LOCUS       NM_178502               2028 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens deltex E3 ubiquitin ligase 3 (DTX3), transcript
            variant 1, mRNA.
ACCESSION   NM_178502
VERSION     NM_178502.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2028)
  AUTHORS   Scalia,P., Merali,C., Barrero,C., Suma,A., Carnevale,V., Merali,S.
            and Williams,S.J.
  TITLE     Novel Isoform DTX3c Associates with UBE2N-UBA1 and Cdc48/p97 as
            Part of the EphB4 Degradation Complex Regulated by the Autocrine
            IGF-II/IRA Signal in Malignant Mesothelioma
  JOURNAL   Int J Mol Sci 24 (8), 7380 (2023)
   PUBMED   37108544
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2028)
  AUTHORS   Hu,W., Hu,Y., Pei,Y., Li,R., Xu,F., Chi,X., Mi,J., Bergquist,J.,
            Lu,L., Zhang,L. and Yang,C.
  TITLE     Silencing DTX3L Inhibits the Progression of Cervical Carcinoma by
            Regulating PI3K/AKT/mTOR Signaling Pathway
  JOURNAL   Int J Mol Sci 24 (1), 861 (2023)
   PUBMED   36614304
  REMARK    GeneRIF: Silencing DTX3L Inhibits the Progression of Cervical
            Carcinoma by Regulating PI3K/AKT/mTOR Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2028)
  AUTHORS   Valla,M., Opdahl,S., Ytterhus,B. and Bofin,A.M.
  TITLE     DTX3 copy number increase in breast cancer: a study of associations
            to molecular subtype, proliferation and prognosis
  JOURNAL   Breast Cancer Res Treat 187 (1), 57-67 (2021)
   PUBMED   33616774
  REMARK    GeneRIF: DTX3 copy number increase in breast cancer: a study of
            associations to molecular subtype, proliferation and prognosis.
REFERENCE   4  (bases 1 to 2028)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2028)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2028)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
REFERENCE   7  (bases 1 to 2028)
  AUTHORS   Chastagner,P., Israel,A. and Brou,C.
  TITLE     Itch/AIP4 mediates Deltex degradation through the formation of
            K29-linked polyubiquitin chains
  JOURNAL   EMBO Rep 7 (11), 1147-1153 (2006)
   PUBMED   17028573
  REMARK    GeneRIF: We show here that both molecules (Deltex (DTX) and AIP4)
            interact and partially colocalize to endocytic vesicles, and that
            AIP4 targets DTX for lysosomal degradation.
REFERENCE   8  (bases 1 to 2028)
  AUTHORS   Takeyama,K., Aguiar,R.C., Gu,L., He,C., Freeman,G.J., Kutok,J.L.,
            Aster,J.C. and Shipp,M.A.
  TITLE     The BAL-binding protein BBAP and related Deltex family members
            exhibit ubiquitin-protein isopeptide ligase activity
  JOURNAL   J Biol Chem 278 (24), 21930-21937 (2003)
   PUBMED   12670957
  REMARK    GeneRIF: It is reported that BBAP and the human family of DTX
            proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on
            their capacity for self-ubiquitination.
REFERENCE   9  (bases 1 to 2028)
  AUTHORS   Kishi,N., Tang,Z., Maeda,Y., Hirai,A., Mo,R., Ito,M., Suzuki,S.,
            Nakao,K., Kinoshita,T., Kadesch,T., Hui,C., Artavanis-Tsakonas,S.,
            Okano,H. and Matsuno,K.
  TITLE     Murine homologs of deltex define a novel gene family involved in
            vertebrate Notch signaling and neurogenesis
  JOURNAL   Int J Dev Neurosci 19 (1), 21-35 (2001)
   PUBMED   11226752
REFERENCE   10 (bases 1 to 2028)
  AUTHORS   Matsuno,K., Diederich,R.J., Go,M.J., Blaumueller,C.M. and
            Artavanis-Tsakonas,S.
  TITLE     Deltex acts as a positive regulator of Notch signaling through
            interactions with the Notch ankyrin repeats
  JOURNAL   Development 121 (8), 2633-2644 (1995)
   PUBMED   7671825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK092085.1 and AK094385.1.
            
            On Nov 23, 2018 this sequence version replaced NM_178502.3.
