LOCUS       NM_138287               5768 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens deltex E3 ubiquitin ligase 3L (DTX3L), mRNA.
ACCESSION   NM_138287
VERSION     NM_138287.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5768)
  AUTHORS   Zhu,K., Chatrin,C., Suskiewicz,M.J., Aucagne,V., Foster,B.,
            Kessler,B.M., Gibbs-Seymour,I., Ahel,D. and Ahel,I.
  TITLE     Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L
  JOURNAL   EMBO Rep 25 (10), 4172-4189 (2024)
   PUBMED   39242775
  REMARK    GeneRIF: Ubiquitylation of nucleic acids by DELTEX ubiquitin E3
            ligase DTX3L.
REFERENCE   2  (bases 1 to 5768)
  AUTHORS   Chen,L., Niu,W., Zang,H. and Qiu,Y.
  TITLE     DTX3L Accelerates Pancreatic cancer Progression via FAK/PI3K/AKT
            Axis
  JOURNAL   Biochem Genet 62 (2), 814-830 (2024)
   PUBMED   37460862
  REMARK    GeneRIF: DTX3L Accelerates Pancreatic cancer Progression via
            FAK/PI3K/AKT Axis.
REFERENCE   3  (bases 1 to 5768)
  AUTHORS   Zhu,K., Suskiewicz,M.J., Chatrin,C., Stromland,O., Dorsey,B.W.,
            Aucagne,V., Ahel,D. and Ahel,I.
  TITLE     DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic
            acids
  JOURNAL   Nucleic Acids Res 52 (2), 801-815 (2024)
   PUBMED   38000390
  REMARK    GeneRIF: DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on
            nucleic acids.
REFERENCE   4  (bases 1 to 5768)
  AUTHORS   Lin,S.
  TITLE     DTX3L mediated ubiquitination of cGAS suppresses antitumor immunity
            in pancreatic cancer
  JOURNAL   Biochem Biophys Res Commun 681, 106-110 (2023)
   PUBMED   37774567
  REMARK    GeneRIF: DTX3L mediated ubiquitination of cGAS suppresses antitumor
            immunity in pancreatic cancer.
REFERENCE   5  (bases 1 to 5768)
  AUTHORS   Russo,L.C., Tomasin,R., Matos,I.A., Manucci,A.C., Sowa,S.T.,
            Dale,K., Caldecott,K.W., Lehtio,L., Schechtman,D., Meotti,F.C.,
            Bruni-Cardoso,A. and Hoch,N.C.
  TITLE     The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent
            ADP-ribosylation induced by interferon signaling
  JOURNAL   J Biol Chem 297 (3), 101041 (2021)
   PUBMED   34358560
  REMARK    GeneRIF: The SARS-CoV-2 Nsp3 macrodomain reverses
            PARP9/DTX3L-dependent ADP-ribosylation induced by interferon
            signaling.
REFERENCE   6  (bases 1 to 5768)
  AUTHORS   Yan,Q., Dutt,S., Xu,R., Graves,K., Juszczynski,P., Manis,J.P. and
            Shipp,M.A.
  TITLE     BBAP monoubiquitylates histone H4 at lysine 91 and selectively
            modulates the DNA damage response
  JOURNAL   Mol Cell 36 (1), 110-120 (2009)
   PUBMED   19818714
  REMARK    GeneRIF: Data directly implicate BBAP in the monoubiquitylation and
            additional posttranslational modification of histone H4 and an
            associated DNA damage response.
REFERENCE   7  (bases 1 to 5768)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 5768)
  AUTHORS   Wilting,S.M., de Wilde,J., Meijer,C.J., Berkhof,J., Yi,Y., van
            Wieringen,W.N., Braakhuis,B.J., Meijer,G.A., Ylstra,B.,
            Snijders,P.J. and Steenbergen,R.D.
  TITLE     Integrated genomic and transcriptional profiling identifies
            chromosomal loci with altered gene expression in cervical cancer
  JOURNAL   Genes Chromosomes Cancer 47 (10), 890-905 (2008)
   PUBMED   18618715
  REMARK    GeneRIF: Overexpression of DTX3L, PIK3R4, ATP2C1, and SLC25A36, all
            located at 3q21.1-23 are associated with cervical cancer.
