LOCUS       NM_080820               3953 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens D-aminoacyl-tRNA deacylase 1 (DTD1), transcript
            variant 2, mRNA.
ACCESSION   NM_080820
VERSION     NM_080820.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3953)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3953)
  AUTHORS   Poudel,S., Yao,J., Kemp,M.G. and Leffak,M.
  TITLE     Interaction between DUE-B and Treslin is required to load Cdc45 on
            chromatin in human cells
  JOURNAL   J Biol Chem 293 (37), 14497-14506 (2018)
   PUBMED   30037903
  REMARK    GeneRIF: results suggest that DUE-B acts to identify origins by MCM
            binding and serves as a node for replication protein recruitment
            and Cdc45 transfer to the prereplication complex
REFERENCE   3  (bases 1 to 3953)
  AUTHORS   Gao,Y., Yao,J., Poudel,S., Romer,E., Abu-Niaaj,L. and Leffak,M.
  TITLE     Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding
            element-binding protein in replication initiation
  JOURNAL   J Biol Chem 289 (52), 35987-36000 (2014)
   PUBMED   25258324
  REMARK    GeneRIF: The state of DUE-B phosphorylation is maintained by the
            equilibrium between Cdc7-dependent phosphorylation and
            PP2A-dependent dephosphorylation.
REFERENCE   4  (bases 1 to 3953)
  AUTHORS   Gosenca,D., Kellert,B., Metzgeroth,G., Haferlach,C., Fabarius,A.,
            Schwaab,J., Kneba,M., Scheid,C., Topelt,K., Erben,P., Haferlach,T.,
            Cross,N.C., Hofmann,W.K., Seifarth,W. and Reiter,A.
  TITLE     Identification and functional characterization of
            imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in
            eosinophilia-associated myeloid/lymphoid neoplasms
  JOURNAL   Genes Chromosomes Cancer 53 (5), 411-421 (2014)
   PUBMED   24772479
  REMARK    GeneRIF: LDI-PCR revealed a fusion between DTD1 exon 4 and PDGFRB
            exon 12 in the cases with t(5;14)(q33;q32) and t(5;20)(q33;p11).
REFERENCE   5  (bases 1 to 3953)
  AUTHORS   Pasaje,C.F., Bae,J.S., Park,B.L., Jang,A.S., Uh,S.T., Kim,M.K.,
            Koh,I.S., Kim,J.H., Park,T.J., Lee,J.S., Kim,Y., Park,C.S. and
            Shin,H.D.
  TITLE     Association analysis of DTD1 gene variations with
            aspirin-intolerance in asthmatics
  JOURNAL   Int J Mol Med 28 (1), 129-137 (2011)
   PUBMED   21479357
  REMARK    GeneRIF: DTD1 variants do not affect the abnormalities of the upper
            airways in aspirin-intolerant asthma patients
REFERENCE   6  (bases 1 to 3953)
  AUTHORS   Kemp,M., Bae,B., Yu,J.P., Ghosh,M., Leffak,M. and Nair,S.K.
  TITLE     Structure and function of the c-myc DNA-unwinding element-binding
            protein DUE-B
  JOURNAL   J Biol Chem 282 (14), 10441-10448 (2007)
   PUBMED   17264083
REFERENCE   7  (bases 1 to 3953)
  AUTHORS   Sibani,S., Price,G.B. and Zannis-Hadjopoulos,M.
  TITLE     Ku80 binds to human replication origins prior to the assembly of
            the ORC complex
  JOURNAL   Biochemistry 44 (21), 7885-7896 (2005)
   PUBMED   15910003
REFERENCE   8  (bases 1 to 3953)
  AUTHORS   Casper,J.M., Kemp,M.G., Ghosh,M., Randall,G.M., Vaillant,A. and
            Leffak,M.
  TITLE     The c-myc DNA-unwinding element-binding protein modulates the
            assembly of DNA replication complexes in vitro
  JOURNAL   J Biol Chem 280 (13), 13071-13083 (2005)
   PUBMED   15653697
  REMARK    GeneRIF: DUE-B, a c-myc DNA-unwinding element-binding protein,
            plays an important role in replication in vivo.
REFERENCE   9  (bases 1 to 3953)
  AUTHORS   Meng,X., Chen,J., Yang,Q., Wang,S., Chao,Y., Ying,K., Xie,Y. and
            Mao,Y.
  TITLE     Cloning and identification of a novel cDNA which may be associated
            with FKBP25
  JOURNAL   Biochem Genet 40 (9-10), 303-310 (2002)
   PUBMED   12392168
  REMARK    GeneRIF: cloning and identification of novel cDNA which may be
            associated with FKBP25
REFERENCE   10 (bases 1 to 3953)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC100924.2, AW022517.1 and
            AL121780.11.
            
            On Jun 2, 2019 this sequence version replaced NM_080820.5.
            
            Summary: The protein encoded by this gene is similar in sequence to
            histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into
            D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA
            unwinding element and plays a role in the initiation of DNA
            replication. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Dec
            2015].
