LOCUS       NM_015177               6003 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens deltex E3 ubiquitin ligase 4 (DTX4), transcript
            variant 1, mRNA.
ACCESSION   NM_015177 XM_166213 XM_937661
VERSION     NM_015177.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6003)
  AUTHORS   Cui,Y., Luo,J., Bai,N. and Yu,Z.
  TITLE     Deltex E3 ubiquitin ligase 4 promotes thyroid cancer progression
            through stearoyl-CoA desaturase 1
  JOURNAL   Funct Integr Genomics 23 (3), 280 (2023)
   PUBMED   37612343
  REMARK    GeneRIF: Deltex E3 ubiquitin ligase 4 promotes thyroid cancer
            progression through stearoyl-CoA desaturase 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6003)
  AUTHORS   Kodani,A., Knopp,K.A., Di Lullo,E., Retallack,H., Kriegstein,A.R.,
            DeRisi,J.L. and Reiter,J.F.
  TITLE     Zika virus alters centrosome organization to suppress the innate
            immune response
  JOURNAL   EMBO Rep 23 (9), e52211 (2022)
   PUBMED   35793002
REFERENCE   3  (bases 1 to 6003)
  AUTHORS   Chastagner,P., Rubinstein,E. and Brou,C.
  TITLE     Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and
            bilateral endocytosis before ADAM10 processing
  JOURNAL   Sci Signal 10 (483) (2017)
   PUBMED   28611181
  REMARK    GeneRIF: Notch is ligand activated and undergoes DTX4-mediated
            ubiquitylation and bilateral endocytosis before ADAM10 processing
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6003)
  AUTHORS   Lin,M., Zhao,Z., Yang,Z., Meng,Q., Tan,P., Xie,W., Qin,Y.,
            Wang,R.F. and Cui,J.
  TITLE     USP38 Inhibits Type I Interferon Signaling by Editing TBK1
            Ubiquitination through NLRP4 Signalosome
  JOURNAL   Mol Cell 64 (2), 267-281 (2016)
   PUBMED   27692986
REFERENCE   5  (bases 1 to 6003)
  AUTHORS   Cui,J., Li,Y., Zhu,L., Liu,D., Songyang,Z., Wang,H.Y. and Wang,R.F.
  TITLE     NLRP4 negatively regulates type I interferon signaling by targeting
            the kinase TBK1 for degradation via the ubiquitin ligase DTX4
  JOURNAL   Nat Immunol 13 (4), 387-395 (2012)
   PUBMED   22388039
  REMARK    GeneRIF: Our results provide molecular insight into the mechanisms
            by which NLRP4-DTX4 targets TBK1 for degradation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6003)
  AUTHORS   Storck,S., Delbos,F., Stadler,N., Thirion-Delalande,C., Bernex,F.,
            Verthuy,C., Ferrier,P., Weill,J.C. and Reynaud,C.A.
  TITLE     Normal immune system development in mice lacking the Deltex-1 RING
            finger domain
  JOURNAL   Mol Cell Biol 25 (4), 1437-1445 (2005)
   PUBMED   15684394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001258.4, BF195769.1, AB023154.1 and AP002358.3.
