LOCUS       NM_175940               5483 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens dual oxidase 1 (DUOX1), transcript variant 2, mRNA.
ACCESSION   NM_175940
VERSION     NM_175940.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5483)
  AUTHORS   Conner,G.E.
  TITLE     NADPH Alters DUOX1 Calcium Responsiveness
  JOURNAL   Redox Biol 75, 103251 (2024)
   PUBMED   38936256
  REMARK    GeneRIF: NADPH Alters DUOX1 Calcium Responsiveness.
REFERENCE   2  (bases 1 to 5483)
  AUTHORS   Wei,C., Li,L., Qiao,Y., Chen,Y., Zhang,C., Xie,J., Fang,J.,
            Liang,Z., Huang,D. and Wu,D.
  TITLE     Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor
            microenvironment and predict overall survival of lung
            adenocarcinoma patients
  JOURNAL   Medicine (Baltimore) 103 (22), e38322 (2024)
   PUBMED   39259123
  REMARK    GeneRIF: Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor
            microenvironment and predict overall survival of lung
            adenocarcinoma patients.
REFERENCE   3  (bases 1 to 5483)
  AUTHORS   Li,Y.S., Xia,J., Chen,C.Y., Ren,S.H. and He,M.R.
  TITLE     Upregulated dual oxidase 1-induced oxidative stress and
            caspase-1-dependent pyroptosis reflect the etiologies of heart
            failure
  JOURNAL   BMC Mol Cell Biol 25 (1), 16 (2024)
   PUBMED   38750444
  REMARK    GeneRIF: Upregulated dual oxidase 1-induced oxidative stress and
            caspase-1-dependent pyroptosis reflect the etiologies of heart
            failure.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5483)
  AUTHORS   Huang,L., Chen,G., He,J. and Wang,P.
  TITLE     ZC3H13 reduced DUOX1-mediated ferroptosis in laryngeal squamous
            cell carcinoma cells through m6A-dependent modification
  JOURNAL   Tissue Cell 84, 102187 (2023)
   PUBMED   37536262
  REMARK    GeneRIF: ZC3H13 reduced DUOX1-mediated ferroptosis in laryngeal
            squamous cell carcinoma cells through m6A-dependent modification.
REFERENCE   5  (bases 1 to 5483)
  AUTHORS   Biakina,O., Mitina,Y., Gognieva,D., Axenova,M., Ermolaeva,A.,
            Bestavashvili,A., Fadeev,V., Syrkin,A. and Kopylov,P.
  TITLE     DUOX1 Gene Missense Mutation Confers Susceptibility on Type 2
            Amiodarone-Induced Thyrotoxicosis
  JOURNAL   Int J Mol Sci 24 (4), 4016 (2023)
   PUBMED   36835420
  REMARK    GeneRIF: DUOX1 Gene Missense Mutation Confers Susceptibility on
            Type 2 Amiodarone-Induced Thyrotoxicosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5483)
  AUTHORS   Lambeth,J.D.
  TITLE     Nox/Duox family of nicotinamide adenine dinucleotide (phosphate)
            oxidases
  JOURNAL   Curr Opin Hematol 9 (1), 11-17 (2002)
   PUBMED   11753072
  REMARK    Review article
REFERENCE   7  (bases 1 to 5483)
  AUTHORS   Edens,W.A., Sharling,L., Cheng,G., Shapira,R., Kinkade,J.M.,
            Lee,T., Edens,H.A., Tang,X., Sullards,C., Flaherty,D.B.,
            Benian,G.M. and Lambeth,J.D.
  TITLE     Tyrosine cross-linking of extracellular matrix is catalyzed by
            Duox, a multidomain oxidase/peroxidase with homology to the
            phagocyte oxidase subunit gp91phox
  JOURNAL   J Cell Biol 154 (4), 879-891 (2001)
   PUBMED   11514595
REFERENCE   8  (bases 1 to 5483)
  AUTHORS   Caillou,B., Dupuy,C., Lacroix,L., Nocera,M., Talbot,M., Ohayon,R.,
            Deme,D., Bidart,J.M., Schlumberger,M. and Virion,A.
  TITLE     Expression of reduced nicotinamide adenine dinucleotide phosphate
            oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid
            tissues
  JOURNAL   J Clin Endocrinol Metab 86 (7), 3351-3358 (2001)
   PUBMED   11443211
REFERENCE   9  (bases 1 to 5483)
  AUTHORS   De Deken,X., Wang,D., Many,M.C., Costagliola,S., Libert,F.,
            Vassart,G., Dumont,J.E. and Miot,F.
  TITLE     Cloning of two human thyroid cDNAs encoding new members of the
            NADPH oxidase family
  JOURNAL   J Biol Chem 275 (30), 23227-23233 (2000)
   PUBMED   10806195
REFERENCE   10 (bases 1 to 5483)
  AUTHORS   Dupuy,C., Ohayon,R., Valent,A., Noel-Hudson,M.S., Deme,D. and
            Virion,A.
