LOCUS       NM_015375               8010 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dual serine/threonine and tyrosine protein kinase
            (DSTYK), transcript variant 1, mRNA.
ACCESSION   NM_015375
VERSION     NM_015375.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8010)
  AUTHORS   Martino,J., Liu,Q., Vukojevic,K., Ke,J., Lim,T.Y., Khan,A.,
            Gupta,Y., Perez,A., Yan,Z., Milo Rasouly,H., Vena,N., Lippa,N.,
            Giordano,J.L., Saraga,M., Saraga-Babic,M., Westland,R., Bodria,M.,
            Piaggio,G., Bendapudi,P.K., Iglesias,A.D., Wapner,R.J., Tasic,V.,
            Wang,F., Ionita-Laza,I., Ghiggeri,G.M., Kiryluk,K., Sampogna,R.V.,
            Mendelsohn,C.L., D'Agati,V.D., Gharavi,A.G. and Sanna-Cherchi,S.
  TITLE     Mouse and human studies support DSTYK loss of function as a
            low-penetrance and variable expressivity risk factor for congenital
            urinary tract anomalies
  JOURNAL   Genet Med 25 (12), 100983 (2023)
   PUBMED   37746849
  REMARK    GeneRIF: Mouse and human studies support DSTYK loss of function as
            a low-penetrance and variable expressivity risk factor for
            congenital urinary tract anomalies.
REFERENCE   2  (bases 1 to 8010)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 8010)
  AUTHORS   Kelam,N., Racetin,A., Polovic,M., Benzon,B., Ogorevc,M.,
            Vukojevic,K., Glavina Durdov,M., Dunatov Huljev,A., Kuzmic
            Prusac,I., Caric,D., Raguz,F. and Kostic,S.
  TITLE     Aberrations in FGFR1, FGFR2, and RIP5 Expression in Human
            Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)
  JOURNAL   Int J Mol Sci 23 (24), 15537 (2022)
   PUBMED   36555181
  REMARK    GeneRIF: Aberrations in FGFR1, FGFR2, and RIP5 Expression in Human
            Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8010)
  AUTHORS   Valencia,K., Echepare,M., Teijeira,A., Pasquier,A., Bertolo,C.,
            Sainz,C., Tamayo,I., Picabea,B., Bosco,G., Thomas,R., Agorreta,J.,
            Lopez-Picazo,J.M., Frigola,J., Amat,R., Calvo,A., Felip,E.,
            Melero,I. and Montuenga,L.M.
  TITLE     DSTYK inhibition increases the sensitivity of lung cancer cells to
            T cell-mediated cytotoxicity
  JOURNAL   J Exp Med 219 (12) (2022)
   PUBMED   36169652
  REMARK    GeneRIF: DSTYK inhibition increases the sensitivity of lung cancer
            cells to T cell-mediated cytotoxicity.
REFERENCE   5  (bases 1 to 8010)
  AUTHORS   Ogbu,S.C., Rojas,S., Weaver,J., Musich,P.R., Zhang,J., Yao,Z.Q. and
            Jiang,Y.
  TITLE     DSTYK Enhances Chemoresistance in Triple-Negative Breast Cancer
            Cells
  JOURNAL   Cells 11 (1), 97 (2021)
   PUBMED   35011659
  REMARK    GeneRIF: DSTYK Enhances Chemoresistance in Triple-Negative Breast
            Cancer Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8010)
  AUTHORS   Peng,J., Dong,W., Chen,Y., Mo,R., Cheng,J.F., Hui,C.C., Mohandas,N.
            and Huang,C.H.
  TITLE     Dusty protein kinases: primary structure, gene evolution, tissue
            specific expression and unique features of the catalytic domain
  JOURNAL   Biochim Biophys Acta 1759 (11-12), 562-572 (2006)
   PUBMED   17123648
  REMARK    GeneRIF: Confocal imaging of transiently expressed human Dusty-GFP
            fusion proteins showed a cytoplasmic distribution.
REFERENCE   7  (bases 1 to 8010)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 8010)
  AUTHORS   Zha,J., Zhou,Q., Xu,L.G., Chen,D., Li,L., Zhai,Z. and Shu,H.B.
  TITLE     RIP5 is a RIP-homologous inducer of cell death
  JOURNAL   Biochem Biophys Res Commun 319 (2), 298-303 (2004)
   PUBMED   15178406
REFERENCE   9  (bases 1 to 8010)
  AUTHORS   Blumen,S.C., Bevan,S., Abu-Mouch,S., Negus,D., Kahana,M.,
            Inzelberg,R., Mazarib,A., Mahamid,A., Carasso,R.L., Slor,H.,
            Withers,D., Nisipeanu,P., Navon,R. and Reid,E.