REFERENCE   9  (bases 1 to 5768)
  AUTHORS   Juszczynski,P., Kutok,J.L., Li,C., Mitra,J., Aguiar,R.C. and
            Shipp,M.A.
  TITLE     BAL1 and BBAP are regulated by a gamma interferon-responsive
            bidirectional promoter and are overexpressed in diffuse large
            B-cell lymphomas with a prominent inflammatory infiltrate
  JOURNAL   Mol Cell Biol 26 (14), 5348-5359 (2006)
   PUBMED   16809771
  REMARK    GeneRIF: BAL1 and BBAP are located on chromosome 3q21 in a
            head-to-head orientation and are regulated by a
            IFN-gamma-responsive bidirectional promoter.
REFERENCE   10 (bases 1 to 5768)
  AUTHORS   Takeyama,K., Aguiar,R.C., Gu,L., He,C., Freeman,G.J., Kutok,J.L.,
            Aster,J.C. and Shipp,M.A.
  TITLE     The BAL-binding protein BBAP and related Deltex family members
            exhibit ubiquitin-protein isopeptide ligase activity
  JOURNAL   J Biol Chem 278 (24), 21930-21937 (2003)
   PUBMED   12670957
  REMARK    GeneRIF: It is reported that BBAP and the human family of DTX
            proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on
            their capacity for self-ubiquitination.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092908.9.
            
            On Jul 29, 2008 this sequence version replaced NM_138287.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125086.1, SRR1803614.119827.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296161.9/ ENSP00000296161.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AC092908.9         135603-135878       c
            277-488             AC092908.9         134146-134357       c
            489-2024            AC092908.9         130192-131727       c
            2025-2242           AC092908.9         129544-129761       c
            2243-5768           AC092908.9         125013-128538       c
FEATURES             Location/Qualifiers
     source          1..5768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..5768
                     /gene="DTX3L"
                     /gene_synonym="BBAP; RNF143"
                     /note="deltex E3 ubiquitin ligase 3L"
                     /db_xref="GeneID:151636"
                     /db_xref="HGNC:HGNC:30323"
                     /db_xref="MIM:613143"
     exon            1..276
                     /gene="DTX3L"
                     /gene_synonym="BBAP; RNF143"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2312
                     /gene="DTX3L"
                     /gene_synonym="BBAP; RNF143"
                     /EC_number="2.3.2.27"
                     /note="B-lymphoma- and BAL-associated protein; rhysin2;
                     rhysin-2; deltex 3-like; deltex 3 like, E3 ubiquitin
                     ligase; RING-type E3 ubiquitin transferase DTX3L"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase DTX3L"
                     /protein_id="NP_612144.1"
                     /db_xref="CCDS:CCDS3015.1"
                     /db_xref="GeneID:151636"
                     /db_xref="HGNC:HGNC:30323"
                     /db_xref="MIM:613143"