            
            Summary: DTX3 functions as an E3 ubiquitin ligase (Takeyama et al.,
            2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the shorter isoform (a). Both variants 1 and
            2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.445099.1, AK092085.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337737.8/ ENSP00000338050.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               AK092085.1         4-477
            475-2028            AK094385.1         286-1839
FEATURES             Location/Qualifiers
     source          1..2028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..2028
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /note="deltex E3 ubiquitin ligase 3"
                     /db_xref="GeneID:196403"
                     /db_xref="HGNC:HGNC:24457"
                     /db_xref="MIM:613142"
     exon            1..35
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /inference="alignment:Splign:2.1.0"
     exon            36..196
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /inference="alignment:Splign:2.1.0"
     exon            197..259
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /inference="alignment:Splign:2.1.0"
     exon            260..335
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1378
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1;
                     protein deltex-3; RING finger protein 154; probable E3
                     ubiquitin-protein ligase DTX3; deltex 3, E3 ubiquitin
                     ligase; deltex homolog 3; RING-type E3 ubiquitin
                     transferase DTX3"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase DTX3
                     isoform a"
                     /protein_id="NP_848597.1"
                     /db_xref="CCDS:CCDS41800.1"
                     /db_xref="GeneID:196403"
                     /db_xref="HGNC:HGNC:24457"
                     /db_xref="MIM:613142"
                     /translation="MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEH
                     RVSILIDGETSDIYVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGEL
                     MGCLALGGGGEHPEMHRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQ
                     ESTCPICLGEIQNAKTLEKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGR
                     MLVSKDATLLLPSYEKYGTIVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGN
                     KVLTLFRKAFDQRLTFTIGTSMTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTR
                     VQEELRAKGITDD"
     exon            336..1084
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1302
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..2028
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2005..2010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /note="hexamer: AATAAA"
     polyA_site      2028
                     /gene="DTX3"
                     /gene_synonym="deltex3; RNF154"
                     /note="major polyA site"
ORIGIN      
        1 agtcatgtga ccggcaatgg cggcgctgac gagagctgca tttggaagtg ttgtggagac
       61 agccccgtag cccaatgcga ccagactcag ggaaaacatc aggcccctcc agctgagccc
      121 ttgtgtgagc cccgcccctc cctaaatgcc agacttggga gctgacagac agcactgcct
      181 gtgctgggtt taaaagtcct ggtcagctga gtggaaatag aaggatttct gctgccatca
      241 tcttccatgg gctttccagg tcacacgacc tacaagtagg gagcagggaa agaagagtga
      301 gcctgcatgc caattctaag ctcttcagga tcaaatgtcg ttcgtcctgt ccagaatggc
      361 agcctgtgga ggcacctgca agaacaaagt gactgtgtcc aagcccgtgt gggacttcct
      421 gagcaaagag accccagccc ggctggcccg gcttcgggag gagcaccgtg tgtccatcct
      481 catagatggc gagacttctg acatctatgt tctccagctt tccccacagg gtcctccccc
      541 ggcccctcca aatgggctct acctagcccg gaaggctctc aaggggctgc taaaagaggc
      601 agagaaagag ctgaagaaag ctcagaggca gggggagctg atgggctgcc tggctctggg
      661 gggtggaggg gagcaccctg agatgcaccg cgcaggccca ccccctctcc gagcagcccc
      721 acttctgccc ccaggagctc gggggctccc ccctcctcct ccccccctgc ccccacctct
      781 tcctcctcgc cttcgggagg aggcagaaga gcaggagagc acctgcccca tctgtctggg
      841 ggagatccag aatgccaaga cattggagaa gtgccggcat tcattctgcg agggctgcat
      901 cacccgggct ctgcaggtga aaaaggcctg ccccatgtgc ggccgcttct atgggcagct
      961 ggtgggcaac cagccccaga atgggcggat gctggtctct aaggacgcca ccctcctact
     1021 gcccagctat gagaagtacg gcaccattgt catccagtac gtcttcccgc ccggtgtcca
     1081 gggggctgaa cacccaaacc caggagttcg gtatcctggc accacacggg tggcctacct
     1141 cccggactgc cctgagggca acaaggtgct gaccctgttc cgcaaggcgt ttgaccagcg
     1201 tctcaccttc actatcggca cgtccatgac cacagggaga ccgaatgtca tcacctggaa
     1261 cgacatccac cacaagacca gctgcacagg gggaccccag ctgtttgggt acccagaccc
     1321 cacctacctg acccgggtgc aagaggagct gagagcgaag ggtatcacag atgactgaag
     1381 gacatcgcct ttgccaaggc ccctgctgtc tgcctctact aggacccagc agaagcctct
     1441 ttctcctctc tgccccctgc cccccacacc acacctgtag gggacctgtc tgactgggaa
     1501 gggagttccg agagggaggg ggcaatccct tcccccatcc cccactggcc aagtgtttca
     1561 atgcagtgtg agccactccc ttctggcaga ggccgacctc caaggctctg ttctcccctc
     1621 cccgtgtaca tatactcccg gtttccctgc ccctccattg cccttggctt tttctggtat
     1681 gtgctgtgct ccacgaccaa gccgagaaag gacctagggt ggggaaggga gggtctcttg
     1741 attcctaacc gcccccacat actgctccac cgctgaactt cgggtgccgg ggaggagaaa
     1801 ttgggctgat gtgagctccc cgtcacccgc catggagccg gctgtgtgtg ttcatcagat
     1861 acagttctcc cttaaccttg tcctttctct cctgtgtctc agtctccgtc agtctgtctt
     1921 tctccgctct tctctgaccc ctgtgaggaa cctccttacc ctgttctgga atcgctgcca
     1981 gactgtagct tttaatttaa taaaaataaa gtaaaatatg caactctt
//
