LOCUS       NM_001102594            2641 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens deltex E3 ubiquitin ligase 2 (DTX2), transcript
            variant 2, mRNA.
ACCESSION   NM_001102594
VERSION     NM_001102594.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2641)
  AUTHORS   Ma,Z., Zhao,X., Zhang,X., Xu,G. and Liu,F.
  TITLE     [DTX2 overexpression promotes migration and invasion of colorectal
            cancer cells through the Notch2/Akt axis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (3), 340-348 (2023)
   PUBMED   37087577
  REMARK    GeneRIF: [DTX2 overexpression promotes migration and invasion of
            colorectal cancer cells through the Notch2/Akt axis].
REFERENCE   2  (bases 1 to 2641)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2641)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2641)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2641)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2641)
  AUTHORS   Hiller,M., Huse,K., Szafranski,K., Jahn,N., Hampe,J., Schreiber,S.,
            Backofen,R. and Platzer,M.
  TITLE     Single-nucleotide polymorphisms in NAGNAG acceptors are highly
            predictive for variations of alternative splicing
  JOURNAL   Am J Hum Genet 78 (2), 291-302 (2006)
   PUBMED   16400609
REFERENCE   7  (bases 1 to 2641)
  AUTHORS   Takeyama,K., Aguiar,R.C., Gu,L., He,C., Freeman,G.J., Kutok,J.L.,
            Aster,J.C. and Shipp,M.A.
  TITLE     The BAL-binding protein BBAP and related Deltex family members
            exhibit ubiquitin-protein isopeptide ligase activity
  JOURNAL   J Biol Chem 278 (24), 21930-21937 (2003)
   PUBMED   12670957
  REMARK    GeneRIF: It is reported that BBAP and the human family of DTX
            proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on
            their capacity for self-ubiquitination.
REFERENCE   8  (bases 1 to 2641)
  AUTHORS   Yamamoto,N., Yamamoto,S., Inagaki,F., Kawaichi,M., Fukamizu,A.,
            Kishi,N., Matsuno,K., Nakamura,K., Weinmaster,G., Okano,H. and
            Nakafuku,M.
  TITLE     Role of Deltex-1 as a transcriptional regulator downstream of the
            Notch receptor
  JOURNAL   J Biol Chem 276 (48), 45031-45040 (2001)
   PUBMED   11564735
REFERENCE   9  (bases 1 to 2641)
  AUTHORS   Kishi,N., Tang,Z., Maeda,Y., Hirai,A., Mo,R., Ito,M., Suzuki,S.,
            Nakao,K., Kinoshita,T., Kadesch,T., Hui,C., Artavanis-Tsakonas,S.,
            Okano,H. and Matsuno,K.
  TITLE     Murine homologs of deltex define a novel gene family involved in
            vertebrate Notch signaling and neurogenesis
  JOURNAL   Int J Dev Neurosci 19 (1), 21-35 (2001)
   PUBMED   11226752
REFERENCE   10 (bases 1 to 2641)
  AUTHORS   Matsuno,K., Diederich,R.J., Go,M.J., Blaumueller,C.M. and
            Artavanis-Tsakonas,S.
  TITLE     Deltex acts as a positive regulator of Notch signaling through
            interactions with the Notch ankyrin repeats
  JOURNAL   Development 121 (8), 2633-2644 (1995)
   PUBMED   7671825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA003606.1, AB040961.1, AY225124.1, BC018555.1 and BC008856.2.
            
            On Nov 20, 2020 this sequence version replaced NM_001102594.2.
            
            Summary: DTX2 functions as an E3 ubiquitin ligase (Takeyama et al.,
            2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1, and encodes isoform A. Variants 1-3 encode
            the same isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093079.1, AB040961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430490.7/ ENSP00000411986.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DA003606.1         55-78
            25-660              AB040961.1         1-636
            661-1532            AY225124.1         279-1150
            1533-1642           BC018555.1         1661-1770
            1643-2641           BC008856.2         1452-2450
FEATURES             Location/Qualifiers
     source          1..2641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..2641
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /note="deltex E3 ubiquitin ligase 2"
                     /db_xref="GeneID:113878"
                     /db_xref="HGNC:HGNC:15973"
                     /db_xref="MIM:613141"
     exon            1..128
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            129..293
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            294..650
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..2251
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 2;
                     protein deltex-2; zinc ion binding protein; ring finger
                     protein 58; deltex homolog 2; hDTX2; deltex2; probable E3
                     ubiquitin-protein ligase DTX2; deltex 2, E3 ubiquitin
                     ligase; RING-type E3 ubiquitin transferase DTX2"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase DTX2
                     isoform a"
                     /protein_id="NP_001096064.1"
                     /db_xref="CCDS:CCDS5587.1"
                     /db_xref="GeneID:113878"