  TITLE     A locus for complicated hereditary spastic paraplegia maps to
            chromosome 1q24-q32
  JOURNAL   Ann Neurol 54 (6), 796-803 (2003)
   PUBMED   14681889
REFERENCE   10 (bases 1 to 8010)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093422.3, BC060870.1 and
            AY429674.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015375.2.
            
            Summary: This gene encodes a dual serine/threonine and tyrosine
            protein kinase which is expressed in multiple tissues. It is
            thought to function as a regulator of cell death. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY429674.1, SRR1803612.60623.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367162.8/ ENSP00000356130.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC093422.3         104662-104764       c
            104-131             BC060870.1         1-28
            132-2087            AY429674.1         1-1956
            2088-2088           AC093422.3         54347-54347         c
            2089-2194           AY429674.1         1958-2063
            2195-2195           AC093422.3         53253-53253         c
            2196-8010           AY429674.1         2065-7879
FEATURES             Location/Qualifiers
     source          1..8010
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..8010
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /note="dual serine/threonine and tyrosine protein kinase"
                     /db_xref="GeneID:25778"
                     /db_xref="HGNC:HGNC:29043"
                     /db_xref="MIM:612666"
     exon            1..432
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2957
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /EC_number="2.7.12.1"
                     /note="isoform 1 is encoded by transcript variant 1; dusty
                     protein kinase; sgK496; dusty PK; sugen kinase 496;
                     spastic paraplegia 23 (autosomal recessive);
                     RIP-homologous kinase; receptor-interacting
                     serine/threonine-protein kinase 5"
                     /codon_start=1
                     /product="dual serine/threonine and tyrosine protein
                     kinase isoform 1"
                     /protein_id="NP_056190.1"
                     /db_xref="CCDS:CCDS1451.1"
                     /db_xref="GeneID:25778"
                     /db_xref="HGNC:HGNC:29043"
                     /db_xref="MIM:612666"
                     /translation="MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQN
                     LRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEK
                     YLQQIVDCLPCILILGQDCNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQ
                     TRVSLALPGQYELVHTLVAHQGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQ
                     EVDVVVAPCQGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYFSFPV
                     FFFKVPKLGSEIIDSSTRRMESERSPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLV
                     EQSEKLRHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLE
                     YTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDATNMEFKDVIVPENGE
                     PVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDV
                     SVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKR
                     KVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLR
                     VRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKS
                     VVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRD
                     LYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGF
                     CKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCA
                     SKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLC
                     KSNSEQPNRGLDDST"
     exon            433..821
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1491
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1724
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1808
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1985
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2115
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2272
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2405
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2519
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2634
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2769
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..8010
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7989..7994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /note="hexamer: AATAAA"
     polyA_site      8010
                     /gene="DSTYK"
                     /gene_synonym="CAKUT1; DustyPK; HDCMD38P; RHDNS1; RIP5;
                     RIPK5; SPG23"
                     /note="major polyA site"
ORIGIN      
        1 ggtttggttt gtttgcaacg gcagtgacgg aggttgggag ccaggctgac tgcaggcggg
       61 ggcgtcagga ggcggattcc tcctcccttc ggcactgggg ggcggggagg agggaggccg
      121 ggcctgcggc cggggaccga gccgcaaaga cagagcgggc agaggcgatg gagggcgacg
      181 gggtgccatg gggcagcgag cccgtctcgg gtcccggccc cggcggcggc ggaatgatcc
      241 gcgagctgtg ccggggcttc ggccgctacc gccgctacct gggacggctg cgacagaacc
      301 tgcgcgagac ccagaagttc ttccgcgaca tcaagtgctc ccacaaccac acttgtctct
      361 cctccctcac gggcggcggc ggggccgagc gcggccctgc aggcgatgtc gccgaaaccg
      421 ggctgcaggc gggccaactg agctgcattt ccttcccacc taaggaagag aagtacctcc
      481 agcagattgt ggactgcctc ccttgcatac tgatcctcgg ccaggattgt aacgtcaagt
      541 gccagctgtt gaatctgctg ttgggggtgc aggtgcttcc caccaccaag ctgggcagtg
      601 aggagagctg taagcttcgg cgcctccgct tcacctatgg gactcagact cgggtcagcc
      661 tggcgctccc tggacagtat gaactagtgc acacgctggt tgctcatcag ggcaactggg
      721 agaccatccc tgaggaggat ctggaggtcc aagagaacaa tgaggatgct gctcatgttt
      781 tagcggaact ggaggtaacg atgcaccatg ctctcttaca ggaagtggac gttgtggtag
      841 caccatgcca aggcctccgg cccacagtgg atgttctggg tgacttggtg aatgatttct
      901 tgcctgtgat aacctatgca ctccacaaag atgaactctc tgagagggat gagcaagagc
      961 ttcaggaaat ccgaaagtat ttctcctttc ctgtattctt tttcaaagtg ccgaaactgg
     1021 gctcggagat aatagactcc tcaaccagga gaatggagag cgaaagatca ccgctttatc
     1081 gccagctaat tgacctgggc tatctgagca gcagtcactg gaactgtggg gctcctggcc
     1141 aggatactaa agctcagagc atgttggtgg aacagagtga aaagctgaga cacttgagca
     1201 cattttctca ccaggtgtta cagactcgcc tggtggatgc agccaaggcc ctgaacctgg
     1261 tgcactgcca ctgccttgac atctttatta accaggcatt tgacatgcag cgggacctgc
     1321 agatcactcc caaacgtctg gaatatactc gaaaaaagga gaatgagttg tatgaatcat
     1381 tgatgaatat tgccaaccga aagcaggagg aaatgaagga tatgattgtt gagacactta
     1441 ataccatgaa ggaggaactt ctggatgatg ctactaacat ggagtttaaa gacgtcattg
     1501 tccctgagaa tggagaacca gtaggcacca gagagatcaa atgctgcatc cgacagatcc
     1561 aggaactcat catctcccga cttaatcagg cagtggctaa taagctgatc agctcagtgg
     1621 attacctgag ggaaagcttc gtcggaaccc tggaacgatg tctgcagagc ctggagaagt
     1681 ctcaggatgt ctcagttcac atcaccagta attatctcaa acagatctta aatgctgcct
     1741 atcatgttga agtcacgttt cactcagggt cgtcagttac aaggatgcta tgggagcaaa
     1801 tcaaacagat catccagcgc atcacatggg tgagcccacc tgccatcact ctggaatgga
     1861 agaggaaggt ggcccaggaa gccattgaga gcctcagcgc ctccaaattg gctaagagca
     1921 tttgcagcca attccggact cggctcaata gttcccacga ggcttttgca gcctccttgc
     1981 ggcagctgga agctggccac tcaggccggt tagagaaaac ggaagatcta tggctgaggg