  TITLE     Purification of a novel flavoprotein involved in the thyroid NADPH
            oxidase. Cloning of the porcine and human cdnas
  JOURNAL   J Biol Chem 274 (52), 37265-37269 (1999)
   PUBMED   10601291
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF213465.1, AF230495.1,
            AC051619.7 and CB852814.1.
            
            On Nov 23, 2018 this sequence version replaced NM_175940.2.
            
            Summary: The protein encoded by this gene is a glycoprotein and a
            member of the NADPH oxidase family. The synthesis of thyroid
            hormone is catalyzed by a protein complex located at the apical
            membrane of thyroid follicular cells. This complex contains an
            iodide transporter, thyroperoxidase, and a peroxide generating
            system that includes proteins encoded by this gene and the similar
            DUOX2 gene. This protein is known as dual oxidase because it has
            both a peroxidase homology domain and a gp91phox domain. This
            protein generates hydrogen peroxide and thereby plays a role in the
            activity of thyroid peroxidase, lactoperoxidase, and in
            lactoperoxidase-mediated antimicrobial defense at mucosal surfaces.
            Two alternatively spliced transcript variants encoding the same
            protein have been described for this gene. [provided by RefSeq, Jul
            2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF213465.1, BC114628.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389037.7/ ENSP00000373689.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3381              AF213465.1         1-3381
            3382-4816           AF230495.1         3574-5008
            4817-5230           AC051619.7         36204-36617
            5231-5483           CB852814.1         22-274              c
FEATURES             Location/Qualifiers
     source          1..5483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..5483
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /note="dual oxidase 1"
                     /db_xref="GeneID:53905"
                     /db_xref="HGNC:HGNC:3062"
                     /db_xref="MIM:606758"
     exon            1..105
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            106..212
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..4810
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /EC_number="1.6.3.1"
                     /note="NADPH thyroid oxidase 1; nicotinamide adenine
                     dinucleotide phosphate oxidase; flavoprotein NADPH
                     oxidase; long NOX 1; large NOX 1"
                     /codon_start=1
                     /product="dual oxidase 1 precursor"
                     /protein_id="NP_787954.1"
                     /db_xref="CCDS:CCDS32221.1"
                     /db_xref="GeneID:53905"
                     /db_xref="HGNC:HGNC:3062"
                     /db_xref="MIM:606758"
                     /translation="MGFCLALAWTLLVGAWTPLGAQNPISWEVQRFDGWYNNLMEHRW
                     GSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFF
                     GYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPS
                     NPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAA
                     PDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELF
                     QHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMV
                     PPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQI
                     AEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRW
                     QDINPALSRSNDTVLEATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIVLEQFVRL
                     RDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSALQPNVFVWHKGDPCP
                     QPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLRMRNF
                     KRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQ
                     LQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEERQALVENLRGALKESGLSI
                     QEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQADAGTLPLDSSQKVREAL
                     TCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKS
                     RLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEE
                     LTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQDMICPSPRVSARC
                     SRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSCLHQT
                     VQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRG
                     TAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSV
                     GHVVNVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLLILAI
                     MYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIYGG
                     DKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHP
                     FTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWH
                     KFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADII
                     REVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFG
                     RPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF"
     exon            213..296
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..461
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..649
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..851
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1018
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1079
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1176
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1267
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1370
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1543
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1719
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1838
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1976
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2090
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2290
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2476
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2702
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2796
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2972
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3042
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3168
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3347
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3578
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3678
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3728
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..3856
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..4010
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4243
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4402
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..4558
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            4559..4687
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            4688..5483
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5465..5470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /note="hexamer: AATAAA"
     polyA_site      5483
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /note="major polyA site"
ORIGIN      
        1 gcagagctgc agaggcaccg gacgagagag ggctccgcgg gcccagctgg cagccaggcc
       61 ggagacaagt tgcagtcccg ggctctggtg acgccgtggc cgcagggtct ccattttggg
      121 acattctaat ccctgagccc ctattatttt catcatgggc ttctgcctgg ctctagcatg
      181 gacacttctg gttggggcat ggacccctct gggagctcag aaccccattt cgtgggaggt
      241 gcagcgattt gatgggtggt acaacaacct catggagcac agatggggca gcaaaggctc
      301 ccggctgcag cgcctggtcc cagccagcta tgcagatggc gtgtaccagc ccttgggaga
      361 accccacctg cccaaccccc gagaccttag caacaccatc tcaaggggcc ctgcagggct
      421 ggcctccctg agaaaccgca cagtgttggg ggtcttcttt ggctatcacg tgctttcaga
      481 cctggtgagc gtggaaactc ccggctgccc cgccgagttc ctcaacattc gcatcccgcc
      541 cggagacccc atgttcgacc ccgaccagcg cggggacgtg gtgctgccct tccagagaag
      601 ccgctgggac cccgagaccg gacggagtcc cagcaatccc cgggacccgg ccaaccaggt
      661 gacgggctgg ctggacggca gcgccatcta tggttcctcg cattcctgga gcgacgcgct
      721 gcggagcttc tccaggggac agctggcgtc ggggcccgac cccgcttttc cccgagactc
      781 gcagaacccc ctgctcatgt gggcggcgcc cgaccccgcc accgggcaga acgggccccg
      841 ggggctgtac gccttcgggg cagagagagg gaaccgggaa cccttcctgc aggcgctggg
      901 cctgctctgg ttccgctacc acaacctgtg ggcgcagagg ctggcccgcc agcacccaga
      961 ctgggaggac gaggagctgt tccagcacgc acgcaagagg gtcatcgcca cctaccagaa
     1021 catcgctgtg tatgagtggc tgcccagctt cctgcagaaa acactcccgg agtatacagg
     1081 ataccggcca tttctggacc ccagcatctc ctcagagttc gtggcggcct ctgagcagtt
     1141 cctgtccacc atggtgcccc ctggcgtcta catgagaaat gccagctgcc acttccaggg
     1201 ggtcatcaat cggaactcaa gtgtctccag agctctccgg gtctgcaaca gctactggag
     1261 ccgtgagcac ccaagcctac aaagtgctga agatgtggat gcactgctgc tgggcatggc
     1321 ctcccagatc gcagagcgag aggaccatgt gttggttgaa gatgtgcggg atttctggcc
     1381 tgggccactg aagttttccc gcacagacca cctggccagc tgcctgcagc ggggccggga
     1441 tctgggcctg ccctcttaca ccaaggccag ggcagcactg ggcttgtctc ccattacccg
     1501 ctggcaggac atcaaccctg cactctcccg gagcaatgac actgtactgg aggccacagc
     1561 tgccctgtac aaccaggact tatcctggct agagctgctc cctgggggac tcctggagag
     1621 ccaccgggac cctggacctc tgttcagcac catcgtcctt gaacaatttg tgcggctacg
     1681 ggatggtgac cgctactggt ttgagaacac caggaatggg ctgttctcca agaaggagat
