LOCUS       NM_032160               9266 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens dermatan sulfate epimerase like (DSEL), mRNA.
ACCESSION   NM_032160
VERSION     NM_032160.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9266)
  AUTHORS   Sung,Y.J., de las Fuentes,L., Schwander,K.L., Simino,J. and
            Rao,D.C.
  TITLE     Gene-smoking interactions identify several novel blood pressure
            loci in the Framingham Heart Study
  JOURNAL   Am J Hypertens 28 (3), 343-354 (2015)
   PUBMED   25189868
REFERENCE   2  (bases 1 to 9266)
  AUTHORS   Shi,J., Potash,J.B., Knowles,J.A., Weissman,M.M., Coryell,W.,
            Scheftner,W.A., Lawson,W.B., DePaulo,J.R. Jr., Gejman,P.V.,
            Sanders,A.R., Johnson,J.K., Adams,P., Chaudhury,S., Jancic,D.,
            Evgrafov,O., Zvinyatskovskiy,A., Ertman,N., Gladis,M., Neimanas,K.,
            Goodell,M., Hale,N., Ney,N., Verma,R., Mirel,D., Holmans,P. and
            Levinson,D.F.
  TITLE     Genome-wide association study of recurrent early-onset major
            depressive disorder
  JOURNAL   Mol Psychiatry 16 (2), 193-201 (2011)
   PUBMED   20125088
REFERENCE   3  (bases 1 to 9266)
  AUTHORS   Zayed,H., Chao,R., Moshrefi,A., Lopezjimenez,N., Delaney,A.,
            Chen,J., Shaw,G.M. and Slavotinek,A.M.
  TITLE     A maternally inherited chromosome 18q22.1 deletion in a male with
            late-presenting diaphragmatic hernia and microphthalmia-evaluation
            of DSEL as a candidate gene for the diaphragmatic defect
  JOURNAL   Am J Med Genet A 152A (4), 916-923 (2010)
   PUBMED   20358601
  REMARK    GeneRIF: DSEL was selected for study in 125 patients with
            diaphragmatic hernias, as it is involved in the synthesis of
            decorin, a protein that is required for normal collagen formation
            and that is upregulated during myogenesis.
REFERENCE   4  (bases 1 to 9266)
  AUTHORS   Need,A.C., Attix,D.K., McEvoy,J.M., Cirulli,E.T., Linney,K.L.,
            Hunt,P., Ge,D., Heinzen,E.L., Maia,J.M., Shianna,K.V., Weale,M.E.,
            Cherkas,L.F., Clement,G., Spector,T.D., Gibson,G. and
            Goldstein,D.B.
  TITLE     A genome-wide study of common SNPs and CNVs in cognitive
            performance in the CANTAB
  JOURNAL   Hum Mol Genet 18 (23), 4650-4661 (2009)
   PUBMED   19734545
REFERENCE   5  (bases 1 to 9266)
  AUTHORS   Pacheco,B., Malmstrom,A. and Maccarana,M.
  TITLE     Two dermatan sulfate epimerases form iduronic acid domains in
            dermatan sulfate
  JOURNAL   J Biol Chem 284 (15), 9788-9795 (2009)
   PUBMED   19188366
REFERENCE   6  (bases 1 to 9266)
  AUTHORS   Maccarana,M., Olander,B., Malmstrom,J., Tiedemann,K., Aebersold,R.,
            Lindahl,U., Li,J.P. and Malmstrom,A.
  TITLE     Biosynthesis of dermatan sulfate: chondroitin-glucuronate
            C5-epimerase is identical to SART2
  JOURNAL   J Biol Chem 281 (17), 11560-11568 (2006)
   PUBMED   16505484
REFERENCE   7  (bases 1 to 9266)
  AUTHORS   Goossens,D., Van Gestel,S., Claes,S., De Rijk,P., Souery,D.,
            Massat,I., Van den Bossche,D., Backhovens,H., Mendlewicz,J., Van
            Broeckhoven,C. and Del-Favero,J.
  TITLE     A novel CpG-associated brain-expressed candidate gene for
            chromosome 18q-linked bipolar disorder
  JOURNAL   Mol Psychiatry 8 (1), 83-89 (2003)
   PUBMED   12556911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV656576.1 and AC110597.7.