            
            Transcript Variant: This variant (2) has a different 3' structure,
            resulting in a novel 3' coding region and 3' UTR, compared to
            variant 1. The encoded isoform (2) has a distinct C-terminus, and
            is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.143857.1,
                                           ERR1172418.2167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000377452.4/
                                                  ENSP00000366672.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-857               BC100924.2         83-939
            858-1226            AW022517.1         114-482
            1227-3953           AL121780.11        53580-56306
FEATURES             Location/Qualifiers
     source          1..3953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3953
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /note="D-aminoacyl-tRNA deacylase 1"
                     /db_xref="GeneID:92675"
                     /db_xref="HGNC:HGNC:16219"
                     /db_xref="MIM:610996"
     exon            1..62
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..649
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /EC_number="3.1.1.96"
                     /note="isoform 2 is encoded by transcript variant 2;
                     histidyl-tRNA synthetase 2; D-tyrosyl-tRNA(Tyr) deacylase
                     1; histidyl-tRNA synthase-related; D-tyrosyl-tRNA
                     deacylase 1 homolog; gly-tRNA(Ala) deacylase;
                     DNA-unwinding element-binding protein B"
                     /codon_start=1
                     /product="D-aminoacyl-tRNA deacylase 1 isoform 2"
                     /protein_id="NP_543010.3"
                     /db_xref="CCDS:CCDS13138.1"
                     /db_xref="GeneID:92675"
                     /db_xref="HGNC:HGNC:16219"
                     /db_xref="MIM:610996"
                     /translation="MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISLEDTQKELEH
                     MVRKILNLRVFEDESGKHWSKSVMDKQYEILCVSQFTLQCVLKGNKPDFHLAMPTEQA
                     EGFYNSFLEQLRKTYRPELIKDGKFGAYMQVHIQNDGPVTIELESPAPGTATSDPKQL
                     SKLEKQQQRKEKTRAKGPSESSKERNTPRKEDRSASSGAEGDVSSEREP"
     exon            63..153
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /inference="alignment:Splign:2.1.0"
     exon            154..389
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /inference="alignment:Splign:2.1.0"
     exon            390..496
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /inference="alignment:Splign:2.1.0"
     exon            497..668
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /inference="alignment:Splign:2.1.0"
     exon            669..3953
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1183..1188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /note="hexamer: AATAAA"
     regulatory      1201..1206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /note="hexamer: AACAAA"
     polyA_site      1209
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /note="major polyA site"
     polyA_site      1226
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
     regulatory      1898..1903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
                     /note="hexamer: AATAAA"
     polyA_site      1927
                     /gene="DTD1"
                     /gene_synonym="C20orf88; DTD; DUE-B; DUEB; HARS2; pqn-68"
ORIGIN      
        1 actcgcccca gccgccgcca tgaaggccgt ggtgcagcgc gtcacccggg ccagcgtcac
       61 agttggagga gagcagatta gtgccattgg aaggggcata tgtgtgttgc tgggtatttc
      121 cctggaggat acgcagaagg aactggaaca catggtccga aagattctaa acctgcgtgt
      181 atttgaggat gagagtggga agcactggtc gaagagtgtg atggacaaac agtacgagat
      241 tctgtgtgtc agccagttta ccctccagtg tgtcctgaag ggaaacaagc ctgatttcca
      301 cctagcaatg cccacggagc aggcagaggg cttctacaac agcttcctgg agcagctgcg
      361 taaaacatac aggccggagc ttatcaaaga tggcaagttt ggggcctaca tgcaggtgca
      421 cattcagaat gatgggcctg tgaccataga gctggaatcg ccagctcccg gcactgctac
      481 ctctgaccca aagcagctgt caaagctcga aaaacagcag cagaggaaag aaaagaccag
      541 agctaaggga ccttctgaat caagcaagga aagaaacact ccccgaaaag aagaccgcag