     2041 ttcggaaaga tcatgctccc cgcctggccc gcctttctct ggaaagctgt tctttacagg
     2101 atgtcttgct tcatcgtaaa cctaaactgg gacaggaact gggccggggc cagtatggtg
     2161 tggtatacct gtgtgacaac tggggaggac acttcccttg tgccctcaaa tcagttgtcc
     2221 ctccagatga gaagcactgg aatgatctgg ctttggaatt tcactatatg aggtctctgc
     2281 cgaagcatga gcgattggtg gatctccatg gttcagtcat tgactacaac tatggtggtg
     2341 gctccagcat tgctgtgctc ctcattatgg agcggctaca ccgggatctc tacacagggc
     2401 tgaaggctgg gctgaccctg gagacacgtt tgcagatagc actagatgtg gtggagggaa
     2461 tccgcttcct gcacagccag ggacttgtcc atcgtgatat caaactgaaa aatgtgctgc
     2521 tggataagca gaaccgtgcc aagatcactg acttaggatt ctgcaagcca gaggccatga
     2581 tgtcaggcag cattgtgggg acaccaatcc atatggcccc tgaacttttc acagggaagt
     2641 acgataattc cgtggatgtc tacgcttttg gaattctttt ctggtatatc tgctcaggct
     2701 ctgtcaagct ccctgaggca tttgagaggt gtgctagcaa agaccatctc tggaacaatg
     2761 tgcggagggg ggctcgccca gaacgtcttc ctgtgtttga tgaggagtgc tggcagttga
     2821 tggaagcctg ttgggatggc gaccccttga agaggcctct cttgggcatt gtccagccca
     2881 tgctccaggg catcatgaat cggctctgca agtccaattc tgagcagcca aacagaggac
     2941 tagatgattc tacttgaaag caaagacctt tctctttcac tctctagtta tttccttccc
     3001 cctcaccttt tggccatggg gagaatttga catttattca ctataggaca cactcccaag
     3061 ggaactggtg cttgctggga aacttggaac cttcccaggc agggatgact cctggacagt
     3121 gaagagttga atgactgagc atattcagca gctcactgaa gcgccaagct atccctttag
     3181 caaaaaagtg tctcagatgt gtaaaagctg aggaatgtgg tgttctggct tcacaaatga
     3241 aaaggaggca gatgttacca ttgtcttttc actgtatata cttctaagac agcaagcggg
     3301 acactgcagt ggcaatagtg ttaaaaaatc tcattctcat gatttttggc tctagctagg
     3361 aatagtttag tcaggactca gaaaatttga gcttagttct gggattatga aaacatgggg
     3421 acaaaaacaa taacttgtgg atgtctggtt cctgctgtct gcagccaggt atctcaggtt
     3481 gcaatggtca gaagtcccag tgagggagct agaaacagag ctatctgttc ctcatagtgc
     3541 cagtgtgttt acatttatag gaccacatat ccctggtttc tgggggaggg tttcactgtt
     3601 acatcaccaa gaggccctga aaagaggaaa aaaaaaaaaa aagaggccag gcatggtggc
     3661 tcacgcctgt aatctcagca ctttgggagg ctgaggcggg cggatcacaa ggtccagagt
     3721 tcaagagcag cctggccaac atggtgaaac cccgtctcta ctaaagatac aaaaaattag
     3781 ccgggcgtgg tggtgcatgc ctgtaatcca agatactcag gaggctgagg caggagaatc
     3841 gcttgaacct gggaggcgga ggttgcagtg agccgagatc atgccattgc actccagcct
     3901 gggcgacaga gtgagactct gtctcaaaaa aaaaaaaaaa atagaatgtg tatgcatata
     3961 tttgtgtgta tatgtatata tgtgtgtgtg tctatatctc tatctatata gacatacaca
     4021 caggagttat tggatttaga gttactgcta accccagaac agaatctgtt cttttacctt
     4081 tgagtctttt cttttgttta cctcttttca tctcaaagtg ggaaagctcc agataacatg
     4141 gtacttagga gtgagtgtct aagcaaaacc aacccaatgc gaagtatttg ggtgagaact
     4201 gagaggtggg agatgattgg aggccatggc ctatgtacaa acatactgga agaaaaccag
     4261 cttgttttta aaacttaaca caatcagaaa tttttctttt tgtgtttgaa tctaacacac
     4321 tgacgtttgg aaaacttgat caatgagctt ttaaccacga tttctcccgc aatttgttcc
     4381 ttctttttac ctttttaaaa atctgttaga agaaaaaaag cagcagacga aagagaaaaa
     4441 ccctcctctg gtagttctgt gtgtgcccct cacccctgtg tgctagtgtc tgggaagttt
     4501 ccctgaaagg tgggaggcgg gtgggtggtc ttttggaggg ttcctcatga agtgtgcttg
     4561 aggaaagaaa ttctgattct aggcagagga aggggaacaa tttaaatatt ggtgcatctc
     4621 agatgcactt gacttcaagc cttcctcaac caaactggtc cattagattc cgaaaaacag
     4681 gtagacgagg aagtagacag tggaagtgag tagtctccct ccatctgcct aatccccaat
     4741 aactgtggtc tggcccctgt gttcagcccg agagtttgta aaacaggtcc ccaggtaggt
     4801 gtataagatg agttgcaaat tagccgggca tgctggcacg caccagtaat cccagctact
     4861 tgggaggctg aggcaggaga atcacttgaa cccgggaggc agaggtcatg gtgagccgag
     4921 atcacgccac tgcactccag cctgggcaac agagcgagac tctatctcaa aaaaaaacaa
     4981 aaaaaaaaac aaaaaacaaa gatgagtcgc acatctgctg ctgggatttt ctagggttgt
