LOCUS       NM_001144955           13699 bp    mRNA    linear   PRI 27-FEB-2025
DEFINITION  Homo sapiens DTW domain containing 1 (DTWD1), transcript variant 2,
            mRNA.
ACCESSION   NM_001144955
VERSION     NM_001144955.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13699)
  AUTHORS   Son,H.J., Choi,E.J., Yoo,N.J. and Lee,S.H.
  TITLE     Inactivating mutations of tumor suppressor genes KLOTHO and DTWD1
            in colorectal cancers
  JOURNAL   Pathol Res Pract 216 (2), 152816 (2020)
   PUBMED   31924336
  REMARK    GeneRIF: Inactivating mutations of tumor suppressor genes KLOTHO
            and DTWD1 in colorectal cancers.
REFERENCE   2  (bases 1 to 13699)
  AUTHORS   Takakura,M., Ishiguro,K., Akichika,S., Miyauchi,K. and Suzuki,T.
  TITLE     Biogenesis and functions of aminocarboxypropyluridine in tRNA
  JOURNAL   Nat Commun 10 (1), 5542 (2019)
   PUBMED   31804502
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13699)
  AUTHORS   Clark,S.L., Adkins,D.E., Aberg,K., Hettema,J.M., McClay,J.L.,
            Souza,R.P. and van den Oord,E.J.
  TITLE     Pharmacogenomic study of side-effects for antidepressant treatment
            options in STAR*D
  JOURNAL   Psychol Med 42 (6), 1151-1162 (2012)
   PUBMED   22041458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018927.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001144955.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.176455.1,
                                           SRR1660805.84863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403028.8/ ENSP00000385399.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC018927.6         16381-16455
            76-394              AC018927.6         20446-20764
            395-538             AC018927.6         27492-27635
            539-797             AC018927.6         29869-30127
            798-13699           AC018927.6         38664-51565
FEATURES             Location/Qualifiers
     source          1..13699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..13699
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /note="DTW domain containing 1"
                     /db_xref="GeneID:56986"
                     /db_xref="HGNC:HGNC:30926"
                     /db_xref="MIM:621116"
     exon            1..75
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /inference="alignment:Splign:2.1.0"
     exon            76..394
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1045
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /EC_number="2.5.1.25"
                     /note="x 009 protein; DTW domain-containing protein 1"
                     /codon_start=1
                     /product="tRNA-uridine aminocarboxypropyltransferase 1"
                     /protein_id="NP_001138427.1"
                     /db_xref="CCDS:CCDS10132.1"
                     /db_xref="GeneID:56986"
                     /db_xref="HGNC:HGNC:30926"
                     /db_xref="MIM:621116"
                     /translation="MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQ
                     EVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVKLPLKIDIIKHPNET
                     DGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRI
                     QNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTD
                     ERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDN
                     LLFFYSFMYQLIKNAKCSGDKETGKLTH"
     exon            395..538
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /inference="alignment:Splign:2.1.0"
     exon            539..797
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /inference="alignment:Splign:2.1.0"
     exon            798..13699
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1087..1092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /note="hexamer: AATAAA"
     polyA_site      1124
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /note="major polyA site"
     regulatory      2584..2589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /note="hexamer: AATAAA"
     polyA_site      2603
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /note="major polyA site"
     regulatory      8832..8837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /note="hexamer: AATAAA"
     polyA_site      8851
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
     regulatory      11895..11900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /note="hexamer: AATAAA"
     polyA_site      11915
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
     regulatory      13675..13680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /note="hexamer: AATAAA"
     polyA_site      13699
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
ORIGIN      
        1 acggcccggc gcgtggctcg ggctcgggcg gagctggaga cgtgtggagc tgttcgagga
       61 ctcgcgggtg tgcagtgcac ctatgatatg tgttttagaa atagccgtta aactttggtt
      121 tgaatgaaga atgtctctca atccacctat atttctcaaa cgaagtgaag aaaatagttc
      181 aaaatttgtg gaaacaaaac agtcacaaac tacttccata gcttcagaag atccccttca
      241 aaacttatgt ttagcatctc aagaagttct tcaaaaagct cagcaaagtg ggagatcaaa
      301 atgtctcaaa tgtggtggtt ccagaatgtt ctactgctat acatgttatg ttccagttga
      361 aaatgtacct attgaacaga ttccacttgt gaagcttcca ttgaagattg acatcattaa
      421 acatccaaat gaaacagatg gcaaaagtac tgctatacat gcaaaactct tagcacctga
      481 atttgtaaac atttacacgt atccgtgtat tccagaatat gaagaaaagg accatgaagt
      541 tgcactcatt tttcctggac ctcagtctat ctcaataaaa gatatttctt ttcatctgca
      601 aaaaaggatt caaaataatg ttagaggcaa aaatgatgac cctgacaagc catcttttaa
      661 acgcaaaaga actgaagaac aagagttctg tgatttgaat gacagcaagt gcaaaggcac
      721 aacactgaaa aaaattatat ttatagatag cacctggaac caaacaaaca aaatattcac
      781 tgatgagcga cttcaagggt tgttacaagt tgagttgaaa acaagaaaaa cttgcttttg
      841 gcgccatcaa aaaggaaagc cagatacttt cctttctaca attgaagcca tttactactt
      901 tctggtagac taccatactg atatattaaa agagaaatac agagggcaat atgacaatct
      961 tttatttttc tattctttta tgtaccagtt gataaagaat gccaaatgct ctggagataa
     1021 ggaaacagga aaacttacac attagttttt aacaagccac ttatgtcttt ttattttgct
     1081 aacattaata aacttatatt tgtgctttgt tttttcttaa gaaataatca tatataatgc
     1141 ctgtaagacc atttgaaaaa attccagttt catatatatc acttcatatt tcttgaagga
     1201 aattgtatct gggggaattt ttcagagata ctgttgattg aaaaacttac ttcagaagtt