                     /translation="MASHLRPPSPLLVRVYKSGPRVRRKLESYFQSSKSSGGGECTVS
                     TQEHEAPGTFRVEFSERAAKERVLKKGEHQILVDEKPVPIFLVPTENSIKKNTRPQIS
                     SLTQSQAETPSGDMHQHEGHIPNAVDSCLQKIFLTVTADLNCNLFSKEQRAYITTLCP
                     SIRKMEGHDGIEKVCGDFQDIERIHQFLSEQFLESEQKQQFSPSMTERKPLSQQERDS
                     CISPSEPETKAEQKSNYFEVPLPYFEYFKYICPDKINSIEKRFGVNIEIQESSPNMVC
                     LDFTSSRSGDLEAARESFASEFQKNTEPLKQECVSLADSKQANKFKQELNHQFTKLLI
                     KEKGGELTLLGTQDDISAAKQKISEAFVKIPVKLFAANYMMNVIEVDSAHYKLLETEL
                     LQEISEIEKRYDICSKVSEKGQKTCILFESKDRQVDLSVHAYASFIDAFQHASCQLMR
                     EVLLLKSLGKERKHLHQTKFADDFRKRHPNVHFVLNQESMTLTGLPNHLAKAKQYVLK
                     GGGMSSLAGKKLKEGHETPMDIDSDDSKAASPPLKGSVSSEASELDKKEKGICVICMD
                     TISNKKVLPKCKHEFCAPCINKAMSYKPICPTCQTSYGIQKGNQPEGSMVFTVSRDSL
                     PGYESFGTIVITYSMKAGIQTEEHPNPGKRYPGIQRTAYLPDNKEGRKVLKLLYRAFD
                     QKLIFTVGYSRVLGVSDVITWNDIHHKTSRFGGPEMYGYPDPSYLKRVKEELKAKGIE
                     "
     exon            277..488
                     /gene="DTX3L"
                     /gene_synonym="BBAP; RNF143"
                     /inference="alignment:Splign:2.1.0"
     exon            489..2024
                     /gene="DTX3L"
                     /gene_synonym="BBAP; RNF143"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2242
                     /gene="DTX3L"
                     /gene_synonym="BBAP; RNF143"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..5768
                     /gene="DTX3L"
                     /gene_synonym="BBAP; RNF143"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5744..5749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTX3L"
                     /gene_synonym="BBAP; RNF143"
                     /note="hexamer: AATAAA"
     polyA_site      5768
                     /gene="DTX3L"
                     /gene_synonym="BBAP; RNF143"
                     /note="major polyA site"
ORIGIN      
        1 gaaactttgc gcccagtccg cagggcgggc cgcgccttta ccgcccagct gcctcccgga
       61 gcccccgcgc cctcccgacg cgcagagcca tggcctccca cctgcgcccg ccgtccccgc
      121 tcctcgtgcg ggtgtacaag tccggccccc gagtacgaag gaagctggag agctacttcc
      181 agagctctaa gtcctcgggc ggcggggagt gcacggtcag cacccaggaa cacgaagccc
      241 cgggcacctt ccgggtggag ttcagtgaaa gggcagctaa ggagagagtg ttgaaaaaag
      301 gagagcacca aatacttgtt gacgaaaaac ctgtgcccat tttcctggta cccactgaaa
      361 attcaataaa gaagaacacg agacctcaaa tttcttcact gacacaatca caagcagaaa
      421 caccgtctgg tgatatgcat caacatgaag gacatattcc taatgctgtg gattcctgtc
      481 tccaaaagat ctttcttact gtaacagctg acctgaactg taacctgttc tccaaagagc
      541 agagggcata cataaccaca ctgtgcccta gtatcagaaa aatggaaggt cacgatggaa
      601 ttgagaaggt gtgtggtgac ttccaagaca ttgaaagaat acatcaattt ttgagtgagc
      661 agttcctgga aagtgagcag aaacaacaat tttccccttc aatgacagag aggaagccac
      721 tcagtcagca ggagagggac agctgcattt ctccttctga accagaaacc aaggcagaac
      781 aaaaaagcaa ctattttgaa gttcccttgc cttactttga atactttaaa tatatctgtc
      841 ctgataaaat caactcaata gagaaaagat ttggtgtaaa cattgaaatc caggagagtt
