LOCUS       NM_001944               5579 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens desmoglein 3 (DSG3), mRNA.
ACCESSION   NM_001944
VERSION     NM_001944.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5579)
  AUTHORS   Feng,Y., Qian,R., Cui,D., Luan,J., Xu,M., Wang,L., Li,R., Wu,X. and
            Chang,C.
  TITLE     Mutant TP53 promotes invasion of lung cancer cells by regulating
            desmoglein 3
  JOURNAL   J Cancer Res Clin Oncol 150 (6), 312 (2024)
   PUBMED   38900156
  REMARK    GeneRIF: Mutant TP53 promotes invasion of lung cancer cells by
            regulating desmoglein 3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5579)
  AUTHORS   Jiang,N., Sewell,T.B., Kowalski,T.L., Rekab,A., Hills,S.,
            Fazlollahi,L., Lauren,C.T., Morel,K., Mehta,L. and Liao,J.
  TITLE     Homozygous deletion of the DSG3 terminal exon associated with
            acantholytic blistering of the oral and laryngeal mucosa
  JOURNAL   Am J Med Genet A 194 (2), 389-393 (2024)
   PUBMED   37850634
  REMARK    GeneRIF: Homozygous deletion of the DSG3 terminal exon associated
            with acantholytic blistering of the oral and laryngeal mucosa.
REFERENCE   3  (bases 1 to 5579)
  AUTHORS   Didona,D., Scarsella,L., Hudemann,C., Volkmann,K., Zimmer,C.L.,
            Beckert,B., Tikkanen,R., Korff,V., Kuhn,K., Wienzek-Lischka,S.,
            Bein,G., Di Zenzo,G., Bohme,J., Cunha,T., Solimani,F., Pieper,J.,
            Juratli,H.A., Gobel,M., Schmidt,T., Borradori,L., Yazdi,A.S.,
            Sitaru,C., Garn,H., Eming,R., Fleischer,S. and Hertl,M.
  TITLE     Type 2 T-Cell Responses against Distinct Epitopes of the Desmoglein
            3 Ectodomain in Pemphigus Vulgaris
  JOURNAL   J Invest Dermatol 144 (2), 263-272 (2024)
   PUBMED   37717934
  REMARK    GeneRIF: Type 2 T-Cell Responses against Distinct Epitopes of the
            Desmoglein 3 Ectodomain in Pemphigus Vulgaris.
REFERENCE   4  (bases 1 to 5579)
  AUTHORS   Liang,J., Hu,F., Mao,L., Qiu,Y., Jiang,F., Wang,Q., Abulikemu,K.,
            Hong,Y., Ge,X. and Kang,X.
  TITLE     Interleukin-37 inhibits desmoglein-3 endocytosis and keratinocyte
            dissociation via upregulation of Caveolin-1 and inhibition of the
            STAT3 pathway
  JOURNAL   J Eur Acad Dermatol Venereol 37 (9), 1920-1927 (2023)
   PUBMED   37262304
  REMARK    GeneRIF: Interleukin-37 inhibits desmoglein-3 endocytosis and
            keratinocyte dissociation via upregulation of Caveolin-1 and
            inhibition of the STAT3 pathway.
REFERENCE   5  (bases 1 to 5579)
  AUTHORS   Koga,H., Tsuruta,D., Ohyama,B., Ishii,N., Hamada,T., Ohata,C.,
            Furumura,M. and Hashimoto,T.
  TITLE     Desmoglein 3, its pathogenecity and a possibility for therapeutic
            target in pemphigus vulgaris
  JOURNAL   Expert Opin Ther Targets 17 (3), 293-306 (2013)
   PUBMED   23294403
  REMARK    Review article
REFERENCE   6  (bases 1 to 5579)
  AUTHORS   Silos,S.A., Tamai,K., Li,K., Kivirikko,S., Kouba,D.,
            Christiano,A.M. and Uitto,J.
  TITLE     Cloning of the gene for human pemphigus vulgaris antigen
            (desmoglein 3), a desmosomal cadherin. Characterization of the
            promoter region and identification of a keratinocyte-specific
            cis-element
  JOURNAL   J Biol Chem 271 (29), 17504-17511 (1996)
   PUBMED   8663392
REFERENCE   7  (bases 1 to 5579)
  AUTHORS   Roh,J.Y. and Stanley,J.R.
  TITLE     Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in
            keratinocytes requires the cadherin-like intracytoplasmic segment
  JOURNAL   J Invest Dermatol 104 (5), 720-724 (1995)
   PUBMED   7738346
REFERENCE   8  (bases 1 to 5579)
  AUTHORS   Wang,Y., Amagai,M., Minoshima,S., Sakai,K., Green,K.J.,
            Nishikawa,T. and Shimizu,N.
