LOCUS       XM_047417152            7486 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens dual serine/threonine and tyrosine protein
            kinase (DSTYK), transcript variant X6, mRNA.
ACCESSION   XM_047417152
VERSION     XM_047417152.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..7486
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /note="dual serine/threonine and tyrosine protein kinase;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 7 ESTs, 746 long SRA reads, 1
                     Protein, and 95% coverage of the annotated genomic feature
                     by RNAseq alignments, including 22 samples with support
                     for all annotated introns"
                     /db_xref="GeneID:25778"
                     /db_xref="HGNC:HGNC:29043"
                     /db_xref="MIM:612666"
     CDS             406..2433
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /codon_start=1
                     /product="dual serine/threonine and tyrosine protein
                     kinase isoform X6"
                     /protein_id="XP_047273108.1"
                     /db_xref="GeneID:25778"
                     /db_xref="HGNC:HGNC:29043"
                     /db_xref="MIM:612666"
                     /translation="MSPKPGCRREVDVVVAPCQGLRPTVDVLGDLVNDFLPVITYALH
                     KDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESERSPLYRQLIDLG
                     YLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAKALNLVHCHC
                     LDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTM
                     KEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVD
                     YLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWE
                     QIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFA
                     ASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELG
                     RGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSV
                     IDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVH
                     RDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGARPERLPVFD
                     EECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLCKSNSEQPNRGLDDST"
ORIGIN      
        1 ggtttggttt gtttgcaacg gcagtgacgg aggttgggag ccaggctgac tgcaggcggg
       61 ggcgtcagga ggcggattcc tcctcccttc ggcactgggg ggcggggagg agggaggccg
      121 ggcctgcggc cggggaccga gccgcaaaga cagagcgggc agaggcgatg gagggcgacg
      181 gggtgccatg gggcagcgag cccgtctcgg gtcccggccc cggcggcggc ggaatgatcc
      241 gcgagctgtg ccggggcttc ggccgctacc gccgctacct gggacggctg cgacagaacc
      301 tgcgcgagac ccagaagttc ttccgcgaca tcaagtgctc ccacaaccac acttgtctct
      361 cctccctcac gggcggcggc ggggccgagc gcggccctgc aggcgatgtc gccgaaaccg
      421 ggctgcaggc gggaagtgga cgttgtggta gcaccatgcc aaggcctccg gcccacagtg
      481 gatgttctgg gtgacttggt gaatgatttc ttgcctgtga taacctatgc actccacaaa
