LOCUS       NM_001386795            6572 bp    mRNA    linear   PRI 21-OCT-2024
DEFINITION  Homo sapiens dystrobrevin alpha (DTNA), transcript variant 44,
            mRNA.
ACCESSION   NM_001386795
VERSION     NM_001386795.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6572)
  AUTHORS   Nascimento,A., Bruels,C.C., Donkervoort,S., Foley,A.R., Codina,A.,
            Milisenda,J.C., Estrella,E.A., Li,C., Pijuan,J., Draper,I., Hu,Y.,
            Stafki,S.A., Pais,L.S., Ganesh,V.S., O'Donnell-Luria,A.,
            Syeda,S.B., Carrera-Garcia,L., Exposito-Escudero,J., Yubero,D.,
            Martorell,L., Pinal-Fernandez,I., Lidov,H.G.W., Mammen,A.L.,
            Grau-Junyent,J.M., Ortez,C., Palau,F., Ghosh,P.S., Darras,B.T.,
            Jou,C., Kunkel,L.M., Hoenicka,J., Bonnemann,C.G., Kang,P.B. and
            Natera-de Benito,D.
  TITLE     Variants in DTNA cause a mild, dominantly inherited muscular
            dystrophy
  JOURNAL   Acta Neuropathol 145 (4), 479-496 (2023)
   PUBMED   36799992
  REMARK    GeneRIF: Variants in DTNA cause a mild, dominantly inherited
            muscular dystrophy.
REFERENCE   2  (bases 1 to 6572)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 6572)
  AUTHORS   Malakootian,M., Jalilian,M., Kalayinia,S., Hosseini Moghadam,M.,
            Heidarali,M. and Haghjoo,M.
  TITLE     Whole-exome sequencing reveals a rare missense variant in DTNA in
            an Iranian pedigree with early-onset atrial fibrillation
  JOURNAL   BMC Cardiovasc Disord 22 (1), 37 (2022)
   PUBMED   35148685
  REMARK    GeneRIF: Whole-exome sequencing reveals a rare missense variant in
            DTNA in an Iranian pedigree with early-onset atrial fibrillation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6572)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6572)
  AUTHORS   Fu,G., Pei,Z. and Song,N.
  TITLE     Oncogenic microRNA-301b regulates tumor repressor dystrobrevin
            alpha to facilitate cell growth, invasion and migration in
            esophageal cancer
  JOURNAL   Esophagus 18 (2), 315-325 (2021)
   PUBMED   32737801
  REMARK    GeneRIF: Oncogenic microRNA-301b regulates tumor repressor
            dystrobrevin alpha to facilitate cell growth, invasion and
            migration in esophageal cancer.
REFERENCE   6  (bases 1 to 6572)
  AUTHORS   Sadoulet-Puccio,H.M., Feener,C.A., Schaid,D.J., Thibodeau,S.N.,
            Michels,V.V. and Kunkel,L.M.
  TITLE     The genomic organization of human dystrobrevin
  JOURNAL   Neurogenetics 1 (1), 37-42 (1997)
   PUBMED   10735273
REFERENCE   7  (bases 1 to 6572)
  AUTHORS   Blake,D.J., Nawrotzki,R., Peters,M.F., Froehner,S.C. and
            Davies,K.E.
  TITLE     Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic
            protein
  JOURNAL   J Biol Chem 271 (13), 7802-7810 (1996)
   PUBMED   8631824
REFERENCE   8  (bases 1 to 6572)
  AUTHORS   Ahn,A.H., Freener,C.A., Gussoni,E., Yoshida,M., Ozawa,E. and
            Kunkel,L.M.
  TITLE     The three human syntrophin genes are expressed in diverse tissues,
            have distinct chromosomal locations, and each bind to dystrophin
            and its relatives
  JOURNAL   J Biol Chem 271 (5), 2724-2730 (1996)
   PUBMED   8576247
REFERENCE   9  (bases 1 to 6572)
  AUTHORS   Ahn,A.H. and Kunkel,L.M.
  TITLE     Syntrophin binds to an alternatively spliced exon of dystrophin
  JOURNAL   J Cell Biol 128 (3), 363-371 (1995)
   PUBMED   7844150
REFERENCE   10 (bases 1 to 6572)
  AUTHORS   Khurana,T.S., Engle,E.C., Bennett,R.R., Silverman,G.A., Selig,S.,
            Bruns,G.A. and Kunkel,L.M.