            
            On Nov 23, 2018 this sequence version replaced NM_015177.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023154.1, SRR9304715.659026.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227451.4/ ENSP00000227451.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AP001258.4         116831-117037
            208-360             BF195769.1         60-212
            361-2894            AB023154.1         1-2534
            2895-3673           AP002358.3         25029-25807
            3674-3945           AB023154.1         3314-3585
            3946-5775           AB023154.1         3592-5421
            5776-6002           AB023154.1         5424-5650
            6003-6003           AP002358.3         28137-28137
FEATURES             Location/Qualifiers
     source          1..6003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..6003
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /note="deltex E3 ubiquitin ligase 4"
                     /db_xref="GeneID:23220"
                     /db_xref="HGNC:HGNC:29151"
                     /db_xref="MIM:616110"
     exon            1..675
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /inference="alignment:Splign:2.1.0"
     CDS             465..2324
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein deltex-4; deltex4; RING finger protein 155; deltex
                     4 homolog; deltex 4, E3 ubiquitin ligase; E3
                     ubiquitin-protein ligase DTX4; deltex homolog 4; RING-type
                     E3 ubiquitin transferase DTX4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase DTX4 isoform 1"
                     /protein_id="NP_055992.1"
                     /db_xref="CCDS:CCDS44612.1"
                     /db_xref="GeneID:23220"
                     /db_xref="HGNC:HGNC:29151"
                     /db_xref="MIM:616110"
                     /translation="MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSV
                     VLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSW
                     TPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLI
                     YPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTR
                     KNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPAS
                     PPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGI
                     TGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEE
                     VLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHVYHIYCLV
                     AMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIP
                     PGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTG
                     ESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD"
     exon            676..1399
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1461
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1623
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1685
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1838
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2000
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2090
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..6003
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5563..5568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /note="hexamer: AATAAA"
     regulatory      5574..5579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /note="hexamer: AATGAA"
     polyA_site      5585
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /note="major polyA site"
     polyA_site      5590
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /note="major polyA site"
     regulatory      5981..5986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTX4"
                     /gene_synonym="RNF155"
                     /note="hexamer: AATAAA"
     polyA_site      6003
