LOCUS       NM_001363711            6361 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens dual oxidase 2 (DUOX2), transcript variant 2, mRNA.
ACCESSION   NM_001363711 XM_005254421
VERSION     NM_001363711.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6361)
  AUTHORS   Baz-Redon,N., Antolin,M., Clemente,M., Campos,A., Mogas,E.,
            Fernandez-Cancio,M., Zafon,E., Garcia-Arumi,E., Soler,L.,
            Gonzalez-Llorens,N., Aguilar-Riera,C., Camats-Tarruella,N. and
            Yeste,D.
  TITLE     Patients with Thyroid Dyshormonogenesis and DUOX2 Variants:
            Molecular and Clinical Description and Genotype-Phenotype
            Correlation
  JOURNAL   Int J Mol Sci 25 (15), 8473 (2024)
   PUBMED   39126042
  REMARK    GeneRIF: Patients with Thyroid Dyshormonogenesis and DUOX2
            Variants: Molecular and Clinical Description and Genotype-Phenotype
            Correlation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6361)
  AUTHORS   Uehara,E., Abe,K., Tanase-Nakao,K., Muroya,K., Hattori,A.,
            Matsubara,K., Fukami,M. and Narumi,S.
  TITLE     Molecular and Clinical Features of Congenital Hypothyroidism Due to
            Multiple DUOX2 Variants
  JOURNAL   Thyroid 34 (7), 827-836 (2024)
   PUBMED   38757580
  REMARK    GeneRIF: Molecular and Clinical Features of Congenital
            Hypothyroidism Due to Multiple DUOX2 Variants.
REFERENCE   3  (bases 1 to 6361)
  AUTHORS   Kasumba,D.M., Huot,S., Caron,E., Fortin,A., Laflamme,C., Zamorano
            Cuervo,N., Lamontagne,F., Pouliot,M. and Grandvaux,N.
  TITLE     DUOX2 regulates secreted factors in virus-infected respiratory
            epithelial cells that contribute to neutrophil attraction and
            activation
  JOURNAL   FASEB J 37 (2), e22765 (2023)
   PUBMED   36607642
  REMARK    GeneRIF: DUOX2 regulates secreted factors in virus-infected
            respiratory epithelial cells that contribute to neutrophil
            attraction and activation.
REFERENCE   4  (bases 1 to 6361)
  AUTHORS   Parlato,M. and Cerf-Bensussan,N.
  TITLE     Another Breach in the Wall: Impaired Epithelial DUOX2 Activity
            Fuels Metabolic Syndrome
  JOURNAL   Cell Mol Gastroenterol Hepatol 16 (4), 648-649 (2023)
   PUBMED   37517801
  REMARK    GeneRIF: Another Breach in the Wall: Impaired Epithelial DUOX2
            Activity Fuels Metabolic Syndrome.
REFERENCE   5  (bases 1 to 6361)
  AUTHORS   Wei,X., Xue,M., Kang,C., Gao,L., Zhang,M., Ma,C., Jia,W., Zheng,Y.,
            Cao,L., Chen,P., Jiang,S., Chu,F.F. and Gao,Q.
  TITLE     Increased NOX1 and DUOX2 expression in the colonic mucosa of
            patients with chronic functional constipation
  JOURNAL   Medicine (Baltimore) 101 (32), e30028 (2022)
   PUBMED   35960091
  REMARK    GeneRIF: Increased NOX1 and DUOX2 expression in the colonic mucosa
            of patients with chronic functional constipation.
REFERENCE   6  (bases 1 to 6361)
  AUTHORS   Edens,W.A., Sharling,L., Cheng,G., Shapira,R., Kinkade,J.M.,
            Lee,T., Edens,H.A., Tang,X., Sullards,C., Flaherty,D.B.,
            Benian,G.M. and Lambeth,J.D.
  TITLE     Tyrosine cross-linking of extracellular matrix is catalyzed by
            Duox, a multidomain oxidase/peroxidase with homology to the
            phagocyte oxidase subunit gp91phox
  JOURNAL   J Cell Biol 154 (4), 879-891 (2001)
   PUBMED   11514595
REFERENCE   7  (bases 1 to 6361)
  AUTHORS   Caillou,B., Dupuy,C., Lacroix,L., Nocera,M., Talbot,M., Ohayon,R.,
            Deme,D., Bidart,J.M., Schlumberger,M. and Virion,A.
