LOCUS       NM_016448               4409 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens denticleless E3 ubiquitin protein ligase homolog
            (DTL), transcript variant 1, mRNA.
ACCESSION   NM_016448
VERSION     NM_016448.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4409)
  AUTHORS   Zhang,Y., Wang,C., Wu,L., Bai,C., Huang,K., Yao,L., Zhang,Z.,
            Ye,L., Liu,R., Ge,X., Xu,M., Zhao,Y. and Cao,Q.
  TITLE     Epithelial CRL4DCAF2 Is Critical for Maintaining Intestinal
            Homeostasis Against DSS-Induced Colitis by Regulating the
            Proliferation and Repair of Intestinal Epithelial Cells
  JOURNAL   Dig Dis Sci 69 (1), 66-80 (2024)
   PUBMED   37968554
  REMARK    GeneRIF: Epithelial CRL4[DCAF2] Is Critical for Maintaining
            Intestinal Homeostasis Against DSS-Induced Colitis by Regulating
            the Proliferation and Repair of Intestinal Epithelial Cells.
REFERENCE   2  (bases 1 to 4409)
  AUTHORS   Palla,A.H.
  TITLE     Regular or DCAF2: How CRL4DCAF2 Affects IBD-Related Mucosal Injury
  JOURNAL   Dig Dis Sci 69 (1), 3-4 (2024)
   PUBMED   37968553
  REMARK    GeneRIF: Regular or DCAF2: How CRL4[DCAF2] Affects IBD-Related
            Mucosal Injury.
REFERENCE   3  (bases 1 to 4409)
  AUTHORS   Luo,X., Liu,J., Wang,X., Yuan,J. and Zhang,Y.
  TITLE     Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant
            progression by regulating DCUN1D1 expression
  JOURNAL   J Biochem Mol Toxicol 37 (11), e23462 (2023)
   PUBMED   37522575
  REMARK    GeneRIF: Circ-DTL sponges miR-758-3p to accelerate cervical cancer
            malignant progression by regulating DCUN1D1 expression.
REFERENCE   4  (bases 1 to 4409)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 4409)
  AUTHORS   Dong,R., Zhang,D., Han,B., Xu,L., Zhang,D., Cheng,Z. and Qiu,X.
  TITLE     DTL is a Novel Downstream Gene of E2F1 that Promotes the
            Progression of Hepatocellular Carcinoma
  JOURNAL   Curr Cancer Drug Targets 23 (10), 817-828 (2023)
   PUBMED   37171007
  REMARK    GeneRIF: DTL is a Novel Downstream Gene of E2F1 that Promotes the
            Progression of Hepatocellular Carcinoma.
REFERENCE   6  (bases 1 to 4409)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
  REMARK    GeneRIF: These studies uncover diverse substrate receptors for Cul4
            and identify Cdt2 as a conserved component of the Cul4-Ddb1 E3 that
            is essential to destroy Cdt1 and ensure proper cell cycle
            regulation of DNA replication.
REFERENCE   7  (bases 1 to 4409)
  AUTHORS   Higa,L.A., Banks,D., Wu,M., Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and
            regulates CDT1 proteolysis in response to DNA damage
  JOURNAL   Cell Cycle 5 (15), 1675-1680 (2006)
   PUBMED   16861906
  REMARK    GeneRIF: L2DTL and PCNA interact with CUL4/DDB1 complexes and are
            involved in CDT1 degradation after DNA damage.
REFERENCE   8  (bases 1 to 4409)
  AUTHORS   Banks,D., Wu,M., Higa,L.A., Gavrilova,N., Quan,J., Ye,T.,
            Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     L2DTL/CDT2 and PCNA interact with p53 and regulate p53
            polyubiquitination and protein stability through MDM2 and
            CUL4A/DDB1 complexes
  JOURNAL   Cell Cycle 5 (15), 1719-1729 (2006)
   PUBMED   16861890
  REMARK    GeneRIF: PCNA, L2DTL and the DDB1-CUL4A complex play critical and
            differential roles in regulating the protein stability of p53 and
            MDM2/HDM2 in unstressed and stressed cells.