     1261 atttgctcag tgaaacctca gtttcattac tacattttaa tatagtgtgt tatgtctctg
     1321 tgattagata taacatattc cattagatct aattagctat ttatttcaac atctttatat
     1381 cttttcacct gtactcatga ccacctttag aagtaaatgg ggttacaatc tgctggctga
     1441 aaaataggtc ataagtgatt tttcttgagg ttagtagcaa acataggcag aactagaatt
     1501 agaattctgg tatctagggc tgtttcttta agtcctaagg ttgttaaaag cagagactct
     1561 ggagctagac tacctgaatc taaatctcag cctttctgct tatcagccat gtcattttct
     1621 tccatttgta caaagcaggc aatactgagc aactacctta taggaataac tgagttaata
     1681 tctaaggggc tttcagcagt acctgaaata tagtaagtgt tacatatatg tttactcttt
     1741 ttattttatt tggaattgtg aactgataat aattgaagcc tacctgctag tggccatctc
     1801 tgctgccagg tgaaaagagc ctgacttaga atgaagtcag cgaaggaaag cagagtggag
     1861 agaaaaagag agactgagtc ctgatgacat catttattta cctagaccta gctgcttgtg
     1921 aatagagccc tactgtgctg aatagcttct gtctgctctt ttctattctg ctccctgctc
     1981 tgtgaggtag gttcctttgc tctcttgctt ttggttgggt tcaacaaatg ggaagcacca
     2041 gtgggagatt agaagttgag aggaaaatga aatgatgtta tttatttccc tggctccttt
     2101 cctgccatgt catcatcagt tggctgtgtt cctctactaa atagtacctt atcaggaatc
     2161 ctatctcttc tgttcccaag cagttacccc agttacctca ctaggtttag ttcctgctcc
     2221 ctccctttac cccttttcac ttagggttgg taatagctta cagttattac tagccccagt
     2281 atagttcact acaacttgtt gctttaccta aaccctgctc atacatttgt aaatactgta
     2341 gttgttttat tacactcttc tcaaatgtcc ccacttgaaa tagccttcta tttcttttgg
     2401 ggactctgat aaattcacct gtttgggtga aataatagca catttcctga agtatataca
     2461 gtgggacaca tgatgtttta tgggggaaag agttcttggt gaaattagtt tgctgtacat
     2521 tacgttgttt ccctcccagg gattcagaag gcaaaacata ttaaaggttc tgaaaagtcc
     2581 tgaaataaac attttgaact ttatttaagc tgatatatct taaacttact tgaatatgta
     2641 gcacctatta acatgccatg gaaataggac gtttggagta ttgtaattaa gaacaattcc
     2701 tattaatata catggggcaa ctgagaatta aagaggtaag taaattattg atagatcata
     2761 cacctagtta gtagcagagc ctgttctaga atctggaact tctgatttgg tttggttcag
     2821 taaggtcacc attatattat gctattcata aaaaggaatg tggattatat aaggcttgaa
     2881 cattattagt cttacagtct tagccaaata aactaactgg cttgcttatt ttagcagtta
     2941 ttctacaaga atggaattaa aatagatttt ttttttcatg tttagaactt ggccctggga
     3001 atagaggaag gcttgaattg atttaagcag ggccaaagtt ggatttctct aggctaaatt
     3061 tggacttccc tgagccaaaa tctattgcat ttaactggct ttacaaacca actaaacata
     3121 acagttcaga gggaaaagaa aaaaaaaagc gagagacaga gaacaattct atcactcatt
     3181 tgcctccatc tctcagctgg cataagaaag atgacccacg tacttcataa gagcctaatt
     3241 tacagctaag gccagataaa atctcaggtt cttttcaaaa gaagttagta atacctatta
     3301 gaacaatgaa ttgactatac ttgtcttagt tttttttgtt tgttttttgt tttttgtttt
     3361 tttggtgtga tagatgtaac agtggcccta attctttatc cttgcttgta ttcatggtca
     3421 tttttcaggt tcctttgaag tactcccccc actgtgattc tgggtcatct gcattcagag
     3481 atttagtgca tttttactta cacttgtgct tctgctgttg acataagaat atgcatggct
     3541 gagttagcct gctggagcat gagactccat ggaacagagc caggttgccc tggtcaccct
     3601 cactgaatct tgtctagatt ggctgatggc cagccaaacc caagatatgt gaatgattcc
     3661 agccaagatc agcagagtca tctaactgac acctacctga ttccaaacat gtgagcaagg