     5041 ctatgacaga atgaccatct tttaaatatt aatggagtat aaatggagtc tataatgggt
     5101 ctttcatata acttttaact ctttggctat cctgggctct gatcatgata tgtttgagca
     5161 tagtagctcc ctaaactctt ggagcctttc agaaattcca tgtagtgcta ataacctttt
     5221 tacttgcaaa tgataaagta actgactcag tgtctttggg ctctgcaggc tttagccttg
     5281 ttttggtagg atgttcagta tattctcaga atttttacca cctatttagc tatacttcaa
     5341 gtactctatt ctctgcacta acttactgtc cttctgggaa ctatgatggg gcttcaaggg
     5401 agtcaggtgt caagaaagga ggggtaagta ctctctactt gctggaaaat cattgtaagt
     5461 ctgttgtgta tgaaatttta ggaaaagtct tatatagttc cctttccaga ctgttttctt
     5521 ttgactctaa ctataatcat aagtctgtgc ttccattatg aaggtcacat tcctagcatt
     5581 cttgggaagt attagctcat actctcattc acatatggga ggttagattt ttttcctcta
     5641 cccagagtcc ctttttagtt taccccacgg cttagtttgc tgtcagatac cagttctcta
     5701 gcagattccc caacagtttt ttccccagtg gggagggtgg aagggaggga ctgatataag
     5761 taaggagatg agtagttgtg ttacagttca ttttctttaa aaaaaagtat tttgagaaaa
     5821 ggtgcaaaat attcttgaaa gtctctaggc cagccaaagt ccacatatgg atatttgggg
     5881 atgttattta aatactcagc aggctgagtg caggtatacg tgtgtataga gtgtgtatac
     5941 tttgcttttg ttttataaca ttgtcagcta attttggctt tgttctttgg catccattct
     6001 tattataagt gatggaatgc catgaaatgt actgtattgt atattacttg ggaggacact
     6061 aggttttcaa agaagtctgg cagcacttgg gttatagagg gctcagcatg accaaagtcc
     6121 taaagatttt acctcccagc tttggttgta tgtgttccca agtggtgagg tgagattgtg
     6181 gctggaggaa gaaaaaggat ggcatgaaag aatgaccctt attgtggtct gtccttctaa
     6241 tcaacataat tagggcagct taccccaaca tgaaaatgat gacctggcca tttttaatgg
     6301 ccagagcttg aagtctggtc tctcattttg tttcagaaat gagtgagagg ccttcctgca
     6361 gagcagtcag gagaaatggt ggagcctggg gccctggaat ggctgaccct gtgcctagag
     6421 agctgatggc aagggctgtc tggcatggct catttgggtg gggtttcccc aggcatacct
     6481 tagttccctg atcctctgca aagagtagct cattgactga gcaagcgctt caggaggact
     6541 gtgctggttg ttcccagacc aaagagagtc acttttgact ccatcaactt caaggggaca
     6601 gagcctaggc agcagattct cctaattttt aacactaaaa ttcaaggaag cagtggagga
     6661 aagaatgcat tactaccaca gatagaaata ggggactcat agaactctcg actagtacct
     6721 gtcagctctc aaatgcattc ttgtgtcttt gcttgagctg ccaaagaagg gtcacaaagt
     6781 gttcttcctc atggaagaag tgcctcgggg ttgcagggct gcaaagtgac aactgcactg
     6841 aatgacactt tattttttgg ctttggctta ttatttagca ctgggaggcc caggggaatt
     6901 ggtgattaca gtagcacttt gggaagttaa agcccccttt gggcttgctt tggagagatg
     6961 atggcatgct tggtattcca tttggataat caggaagcct ccctagtcca tccatattgt
     7021 gtcagagtgg gattaacaac cctggaagag tccactgcca aaagagtagt tgctttcctg
     7081 gaatttccaa agcttttgga ttttctggat caagtaaccc actttttaaa acctgaggtc
     7141 aggagttcga gaccagcctg gtaacatggt gaaaccccgt ctctattaaa aatagaaaaa
     7201 attagccagg catggtggcg ggcacctata gtcccagcta ctcaggaggc tgaggtagga
     7261 gaattgcttg aacccaggag acagaggctg cattgagcca agatcacacc actgcactcc
     7321 agcctgggca gcagagcaag actccatctc aaaaaaaaaa aaaagaaaaa gaaaaagaag
     7381 gttaatcctt cagttatgga ggtgggatga atagagcttg tttgatgtta aagtgggtaa
     7441 ggagggagtg gccttgagac acttgtattc caaactctcc tggaggtttc cagtagcact
     7501 actgttccta aaagggtttc atttttaact tcatctgttt tgttaacatc cagtccaatt
     7561 gaggtgatct cagaggtgca tcaggacatc tagcactggg gaggccacct tgcccagata
     7621 gttgaaaaga aaattggtct gggcagcctg ttgtcttttg tcttcatgta atgttttttc
     7681 tttgttttaa aggactaatg tttattacag tgttaaataa aagtgtaaga tactaagtgt
     7741 gtagaataaa agtgcaataa caaaagacaa tgactttggc acacacttca gtctttatcc
     7801 tctctccttt cttgtgctac ctggctcttt ccataatatt gttacagcag gaccgtctta
     7861 attgtgtgca ttttgaagag atgcgactct gggttaatct tcattagtgt aatattgaag
     7921 ggttgggttt ggttttatag agtattctgt atacttgttg ggatacacaa ataccagatg
     7981 tgctgtataa taaagatcac attaacgttt
//