  TITLE     Expression of reduced nicotinamide adenine dinucleotide phosphate
            oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid
            tissues
  JOURNAL   J Clin Endocrinol Metab 86 (7), 3351-3358 (2001)
   PUBMED   11443211
REFERENCE   8  (bases 1 to 6361)
  AUTHORS   Dupuy,C., Pomerance,M., Ohayon,R., Noel-Hudson,M.S., Deme,D.,
            Chaaraoui,M., Francon,J. and Virion,A.
  TITLE     Thyroid oxidase (THOX2) gene expression in the rat thyroid cell
            line FRTL-5
  JOURNAL   Biochem Biophys Res Commun 277 (2), 287-292 (2000)
   PUBMED   11032719
REFERENCE   9  (bases 1 to 6361)
  AUTHORS   De Deken,X., Wang,D., Many,M.C., Costagliola,S., Libert,F.,
            Vassart,G., Dumont,J.E. and Miot,F.
  TITLE     Cloning of two human thyroid cDNAs encoding new members of the
            NADPH oxidase family
  JOURNAL   J Biol Chem 275 (30), 23227-23233 (2000)
   PUBMED   10806195
REFERENCE   10 (bases 1 to 6361)
  AUTHORS   Dupuy,C., Ohayon,R., Valent,A., Noel-Hudson,M.S., Deme,D. and
            Virion,A.
  TITLE     Purification of a novel flavoprotein involved in the thyroid NADPH
            oxidase. Cloning of the porcine and human cdnas
  JOURNAL   J Biol Chem 274 (52), 37265-37269 (1999)
   PUBMED   10601291
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091117.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001363711.1.
            
            Summary: The protein encoded by this gene is a glycoprotein and a
            member of the NADPH oxidase family. The synthesis of thyroid
            hormone is catalyzed by a protein complex located at the apical
            membrane of thyroid follicular cells. This complex contains an
            iodide transporter, thyroperoxidase, and a peroxide generating
            system that includes this encoded protein and DUOX1. This protein
            is known as dual oxidase because it has both a peroxidase homology
            domain and a gp91phox domain. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF230496.1, AF267981.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389039.11/ ENSP00000373691.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC091117.5         164641-164840       c
            201-284             AC091117.5         164010-164093       c
            285-374             AC091117.5         163655-163744       c
            375-539             AC091117.5         163222-163386       c
            540-727             AC091117.5         162436-162623       c
            728-929             AC091117.5         162052-162253       c
            930-1096            AC091117.5         161779-161945       c
            1097-1157           AC091117.5         161318-161378       c
            1158-1254           AC091117.5         161096-161192       c
            1255-1345           AC091117.5         160558-160648       c
            1346-1448           AC091117.5         160192-160294       c
            1449-1612           AC091117.5         159457-159620       c
            1613-1788           AC091117.5         158715-158890       c
            1789-1907           AC091117.5         158013-158131       c
            1908-2045           AC091117.5         157500-157637       c
            2046-2159           AC091117.5         157196-157309       c
            2160-2362           AC091117.5         156793-156995       c
            2363-2548           AC091117.5         156311-156496       c
            2549-2774           AC091117.5         154808-155033       c
            2775-2868           AC091117.5         154628-154721       c
            2869-3065           AC091117.5         152461-152657       c
            3066-3135           AC091117.5         151873-151942       c
            3136-3219           AC091117.5         151423-151506       c
            3220-3398           AC091117.5         150718-150896       c
            3399-3629           AC091117.5         150330-150560       c
            3630-3729           AC091117.5         150051-150150       c
            3730-3779           AC091117.5         148677-148726       c
            3780-3907           AC091117.5         148282-148409       c
            3908-4061           AC091117.5         147906-148059       c
            4062-4294           AC091117.5         146496-146728       c
            4295-4453           AC091117.5         146105-146263       c
            4454-4609           AC091117.5         145604-145759       c
            4610-4738           AC091117.5         145231-145359       c