     3721 aatgtctatt atgccaccaa tgtcttatag ctatttattg tggctataga tatctcatct
     3781 ttggatgcat tatcagatca tcttcttcaa gtaccttaga agattctcag tctcatgttt
     3841 cttgggctct tgaccacttg ctttgcctta gctaccacct catatagtaa cagattacca
     3901 gcaggtttgt atgattcctc tgcttgagat caattagcca tatgttcaga atccctggcc
     3961 tataacaaca cttctgtgct ttaaaaaccc catgccacaa tgactgttaa aagggctagg
     4021 cgatgtagtc tggtaggttt gtgaagttaa ctgtctgaaa aacttggatc aatggactag
     4081 aaaaagctgc tgggtaaatt gctcttcttc tgatggactg tatagagaca ctgtttttca
     4141 tcttgcctgt ccagaagcgt actctgtggc caagcaagtg tacttgccac atgattggca
     4201 gtgtctcttc atggcttttc atgaaacagc agcaagtgct acacagtaat ttatcagttt
     4261 gcatttgcct cccattattg ccagcctcac ttcctttctt cctcgctctt accagcctgg
     4321 attgtacctt taataaagta gtggatatat ttcctttagg gtctcttttt ctagggaagt
     4381 caggtgtttt agtctggatt tagttagaaa agcagcatcg ttacaagtat tacatgaata
     4441 aagaagttta gtaaagaaat taaggtttac cccaatgtga gaattactgg ggtaataaag
     4501 gtctggaagg ctgcagcaga agagatttag agaagcagtg actaactagg tcagccggag
     4561 attctcaaag tactcatgac ttcatttgta gaaacatgta tatcttaagc atatcaagtg
     4621 tctcattcct ctaatctttc taggagccct ttggttcatc ctgaaggtcc ccctaaatcc
     4681 cttcagaagt cttaaaaagg agtaaatggc cacacctttt atttgttctt ttctttgagg
     4741 ccatgttaat ggcagtccct tgatttggtc tttgtactag gctgttttta atgatcacat
     4801 tttatttgat gagaaacaat tttattttct agttctgcat atcctaggtt atgtatttca
     4861 tttcagttcc atttccatac ccattgcctt aattttgagc ttgtctgttt cttacatttc
     4921 tcattttgac agaataagct gactgttatt aagtacaata gataaggtac ctaagagcct
     4981 cgaaacatca ccaaatacca tgaatgcatt aggtatattt tttgtcttcc atgttactgg
     5041 aagcattaat tatagcaact ttttatctcc aaatactgac aattaaaaga ccctagtgaa
     5101 aactttaacc aaacacttac tgaccctaca ttgaaggcca ccagccaaaa atcaccaccc
     5161 atacataaga gccaaacatc actagacact tggtgaaatc cttcaaatat aaaaggggaa
     5221 aaggagggga gaaaatccaa aggaaataga caaacggaga ataatggcaa caaaaaaaaa
     5281 actgtcttca aaataagagt atattatatt cacaaaacaa gaataggaga gtgtgaaaaa
     5341 gaacaagcaa taaaaaagat ctcagaaatt taaaaagtga ttgctgaaat aaaaattaaa
     5401 tataagagtt gaagataaaa tatagcataa gaatagaaaa ttctgaattc caaataccta
     5461 aggccaatct tagttaaaag ttgtaaatgc aaccataggc tacatgttac attgtattta
     5521 attaaaaacc ttaagaggaa aggcaataga gcttgtaaca gctattaccc ttggttgtaa
     5581 aggagaaggt tggagattat ttgtatacca actacttaag tttacaaaaa ataatgagca
     5641 ttaggtagat ggaatgaaag tctattcata cactgtatat taagctctat atacactgca
     5701 tatcatcatc atgacattga gtttctagct ggattgcaga gatgagccaa agcgcttctc
     5761 cccaaattat tatttattca tttttgagac agagtctcac tcttgtctcc caggctgcag
     5821 tgcagtggtg cgatctcagc tcactacaac ctccacctcc caagttcaag caattatcat
     5881 gccttagccc cccgagtagc tgggatcaca ggcatgtgcc accacacccc gctaattttt
     5941 gtatttttag tagagatgga gttttgtcat gtttggccag ccttatctga aactcctgac
     6001 ctcaagtgat cctgcctttg cttcccaaag tgctgggatt aacaggcctg agccacaaca
     6061 cccagcctaa attattttta attatgacat tttttgtatt cccttgaggc actgacaact
     6121 atagtcttat tttatatgtt atagtgaatc atatttatct cattatatat tacagaatat
     6181 tttgtttgat ggagaaaatt cactgacctg tgctgtaatg tttataccag caattagctg