REFERENCE   9  (bases 1 to 4409)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 4409)
  AUTHORS   Cheung,W.M., Chu,A.H., Chu,P.W. and Ip,N.Y.
  TITLE     Cloning and expression of a novel nuclear matrix-associated protein
            that is regulated during the retinoic acid-induced neuronal
            differentiation
  JOURNAL   J Biol Chem 276 (20), 17083-17091 (2001)
   PUBMED   11278750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092814.2, AL592297.5 and AL606468.8.
            
            On Nov 23, 2018 this sequence version replaced NM_016448.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF195765.1, SRR11853565.2808.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366991.5/ ENSP00000355958.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC092814.2         146904-147098
            196-321             AC092814.2         154149-154274
            322-420             AC092814.2         155816-155914
            421-482             AC092814.2         158307-158368
            483-603             AC092814.2         158453-158573
            604-669             AL592297.5         5795-5860
            670-782             AL592297.5         7828-7940
            783-856             AL592297.5         9723-9796
            857-960             AL606468.8         2632-2735
            961-1065            AL606468.8         3007-3111
            1066-1178           AL606468.8         6509-6621
            1179-1268           AL606468.8         12581-12670
            1269-1404           AL606468.8         15023-15158
            1405-2237           AL606468.8         34660-35492
            2238-4409           AL606468.8         37250-39421
FEATURES             Location/Qualifiers
     source          1..4409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..4409
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /note="denticleless E3 ubiquitin protein ligase homolog"
                     /db_xref="GeneID:51514"
                     /db_xref="HGNC:HGNC:30288"
                     /db_xref="MIM:610617"
     exon            1..195
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2336
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RA-regulated nuclear matrix-associated protein;
                     denticleless protein homolog; DDB1- and CUL4-associated
                     factor 2; lethal(2) denticleless protein homolog; retinoic
                     acid-regulated nuclear matrix-associated protein"
                     /codon_start=1
                     /product="denticleless protein homolog isoform 1"
                     /protein_id="NP_057532.4"
                     /db_xref="CCDS:CCDS1502.1"
                     /db_xref="GeneID:51514"
                     /db_xref="HGNC:HGNC:30288"
                     /db_xref="MIM:610617"
                     /translation="MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYG
                     ETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVF
                     DLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGG
                     RDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQS
                     VTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSS
                     LILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVS
                     GSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNR
                     GLEEKPGGDKLSTVGWASQKKKESRPGLVTVTSSQSTPAKAPRAKCNPSNSSPSSAAC
                     APSCAGDLPLPSNTPTFSIKTSPAKARSPINRRGSVSSVSPKPPSSFKMSIRNWVTRT
                     PSSSPPITPPASETKIMSPRKALIPVSQKSSQAEACSESRNRVKRRLDSSCLESVKQK
                     CVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSKDSLGPTKSSKIEGAGTSISEPPSP