  TITLE     (CA) repeat polymorphism in the chromosome 18 encoded
            dystrophin-like protein
  JOURNAL   Hum Mol Genet 3 (5), 841 (1994)
   PUBMED   8081380
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022601.6 and AC068506.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene belongs to the
            dystrobrevin subfamily of the dystrophin family. This protein is a
            component of the dystrophin-associated protein complex (DPC), which
            consists of dystrophin and several integral and peripheral membrane
            proteins, including dystroglycans, sarcoglycans, syntrophins and
            alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma
            and its disruption is associated with various forms of muscular
            dystrophy. Mutations in this gene are associated with left
            ventricular noncompaction with congenital heart defects. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been identified for this gene. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.716853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444659.6/ ENSP00000405819.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC022601.6         66402-66549
            149-216             AC022601.6         112080-112147
            217-297             AC022601.6         122065-122145
            298-511             AC022601.6         150141-150354
            512-597             AC068506.10        133559-133644       c
            598-752             AC068506.10        127750-127904       c
            753-858             AC068506.10        123849-123954       c
            859-1025            AC068506.10        121533-121699       c
            1026-1150           AC068506.10        118948-119072       c
            1151-1234           AC068506.10        112187-112270       c
            1235-1324           AC068506.10        110374-110463       c
            1325-1402           AC068506.10        101692-101769       c
            1403-1495           AC068506.10        101026-101118       c
            1496-1583           AC068506.10        91480-91567         c
            1584-1681           AC068506.10        87935-88032         c
            1682-1795           AC068506.10        81465-81578         c
            1796-1892           AC068506.10        75801-75897         c
            1893-2052           AC068506.10        64465-64624         c
            2053-2142           AC068506.10        62055-62144         c
            2143-2311           AC068506.10        60144-60312         c
            2312-2444           AC068506.10        57662-57794         c
            2445-2493           AC068506.10        55087-55135         c
            2494-6572           AC068506.10        48019-52097         c
FEATURES             Location/Qualifiers
     source          1..6572
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6572
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /note="dystrobrevin alpha"
                     /db_xref="GeneID:1837"
                     /db_xref="HGNC:HGNC:3057"
                     /db_xref="MIM:601239"
     exon            1..148
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            149..216
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2462
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /note="isoform 24 is encoded by transcript variant 44;
                     dystrophin-related protein 3"
                     /codon_start=1
                     /product="dystrobrevin alpha isoform 24"
                     /protein_id="NP_001373724.1"
                     /db_xref="CCDS:CCDS92448.1"
                     /db_xref="GeneID:1837"
                     /db_xref="HGNC:HGNC:3057"