     6241 attgatttac tatgacctca ctctttattc agcagttctg ccactattac tagctaatcc
     6301 aacaacgagg ccttattttg gctttctttc gaaaggtcat ttctgacccc agcttgaagt
     6361 ttgtttattt tcacttgaag agatctctca gaaagtcaaa gaaaatagga ggaaaaaaac
     6421 ttaagattaa gggccaatct aagaggtcct tcatttgaat aataggagta acagaatggg
     6481 aaaggcgtgg aaaaaaattt gtgatttcta aaattgagga cattaagtca ttagagtaaa
     6541 aaaaagatgt acattaaggc ttatcatcaa ggaatttcag aacactgtgg atagaaaata
     6601 ctaaaagatt tcaaacagaa gaaataggtc gtatatcgac caataatcag gatattaaag
     6661 gacttcttaa caacattgga aactagaaga catggggtga tgcctttaga actttaagtg
     6721 aaaatagttt tctatttgga ttctattttt agtcatgcaa ttaatcaagt atgaatatag
     6781 tataaagaca cagaaggtct caaaggtatt acctcccata tattcttgag ataaagatgc
     6841 ttaggagaat actgaagatg ttttccagta aaacggagaa ggaaaccaaa aaccaaaaaa
     6901 gagagcatta agaagtcagc aggccaggcg cggtggctca cgcctctaat cccagcactt
     6961 taggaggcca aggcaggtgg atcgcctgag gtctggagtt taagaccagc ctggctaaca
     7021 tggcgaaact ctgtctctac taaaaataca aaaattagtc gggtgtgatg gcatgtgtct
     7081 gtaatcccag ctactcggga ggctgaagca ggagaatcac ttagaacctg ggaggcagaa
     7141 gttgtagtga gccgagatgg tgccattgca ctccagcctg ggtgacagag tgagactccg
     7201 tctcaaaaaa aataaataaa aaaataaaaa gtcagcaaag ggaagtttca gggtttcagg
     7261 attcattcat ccattctaaa aaattttgag tgcatactat gtgtcaaatt attgtctagg
     7321 tgatggctat agcatgccga ggtagtaagt gctaagaaga aaataaagca gagtaaggaa
     7381 ctgatagtga ctggtgcagg aaaggggtgc cagtttaaat agcatggtca gatggaaaag
     7441 cctgtgataa ggtaaaattg agcagagacc taaatgagag agagtgaacc atgcgaataa
     7501 ttaagtgaat aatgttttaa ttatagggaa caatatgtgt gtgtctatat atatatatac
     7561 acacaaaggt actgaggcag cagtatactt ggcatgtttg aggaataaca aggacactag
     7621 tttggaacag tgtgtgggag ggaaaaaatg atagaagatg acatcatagg gagtaatggt
     7681 gtggagccat ggtaagatgt taagatttta ctctgagtga tgagatagga agccatcaga
     7741 gaatttaagc aaatgagtga caggatctga cttatatttt taaaggatta tttggcttct
     7801 ttatgaaaaa tagactgcaa gagagtaaga aataaaatag gaagatcaat tagaatgcta
     7861 tttcagtagt ccatttgaga gatgatattt gcctggacaa gggttgtgat catgggcgag
     7921 tggtacagaa tgacaagatc ctgcatgtat ttttaaggta gagccagtat ttgcagatag
     7981 tttagacatt gtggtagata tgaaaatgtg ctgcctatat cccccttcta ggaaggactt
     8041 gctaattagc tgcagggagt gtgaagaaca gaaatccacc agtatcagca cttcatctgc
     8101 aacagctata gaaaaagctt cacctgaggt taccctcgtc ttagatctca gggcagccct
     8161 cagtggagat gtaaggcctt gctacttcag cctcatttat tacactgtca ggcaaaacct
     8221 tcctcagagc tccctctatt acaacttaat ttcttcttct gcccaatcct gcttcctccc
     8281 cttcccctga aaggtgacac tttctaataa acatcttaca ccccaaactc catctcagca
     8341 ttcctcttta gaggactcga cctgtggtaa ttgttagtag gagtgatctg agctgccaat
     8401 gagaatccca tcacatgtgg cacatggaac aaaagcccat ggctcaaggt ggtaactttt
     8461 attagtggta aaatgagaag atttacccac ggaagagaat gtgccagcaa gtgcagtata
     8521 tcaggtattt gagactcatg aaggaaatag taaatttaag aataacagaa ttgaatggcc
     8581 aagtgccact aatgctctgt agaaagaggg cttctttggt tgcatacaaa tctcatctag
     8641 aatttaatag tccaagtagc caaactggta tttgtcctta agaataaata ctggaagatc