                     ISPYASESCGTLPLPLRPCGEGSEMVGKENSSPENKNWLLAMAAKRKAENPSPRSPSS
                     QTPNSRRQSGKKLPSPVTITPSSMRKICTYFHRKSQEDFCGPEHSTEL"
     exon            196..321
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            322..420
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            421..482
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            483..603
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            604..669
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            670..782
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            783..856
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            857..960
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1065
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1178
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1268
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1404
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..2237
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..4409
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2813..2818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /note="hexamer: AATACA"
     polyA_site      2832
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
     regulatory      4223..4228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /note="hexamer: AATAAA"
     polyA_site      4241
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /note="major polyA site"
     regulatory      4383..4388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
                     /note="hexamer: AATAAA"
     polyA_site      4409
                     /gene="DTL"
                     /gene_synonym="CDT2; DCAF2; L2DTL; RAMP"
ORIGIN      
        1 ggagtttggc ggccggggct tacagtggcg ggagttggag gcgataacga tttgtgttgt
       61 gagaggcgca agctgcgatt tctgctgaac ttggaggcat ttctacgact tttctctcag
      121 ctgaggcttt tcctccgacc ctgatgctct tcaattcggt gctccgccag ccccagcttg
      181 gcgtcctgag aaatggatgg tcttcacaat accctcttca atcccttctg actggttatc
      241 agtgcagtgg taatgatgaa cacacttctt atggagaaac aggagtccca gttcctcctt
      301 ttggatgtac cttctcttct gctcccaata tggaacatgt actagcagtt gccaatgaag
      361 aaggctttgt tcgattgtat aacacagaat cacaaagttt cagaaagaag tgcttcaaag
      421 aatggatggc tcactggaat gccgtctttg acctggcctg ggttcctggt gaacttaaac
      481 ttgttacagc agcaggtgat caaacagcca aattttggga cgtaaaagct ggtgagctga
      541 ttggaacatg caaaggtcat caatgcagcc tcaagtcagt tgccttttct aagtttgaga
      601 aagctgtatt ctgtacgggt ggaagagatg gcaacattat ggtctgggat accaggtgca
      661 acaaaaaaga tgggttttat aggcaagtga atcaaatcag tggagctcac aatacctcag
      721 acaagcaaac cccttcaaaa cccaagaaga aacagaattc aaaaggactt gctccttctg
      781 tggatttcca gcaaagtgtt actgtggtcc tctttcaaga cgagaatacc ttagtctcag
      841 caggagctgt ggatgggata atcaaagtat gggatttacg taagaattat actgcttatc
      901 gacaagaacc catagcatcc aagtctttcc tgtacccagg tagcagcact cgaaaacttg
      961 gatattcaag tctgattttg gattccactg gctctacttt atttgctaat tgcacagacg
     1021 ataacatcta catgtttaat atgactgggt tgaagacttc tccagtggct attttcaatg
     1081 gacaccagaa ctctaccttt tatgtaaaat ccagccttag tccagatgac cagtttttag
     1141 tcagtggctc aagtgatgaa gctgcctaca tatggaaggt ctccacaccc tggcaacctc
     1201 ctactgtgct cctgggtcat tctcaagagg tcacgtctgt gtgctggtgt ccatctgact
     1261 tcacaaagat tgctacctgt tctgatgaca atacactaaa aatctggcgc ttgaatagag
     1321 gcttagagga gaaaccagga ggtgataaac tttccacggt gggttgggcc tctcagaaga
     1381 aaaaagagtc aagacctggc ctagtaacag taacgagtag ccagagtact cctgccaaag
     1441 cccccagggc aaagtgcaat ccatccaatt cttccccgtc atccgcagct tgtgccccaa
