcacag ggacccccgt gcagcagctg aatgagacca tcaattacaa cgaggagttc
      721 acctggcgcc tgggtgagaa ctatgctgag gagtatgcaa aggctctgga gaaggggctg
      781 ccagaccctg tgttgtacct agctgagaag ttcactccaa gaagcccatg tggcctatac
      841 cgccagtacc gcctggcggg acactacacc tcagccatgc tatgggtggc attcctctgc
      901 tggctgctgg ccaatgtgat gctctccatg cctgtgctgg tatatggtgg ctacatgcta
      961 ttggccacgg gcatcttcca gctgttggct ctgctcttct tctccatggc cacatcactc
     1021 acctcaccct gtcccctgca cctgggcgct tctgtgctgc atactcacca tgggcctgcc
     1081 ttctggatca cattgaccac aggactgctg tgtgtgctgc tgggcctggc tatggcggtg
     1141 gcccacagga tgcagcctca caggctgaag gctttcttca accagagtgt ggatgaagac
     1201 cccatgctgg agtggagtcc tgaggaaggt ggactcctga gcccccgcta ccggtccatg
     1261 gctgacagtc ccaagtccca ggacattccc ctgtcagagg cttcctccac caaggcatac
     1321 tgtaaggagg cacaccccaa agatcctgat tgtgctttat aacattcctc cccgtggagg
     1381 ccacctggac ttccagtctg gctccaaacc tcattggcgc cccataaaac cagcagaact
     1441 gccctcaggg tggctgttac cagacaccca gcaccaatct acagacggag tagaaaaagg
     1501 aggctctata tactgatgtt aaaaaacaaa acaaaacaaa aagccctaag ggactgaaga
     1561 gatgctgggc ctgtccataa agcctgttgc catgataagg ccaagcaggg gctagcttat
     1621 ctgcacagca acccagcctt tccgtgctgc cttgcctctt caagatgcta ttcactgaaa
     1681 cctaacttca cccccataac accagcaggg tgggggttac atatgattct cctatggttt
     1741 cctctcatcc ctcggcacct cttgttttcc tttttcctgg gttccttttg ttcttccttt
     1801 acttctccag cttgtgtggc cttttggtac aatgaaagac agcactggaa aggaggggaa
     1861 accaaacttc tcatcctagg tctaacatta accaactatg ccacattctc tttgagcttc
     1921 agttcccaaa tttgctacat aagattgcaa gacttgccaa gaatcttggg atttatcttt
     1981 ctatgccttg ctgacaccta ccttggccct caaacaccac ctcacaagaa gccaggtggg
     2041 aagttaggga atcaactcca aaacgctatt ccttcccacc ccactcagct gggctagctg
     2101 agtggcatcc aggacggggg agtgggtgac ctgcctcatc actgccacct aacgtccccc
     2161 tggggtggtt cagaaagatg ctagctctgg tagggtccct ccggcctcac tagagggcgc
     2221 ccctattact ctggagtcga cgcagagaat caggtttcac agcactgcgg agagtgtact
     2281 aggctgtctc cagcccagcg aagctcatga ggacgtgcga ccccggcgcg gagaagccat
     2341 gaaaattaat gggaaaaaca gtttttaaaa aacaaaagaa aaaaaggttt atttacagat
     2401 cgccccagga gactttccct ggtgcctgcg gatgtccgag gcctcgcgcc agcagcgctc
     2461 agtgcccttc ctggagctct cctggcccag gcctggcggg cactgcttcc cggcctgcga
     2521 tgtcccaagg cggggaagga gtccagattg ggtccccctc acaggttagt ggtgatacat
     2581 tttaagtctg ggagagcggc ctgcttgtgc agtgggtcgc cgaggataag aggtgagccc
     2641 cctctctcct ggctgcagtc cttggcgctt tggtccagaa gggtgcgaag agcgctgggc
     2701 cgaacatact ggagactcac cacggcccct ccgaggaaga ggcacaggac gcctgtggcg
     2761 gtggggatcg aaagaaagga gggcatgtgg agtcagggct atgttgccca ggctggtctc
     2821 gaactctggc ctcaaacgac cttcctgcct cgacctccca aagtgctggg attacaggcg
     2881 tgatgcccgg gccttcttcc atcttttgga gcctacccct tgtgttacct cccgccacac
     2941 acctctaatc tgaattacat gaaacacggc aagacaccaa acccttctga gccccccact
     3001 tttcatctgt aaaatggtca taacagtgcc tgtttctgcg aactattgag aggggcaaat
     3061 agggtaatag atgtgaattc attctgtaaa ctggaaagtg ca
//