      541 gatgaactct ctgagaggga tgagcaagag cttcaggaaa tccgaaagta tttctccttt
      601 cctgtattct ttttcaaagt gccgaaactg ggctcggaga taatagactc ctcaaccagg
      661 agaatggaga gcgaaagatc accgctttat cgccagctaa ttgacctggg ctatctgagc
      721 agcagtcact ggaactgtgg ggctcctggc caggatacta aagctcagag catgttggtg
      781 gaacagagtg aaaagctgag acacttgagc acattttctc accaggtgtt acagactcgc
      841 ctggtggatg cagccaaggc cctgaacctg gtgcactgcc actgccttga catctttatt
      901 aaccaggcat ttgacatgca gcgggacctg cagatcactc ccaaacgtct ggaatatact
      961 cgaaaaaagg agaatgagtt gtatgaatca ttgatgaata ttgccaaccg aaagcaggag
     1021 gaaatgaagg atatgattgt tgagacactt aataccatga aggaggaact tctggatgat
     1081 gctactaaca tggagtttaa agacgtcatt gtccctgaga atggagaacc agtaggcacc
     1141 agagagatca aatgctgcat ccgacagatc caggaactca tcatctcccg acttaatcag
     1201 gcagtggcta ataagctgat cagctcagtg gattacctga gggaaagctt cgtcggaacc
     1261 ctggaacgat gtctgcagag cctggagaag tctcaggatg tctcagttca catcaccagt
     1321 aattatctca aacagatctt aaatgctgcc tatcatgttg aagtcacgtt tcactcaggg
     1381 tcgtcagtta caaggatgct atgggagcaa atcaaacaga tcatccagcg catcacatgg
     1441 gtgagcccac ctgccatcac tctggaatgg aagaggaagg tggcccagga agccattgag
     1501 agcctcagcg cctccaaatt ggctaagagc atttgcagcc aattccggac tcggctcaat
     1561 agttcccacg aggcttttgc agcctccttg cggcagctgg aagctggcca ctcaggccgg
     1621 ttagagaaaa cggaagatct atggctgagg gttcggaaag atcatgctcc ccgcctggcc
     1681 cgcctttctc tggaaagctg ttctttacag gatgtcttgc ttcatcgtaa acctaaactg
     1741 ggacaggaac tgggccgggg ccagtatggt gtggtatacc tgtgtgacaa ctggggagga
     1801 cacttccctt gtgccctcaa atcagttgtc cctccagatg agaagcactg gaatgatctg
     1861 gctttggaat ttcactatat gaggtctctg ccgaagcatg agcgattggt ggatctccat
     1921 ggttcagtca ttgactacaa ctatggtggt ggctccagca ttgctgtgct cctcattatg
     1981 gagcggctac accgggatct ctacacaggg ctgaaggctg ggctgaccct ggagacacgt
     2041 ttgcagatag cactagatgt ggtggaggga atccgcttcc tgcacagcca gggacttgtc
     2101 catcgtgata tcaaactgaa aaatgtgctg ctggataagc agaaccgtgc caagatcact
     2161 gacttaggat tctgcaagcc agaggccatg atgtcaggca gcattgtggg gacaccaatc
     2221 catatggccc ctgaactttt cacaggggct cgcccagaac gtcttcctgt gtttgatgag
     2281 gagtgctggc agttgatgga agcctgttgg gatggcgacc ccttgaagag gcctctcttg
     2341 ggcattgtcc agcccatgct ccagggcatc atgaatcggc tctgcaagtc caattctgag
     2401 cagccaaaca gaggactaga tgattctact tgaaagcaaa gacctttctc tttcactctc
     2461 tagttatttc cttccccctc accttttggc catggggaga atttgacatt tattcactat
     2521 aggacacact cccaagggaa ctggtgcttg ctgggaaact tggaaccttc ccaggcaggg
     2581 atgactcctg gacagtgaag agttgaatga ctgagcatat tcagcagctc actgaagcgc
     2641 caagctatcc ctttagcaaa aaagtgtctc agatgtgtaa aagctgagga atgtggtgtt
     2701 ctggcttcac aaatgaaaag gaggcagatg ttaccattgt cttttcactg tatatacttc
     2761 taagacagca agcgggacac tgcagtggca atagtgttaa aaaatctcat tctcatgatt
     2821 tttggctcta gctaggaata gtttagtcag gactcagaaa atttgagctt agttctggga