     1501 gctgtgctgg agacctccct cttccttcaa atactcctac gttctctatt aaaacctctc
     1561 ctgccaaggc ccggtctccc atcaacagaa gaggctctgt ctcctccgtc tctcccaagc
     1621 caccttcatc tttcaagatg tcgattagaa actgggtgac ccgaacacct tcctcatcac
     1681 cacccatcac tccacctgct tcggagacca agatcatgtc tccgagaaaa gcccttattc
     1741 ctgtgagcca gaagtcatcc caagcagagg cttgctctga gtctagaaat agagtaaaga
     1801 ggaggctaga ctcaagctgt ctggagagtg tgaaacaaaa gtgtgtgaag agttgtaact
     1861 gtgtgactga gcttgatggc caagttgaaa atcttcattt ggatctgtgc tgccttgctg
     1921 gtaaccagga agaccttagt aaggactctc taggtcctac caaatcaagc aaaattgaag
     1981 gagctggtac cagtatctca gagcctccgt ctcctatcag tccgtatgct tcagaaagct
     2041 gtggaacgct acctcttcct ttgagacctt gtggagaagg gtctgaaatg gtaggcaaag
     2101 agaatagttc cccagagaat aaaaactggt tgttggccat ggcagccaaa cggaaggctg
     2161 agaatccatc tccacgaagt ccgtcatccc agacacccaa ttccaggaga cagagcggaa
     2221 agaaattgcc aagcccggtc accatcacgc ccagctccat gaggaaaatc tgcacatact
     2281 tccatagaaa gtcccaggag gacttctgtg gtcctgaaca ctcaacagaa ttatagattc
     2341 taatctgagt gagttactga gctttggtcc actaaaacaa gctgagcttt ggtccactaa
     2401 aacaagatga aaaatacaag agtgactcta taactctggt ctttaagaaa gctgcctttt
     2461 catttttaga caaaatcttt tcaacgctga aatgtaccta atctggttct actaccataa
     2521 tgtatatgca gcttcccgag gatgaatgct gtgtttaaat ttcataaagt aaatttgtca
     2581 ctctagcatt ttgaatgaat agtcttcact ttttaaatta ttcatcttct ctataataat
     2641 gacatcccag ttcatggagg caaaaaacaa gtttcttgtt atcctgaaac tttctatgct
     2701 cagtggaaag tatctgccag ccacagcatg aggcctgtga aggctgactg agaaatcctc
     2761 tgctgaagac ccctggttct gttctgcctc caacatgtat aattttattt gaaatacata
     2821 atcttttcac tatgcttttg tggggttttt tttaagtatg tgtaaaaatg tgatgctcag
     2881 ataagtacat ttatatcagt tcagtgttaa aatgcagtct cttgagttaa agtcatcttt
     2941 attttaaatg cagtgataaa tgtcaactct tcggagaaac taggagaaca acaacagaaa
     3001 gctgtgtttg tcttttttct ctcaaatata tctcccgtat gagatttcag gtccccatgt
     3061 tttcaccaag caatctgcta tgtcagccaa cccaacatca ctttctacag gaggttatga
     3121 tttttgccat ttactagagg aagatgtttt atgaaatcaa tttggggttt gaattcaggt
     3181 gcagtcatca gttctttagg ggctgcaatg ttttaaaaaa aataagtcat cagattttaa
     3241 gaaaaaagtg atgatttctt attgatattt ttgtaacaga atatagctct taactgaaaa
     3301 tccagaacca gaaacataaa tcttgagttt cttttcatgt acataaaaag caatagcctt
     3361 ttagtataga tagccctgag ccaaaaagta atagaatttt ctctagatat ttaatacaga
     3421 gagtgtatag actgactcta agttaataat gtgcaaaata tcttaaacat ccctcccctt
     3481 attcaacaat tatgtatcag tgatcttgaa ccattgtttt atatttttca cctttgtaac
     3541 ctcatggaaa gaggctttac atactttcta tgtactattt acttagaagg gagccccctt
     3601 ccagtcatga aacttcattt gttttatcca tatccctgag gactgtgtag actttatgtc
     3661 agtttttgtc attatttgaa aatctattct gacaactttt taattccttt gatcttataa
     3721 gttaaagctg taacaactga aattgcatgg atcaagtaag catagtttta tccagggaga
     3781 aaaataaaag gaagccatag aattgctctg gtcaaaacca agcacaccat agccttaact
     3841 gaatatttag gaaatctgcc taatctgctt atatttggtg tttgtttttt gactgttggg
     3901 ctttgggaag atgttattta tgaccaatat ctgccagtaa cgctgtttat ctcacttgct
     3961 ttgaaagcca atgggggaaa aaaatccatg aaaaaaaaaa gattgataaa gtagatgatt
     4021 ttgtttgtat ccctacccat ctcctggcag ccctactgag tgaaattggg atacatttgg
     4081 ctgtcagaaa ttataccgag tctactgggt ataacatgtc tcacttggaa agctagtact
     4141 tttaaatggg tgccaaaggt caactgtaat gagataatta tccctgcctg tgtccatgtc
     4201 agactttgag ctgatcctga ataataaagc cttttacctt atctgatgtc cttttctgag
     4261 ctttttgcat tacctagaag cagtctacaa aaaagaacta tagtagtcaa gaatcccttc
     4321 tacttgttca ttaaaatgtt tattcccaaa gttataatct atttcaagct gaaagagctt
     4381 ttaataaaaa acatcttgct tggatcaga
//