      901 ctccaaatat ggtctgttta gatttcacct caagtcgatc aggtgacctg gaagcagctc
      961 gtgagtcttt tgctagtgaa tttcagaaga acacagaacc tctgaagcaa gaatgtgtct
     1021 ctttagcaga cagtaagcag gcaaataaat tcaaacagga attgaatcac cagtttacaa
     1081 agctccttat aaaggagaaa ggaggcgaat taactctcct tgggacccaa gatgacattt
     1141 cagctgccaa acaaaaaatc tctgaagctt ttgtcaagat acctgtgaaa ctatttgctg
     1201 ccaattacat gatgaatgta attgaggttg atagtgccca ctataaactt ttagaaactg
     1261 aattactaca ggagatatca gagatcgaaa aaaggtatga catttgcagc aaggtttctg
     1321 agaaaggtca gaaaacctgc attctgtttg aatccaagga caggcaggta gatctatctg
     1381 tgcatgctta tgcaagtttc atcgatgcct ttcaacatgc ctcatgtcag ttgatgagag
     1441 aagttctttt actgaagtct ttgggcaagg agagaaagca cttacatcag accaagtttg
     1501 ctgatgactt tagaaaaaga catccaaatg tacactttgt gctaaatcaa gagtcaatga
     1561 ctttgactgg tttgccaaat caccttgcaa aggcgaagca gtatgttcta aaaggaggag
     1621 gaatgtcttc attggctgga aagaaattga aagagggtca tgaaacaccg atggacattg
     1681 atagcgatga ttccaaagca gcttctccgc cactcaaggg ctctgtgagt tctgaggcct
     1741 cagaactgga caagaaggaa aagggcatct gtgtcatctg tatggacacc attagtaaca
     1801 aaaaagtgct accaaagtgc aagcatgaat tctgcgcccc ttgtatcaac aaagccatgt
     1861 catataagcc aatctgtccc acatgccaga cttcctatgg tattcagaaa ggaaatcagc
     1921 cagagggaag catggttttc actgtttcaa gagactcact tccaggttat gagtcctttg
     1981 gcaccattgt gattacttat tctatgaaag caggcataca aacagaagaa cacccaaacc
     2041 caggaaagag ataccctgga atacagcgaa ctgcatactt gcctgataat aaggaaggaa
     2101 ggaaggtttt gaaactgctt tatagggcct ttgaccaaaa gctgattttt acagtggggt
     2161 actctcgcgt attaggagtc tcagatgtca tcacttggaa tgatattcac cacaaaacat
     2221 cccggtttgg aggaccagaa atgtatggct atcctgatcc ttcttacctg aaacgtgtca
     2281 aagaggagct gaaagccaaa ggaattgagt aagacaactg ctggaagatg tcttaaatca
     2341 agctttcaaa aaaatatatt ttaggaggct gatttaatgc cagtctaaat ccttatgtag
     2401 aaaggacttt gaaatttttc ttctcaagaa atggtttgta taagaataac aatctgctag
     2461 tctgtcattt ctggagtgat actttttttt ttgagacgga gtctgctctg tcgctcgcgc
     2521 tggagtgcag tggcatgatc tcggctcact gcaagctccg cctcccaggt tcatgccatt
     2581 ctcctacctc agcctcccga gtagctggga ctacaggcgc ccaccaccat gcccggctaa
     2641 tttttgtttt tgtattttta gtagagacag ggtttcactg tgttagccag gatggtctcg
     2701 atctcctgac ctcgtgatcc gcccgcctca gccttccaaa gtgttgggat tataggcgtg
     2761 agccaccgcg cccagccctg gagtgatact ttttatggaa gacaaaagcc ccccaaatct
     2821 gtgtaaaatc tgctgcaaag gtgtcatccc tcttgtgtca tcactggggt tagaggtggg
     2881 tccgaaataa tcttctgtgt ccttcagttg gactctcggc tgccaattga tctctttttc
     2941 attgccatct ctggggtggt tctttggttt tttgtgtgtt ttccccttca tctctacctg
     3001 tgaaagtgaa attctattgt aaatgggagg aaaaagggtt ggttgtgaaa aattaaagac
     3061 ccacattctg ctttcttact catggtaaga aaagtggcca tgagtagaga ttgggcaagc
     3121 attggtaata aatggaataa gactattatt attattattt gagatggagt ctcactctgt
     3181 cacccaggct ggaatgcagt ggtgtgatct tggctcactg caacctccac ttcccgggtt
     3241 caagcgattc tcctgcctca gcctcctgag tagctgggat tacaggtgtg tgcctccaca