     2881 ttatgaaaac atggggacaa aaacaataac ttgtggatgt ctggttcctg ctgtctgcag
     2941 ccaggtatct caggttgcaa tggtcagaag tcccagtgag ggagctagaa acagagctat
     3001 ctgttcctca tagtgccagt gtgtttacat ttataggacc acatatccct ggtttctggg
     3061 ggagggtttc actgttacat caccaagagg ccctgaaaag aggaaaaaaa aaaaaaaaga
     3121 ggccaggcat ggtggctcac gcctgtaatc tcagcacttt gggaggctga ggcgggcgga
     3181 tcacaaggtc cagagttcaa gagcagcctg gccaacatgg tgaaaccccg tctctactaa
     3241 agatacaaaa aattagccgg gcgtggtggt gcatgcctgt aatccaagat actcaggagg
     3301 ctgaggcagg agaatcgctt gaacctggga ggcggaggtt gcagtgagcc gagatcatgc
     3361 cattgcactc cagcctgggc gacagagtga gactctgtct caaaaaaaaa aaaaaaatag
     3421 aatgtgtatg catatatttg tgtgtatatg tatatatgtg tgtgtgtcta tatctctatc
     3481 tatatagaca tacacacagg agttattgga tttagagtta ctgctaaccc cagaacagaa
     3541 tctgttcttt tacctttgag tcttttcttt tgtttacctc ttttcatctc aaagtgggaa
     3601 agctccagat aacatggtac ttaggagtga gtgtctaagc aaaaccaacc caatgcgaag
     3661 tatttgggtg agaactgaga ggtgggagat gattggaggc catggcctat gtacaaacat
     3721 actggaagaa aaccagcttg tttttaaaac ttaacacaat cagaaatttt tctttttgtg
     3781 tttgaatcta acacactgac gtttggaaaa cttgatcaat gagcttttaa ccacgatttc
     3841 tcccgcaatt tgttccttct ttttaccttt ttaaaaatct gttagaagaa aaaaagcagc
     3901 agacgaaaga gaaaaaccct cctctggtag ttctgtgtgt gcccctcacc cctgtgtgct
     3961 agtgtctggg aagtttccct gaaaggtggg aggcgggtgg gtggtctttt ggagggttcc
     4021 tcatgaagtg tgcttgagga aagaaattct gattctaggc agaggaaggg gaacaattta
     4081 aatattggtg catctcagat gcacttgact tcaagccttc ctcaaccaaa ctggtccatt
     4141 agattccgaa aaacaggtag acgaggaagt agacagtgga agtgagtagt ctccctccat
     4201 ctgcctaatc cccaataact gtggtctggc ccctgtgttc agcccgagag tttgtaaaac
     4261 aggtccccag gtaggtgtat aagatgagtt gcaaattagc cgggcatgct ggcacgcacc
     4321 agtaatccca gctacttggg aggctgaggc aggagaatca cttgaacccg ggaggcagag
     4381 gtcatggtga gccgagatca cgccactgca ctccagcctg ggcaacagag cgagactcta
     4441 tctcaaaaaa aaacaaaaaa aaaaacaaaa aacaaagatg agtcgcacat ctgctgctgg
     4501 gattttctag ggttgtctat gacagaatga ccatctttta aatattaatg gagtataaat
     4561 ggagtctata atgggtcttt catataactt ttaactcttt ggctatcctg ggctctgatc
     4621 atgatatgtt tgagcatagt agctccctaa actcttggag cctttcagaa attccatgta
     4681 gtgctaataa cctttttact tgcaaatgat aaagtaactg actcagtgtc tttgggctct
     4741 gcaggcttta gccttgtttt ggtaggatgt tcagtatatt ctcagaattt ttaccaccta
     4801 tttagctata cttcaagtac tctattctct gcactaactt actgtccttc tgggaactat
     4861 gatggggctt caagggagtc aggtgtcaag aaaggagggg taagtactct ctacttgctg
     4921 gaaaatcatt gtaagtctgt tgtgtatgaa attttaggaa aagtcttata tagttccctt
     4981 tccagactgt tttcttttga ctctaactat aatcataagt ctgtgcttcc attatgaagg
     5041 tcacattcct agcattcttg ggaagtatta gctcatactc tcattcacat atgggaggtt
     5101 agattttttt cctctaccca gagtcccttt ttagtttacc ccacggctta gtttgctgtc