                     /db_xref="MIM:601239"
                     /translation="MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFV
                     QKKCNLHLVDIWNVIEALRENALNNLDPNTELNVSRLEAVLSTIFYQLNKRMPTTHQI
                     HVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIMDKLRYIFSMISDSSG
                     VMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLMSDPP
                     PQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHA
                     GGSHSNQHQMKEYTSWKSPAKKLTNALSKSLSCASSREPLHPMFPDQPEKPLNLAHIV
                     PPRPVTSMNDTLFSHSVPSSGSPFITRRLPEGISASSPVAEEHSLIKLYVNQLDHGAR
                     SPPKDSEVEQNKLLARAAPAFLKGKGIQYSLNVADRLADEHVLIGLYVNMLRNNPSCM
                     LESSNRLDEEHRLIARYAARLAAESSSSQPPQQRSAPDISFTIDANKQQRQLIAELEN
                     KNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESR
                     RELMVQLEGLMKLLKTQGAGSPRSSPSHTISRPIPMPIRSASACSTPTHTPQDSLTGV
                     GGDVQEAFAQSSRRNLRNDLLVAADSITNTMSSLVKELNSEVGSETESNVDSEFARTQ
                     FEDLVPSPTSEKAFLAQIHARKPGYIHSGATTSTMRGDMVTEDADPYVQPEDENYEND
                     SVRQLENELQMEEYLKQKLQDEAYQVSLQG"
     exon            217..297
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..511
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            512..597
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..752
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..858
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1025
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1150
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1234
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1324
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1402
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1495
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1583
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1681
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1795
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1892
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2052
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2142
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2311
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2444
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2493
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..6572
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6105..6110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /note="hexamer: ATTAAA"
     polyA_site      6130
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /note="major polyA site"
     regulatory      6554..6559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
                     /note="hexamer: AATAAA"
     polyA_site      6572
                     /gene="DTNA"
                     /gene_synonym="D18S892E; DRP3; DTN; DTN-A; LVNC1; MMCKR2"
ORIGIN      
        1 aagaatgaac acagcttttt attgaagtta aaggttactt tggagtttgt ttggaaatgt
       61 gtaaggtcaa atactatagt tttcagcata tgtagtactt cagaggaaga attaaggggc
      121 atgttggtgc atttaactac aaaaccagaa tgattgaaga tagtgggaaa agaggaaata
      181 ccatggcaga aagaagacag ctgtttgcag agatgagggc tcaagatctg gatcgcatcc
      241 gactctccac ctacagaaca gcatgcaagc ttaggtttgt tcagaagaaa tgcaatttgc
      301 acctggtgga catatggaat gtcatagaag cattgcggga aaatgctctg aacaacctgg
      361 acccaaacac tgaactcaac gtgtcccgct tagaggctgt gctctccact attttttacc
      421 agctcaacaa acggatgcca accactcacc aaatccatgt ggagcagtcc atcagcctcc
      481 tccttaactt cctgcttgca gcgtttgatc cggaaggcca tggtaaaatt tcagtatttg
      541 ctgtcaaaat ggctttagcc acattgtgtg gagggaagat catggacaaa ttaagatata
      601 ttttctcaat gatttctgac tccagtgggg tgatggttta tggacgatat gaccaattcc