     3301 cccggctaat tttttgtatt tttagtagag acggggtttt gccatgttgg ccaggctggt
     3361 ttcaaactcc tgagctcaaa tgatcctcct gccttggcct cccaaagtgc tggaattaca
     3421 ggcatgagcc accacaccca cacaagacta tcatttttaa tgaccaagag cctagtatat
     3481 agttggtgcc tgtcttagtc tgtttgtgtt gctataaaag aacacctgag actgggtaat
     3541 tgataaagaa aaaggtttgt ttggctcaca attttgctgg ctagaaggtt gggcatccgg
     3601 tgaaagcctc aggctgcttc cattcatagc aaagggcagc cagtgtgtgc agaaatcaaa
     3661 tgacagagag gaagtgagag agagaggtgt cggggaggtg ccaggctctt tttaacaagc
     3721 agttcttcag gaactaagag tgagtcactc ccatgagaac agcaccaagc cattcatggg
     3781 ggaatctgcc cccatgaccc agacccctcc cgttaggctt cacctccaac actgaggatc
     3841 aaatttcaac atgagatttg gaggaggtca aacaaactaa actgtagcag tgtttcataa
     3901 aattgtttgc ctgactcagg ttgctagtaa gccagcagag ggatatttgc ctcctaaatc
     3961 tttggcagag gcaggagtaa ggaagccatt tctggagtcc ttgctactaa tttggaaaac
     4021 tgagcttctt tctttcattg ctttttccct taagagacaa gtccttacta tattgccctg
     4081 tctctcaagg gaagacatca agactggact tgaactcctg ggctcaagcc atcccccaac
     4141 cttggcctct cgagtagatg ggattatagg catgtgccac ggtgcctgac ttgagtttct
     4201 tattctagaa cacttggagc ctgaactctg accaggcccc tcacttgagc ctttgctttc
     4261 tgctccttgt aaactgccat attgggtgca cttgccctgc cacagtaatg ctatatattt
     4321 ctgagcattg tttttctcta gataatttta tatttttgag tataccccac ttccaagtgt
     4381 tttttgtttt gttttgcttt gtttttgttg ttgttgtttt gagacagggt ctcactgtgt
     4441 cccccaggct ggagtgcagt ggcacaatga cgactcactg cagcctcaac ctcctggggc
     4501 caagtgatcc tcccacctca gcctctcaag tggctgggac cacagaagtg caccaccatg
     4561 cctggctttt tttttttttt ttggtcgaga tggggtgtcc ctgtgttgcc cagactggtc
     4621 ttgaactcct ggactcaagg gatcctcctg tcttgggctc ccaaagtgtt gggattacag
     4681 gcgtgagtga ccatgcctag ctcacttcca ggtttaacag acaaaataaa cttactctag
     4741 tttccatctc tatcatttta taataaccgt agcccacatt gtagtagttt ttcagctctt
     4801 tactaagtcc caccaattca tgttttcacc cttaaaatct ttctcactga tactctctct
     4861 ggacagaaaa aaggtgaaat aagcctacta taaggaatat atgacatgct aaattttatt
     4921 tttaaacggt tcttcaagtc agattaaagt aataatagca aattatgtga ttatccatgt
     4981 cccagcctct ctccaaaaaa atagtaaaca agatgtcttc ttcttttccc aaagatacac
     5041 atacacacat gtacaaattt ttttatcaga taataatagc taatatttaa tgagtactta
     5101 ccttagtttg tcccctttac aacagcttta catctgtgtg attgatacag ttcatattcc
     5161 cattttataa ctgagaaaac tggtgcacag agaggataag caacttgcca aaggtcacac
     5221 agttaataag tggaaatgct ggggtatgaa ccaggtagtc tgcccccata gctctgcccc
     5281 ccagagctgt actgtctccc atgagggtac ttctccatgg agcagcctga ggcgatccct
     5341 ttattctggg cttctctcag aaatggattc ccacacagta ttcaaagcaa atttccccag
     5401 aggaaatcct attggaagaa cttaaaaact cagaatcttt ttctttgtcc agagagttga
     5461 ggaagcttaa gctaaatgat acatgttttt aaaaaaaaat cagattataa atttagtttt
     5521 tggtgattca ttaaattctt tactattata gttattttct agctgttcat cttttagcta
     5581 aatttgttcc aaagaagcaa aagtttggtt tctactaagt tctggattct ggatgggaga
     5641 ttgcactgtg tgtgacatgc aagtttcatg gtgtgggaga ttgcagagca tttgggttac
     5701 tgcttttact ctttggaagc tgttatcatc tgtatctgct ttaaataaag ttaaagattt
     5761 ggaacaaa
//