            4739-6361           AC091117.5         143318-144940       c
FEATURES             Location/Qualifiers
     source          1..6361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..6361
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /note="dual oxidase 2"
                     /db_xref="GeneID:50506"
                     /db_xref="HGNC:HGNC:13273"
                     /db_xref="MIM:606759"
     exon            1..200
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            201..284
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..4861
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /EC_number="1.6.3.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; dual oxidase-like domains 2; flavoprotein NADPH
                     oxidase; NADPH thyroid oxidase 2; NADH/NADPH thyroid
                     oxidase p138-tox; NADPH oxidase/peroxidase DUOX2;
                     nicotinamide adenine dinucleotide phosphate oxidase; long
                     NOX 2; large NOX 2; p138 thyroid oxidase"
                     /codon_start=1
                     /product="dual oxidase 2 isoform 2 precursor"
                     /protein_id="NP_001350640.1"
                     /db_xref="CCDS:CCDS86454.1"
                     /db_xref="GeneID:50506"
                     /db_xref="HGNC:HGNC:13273"
                     /db_xref="MIM:606759"
                     /translation="MLRARPEALMLLGALLTGSLGPSGSQDALSLPWEVQRYDGWFNN
                     LRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRT
                     VLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPE
                     TGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNP
                     LLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDW
                     EDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQ
                     FFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLL
                     GMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGL
                     DIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQF
                     VRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGA
                     PCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRG
                     REHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQLLSDRCLQVLNRHLTVL
                     RVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRW
                     ALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQADAGTLPLDSSQKV
                     REALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSP
                     EDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQ
                     DKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPG
                     ERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQKLQQ
                     YKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAA
                     SVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHA
                     VNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYV
                     FASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKL
                     VSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTL
                     TSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFE
                     VSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEV
                     EENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPP
                     FEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF"
     exon            285..374
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..539
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..727
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..929
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1096
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1157
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1254
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1345
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1448
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1612
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1788
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1907
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2045
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2159
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2362
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2548
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2774
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2868
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3065