                     /gene="DTX4"
                     /gene_synonym="RNF155"
ORIGIN      
        1 attccgagcg cggccgtgcg gcgagatccc accccggcgt ctgcagaggc cgaggcgcaa
       61 ctggtgcgag ggctgggtcc ttgcctcgcc gtcagcccca gctcgcggcc gccggggctc
      121 gggccgcgcg cccgccgagt ggcttttgca aggcgggggc ctgtttgcag agagccgggc
      181 atttgcatga agcgactcga ccccacagag cagcggcagc agcagcggac cccggcggcg
      241 gcggcggcgc gcggtcccag ccaggcggcc ccggtgtccc ggccccggtg gatgcacggc
      301 tggggaggag cccatgggcc ggagctgagg ctgcccgggg cggcggggcg cggggcaggg
      361 ggcgcggtcg aggcccggag gcggcggcgc aggaggaagc ggaggaggtc gggcgctcgg
      421 ggcccgggag gcgggccgcg cagcgccgca gccccgggct cgccatgctc ctggcctcgg
      481 ccgtggtggt ctgggaatgg ctgaacgagc acggccgctg gcgtccctac agcccagcgg
      541 tgagccacca catcgaggcg gtggtccgcg ccggcccccg cgcggggggc agcgtggtgc
      601 tgggccaggt ggacagccgt ctcgcgccct acatcatcga cctgcagtcc atgaaccagt
      661 tccgccaaga cacgggaact ctccgcccag ttcgccgcaa ctactacgac ccctcctcgg
      721 cccctgggaa gggcgtggtg tgggagtggg agaacgacaa tggctcctgg acgccctacg
      781 acatggaagt gggcatcacc atccagcatg cctatgagaa gcagcacccc tggatcgacc
      841 tcacttccat tggctttagc tacgtaattg acttcaacac catgggccag atcaaccgtc
      901 agacccagcg ccaacgccgc gtccgccggc gcctcgacct catctacccc atggtcacag
      961 ggaccttgcc taaggctcag tcctggccag tcagccctgg gccagccacc tcgcccccca
     1021 tgtccccctg ctcctgtccc cagtgtgtct tggtgatgag tgttaaggca gccgtggtca
     1081 atggcagcac tgggccccta cagctgccag tgacccgcaa gaacatgccg cctcctggag
     1141 tggtcaagct acccccactg ccaggctctg gggccaagcc actggacagc acaggcacca
     1201 ttcgaggccc actgaagacc gccccatcgc aggtgatccg gagacaagcc tccagcatgc
     1261 ccactgggac aaccatgggc tctcctgcca gtcccccagg acccaacagc aagaccggaa
     1321 gggtggccct ggccaccttg aatcgtacca acctgcagcg actggccatt gcccagtccc
     1381 gggtgctgat cgcctctggg gtccccacag tcccagtgaa gaacctaaat gggtccagtc
     1441 ctgtcaaccc tgccttggca ggaatcactg ggatcctcat gagtgcagcg gggctgcctg
     1501 tgtgtctcac caggccacca aagctggtcc tacacccacc ccccgtcagc aagagtgaaa
     1561 taaaatccat cccaggggtt tccaacacaa gccgcaagac caccaaaaaa caagccaaga
     1621 aaggtaaaac cccagaggaa gtgctaaaaa aatatctaca gaaagtccgg cacccaccag
     1681 atgaggactg caccatctgt atggaacgcc tcacggcccc ctcaggctac aagggcccgc
     1741 agcctacggt aaaacctgac ctggtaggga agctgtccag atgcggccac gtctaccaca
     1801 tctactgctt ggttgccatg tacaacaatg ggaacaagga tggaagtttg cagtgtccaa
     1861 cctgcaagac catttatggg gtgaagacag gcacccaacc tccagggaag atggagtacc
     1921 acctcatccc ccactccttg cctggccacc cagactgcaa aaccatccgg atcatctaca
     1981 gcatcccccc cggcattcag ggaccggaac acccgaatcc tgggaagagt ttcagcgccc
     2041 gaggcttccc acgacactgt taccttccgg acagcgagaa agggagaaaa gttctgaagc
     2101 tgctgctcgt ggcctgggat cgccgcctca tttttgccat tggcacctcc agcaccacag
     2161 gcgagtcaga caccgtcatc tggaatgagg tccaccacaa gacagagttt ggctctaatc
     2221 tcactggcca tggctaccca gatgccaatt acctggataa tgtgctggct gaactggctg
     2281 cccagggcat ctctgaggac agcactgccc aggagaagga ctgaggccag aaaagctttg
     2341 aggtgggagg ggccatggag actgcaggac aggaagtgag gagagtgagt caatgtagaa
     2401 gaagttggtg tcctgccctc ccaactttct atcctcccct cctgccctgt gtccatccct
     2461 catccctccc aaccacagtg ggagccagac tgaatatagc gacatcattc ataaatctca
     2521 tccaacacaa agggagatgg gatgagggcc atcctgggtc tgttcccatg gagtttttgg
     2581 tgctgggtag gcaggaatcc cctccctacc ccacctccca agtaggggca tggtcagcac
     2641 acctagggta tgggcagtgc ttaggcactc catatcctgg ctttgggaag ccggggtttc
     2701 ttgcctcagc cggcttcttg ctacttccac tctgctttga gactggagtt tctgctattc
     2761 tccctctgct ggaggcaggg agctctcact gtgcaaggtt ggggggtggg caaaggggtg
     2821 aatcactaaa ctgctgtgac atcagaaact gatgccttgg tgtagagcaa ggaagcactt
     2881 cttcccaaga gggtcggaga aggaaaagcc tctgggagca cattctgctg tcatcacagt
     2941 ccttggcttc tctgggccct cctctcctcc tcacagctct cacctgtcca aagaggcatc