     5161 agataccagt tctctagcag attccccaac agttttttcc ccagtgggga gggtggaagg
     5221 gagggactga tataagtaag gagatgagta gttgtgttac agttcatttt ctttaaaaaa
     5281 aagtattttg agaaaaggtg caaaatattc ttgaaagtct ctaggccagc caaagtccac
     5341 atatggatat ttggggatgt tatttaaata ctcagcaggc tgagtgcagg tatacgtgtg
     5401 tatagagtgt gtatactttg cttttgtttt ataacattgt cagctaattt tggctttgtt
     5461 ctttggcatc cattcttatt ataagtgatg gaatgccatg aaatgtactg tattgtatat
     5521 tacttgggag gacactaggt tttcaaagaa gtctggcagc acttgggtta tagagggctc
     5581 agcatgacca aagtcctaaa gattttacct cccagctttg gttgtatgtg ttcccaagtg
     5641 gtgaggtgag attgtggctg gaggaagaaa aaggatggca tgaaagaatg acccttattg
     5701 tggtctgtcc ttctaatcaa cataattagg gcagcttacc ccaacatgaa aatgatgacc
     5761 tggccatttt taatggccag agcttgaagt ctggtctctc attttgtttc agaaatgagt
     5821 gagaggcctt cctgcagagc agtcaggaga aatggtggag cctggggccc tggaatggct
     5881 gaccctgtgc ctagagagct gatggcaagg gctgtctggc atggctcatt tgggtggggt
     5941 ttccccaggc ataccttagt tccctgatcc tctgcaaaga gtagctcatt gactgagcaa
     6001 gcgcttcagg aggactgtgc tggttgttcc cagaccaaag agagtcactt ttgactccat
     6061 caacttcaag gggacagagc ctaggcagca gattctccta atttttaaca ctaaaattca
     6121 aggaagcagt ggaggaaaga atgcattact accacagata gaaatagggg actcatagaa
     6181 ctctcgacta gtacctgtca gctctcaaat gcattcttgt gtctttgctt gagctgccaa
     6241 agaagggtca caaagtgttc ttcctcatgg aagaagtgcc tcggggttgc agggctgcaa
     6301 agtgacaact gcactgaatg acactttatt ttttggcttt ggcttattat ttagcactgg
     6361 gaggcccagg ggaattggtg attacagtag cactttggga agttaaagcc ccctttgggc
     6421 ttgctttgga gagatgatgg catgcttggt attccatttg gataatcagg aagcctccct
     6481 agtccatcca tattgtgtca gagtgggatt aacaaccctg gaagagtcca ctgccaaaag
     6541 agtagttgct ttcctggaat ttccaaagct tttggatttt ctggatcaag taacccactt
     6601 tttaaaacct gaggtcagga gttcgagacc agcctggtaa catggtgaaa ccccgtctct
     6661 attaaaaata gaaaaaatta gccaggcatg gtggcgggca cctatagtcc cagctactca
     6721 ggaggctgag gtaggagaat tgcttgaacc caggagacag aggctgcatt gagccaagat
     6781 cacaccactg cactccagcc tgggcagcag agcaagactc catctcaaaa aaaaaaaaaa
     6841 gaaaaagaaa aagaaggtta atccttcagt tatggaggtg ggatgaatag agcttgtttg
     6901 atgttaaagt gggtaaggag ggagtggcct tgagacactt gtattccaaa ctctcctgga
     6961 ggtttccagt agcactactg ttcctaaaag ggtttcattt ttaacttcat ctgttttgtt
     7021 aacatccagt ccaattgagg tgatctcaga ggtgcatcag gacatctagc actggggagg
     7081 ccaccttgcc cagatagttg aaaagaaaat tggtctgggc agcctgttgt cttttgtctt
     7141 catgtaatgt tttttctttg ttttaaagga ctaatgttta ttacagtgtt aaataaaagt
     7201 gtaagatact aagtgtgtag aataaaagtg caataacaaa agacaatgac tttggcacac
     7261 acttcagtct ttatcctctc tcctttcttg tgctacctgg ctctttccat aatattgtta
     7321 cagcaggacc gtcttaattg tgtgcatttt gaagagatgc gactctgggt taatcttcat
     7381 tagtgtaata ttgaagggtt gggtttggtt ttatagagta ttctgtatac ttgttgggat
     7441 acacaaatac cagatgtgct gtataataaa gatcacatta acgttt
//