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3135
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3219
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3398
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3629
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3729
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3779
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..3907
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..4061
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4062..4294
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4295..4453
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4454..4609
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4610..4738
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4739..6361
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6331..6336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /note="hexamer: AATAAA"
     polyA_site      6361
                     /gene="DUOX2"
                     /gene_synonym="LNOX2; NOXEF2; P138-TOX; TDH6; THOX2"
                     /note="major polyA site"
ORIGIN      
        1 acactggcgc aggtctgtcc tgagccgaca cctgcacagt ggcgagacca aggacccaga
       61 gagaaaggtg agagtgcagc cggggaggct gaggatcggc ggagctggaa gagtgagggt
      121 gaaggcaaga agtagagcac agaagcaaag attttaagag gaaagaagac atctgaaccc
      181 aacaccaccc taaaccacag gctgcagggt tggcatgctc cgtgcaagac cagaggcact
      241 gatgctcctg ggagctcttc tgactggatc cctgggtcca tcgggcagtc aggacgcact
      301 ctcactgccc tgggaagtgc agcgctatga cggctggttt aacaacctga ggcaccacga
      361 gcgtggtgct gttggctgcc ggttgcagcg ccgcgtacca gccaattacg ccgacggtgt
      421 gtatcaggct ctggaggagc cgcagctgcc caacccgcgc cggctcagca acgcagccac
      481 gcggggcata gccggcctgc cgtcgctcca caaccgcacc gtactggggg tcttctttgg
      541 ctaccatgtt ctttccgacg tggtgagcgt ggaaacgccc ggttgccccg ccgagttcct
      601 caacatccgc atcccacctg gagaccccgt gttcgacccc gaccagcgcg gggacgtggt
      661 gctgcccttc cagaggagcc gctgggaccc cgagaccgga cggagtccca gcaacccccg
      721 ggacctggcc aaccaggtga cgggctggct ggacggcagc gccatctatg gctcctcgca
      781 ctcctggagc gacgcgctgc ggagcttctc ggggggacag ctggcgtcgg ggcccgaccc
      841 cgctttcccc cgagactcgc agaaccccct gctcatgtgg gcggcgcccg accccgccac
      901 cgggcagaac gggccccggg ggctgtacgc cttcggggca gagagaggga accgggaacc
      961 cttcctgcag gcgctgggcc tgctctggtt ccgctaccac aacctgtggg cgcagaggct
     1021 ggcccgccag cacccagact gggaggacga ggagctgttc cagcacgcac gcaagagggt
     1081 catcgccacc taccagaaca tcgctgtgta tgagtggctg cccagcttcc tgcagaaaac
     1141 actcccggag tatacaggat accgtccttt cctagacccc agcatctccc cggaatttgt
     1201 ggtggcctct gagcagttct tctctaccat ggtgccccct ggtgtctaca tgagaaatgc
     1261 cagctgtcat ttccggaagg tcctgaacaa gggttttcaa agctcccaag ctctcagggt
     1321 ctgcaacaac tactggattc gggagaaccc caatctgaac agtacccagg aggtgaatga
     1381 gctgctgctg ggaatggcct cccagatttc ggagttggag gacaacatag tggttgaaga
     1441 tctgagggat tactggcctg gccctggcaa attctcccgt acagactatg tggccagcag
     1501 catccaacgt ggccgagata tggggctgcc cagctatagc caggccctgc tggcctttgg
     1561 gctggacatc ccaaggaact ggagtgatct caaccctaat gtggaccccc aggtgctgga
     1621 ggccacagct gccctgtaca accaggacct atcccagcta gagctgctcc ttggggggct
     1681 cctggagagc catggggacc ctggacccct gttcagtgcc attgtcctcg accagtttgt
     1741 acggctgcgg gatggtgacc gctactggtt tgagaacacc aggaatgggc tgttctccaa
     1801 gaaggagatt gaagacatcc gaaataccac cctgcgggac gtgctggtcg ctgttatcaa
     1861 cattgacccc agtgccctgc agcccaatgt ctttgtctgg cataaaggtg caccctgccc
     1921 tcaacctaag cagctcacaa ctgacggcct gccccagtgt gcacccctga ctgtgcttga
     1981 cttctttgaa ggcagcagcc ctggttttgc catcaccatc attgctctct gctgccttcc
     2041 cttagtgagt ctgcttctct ctggagtggt ggcctatttc cggggccgag aacacaagaa
     2101 gctacaaaag aaactcaaag agagcgtgaa gaaggaagca gccaaagatg gagtgccagc
     2161 gatggagtgg ccaggcccca aggagaggag cagtcccatc atcatccagc tgctgtcaga
     2221 caggtgtctg caggtcctga acaggcatct cactgtgctc cgtgtggtcc agctgcagcc
     2281 tctgcagcag gtcaacctca tcctgtccaa caaccgagga tgccgcaccc tgctgctcaa
     2341 gatccctaag gagtatgacc tggtgctgct gtttagttct gaagaggaac ggggcgcctt
     2401 tgtgcagcag ctatgggact tctgcgtgcg ctgggctctg ggcctccatg tggctgagat
     2461 gagcgagaag gagctattta ggaaggctgt gacaaagcag cagcgggaac gcatcctgga
     2521 gatcttcttc agacaccttt ttgctcaggt gctggacatc aaccaggccg acgcagggac
     2581 cctgcccctg gactcctccc agaaggtgcg ggaggccctg acctgcgagc tgagcagggc
     2641 cgagtttgcc gagtccctgg gcctcaagcc ccaggacatg tttgtggagt ccatgttctc
     2701 tctggctgac aaggatggca atggctacct gtccttccga gagttcctgg acatcctggt