     8701 aagcacagaa agtctagaat agaggcatgt gaatggacat acttgtgtca agtatgtaca
     8761 tgaactgtga aggtctctgt attacgtgca gtgcccacca gagagcattc agtactgaag
     8821 agtctctaaa caataaagca aactaaacac attgcctagt tgacgtcatc cttcctgctt
     8881 cagttattcg ccacccagtg ctagcacagt gggcacatga atggaatgtc cactgtggaa
     8941 aggatgaaga ctaagcatag ggttcagtag cttgagtttc aacttaccaa ggctgcctta
     9001 gctgctgctg ctgttgaatg tccaacctac aagcaacaca gacaatactg cacccctgat
     9061 ataataccat tcttcaatat caagttggtt acattgggcc ccttccacac tggaaggacc
     9121 agcatttcct tgtcatagaa atagacacaa tttccagata ggagtttgct tttcctcttt
     9181 gcagagcctc agtcagtatc accatttgag tttacttagt attgtattga ccagcatgcg
     9241 atctcacatt atatcatatc agatccggaa acctatttta tggaaaacca agcgcaggag
     9301 tggacccata tccacaggat ccactaataa tatcactttt ttcaccactt ggaatttgtc
     9361 agcttgatag aacattggaa caacctgctg aaggtacagc tgaacaccag ctcataggca
     9421 aattctacaa ggataggatg ccatactcca agatacagag tatgtactgg atcaattatc
     9481 cttatatagc atgtgcccca atatgaagaa taaatgggtc ttggaaccca tttattccta
     9541 ggggtagatg caaagagagt agaagaagag gtgcctcccc tccgtgccat cacttttaat
     9601 gacccatatg gtactttgca cctcttcata actctgaact ctgcagtgag aggtcttggt
     9661 cccacaaggg gacacagttt tgctgagaga tatataaaaa atctcactga aaaacataag
     9721 ctgcagcagc tacctggata ctttcggttc cttgtgtctg tctagggagc agcagccaat
     9781 aaaaggagtc aagatcagtt gaccctaatc aagaggagat tggaatcctg gttacacaat
     9841 ctgggcagaa gtaataaatg tggtgcccaa gtgataaacc taccaaattg agactaatgt
     9901 gtaggtgtgg caacccatcc tcaaaagggc atgatggcct ggaactcagg cctctcaagg
     9961 aatgtgggtc tgaattatac cagataaacc accaggagca gcagaggtgg tagcagaggc
    10021 tgagggaaat ctagaattga tagtggagga tgaggggatg tgacaagtat tgatggcatt
    10081 cccaagcccc actgcagcag caagcactgt aatttgtccc actaatctcc catcttctaa
    10141 atttctgaga ggtcaagaaa agaggtctct tgattccttt aggaactgct ccctaagcat
    10201 acagggagac atagatctat gtggagcaaa gggtggattg taataagcaa agagatacac
    10261 tgcctgattc actttaagaa aggactgacc tcccagttgc aaggaatgag gtcagcagcc
    10321 tccaactgtc agctccttca gagtctgctt caactgcaga aggacactgt gcttgaggtc
    10381 atacccttcc catgtctggt gactgaagtc cagctgaatg tagctgccaa agttacctta
    10441 atgcccatgg gaagcaaaaa atcaaagagt ttaaacagaa ttttgagaaa tcccaaatca
    10501 gttttttttc agcatatgac attttggagt agtttgttat tcagcaatag ataacagaaa
    10561 ttggtatcag gagtggggtg ttaccataac aaaaggttaa accttacatg gtaaaaagga
    10621 ctttgcctct gtcattaagt taagcacttt gaaatgtaga gattatcctg aattatctag
    10681 gtaggctcaa tataagcatg agtccttaaa agtggaagac ggatacatga gaggatgtca
    10741 gaatgatgtg aaatgagaag aactcaacct gctattgttg gctttacagg tgagtgatag
    10801 gaaccacaag ccccaagcag cctctggaag ctggaaaaag caaagaaaca gattctttcc
    10861 agagtgtcca gaaaggaatg cagttcagct aacatcttga ttttagatca gtgagatttt
    10921 tgtgttggac ttctacagaa ctatataaga ataaattgtg ttgcttaagc acactataat
    10981 acatgtggca agaagctgcc agctaagcct tgaagaatag tgaacaaact cttactggag
    11041 gatgggaagg cagtaaataa attattgaat tattgaaata aatggaggat tgagttatgc
    11101 attgacagaa tgcttagcaa taattttgct tgtcttaatg tggaacagaa aatgaaactt
    11161 aatagcttgt agatgtctta aggagatttc caggtgaatg ttgaaagtac tgatgaactt