      601 tgccagcagc ggggctgagg gcgacgtgtc ctctgaacgg gagccgtagc tcaggaggca
      661 gaattcagtg tgttatcatt gggcagaact ggatcctgaa aaattcaaga tgctaagcac
      721 ctacactact ttaagaattt ggaactgaaa catgaagagg aagacagaaa taagaatttg
      781 ggaacctgaa tagctctgca aaaaacacca aaggaccgtt ttatcgtttt ctgttgttgc
      841 tgtggtggag tgatgcagtg ggcactgccg gtgggccagg gggcgggtgc gcatgtggta
      901 gaaggtgtgc gctcgtgcct cccccacaga aaggctttgt tggtttctac cacatcttgg
      961 cttgcttttg gaacaggctg gcccagcatc atttgtcatc aagtccactg tggtgtattc
     1021 tgcgtgtcca tggcgggggt tctccaatac actcacactg tccatgttct ttttattgcc
     1081 agggcccgtg ttgaagtgtc aagagagcaa tcatcaatga taatgtattg tgtgagacct
     1141 ttgcatcttg taaattttct cttttttcta aaaataaata ataataaaat cctaaatctc
     1201 aacaaaccac tttattatca aacaaattct gctctgtttc tgcataacga tgatgtccat
     1261 agaaatgcaa tgcgtctgac ctctctctat gcgtatctac acttcttttc acataagtct
     1321 ctcgcaagag ggccttctct aactggccca cacaggctcc tgagtccagg tgggagcctg
     1381 tctagccagt ttacaattga tgacatggta cttggaagtg agatgtcagg aaaagggagt
     1441 gtgggtcaga agatagtcca gtttcagaat ggccacactg ttctgagacc aagtgtggag
     1501 ccacatctgg tgtatccagc tttgggaggt ggaggaaggc ctcagcatgg cgggtggtgc
     1561 agataccctt tatccagtag ctacatggtt gtccatgtat ccaagtcacc acacccagca
     1621 ctctgggaag aaagaatcac attctgccaa agtaatttct cagttaaatt tcagtctact
     1681 ggtggcacac tcagagtagt cattttttga catatgattt aatagcttta tttatatatc
     1741 taataacgct cgcatatatg ctctctggaa aatatttttg tatatagaag agacatcctt
     1801 aattgtgatt tttataatgc tgaaactctg tcttctgtga cctctataat aacttctgaa
     1861 tccatctagt ctgacccagt catctacttc aaatgataat aaatcagaaa atgtggaaaa
     1921 caaaaaagct caaaacacat ctcttggaat atagagttgg aaaagggtct gccagactgc
     1981 tttgttctaa accaattcag atggtccagt gtaattcaca atggtttaaa cctctagatt
     2041 tgaagtcatt acatcccaga tgcagaccct ggccagctcc ctaagctgtg tgggcagtga
     2101 ggtcccagaa gctctgctgt ttgagttatc taagcagggt tttacagagt gaattcaaat
     2161 tcactttaaa gctacttgaa cctacatgtc gataaactca gttgtagggt ttggcttgct
     2221 ggataactgt catgtttctc caccacagca ttttattgcc accaattaat gcttattgaa
     2281 cagttgcagc ctgtccttgt agtaaggggt aacgaggatt gcatagagat acgacctaag
     2341 gatcatgaca tttggatggt ggtaaaatgc taaaggcctt tgttggtcac agcccagttc
     2401 ctggctccca ttctaaaggg acagagacat accagagagt gagcaccatg tggtcaagtt
     2461 gctgaagggt ctgaaaccgt aaaggaagag ctgaaggagc tggggctgtt tcatctggga
     2521 ggggaactct aaatgtttga aagatgtgga agagaagctg ggtcaggaac aaaaatagga
     2581 gcaatgggtg taagttgcat caacgtagat tctggcattc taacaacatg attcaaaagt
     2641 ggaaggtgat gttgggagct tttggtgttt gagcagaaat tctgagccta tatgtgtgag
     2701 gggggatctt tgattaatta aaacatcttc ctcacagtat gcaggaacat ggtaaaagaa
     2761 agcatttact acttttgtaa acattttgga ttgaagagaa cttttccatc atcctgaaaa
     2821 tcactttcaa ctcctgggat cagagaaata gcagtgaata caccgaagtc tggcctaaga
     2881 gggtcagatc taaccacagg gccagattat agagaaaaat gaaagctcaa gaagaaaccc
     2941 cataatatct gcagctgcct caaaaaggtg gttaatttcc acccccacct acactcctga
     3001 aggtcctttc ctagttgctt tgaaactaat ggctaaaatt agattttggg tggcattctt
     3061 gtggagaata aatctctcag tctttacatc tctcccaaca tctctgcctc cttctttctg
     3121 cttatttata aagcatactg cttattgtcc attaaaacat catttgaatg aggatgggag
     3181 aggagaatcg taccatgtat ggcttttctg agaagccttg gcagatcaca gacccaggac
     3241 tttaaacaga gtgctgtgcc gataacactg catagcagga cccatttaat cttgcctttg
     3301 gtggtttact ttacaggaga ccaagctctt gtggctacac aaaacataga ccaaataaag
     3361 gcatctttgg gggctggatg tccatagcag cacctcatgg ttagtggtcc cagggagggc
     3421 attttctcta ccaagcagtg tcctggctca gatgggtgcc agctggcata tatatggaca
     3481 atttggcatt tcattgattt gatcataagg aacaaatagt tccgcaaaca ccctatttcc
     3541 tttgatatgg taacatttga gtaactccaa agccagagag gcaatctttt ctatctctgg
     3601 tttgtcagat tttctgccgt ttttcagcca ggcactttaa gaattcttaa tttgttgttc
     3661 gttattgatt caggtccttt aaaaatagag ttaaacaccc tcatctcaga agacatggaa
     3721 taatatcaaa agtaaagcca cccactggct gcatcagaaa agaagaggga ggccgggcgc
     3781 ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcgggtgga tcacgaggtc
     3841 agtagatcaa gaccatcctg gctaacacag tgaaaccccg tctctactaa aaatacaaaa
     3901 aattagccgg gcgtggtggc gggtgcctta gtcccagcta ctcgggaggc tga
//