     1741 tgaagaaatc cgaaatacca ccctgcagga cgtgctggtc gctgttatca acattgaccc
     1801 cagtgctctg cagcccaatg tctttgtctg gcataaagga gacccctgtc cgcagccgag
     1861 acagctcagc actgaaggcc tgccagcgtg tgctccctct gttgttcgtg actattttga
     1921 gggcagtgga tttggcttcg gggtcaccat cgggaccctc tgttgcttcc ctttggtgag
     1981 cctgctcagt gcctggattg ttgcccggct ccggatgaga aatttcaaga ggctccaggg
     2041 ccaggaccgc cagagcatcg tgtctgagaa gctcgtggga ggcatggaag ctttggaatg
     2101 gcaaggccac aaggagccct gccggcccgt gcttgtgtac ctgcagcccg ggcagatccg
     2161 tgtggtagat ggcaggctca ccgtgctccg caccatccag ctgcagcctc cacagaaggt
     2221 caacttcgtc ctgtccagca accgtggacg ccgcactctg ctgctcaaga tccccaagga
     2281 gtatgacctg gtgctgctgt ttaacttgga ggaagagcgg caggcgctgg tggaaaatct
     2341 ccggggagct ctgaaggaga gcgggttgag catccaggag tgggagctgc gggagcagga
     2401 gctgatgaga gcagctgtga cacgggagca gcggaggcac ctcctggaga cctttttcag
     2461 gcaccttttc tcccaggtgc tggacatcaa ccaggccgac gcagggaccc tgcccctgga
     2521 ctcctcccag aaggtgcggg aggccctgac ctgtgagctg agcagggccg agtttgccga
     2581 gtccctgggc ctcaagcccc aggacatgtt tgtggagtcc atgttctctc tggctgacaa
     2641 ggatggcaat ggctacctgt ccttccgaga gttcctggac atcctggtgg tcttcatgaa
     2701 aggctctcct gaggaaaagt ctcgccttat gttccgcatg tacgactttg atgggaatgg
     2761 cctcatttcc aaggatgagt tcatcaggat gctgagatcc ttcatcgaga tctccaacaa
     2821 ctgcctgtcc aaggcccagc tggctgaggt ggtggagtcc atgttccggg agtcgggatt
     2881 ccaggacaag gaggaactga catgggaaga ttttcacttc atgctgcggg accacaatag
     2941 cgagctccgc ttcacgcagc tctgtgtcaa aggggtggag gtgcctgaag tcatcaagga
     3001 cctctgccgg cgagcctcct acatcagcca ggatatgatc tgtccctctc ccagagtgag
     3061 tgcccgctgt tcccgcagcg acattgagac tgagttgaca cctcagagac tgcagtgccc
     3121 catggacaca gaccctcccc aggagattcg gcggaggttt ggcaagaagg taacgtcatt
     3181 ccagcccttg ctgttcactg aggcgcaccg agagaagttc caacgcagct gtctccacca
     3241 gacggtgcaa cagttcaagc gcttcattga gaactaccgg cgccacatcg gctgcgtggc
     3301 cgtgttctac gccatcgctg gggggctttt cctggagagg gcctactact acgcctttgc
     3361 cgcacatcac acgggcatca cagacaccac ccgcgtggga atcatcctgt cgcggggcac
     3421 agcagccagc atctctttca tgttctccta catcttgctc accatgtgcc gcaacctcat
     3481 caccttcctg cgagaaacct tcctcaaccg ctacgtgccc ttcgacgccg ccgtggactt
     3541 ccatcgcctc attgcctcca ccgccatcgt cctcacagtc ttacacagtg tgggccatgt
     3601 ggtgaatgtg tacctgttct ccatcagccc cctcagcgtc ctctcttgcc tctttcctgg
     3661 cctcttccat gatgatgggt ctgagctccc ccagaagtat tactggtggt tcttccagac
     3721 cgtaccaggc ctcacggggg ttgtgctgct cctgatcctg gccatcatgt atgtctttgc
     3781 ctcccaccac ttccgccgcc gcagtttccg gggcttctgg ctgacccacc acctctacat
     3841 cctgctctat gtcctgctca tcatccatgg tagctttgcc ctgatccagc tgccccgttt
     3901 ccacatcttc ttcctggtcc cagcaatcat ctatgggggc gacaagctgg tgagcctgag
     3961 ccggaagaag gtggagatca gcgtggtgaa ggcggagctg ctgccctcag gagtgaccca
     4021 cctgcggttc cagcggcccc agggctttga gtacaagtca gggcagtggg tgcggatcgc
     4081 ttgcctggct ctggggacca ccgagtacca ccccttcaca ctgacctctg cgccccatga
     4141 ggacacgctt agcctgcaca tccgggcagc agggccctgg accactcgcc tcagggagat
     4201 ctactcagcc ccgacgggtg acagatgtgc cagataccca aagctgtacc ttgatggacc
     4261 atttggagag ggccaccagg agtggcataa gtttgaggtg tcagtgttag tgggaggggg
     4321 cattggggtc accccttttg cctccatcct caaagacctg gtcttcaagt catccgtcag
     4381 ctgccaagtg ttctgtaaga agatctactt catctgggtg acgcggaccc agcgtcagtt
     4441 tgagtggctg gctgacatca tccgagaggt ggaggagaat gaccaccagg acctggtgtc
     4501 tgtgcacatc tacatcaccc agctggctga gaagttcgac ctcaggacca ctatgctgta
     4561 catctgtgag cggcacttcc agaaggttct gaaccggagt ctattcacag gcctgcgctc
     4621 catcacccac tttggccgtc ccccctttga gcccttcttc aactccctgc aggaggtcca
     4681 cccccaggtc cggaagatcg gggtgtttag ctgtggcccc cctggcatga ccaagaatgt
     4741 ggaaaaggcc tgtcagctca tcaacaggca ggaccggact cacttctccc accattatga
     4801 gaacttctag gcccctgccc gggggttctg cccactgccc agttgagcag aggtttgagc
     4861 ccacacctca cctctgttct tcctatttct ggctgcctca gccttctctg atttcccacc
     4921 tcccaacctt gttccaggtg gccatagtca gtcaccatgt gtgggctcag ggacccccag
     4981 gaccaggatg tgtctcagcc tggagaaatg gtgggggggc agtgtctagg gactagagtg
     5041 agaagtaggg gagctactga tttggggcaa agtgaaacct ctgcttccag acttcagaaa
     5101 caaatctcag aagacaagct gacctgacaa gtactatgtg tgtgcatgtc tgtatgtgtg
     5161 ttggggcggt gagtgtaagg atgcagtggg agcatggatg ctggcatctt agaaccctcc
     5221 ctactcccat acctcctcct cttctgggct ccccactgtc agacgggctg gcaaatgcct
     5281 tgcaggaggt agaggctgga cccatggcaa gccatttaca gaaacccact cggcacccca
     5341 gtctaacacc acaactaatt tcacccaagg ttttaagcac gttctttcat cagaccctgg
     5401 cccaatacct atgtatgcaa tgctcctcag ccctcttctc cctgctccag tagtctccct
     5461 tccaaataaa tcacttttct gcc
//