      661 ttcgggaagt tctcaaacta cccacggcag tttttgaagg tccttcattt ggttacacag
      721 aacagtcagc cagatcctgt ttctcccaac agaaaaaagt cacgttaaat ggtttcttgg
      781 acacgcttat gtcagatcct cccccgcagt gtctggtctg gttgcctctt ctgcatcgac
      841 tagcaaatgt ggaaaatgtc ttccatccgg ttgagtgttc ctactgccac agtgagagta
      901 tgatgggatt tcgctaccga tgccaacagt gtcacaatta ccagctctgt caggactgct
      961 tctggagggg acatgccggt ggttctcata gcaaccagca ccaaatgaaa gagtacacgt
     1021 catggaaatc acctgctaag aagctgacta atgcattaag caagtccctg agctgtgctt
     1081 ccagccgtga acctttgcac cccatgttcc cagatcagcc tgagaagcca ctcaacttgg
     1141 ctcacatcgt gcctcccaga cctgtaacca gcatgaacga caccctgttc tcccactctg
     1201 ttccctcctc aggaagtcct tttattacca ggaggttacc tgagggaata agtgcatcca
     1261 gccctgtggc tgaagagcat tccctcataa agctgtacgt aaatcagctt gatcacggtg
     1321 cacgctctcc tcccaaggac agtgaagtag agcagaacaa actgctggct agggctgctc
     1381 cagcttttct gaagggcaaa gggatacagt acagcctgaa tgtggcagac aggctagctg
     1441 atgaacatgt tctcatcggg ttgtatgtca acatgctccg gaacaacccc tcatgcatgc
     1501 ttgagagttc aaaccggctt gatgaagaac acaggctaat tgccaggtat gcggcaaggc
     1561 tggcagcaga gtcctcttcg tctcagccac ctcagcagag aagtgctcct gacatctctt
     1621 tcaccatcga tgcgaataag cagcaaaggc agctgattgc tgagctagaa aacaagaaca
     1681 gagaaatctt acaggagatc cagagacttc ggctagagca tgaacaagct tctcagccca
     1741 cgccagagaa ggcacagcaa aaccccaccc tgctggcaga actccggctc ctcagacagc
     1801 gcaaagatga gctggaacag agaatgtctg ctctccagga gagccggaga gagctaatgg
     1861 tccagttgga gggtctcatg aagctactaa agactcaggg ggcaggctct ccccgctcct
     1921 cccccagcca caccatcagc aggccaattc ccatgcccat ccggtcagcg tcagcctgct
     1981 ccaccccgac gcacacgccg caggactccc tcacaggagt agggggagat gtacaagagg
     2041 catttgcaca aagttcaaga agaaacttaa ggaatgactt gctagtggct gcagattcca
     2101 tcactaacac tatgtcctct cttgtgaaag agctgaattc tgaggttggg agtgaaacag
     2161 agagtaatgt ggattctgaa tttgcacgga ctcagtttga ggatcttgtt ccctcaccaa
     2221 cctctgaaaa ggcttttcta gcgcaaatcc atgcccgaaa acctgggtac attcacagtg
     2281 gagctaccac aagtaccatg cgtggcgaca tggttacgga ggatgcagat ccctatgtgc
     2341 agcctgaaga tgaaaactat gaaaatgact ctgtccggca gctggagaat gagctccaga
     2401 tggaggaata cctgaaacag aagctgcaag atgaagctta tcaggtcagc ttgcaaggtt
     2461 gaatgcaata tccttttatc acactcctct caagcaagct atagtcagac agatgatgaa
     2521 agtaacatga aaactggtga tgatggagag ccctgtggcc acacagagga ggaagacagc
     2581 agcctggcag cagcctcacc gaagagagga accaccacac ccagcagctc ctgacagacc
     2641 cccaccccta aagatgtgtc ctgatgacta tagtgcagct aactttttgt tctcagattt
     2701 gtagtgcata ggtgtgtgtt tcaagaagga aaaaaaaaga cttctgttca aagttaactt
     2761 atcagctaca tcctctgtaa cgtggttcat ccctggttaa aaagcaaaca aacacaggct
     2821 gaaaacccat gctgctgtta tacacaatgg cagtattaac aagcatttta aacctttgca
     2881 catgatattg aacctgttca gtttacaatg acaatattaa tactgtttat agctagaagt
     2941 ttgatttctg aattctttga gattttagca aaacagttta ttatacactg tacatttttt
     3001 tcacagcaat tggaaaaaaa caaccacttg caatcattca ataaccctga agaatttggt
     3061 tcctgagtgt acaaactcag agcccggaag ccaagaaggg tccttggcct gcacggtctg
     3121 tagttgactc caagtctctg tgagcagtga cttgaaccaa acacaccagg aataatccat
     3181 tctttggggc ctctttccaa ctcgaggttg ttttctttca agatactcta atcagccata
     3241 gaatttagtg taaatatttt tttttccaaa tagatatcat attcaaaaaa ggcagcattc
     3301 aaattatata gaatctagtt tttaaaatca gcacagatct tcttaaaaac tgtgaactat
     3361 gttttgaaat actcgttact aaagctgttt ataaaccaca ggtgccataa gatccccaaa
     3421 cggactaaag ttatctctgc tcttccatgg tcttgttcct ctcgttttgg ctttaggaag
     3481 catgtcttta acagcaccgc tcgttcacaa gttcccccat caagttgttt ggaggccttc
     3541 agctttaaat gtacaggctt aaagtgcgct tgcaaacgtt tgctctcctt tttttctgaa