  TITLE     The human genes for desmogleins (DSG1 and DSG3) are located in a
            small region on chromosome 18q12
  JOURNAL   Genomics 20 (3), 492-495 (1994)
   PUBMED   8034325
REFERENCE   9  (bases 1 to 5579)
  AUTHORS   Arnemann,J., Spurr,N.K. and Buxton,R.S.
  TITLE     The human gene (DSG3) coding for the pemphigus vulgaris antigen is,
            like the genes coding for the other two known desmogleins, assigned
            to chromosome 18
  JOURNAL   Hum Genet 89 (3), 347-350 (1992)
   PUBMED   1601426
REFERENCE   10 (bases 1 to 5579)
  AUTHORS   Amagai,M., Klaus-Kovtun,V. and Stanley,J.R.
  TITLE     Autoantibodies against a novel epithelial cadherin in pemphigus
            vulgaris, a disease of cell adhesion
  JOURNAL   Cell 67 (5), 869-877 (1991)
   PUBMED   1720352
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021549.9, DA458544.1,
            M76482.1, DA447747.1, AI608626.1, U51696.1, BX507120.1, BX110234.1
            and BC105997.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001944.2.
            
            Summary: This gene encodes a member of the desmoglein family and
            cadherin cell adhesion molecule superfamily of proteins.
            Desmogleins are calcium-binding transmembrane glycoprotein
            components of desmosomes, cell-cell junctions between epithelial,
            myocardial, and other cell types. The encoded preproprotein is
            proteolytically processed to generate the mature glycoprotein. This
            gene is present in a gene cluster with other desmoglein gene family
            members on chromosome 18. The encoded protein has been identified
            as the autoantigen of the autoimmune blistering disease pemphigus
            vulgaris. [provided by RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290367.1, M76482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257189.5/ ENSP00000257189.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC021549.9         61900-61927         c
            29-68               DA458544.1         1-40
            69-2870             M76482.1           15-2816
            2871-2872           AC021549.9         33673-33674         c
            2873-3390           M76482.1           2819-3336
            3391-3600           DA447747.1         347-556
            3601-3698           AI608626.1         147-244             c
            3699-3846           U51696.1           373-520
            3847-3944           BX507120.1         34-131
            3945-4499           BX110234.1         180-734
            4500-5579           BC105997.1         4-1083
FEATURES             Location/Qualifiers
     source          1..5579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..5579
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /note="desmoglein 3"
                     /db_xref="GeneID:1830"
                     /db_xref="HGNC:HGNC:3050"
                     /db_xref="MIM:169615"
     exon            1..185
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3137
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /note="cadherin family member 6; 130 kDa pemphigus
                     vulgaris antigen"
                     /codon_start=1
                     /product="desmoglein-3 preproprotein"
                     /protein_id="NP_001935.2"
                     /db_xref="CCDS:CCDS11898.1"
                     /db_xref="GeneID:1830"
                     /db_xref="HGNC:HGNC:3050"
                     /db_xref="MIM:169615"
                     /translation="MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAK
                     RRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVV
                     DKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQ
                     IFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEV
                     RTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARI
                     EENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKA
                     LDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTV
                     QKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNM
                     NRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPS
                     VVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISL
                     VLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLL
                     LLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEIT
                     NICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATG
                     TVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAF
                     ACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKL
                     AEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSG
                     SVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSV
                     PGNLAGPTQLRGSHTMLCTEDPCSRLI"
     exon            186..221
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            222..353
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            354..509
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            510..654
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            655..821
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            822..950
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1136
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1408
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1548
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1773
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..2034
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2174
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2238
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2522
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..5579
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5555..5560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /note="hexamer: AATAAA"
     regulatory      5563..5568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /note="hexamer: TATAAA"
     polyA_site      5573
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
     polyA_site      5579
                     /gene="DSG3"
                     /gene_synonym="ABOLM; CDHF6; PVA"
                     /note="major polyA site"
ORIGIN      
        1 ataacagacc atctgtagac tccttcggaa agcagcagag acgctgcaga gggcttttct
       61 tagacatcaa ctgcagacgg ctggcaggat agaagcagcg gctcacttgg actttttcac
      121 cagggaaatc agagacaatg atggggctct tccccagaac tacaggggct ctggccatct
      181 tcgtggtggt catattggtt catggagaat tgcgaataga gactaaaggt caatatgatg
      241 aagaagagat gactatgcaa caagctaaaa gaaggcaaaa acgtgaatgg gtgaaatttg
      301 ccaaaccctg cagagaagga gaagataact caaaaagaaa cccaattgcc aagattactt
      361 cagattacca agcaacccag aaaatcacct accgaatctc tggagtggga atcgatcagc
      421 cgccttttgg aatctttgtt gttgacaaaa acactggaga tattaacata acagctatag
      481 tcgaccggga ggaaactcca agcttcctga tcacatgtcg ggctctaaat gcccaaggac
      541 tagatgtaga gaaaccactt atactaacgg ttaaaatttt ggatattaat gataatcctc
      601 cagtattttc acaacaaatt ttcatgggtg aaattgaaga aaatagtgcc tcaaactcac
      661 tggtgatgat actaaatgcc acagatgcag atgaaccaaa ccacttgaat tctaaaattg
      721 ccttcaaaat tgtctctcag gaaccagcag gcacacccat gttcctccta agcagaaaca
      781 ctggggaagt ccgtactttg accaattctc ttgaccgaga gcaagctagc agctatcgtc
      841 tggttgtgag tggtgcagac aaagatggag aaggactatc aactcaatgt gaatgtaata
      901 ttaaagtgaa agatgtcaac gataacttcc caatgtttag agactctcag tattcagcac
      961 gtattgaaga aaatatttta agttctgaat tacttcgatt tcaagtaaca gatttggatg
     1021 aagagtacac agataattgg cttgcagtat atttctttac ctctgggaat gaaggaaatt
     1081 ggtttgaaat acaaactgat cctagaacta atgaaggcat cctgaaagtg gtgaaggctc
     1141 tagattatga acaactacaa agcgtgaaac ttagtattgc tgtcaaaaac aaagctgaat
     1201 ttcaccaatc agttatctct cgataccgag ttcagtcaac cccagtcaca attcaggtaa
     1261 taaatgtaag agaaggaatt gcattccgtc ctgcttccaa gacatttact gtgcaaaaag
     1321 gcataagtag caaaaaattg gtggattata tcctgggaac atatcaagcc atcgatgagg
     1381 acactaacaa agctgcctca aatgtcaaat atgtcatggg acgtaacgat ggtggatacc
     1441 taatgattga ttcaaaaact gctgaaatca aatttgtcaa aaatatgaac cgagattcta
     1501 ctttcatagt taacaaaaca atcacagctg aggttctggc catagatgaa tacacgggta
     1561 aaacttctac aggcacggta tatgttagag tacccgattt caatgacaat tgtccaacag
     1621 ctgtcctcga aaaagatgca gtttgcagtt cttcaccttc cgtggttgtc tccgctagaa
     1681 cactgaataa tagatacact ggcccctata catttgcact ggaagatcaa cctgtaaagt
     1741 tgcctgccgt atggagtatc acaaccctca atgctacctc ggccctcctc agagcccagg
     1801 aacagatacc tcctggagta taccacatct ccctggtact tacagacagt cagaacaatc
     1861 ggtgtgagat gccacgcagc ttgacactgg aagtctgtca gtgtgacaac aggggcatct
     1921 gtggaacttc ttacccaacc acaagccctg ggaccaggta tggcaggccg cactcaggga
     1981 ggctggggcc tgccgccatc ggcctgctgc tccttggtct cctgctgctg ctgttggccc