     2761 ggtcttcatg aaaggctccc cagaggataa gtcccgtcta atgtttacca tgtatgacct
     2821 ggatgagaat ggcttcctct ccaaggacga attcttcacc atgatgcgat ccttcatcga
     2881 gatctccaac aactgcctgt ccaaggccca gctggccgag gtggtggagt ctatgttccg
     2941 ggagtcggga ttccaggaca aggaggagct gacatgggag gattttcact tcatgctgcg
     3001 ggaccatgac agcgagctcc gcttcacgca gctctgtgtc aaaggtggag gtggaggtgg
     3061 aaatggtatt agagatatct ttaaacaaaa catcagctgt cgagtctcgt tcatcactcg
     3121 gacacctggg gagcgctccc acccccaggg actggggccc cctgccccag aagccccaga
     3181 gctgggaggc cctggactga agaagaggtt tggcaaaaag gcagcagtgc ccactccccg
     3241 gctgtacaca gaggcgctgc aagagaagat gcagcgaggc ttcctagccc aaaagctgca
     3301 gcagtacaag cgcttcgtgg agaactaccg gaggcacatc gtgtgtgtgg caatcttctc
     3361 ggccatctgt gttggcgtgt ttgcagatcg tgcttactac tatggctttg cctcgccacc
     3421 ctcggacatt gcacagacca ccctcgtggg catcatcctg tcacgaggca cggcggccag
     3481 cgtctccttc atgttctctt atatcttgct caccatgtgc cgcaacctca taaccttcct
     3541 gcgagagact ttcctcaacc gctatgtgcc ttttgatgcc gcagtggact tccaccgctg
     3601 gatcgccatg gctgctgttg tcctggccat tttgcacagt gctggccacg cagtcaatgt
     3661 ctacatcttc tcagtcagcc cactcagcct gctggcctgc atattcccca acgtctttgt
     3721 gaatgatggg tccaagcttc cccagaagtt ctattggtgg ttcttccaga ccgtcccagg
     3781 tatgacaggt gtgcttctgc tcctggtcct ggccatcatg tatgtcttcg cctcccacca
     3841 cttccgccgc cgcagcttcc ggggcttctg gctgacccac cacctctaca tcctgctcta
     3901 tgccctgctc atcatccatg gcagctatgc tctgatccag ctgcccactt tccacatcta
     3961 cttcctggtc ccggcaatca tctatggagg tgacaagctg gtgagcctga gccggaagaa
     4021 ggtggagatc agcgtggtga aggcggagct gctgccctca ggagtgacct acctgcaatt
     4081 ccagaggccc caaggctttg agtacaagtc aggacagtgg gtgcggatcg cctgcctggc
     4141 tctggggacc accgagtacc accccttcac actgacctcc gcgccccatg aggacacact
     4201 cagcctgcac atccgggcag tggggccctg gaccactcgc ctcagggaga tctactcatc
     4261 cccaaagggc aatggctgtg ctggataccc aaagctgtac cttgatggac cgtttggaga
     4321 gggccatcag gagtggcata aatttgaggt gtcagtgttg gtgggagggg gcattggggt
     4381 cacccccttt gcctccatcc tcaaagacct ggtcttcaag tcatccttgg gcagccaaat
     4441 gctgtgtaag aagatctact tcatctgggt gacacggacc cagcgtcagt ttgagtggct
     4501 ggctgacatc atccaagagg tggaggagaa cgaccaccag gacctggtgt ctgtgcacat
     4561 ttatgtcacc cagctggctg agaagttcga cctcaggacc accatgctat acatctgcga
     4621 gcggcacttc cagaaagtgc tgaaccggag tctgttcacg ggcctgcgct ccatcaccca
     4681 ctttggccgt ccccccttcg agcccttctt caactccctg caggaggtcc acccacaggt
     4741 gcgcaagatc ggggtgttca gctgcggccc tccaggaatg accaagaatg tagagaaggc
     4801 ctgtcagctc gtcaacaggc aggaccgagc ccacttcatg caccactatg agaacttctg
     4861 agcctgtcct ccctggctgc tgcttccagt atcctgcctt ctcttctgtg cacctaagtt
     4921 gcccagccct gctggcaatc tctccatcag aatccacctt aggcctcagc tggagggctg
     4981 cagagcccct cccaatattg ggagaatatt gacccagaca attatacaaa tgagaaaagg
     5041 caggagacta tgttctacaa ttgcagtgca tgatgattat aagtccacct gtttatcaac
     5101 ggcaccattc ctgcagccct ccagacttcc tgcccttagc aagtgcgcaa ccagtcagga
     5161 tctcccaaag aagataaaga ccactcctca ccccagctca agccatggca ggcgtggcaa
     5221 gcaaagtggg gaggagacag tccctgcttg tgacaagtgt ggaggtgaaa aggtacaata
     5281 gtgcttgtct ccgatagctc cccacatctc taattgactt ccacaaaatc gatgcgttgc
     5341 tttggtattt gcttggactg acatttgagg gaggaggagg ctgggatcct ctggctgaga
     5401 atctcctcag agcccagtgc agaagctgtg atgcttagaa cctggacagc ccgactgcct
     5461 caactctgtc tccaggtcta ttccctccag ctccaaaagg agcagcccta cttctacccc
     5521 ttcccgtccc caaagtgtca gcaactttga ggagggcacc aggaaacaaa gatgcctccc
     5581 cagccctgat attcttgatg tcaccagtga tacccactgc cctgacccct gggcaggccc
     5641 ctctctgcat ctactggagt ggtccctggg ctctggggct gaaggattcc agcctctctg
     5701 ccagatattc agtactcgat ctcaattccc ctcttccaca agagttgggt gaccagctgt
     5761 cctagtttgc ccaggactct ccctgtttta gcactgaaag tctcttgccc caggaaaccc
     5821 catcagtccc aggcagattg ggacagctgg tcaccttacg caagagccag gctgaaacat
     5881 cccctccata ctcagctctt taacttttct tttccttttt catcgggctc tttcctaaaa
     5941 agctgagctg taaaatattt tacatcgagg tataataaat aatcatgtac atgttttacc
     6001 accacccagg tcaagacata gaatgtttca acatttccat caccccagaa actccccttg
     6061 tacccccttc cacttcgtct cccctagctc ctagaagcaa ccactgatgt gatttctacc
     6121 aaatccagtt ttggtcctac taaatatact cttttgagac tggcctcttt tactcaccat
     6181 aatgcctttg taattcatcc atgctgttgt gtgtatcagc agtttgttcc ttttcattgc
     6241 tgagtagtat tctattgtag agatgtacca cagtttgttt attcttctgt tgatggacgt
     6301 ttgggttgtt tctaattttg aatgattata aataaaaatt ctgtgagtgt tcttgtacct
     6361 a
//