                     /db_xref="HGNC:HGNC:15973"
                     /db_xref="MIM:613141"
                     /translation="MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQ
                     QFVQQKGQRFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQ
                     HSAPGRGVVWEWLSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHT
                     QTNKTSSFCRSVRRQAGPPYPVTTIIAPPGHTGVACSCHQCLSGSRTGPVSGRYRHSM
                     TNLPAYPVPQHPPHRTASVFGTHQAFAPYNKPSLSGARSAPRLNTTNAWGAAPPSLGS
                     QPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQA
                     LAGMTSVLMSAIGLPVCLSRAPQPTSPPASRLASKSHGSVKRLRKMSVKGATPKPEPE
                     PEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFH
                     LLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILI
                     VYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGT
                     SSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ"
     exon            651..1290
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1391
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1532
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1612
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1771
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1933
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2023
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2641
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2621..2626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /note="hexamer: AATAAA"
     polyA_site      2641
                     /gene="DTX2"
                     /gene_synonym="RNF58"
                     /note="major polyA site"
ORIGIN      
        1 gagtttcact ctggctgcct tctcctgaga gtcggagcca cagccagagc cctgcccagg
       61 ccgagccgga gctgcagccc gagcgcggtg gtgccctcag ccccgtcctc ttgtcctcct
      121 cagcctcggt gccttggaat ttgtgtcgct gagtcagcaa gcctttcaga tttgcccggt
      181 ttttgttgtt tgtggtttgt atcaagatgg gaactcaaac aagtcattcc tcctaaggag
      241 ctggtgtctt catccagaag ggacagtttg tgccagctct ccagagagaa aagatctgcc
      301 ggaggcgctg ggcaatgacc ccgggactcc aggccagagg ggtctgaagc tgtttgggaa
      361 agcagcggga ctccttggga agatggccat ggccccaagc ccttccctgg tgcaggtgta
      421 caccagcccc gcggctgtgg ccgtgtggga atggcaggac gggctgggca cctggcaccc
      481 ctacagtgcc accgtctgca gcttcatcga gcagcagttt gtccagcaga agggccaacg
      541 ttttgggctt gggagcctgg cccacagcat ccccttgggc caggcagacc cctcgctggc
      601 cccttacatt attgacctcc ccagctggac ccagttccgc caggacaccg gcaccatgcg
      661 ggctgtgcgg agacacctgt tcccccagca ctcagcccct ggccgaggtg tcgtctggga
      721 gtggctgagc gacgatggct cctggactgc ctatgaagcc agcgtctgtg actatctgga
      781 gcagcaggtg gccaggggca accagctcgt ggacttggcc cccctggggt acaactacac
      841 tgtcaactac accacccaca cgcagaccaa caagacttcc agcttctgcc gcagcgtgcg
      901 gcgccaagca gggccgcctt acccggtgac caccatcatc gctccgccgg gccacacagg
      961 cgtcgcctgc tcttgccacc agtgcctcag tggcagcaga actggccccg tgtcaggccg
     1021 ctaccgccac tccatgacca acctccctgc ataccccgtc ccccagcacc ccccacacag
     1081 gaccgcttct gtgtttggga cccaccaggc ctttgcaccg tacaacaaac cctcactctc
     1141 cggggcccgg tctgcgccca ggctgaacac caccaacgcc tggggcgcag ctcctccttc
     1201 cctggggagc cagcccctct accgctccag cctctcccac ctgggaccgc agcacctgcc
     1261 cccaggatcc tccacctccg gtgcagtcag tgcctccctc cccagcggtc cctcaagcag
     1321 cccagggagc gtccctgcca ctgtgcccat gcagatgcca aagcccagca gagtccagca
     1381 ggcgctcgca ggcatgacga gtgttctgat gtcagccatt ggactccctg tgtgtcttag
     1441 ccgcgcaccc cagcccacca gccctcccgc ctcccgtctg gcttccaaaa gtcacggctc
     1501 agttaagaga ttgaggaaaa tgtccgtgaa aggagcgacc ccgaagccag agccagagcc
     1561 agagcaggtc ataaaaaact acacggaaga gctgaaagtg cccccagatg aggactgcat
     1621 catctgcatg gagaagctgt ccacagcgtc tggatacagc gatgtgactg acagcaaggc
     1681 aatcgggtcc ctagctgtgg gccacctcac caagtgcagc catgccttcc acctgctgtg
     1741 cctcctggcc atgtactgca acggcaataa ggatggaagt ctgcagtgtc cctcctgcaa
     1801 aaccatctat ggagagaaga cggggaccca gccccaggga aagatggagg tattacggtt
     1861 ccagatgtcg ctccccggcc acgaggactg cgggaccatc ctcatagttt acagcattcc
     1921 ccatggtatc cagggccctg agcaccccaa tcccggaaag ccgttcactg ccagagggtt
     1981 tccccgccag tgctaccttc cagacaacgc ccagggccgc aaggtcctag agctcctgaa
     2041 ggtggcctgg aagaggcggc tcatcttcac agtgggcacg tccagcacca cgggtgagac
     2101 ggacaccgtg gtatggaacg agatccacca caagacagag atggaccgca acattacggg
     2161 ccacggctat cccgacccca actacctgca gaacgtgctg gctgagctgg ctgcccaggg
     2221 ggtgaccgag gactgcctgg agcagcagtg acctcgcacc ccagcacgcc cgcctctggt
     2281 ggccaccccg ctgccccatg gctggctggg tggccaggca ggaagtgccc agcccgagag
     2341 gctgggaggt ttgttgaggg tgtggggtgt gccccacctg aagccggggc tccccctgcc
     2401 tgcctctctc tcctcctccc ctctgggaat tgggcagccc tgggcagttg tactcatggg
     2461 ggcttaggat gcagctacct cagtgcgcag ggcccgtctg tcctctgggg gctgcttcgg
     2521 gcccgcggtg ctcggggcct ggtgtggggc gagtagagac ttccccagcc tggacgggcg
     2581 tgggttctgg gtcagcttct tttacctcaa ttttgtttgc aataaatgct ctatagccaa
     2641 a
//