     2041 cccttctgct gttgacctgt gactgtgggg caggttctac tgggggagtg acaggtggtt
     2101 ttatcccagt tcctgatggc tcagaaggaa caattcatca gtggggaatt gaaggagccc
     2161 atcctgaaga caaggaaatc acaaatattt gtgtgcctcc tgtaacagcc aatggagccg
     2221 atttcatgga aagttctgaa gtttgtacaa atacgtatgc cagaggcaca gcggtggaag
     2281 gcacttcagg aatggaaatg accactaagc ttggagcagc cactgaatct ggaggtgctg
     2341 caggctttgc aacagggaca gtgtcaggag ctgcttcagg attcggagca gccactggag
     2401 ttggcatctg ttcctcaggg cagtctggaa ccatgagaac aaggcattcc actggaggaa
     2461 ccaataagga ctacgctgat ggggcgataa gcatgaattt tctggactcc tacttttctc
     2521 agaaagcatt tgcctgtgcg gaggaagacg atggccagga agcaaatgac tgcttgttga
     2581 tctatgataa tgaaggcgca gatgccactg gttctcctgt gggctccgtg ggttgttgca
     2641 gttttattgc tgatgacctg gatgacagct tcttggactc acttggaccc aaatttaaaa
     2701 aacttgcaga gataagcctt ggtgttgatg gtgaaggcaa agaagttcag ccaccctcta
     2761 aagacagcgg ttatgggatt gaatcctgtg gccatcccat agaagtccag cagacaggat
     2821 ttgttaagtg ccagactttg tcaggaagtc aaggagcttc tgctttgtcc acctctgggt
     2881 ctgtccagcc agctgtttcc atccctgacc ctctgcagca tggtaactat ttagtaacgg
     2941 agacttactc ggcttctggt tccctcgtgc aaccttccac tgcaggcttt gatccacttc
     3001 tcacacaaaa tgtgatagtg acagaaaggg tgatctgtcc catttccagt gttcctggca
     3061 acctagctgg cccaacgcag ctacgagggt cacatactat gctctgtaca gaggatcctt
     3121 gctcccgtct aatatgacca gaatgagctg gaataccaca ctgaccaaat ctggatcttt
     3181 ggactaaagt attcaaaata gcatagcaaa gctcactgta ttgggctaat aatttggcac
     3241 ttattagctt ctctcataaa ctgatcacga ttataaatta aatgtttggg ttcatacccc
     3301 aaaagcaata tgttgtcact cctaattctc aagtactatt caaattgtag taaatcttaa
     3361 agtttttcaa aaccctaaaa tcatattcgc caggaaattt tcctaaacat tcttaagctt
     3421 ctatttttcc cctgccaaag gaaggtgttt atcattttaa aatgcaatgt gatttagtgg
     3481 attaagcagg agcgctggtt cttgtctcca ttgccttttc ttatatcatt gataatgatg
     3541 taagaatcac aaggggccgg gcgcggtggc tcacgcctgt aatcccagca ctttgggagg
     3601 ccgaggcagg tggatcatga ggtcaggaga tcgagaccat cctggctaac aaggtgaaac
     3661 cccgtctcta ctaaaaatac aaaaaattag ccgggcgcag tggcgggcgc ctgtagtccc
     3721 agctactcgg gaggctgagg caggagaatg gcatgaaccc gggaagcgga gcttgcagtg
     3781 agccgagatt gcgccactgc agtccgcagt ccggcctggg cgacagagcg agactccgtc
     3841 tcaaaaaaaa aaaaaaaaaa agaatcacaa ggtatttgct aaagcatttt gagctgcttg
     3901 gaaaaaggga agtagttgca gtagagtttc ttccatcttc ttggtgctgg gaagccatat
     3961 atgtgtcttt tactcaagct aaggggtata agcttatgtg ttgaatttgc tacatctata
     4021 tttcacatat tctcacaata agagaatttt gaaatagaaa tatcatagaa catttaagaa
     4081 agtttagtat aaataatatt ttgtgtgttt taatcccttt gaagggatct atccaaagaa
     4141 aatattttac actgagctcc ttcctacacg tctcagtaac agatcctgtg ttagtctttg
     4201 aaaatagctc attttttaaa tgtcagtgag tagatgtagc atacatatga tgtataatga
     4261 cgtgtattat gttaacaatg tctgcagatt ttgtaggaat acaaaacatg gcctttttta
     4321 taagcaaaac gggccaatga ctagaataac acatagggca atctgtgaat atgtattata
     4381 agcagcattc cagaaaagta gttggtgaaa taattttcaa gtcaaaaagg gatatggaaa
     4441 gggaattatg agtaacctct attttttaag ccttgctttt aaattaaaca gctacagcca
     4501 tttaagcctt gaggataata aagcttgaga gtaataatgt taggttagca aaggtttaga
     4561 tgtatcactt catgcatgct accatgatag taatgcagct cttcgagtca tttctggtca
     4621 ttcaagatat tcaccctttt gcccatagaa agcaccctac ctcacctgct tactgacatt
     4681 gtcttagctg atcacaagat cattatcagc ctccattatt ccttactgta tataaaatac
     4741 agagttttat attttccttt cttcgttttt caccatattc aaaacctaaa tttgtttttg
     4801 cagatggaat gcaaagtaat caagtgtttg tgctttcacc tagaagggtg tggtcctgaa
     4861 ggaaagaggt cccctaaata tcccccaccc tggtgctcct ccctctccct ggtaccctga
     4921 ctaccaggaa gtcaggtgct agagcagctg gagaagtgca ggcagcctgt gcttccacag
     4981 atgggggtgc tgctgcaaca aggctttcaa tgtgcccatc ttaggtggga gaagctagat
     5041 cctgtgcagc agcctggtaa gtcctgagga ggttccattg ctcttcctgc tgctgtcctt
     5101 tgcttctcaa cggtggctcg ctctacagtc tagagcacat gcagctaact tgtgcctctg
     5161 cttatgcatg agggttaaat taacaaccat aaccttcatt tgaagttcaa aggtgtattc
     5221 aggatcctca aagcatttta accttgccgc ttaaaaccca atttaccgtg aaatgggaat
     5281 tttgctgcat tgttaaactg tagtggaaac catgctatag taataaaggt tatataagag
     5341 agaaattgaa attaaatgtg tttttaaatt tcaaaaaaaa atcaatcttt aggatgactt
     5401 aaaaattgat ttgccatgta aaatgtatct gcatttttta cacaaaactt gttttaagca
     5461 taaaatttta aaactgtact acttgatgta ttatacattt tgaaccatat gtattaaacc
     5521 ataaacagta taatgttgtt ataataaaac aggcaataaa tttataaata aaagctgaa
//