     3601 tgttgattgc cttagctggc cacctggtgt tctgcatgta gccttctgtg gtcatgtgaa
     3661 aggagacagg ctcttctaag ttgagttggg atttttgcac tcagtgaaaa gctgaagtgc
     3721 aaaagagcta tcaaagacaa gaggataaaa gactgggata gtcttttcca aggaccctct
     3781 ttagagggcc ctaaagacct cctttgggaa ttctggggaa aaagaaaaag taatcttcta
     3841 cttgcttcaa gatttgattt ttttaaaaaa gcctgcgacc tattcaatac attatgctta
     3901 aattagcagt ttctctggaa ttcctgtctc tcctttaaaa gaaaggagag aacattttag
     3961 aacaatagtt ctcaaagtgt gttccccgga caagcagcat ctgcaacact taggaaggtc
     4021 ttcgaaatac taatttgtaa gccccacctc aggcctactg aatcagaagc tctgggggtt
     4081 gggtccagaa gtctgtttta gtcaaccctc taggtgattc tgatgctcgc taaaggttga
     4141 gaactactgc tttagaatga agtcgtataa taaagtctct gaaaaggcct tattcagaat
     4201 aagcaagaaa ggttctgtga ttcacttttg cttctggggc tggcaaaaac cttctctgaa
     4261 cccacacacc aagttcgtag ttggtaggtg cccagccaag tcctgacatc ttcatgcccc
     4321 ctctgcagag ggcggctgta cgatgttcac atgtctgcgt ttggtcagac atcatctcct
     4381 tggctgccct ttgaaaccaa atcacttgcc ttggggataa agtgctcaat tggcattagt
     4441 gagaagccca tcctatccct tgacatactt aatcatatat ctctccagag aactcacctg
     4501 acaaatgtct ctgagcacag gctgacacca aagtggcaca actgcacagt tctcagattt
     4561 ctttgcacag attgattttt attgcgggtt ttgttggggt gtcttaatgt tcatctcttt
     4621 tccactgccc atcctctgtg aacccatacc tctctagatg gagcaggtgg ccactggtgc
     4681 ctcatactca gtattgaaaa ccactacatc ccagctacct ataatgctgt cagctcaaaa
     4741 tcatagccag gtagttcttg aactcagaac ttaaatcctg cacgtggcac tccaccactg
     4801 actggaccga gctggcatat gttgtttctt tgtgtttcta catcaaaatg ttcgtctaag
     4861 atttgaactg ttctgctgat aaccttcccc gttgtcatag ctatttcatt gccaaccaac
     4921 tccatcacat ggttgttgat atcgtcatat aaagccattg caaggactct ggaaactgcc
     4981 gccaatgacc aatttctgac taaccagcca ccttttctct ctcttagctc cacgtcagca
     5041 ctgagaccag actcgagcac ccctgtcctg taagcgagac aaaatggcgt gtgttatttt
     5101 ggggttttgt gttttttggt gggtttcttt ccttggctct ccagatttac ttttggggcc
     5161 tgttctaagt gcaaacccag caagtttcac ttgtcctgtc cattagatac aactacatct
     5221 tgcgggggtt gtttctttct tgttccacaa tgaattgcac atccatctcc atcagagctg
     5281 atagcctgtt aataagcact ggtctaacac agccaaccct cctccacagc gccatattaa
     5341 tggaggaggg gaggaaggtg aaatctactg catgggattc aggaaacagt tgtggttggt
     5401 caggacggaa gttggggtaa gtttggttgg tcagagggag ttgtgctgga gattgtgaaa
     5461 aatgggttct tgaatgatct actataaggc agggaaggtt catttgtaag tagtaatgtg
     5521 aactgaattg cattaagagt gtgtggcctt tgttgtgata tactatgtat tttcttatat
     5581 gcatgagcca aactgttgca tcataattta gcactgatgt ctgcttttat tttgatcatc
     5641 tttgtccacc cttattagtt cttggctgtt aaccgtagat agatcttgta aatccagcaa
     5701 cctttggttg ctgcattccc cttggttcga ttccacgcaa ggagccacaa gtgagaactc
     5761 cactgtcctt agaagaaagg gcatttttac ttttgaacca aaaagagaaa aaaaaatcag
     5821 aagtgttgca tcttgaggcg aattaactgt aagacatttt taattatgac tactgcaatt
     5881 tgacaccatt tgaaataatc aattcagaga cactaaagat ttcacaatat tcattggtat
     5941 tgtaaaaaaa aaatactatt gtatggattt ttgtattgct gttaagtatt gttttgtgtg
     6001 tgtgtgtgtg tgtgtgtgtt ggaacctcct ggggacatgt tatattttga agtgattaaa
     6061 ctatttaatt gtgtgtctat attttggagt ggaataattt cttcattaaa aaatgttttt
     6121 aaaaacacta tatcttgggt ggtttattcc tttgtttcag tgaatctttc ctaaagcaac
     6181 gtggagtcag tctgttgaaa gaaggaaggc aggtacttgc agtttaaagc aggacccatt
     6241 gatggaatat tgagccaccg aggcaaaata gctcaccttc tcttgccttg ggggatgcat
     6301 ggtttttacc attctactgt tttattagca tctgtgagca tctaatagaa atactattct
     6361 gctatttatg gaaatcctta ttataattga tatggaagtg agtttgaaat tctaacagct
     6421 aacatatttc atgtttgtat cacacactgt tcttaacact ttatgtgact tcactcaatt
     6481 ctttgaatcc tctgcatcta gccatgtatt ctgcaaatat taagtgctca atggtttttt
     6541 tgttgaatta ctgaataaat gaattagtgg tg
//