     3001 tggttctctc atgtggatgg atggactctg gggttcctct ttggagtggc atcccatgat
     3061 gctgtttcta gaccctctct gatcaaacca gagcctgcat cccactgagc atctgaactg
     3121 tcctcaggga gaggagccca cagccttctt cccaactcat tctagaccag ctcaaagatt
     3181 ccatgagttt catcgagtca ctgtgagtgg agcccatgct gggctctgtg ccctctgtgt
     3241 ctgtgcatgc gcgtgtgtgt gtgggcgtgt gtgcattgct gggccagctt gaagggaagg
     3301 cccgtcatgt ccctgcactc tgttttgcaa gatgccaaac cccagttctg atggggctcc
     3361 aacagccagg ctgtggtcct ttgacgttcc tcacctgttg ccaacctatc ccgtagtgaa
     3421 ctgaaacccc aatgaagaca gaactgtgcc tggggagatg caatgaggtg agggctgaac
     3481 tcatcctttt atatttcttt tcaagattgg atcagagctc atctccatcc agtcttgttt
     3541 ctatgaaggc ttcaatctgt ttccatgcaa atttgctaat cagagcccag agctgctggg
     3601 tccctcatct ccctcatcta ttatagattg acttacagca gggagagaat ctctttagct
     3661 cattcctaat ggagttggga tcacaatatg gtctggtcca atctgcatct tgttgtgtcc
     3721 caagacccta tctcctcccc aacattctta ttgcctttgg ctcccagtaa ggaacgaatt
     3781 gggggccagg gaggagaaca ggggggatca agaagggaaa cccaattccc cctttgaaag
     3841 tgggttcttt gaactatgtg tttgggggaa gttcctctgg atactaattt gaatttatat
     3901 acctcatgtt ttgggggttt gacgtatata tatatatata tatatgcata tatatttcat
     3961 aatatttgga aggtttttga tgctagaaaa atggaaacaa gagaaccttc aaaaatggta
     4021 cttagatggg aactggaggc caatctttca taaagccagc cccatagctg cttgctgtta
     4081 ggcctccagc cattttgaca ttggggtgga tagtcgattc acctgcctgt cagtcgattc
     4141 acctgcctgt cacccagttc tgtggatgtg ctggtgctga gcctttgctc tctttccaaa
     4201 tggttacagg gatgttgatc agctccacca gagggagctc tgatgggagg aattgctctg
     4261 ccatccttgt ccctgtgtct cctgtcggca ggcagccatt gtatctcacc agcagaccag
     4321 gagactggtc ccaaggttac tgcaccacag ggcaatttcc tgccatagtt aggaaggaaa
     4381 cacctgaact aaatggaaga gacatccctg cggtgtttaa tatcacaccc atgccctttg
     4441 tcaggttacc atgtacagag attacttgga gagcctcatg ccgtctctac cttcgcacac
     4501 tggtcaagta tctgctgagc ttcttggccg caaggatgca gaaataggct gagggtccat
     4561 gggaagaaag acacaatgag gcagtaggag gtggggaaga aaagaagaca gactttcaaa
     4621 atggaattag gcactgggga gagatcagtt tccccacatc agggagaaga aggtataggt
     4681 ggggaagggg gtggccagga gcagaaggaa gaagactcaa gatggaaagg gagccgctgt
     4741 gcctgtggca ataccacttg gagaggtcga cttcatacct tcaagccttt tcccctgggc
     4801 ttttgattgt gtctgtgccc cctttcttgt cctctctgca gatgcccagt aggggctacc
     4861 tcatcctcgt gctgttcttg tgtggctttc tgggcagtag ggatcttgaa tttcctttct
     4921 aacactgtgc ccggcaaggc ggggagcatt cctctgccct ttgtcttgtg ccaacctgga
     4981 aaggtgcagt ctagatttca gtgagaaccc tgccagctga gccctgtgca tctactacct
     5041 tgacacagag tgttttccca ctagaagctc tgctctgctc tcctggccca agtaggggat
     5101 tccatgcctt ccctttcatg gtcttagcac cagcagccta gtttctccct tccagagtct
     5161 ccagggatga caaattggat tggagacaaa cctcgtcaga tgctcatccc ctaaaaggtt
     5221 aattgtgtat ttgtggctgc gtgtgccttt gtgttttcat tctcttccca tttttgtaca
     5281 ttttggtctt ctctgtggtt ttatacttgg tcaaaagtac tcgtcttggt attgcactgt
     5341 tgtgtgcatg agaaaactgg gggaaggctc actggtacaa gaaaggaccc ctgacccctt
     5401 tccttctctg tggtccccgg cattagattg ggggttctgg gagaggcagg tgaatgtcct
     5461 aagtgaattg ttctgtttgt aactggaatg tttttgaagt ctttggtgtt gctccgtgaa
     5521 aggacatcgc cacctggtgc tcatgaggtg tctttgcaga acaataaatg gcaaatgaac
     5581 aaccacaaaa ttgttactct tgttggcctt ctgctgtttg tagattagtg cacctatctg
     5641 tgagggattt gggttacctc cctgagtctg taagcaacca caagccctgc cactgggtgg
     5701 gggaagtccc tccccaacca cttaaaaaca aattttccac atattaccca cccacacatt
     5761 tgacctggct agactttgtt tgcctaaagg aacagaccac attgctggga aaatgagtaa
     5821 gtgaacgtgt gggagaaaaa cacttttaga atcacgaata ttcactttta aaggtctctt
     5881 tgcctggctg caatatagtg tgtgtttaaa ttatttacag gctgttgttt ctcaaataaa
     5941 tgtttaatat taatcattcc caaactgaca agaacacaaa aataaaatgc aaatacagag
     6001 cca
//