    11221 attatggctg catctcataa tgtacaggaa gacatttact gagtgaacta aagaaggaac
    11281 tgttcaattt gaaagcagaa tttagaggaa atttttcaac ctagtacttg tcattttttt
    11341 atagaaaagg aaaaatagat ggaagatgga gccaaaatcc cagagggagg agccaagaag
    11401 caaggagagc aatggattag gaaaccacta ccagagggat gaactgaacc acaatcaagg
    11461 aatagcctct tcctttggtg tagggggacc ctgaaaacaa tttaatttta tgcttcctgt
    11521 ttccttgtct ccttttttga atgatagtct ctgtgtggtg ttcctatcct agaaaacctt
    11581 aactgggaca agctactctc aagcatcttc acttgagaaa cagtaactga ggaagtttat
    11641 tgtatctgga catggtttag atgataagat tctgaactta aacttatgcc ataatggagt
    11701 gagactctta gggtacagag taagtacatt tttgcatgtt agtgagacaa gaactgtggc
    11761 cgggggcaga ctgtgatagt ttttgaagat gtccctcaaa caattccttc ccttccttgg
    11821 actcctctct tcagagggta gagtccattt ccttttcctt ttaatctgga ttggccttct
    11881 aactcacttt gaccaataaa atgtggtaaa agtaaggtct ggcagttttc actttcactc
    11941 tcctgaacct tcatattaga attccaggat atccttctag agatatccat atctctaggg
    12001 acatggtgag tccctagaga caccacatgg aaaggccacc tagggaagaa ctgagatgcc
    12061 ccagtcaata gcactgcctt agtcagtttg ggctagtata acagaaatat catagattga
    12121 gtgacttttt ttctttaaaa aaatgagatt gtggaacctg aaaatacagt gtagtaagag
    12181 tggagagaaa ggccacctaa ggaagaactg agacgtccca gtcaatagca ctgccttagt
    12241 cagttggagc tactgtaaca aaaaatatca tagattgagt gacttaaaca acagaaattt
    12301 atatcttaca tttctggaga ctgaaaatat ggaaatccaa gatcagagtt tcagcatggt
    12361 taggtgttta gtgggcgctc ccttcctggt ttgcagacag ccatcttcct gctatatcct
    12421 cacatgatgc agagagagag aactctggta tctttgtccc cttataaggg caccaatctc
    12481 atcatggagg gtcttcaacc tcatggcttc ttggaaccaa attacttccc aaagtcctca
    12541 cctccaaatc tagcacattg aggtttaggg cttcaacata tgaatttcag tgcatagaaa
    12601 gcaccaagtc ctcagacaaa gagaacttga accttctaac tcagcttagc cattatctgc
    12661 atgcaaccac ataagtgacc ctgggtaaca ccatctggag ctgaagaacc accagccagt
    12721 acacagaaat gagaaatttt aaaatggttg atttaggtaa ttaagttttg gggtggttta
    12781 ttacatagca attgataact gatacaacag tcttttcgtt agtagaagag ggggtaagaa
    12841 agaaagactt atgaagaaaa gacctgtaga aaatcgggcc tacgtacctc tatttttttt
    12901 tcatactccc gtgttttttt tagtccatgc tggtggtatc ctcatcaatg caattttctt
    12961 taaaactctg tgagccttta tatcagatta gtccacccca ttagaacaaa agcaacttct
    13021 ataaatattg agacattccc tttctacctt tggctaagaa ttggggtgct atagataatt
    13081 cccaaaagat tatctagcct acagggccga tgaggtatag cttgaagtca ttctaaagtc
    13141 ttcacaaagg atcttacagc ctttgatttt attatcactc tgggaccacg ttttactgtt
    13201 ggcacgttcg gcttttctca tcttttccct gagatcattt atgatgtgga aattactttg
    13261 ctggctgaag ttgggaatag aaaacagtag agaatacttc aagagtattc taggtatgca
    13321 ctaagtttat gggaagatat gccatctaca taatttacct tcctctctag gcccatcata
    13381 aaaatctttg aaaaattaat actacatttt agtatgaata taagttaaac ttagaggtga
    13441 tatctatttt gtggttaaat gtgttataaa catttattta gtgaaataca gtacaattac
    13501 aacaagcatc aatgaatatt taatgagcag ctgttaattt ctgaagcaga aagaaagatg
    13561 aataaaagtt ctggttttac ttttaaaagt gaaggctaac tgttagctca agaaatactt
    13621 tatgtttgtc ctatatgaaa gtgttgattg cacctggttc tttgctgtaa attaaataaa
    13681 aattcaaata tttgtaaaa
//