            
            On Nov 16, 2018 this sequence version replaced NM_032160.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.252380.1,
                                           SRR1803617.93174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467143, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000310045.9/
                                                ENSP00000310565.8
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               AV656576.1         11-384
            375-9266            AC110597.7         134346-143237       c
FEATURES             Location/Qualifiers
     source          1..9266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.1"
     gene            1..9266
                     /gene="DSEL"
                     /gene_synonym="C18orf4; DE-epi2"
                     /note="dermatan sulfate epimerase like"
                     /db_xref="GeneID:92126"
                     /db_xref="HGNC:HGNC:18144"
                     /db_xref="MIM:611125"
     exon            1..360
                     /gene="DSEL"
                     /gene_synonym="C18orf4; DE-epi2"
                     /inference="alignment:Splign:2.1.0"
     exon            361..9266
                     /gene="DSEL"
                     /gene_synonym="C18orf4; DE-epi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1245..4883
                     /gene="DSEL"
                     /gene_synonym="C18orf4; DE-epi2"
                     /EC_number="5.1.3.19"
                     /note="NCAG1; dermatan-sulfate epimerase-like protein"
                     /codon_start=1
                     /product="dermatan-sulfate epimerase-like protein
                     precursor"
                     /protein_id="NP_115536.2"
                     /db_xref="CCDS:CCDS11995.2"
                     /db_xref="GeneID:92126"
                     /db_xref="HGNC:HGNC:18144"
                     /db_xref="MIM:611125"
                     /translation="MALMFTGHLLFLALLMFAFSTFEESVSNYSEWAVFTDDIDQFKT
                     QKVQDFRPNQKLKKSMLHPSLYFDAGEIQAMRQKSRASHLHLFRAIRSAVTVMLSNPT
                     YYLPPPKHADFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFVLEYMDRMVGYKDWLV
                     ENAPGDEVPIGHSLTGFATAFDFLYNLLDNHRRQKYLEKIWVITEEMYEYSKVRSWGK
                     QLLHNHQATNMIALLTGALVTGVDKGSKANIWKQAVVDVMEKTMFLLNHIVDGSLDEG
                     VAYGSYTAKSVTQYVFLAQRHFNINNLDNNWLKMHFWFYYATLLPGFQRTVGIADSNY
                     NWFYGPESQLVFLDKFILKNGAGNWLAQQIRKHRPKDGPMVPSTAQRWSTLHTEYIWY
                     DPQLTPQPPADYGTAKIHTFPNWGVVTYGAGLPNTQTNTFVSFKSGKLGGRAVYDIVH
                     FQPYSWIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPS
                     SQCNKPWEGQLGECAQWLKWTGEEVGDAAGEIITASQHGEMVFVSGEAVSAYSSAMRL
                     KSVYRALLLLNSQTLLVVDHIERQEDSPINSVSAFFHNLDIDFKYIPYKFMNRYNGAM
                     MDVWDAHYKMFWFDHHGNSPMASIQEAEQAAEFKKRWTQFVNVTFQMEPTITRIAYVF
                     YGPYINVSSCRFIDSSNPGLQISLNVNNTEHVVSIVTDYHNLKTRFNYLGFGGFASVA
                     DQGQITRFGLGTQAIVKPVRHDRIIFPFGFKFNIAVGLILCISLVILTFQWRFYLSFR
                     KLMRWILILVIALWFIELLDVWSTCSQPICAKWTRTEAEGSKKSLSSEGHHMDLPDVV
                     ITSLPGSGAEILKQLFFNSSDFLYIRVPTAYIDIPETELEIDSFVDACEWKVSDIRSG
                     HFRLLRGWLQSLVQDTKLHLQNIHLHEPNRGKLAQYFAMNKDKKRKFKRRESLPEQRS
                     QMKGAFDRDAEYIRALRRHLVYYPSARPVLSLSSGSWTLKLHFFQEVLGASMRALYIV
                     RDPRAWIYSMLYNSKPSLYSLKNVPEHLAKLFKIEGGKGKCNLNSGYAFEYEPLRKEL
                     SKSKSNAVSLLSHLWLANTAAALRINTDLLPTSYQLVKFEDIVHFPQKTTERIFAFLG
                     IPLSPASLNQILFATSTNLFYLPYEGEISPTNTNVWKQNLPRDEIKLIENICWTLMDR
                     LGYPKFMD"
     regulatory      4912..4917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSEL"
                     /gene_synonym="C18orf4; DE-epi2"
                     /note="hexamer: AATAAT"
     polyA_site      4945
                     /gene="DSEL"
                     /gene_synonym="C18orf4; DE-epi2"
                     /note="major polyA site"
     regulatory      9248..9253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSEL"
                     /gene_synonym="C18orf4; DE-epi2"
                     /note="hexamer: AATAAA"
     polyA_site      9266
                     /gene="DSEL"
                     /gene_synonym="C18orf4; DE-epi2"
                     /note="major polyA site"
ORIGIN      
        1 acagaggatc ctcggccgcg gcgacatcac cgcctgggca cgcgggcgct gctctggata
       61 cggcgccacc gagagaaccc gccgcccgcg ggtctctgtc ctgcggtccg tggttgcccc
      121 cacaagcgtc cggcgtttcc tgagggcggg cgtgtccggg ccgtgcgggt cgcggggacc
      181 gagcgcggct gaggagaccg agctggggca gcgcctgccg tagcgcggga gacgacgcgg
      241 gggtcttgcg gagccccgcg ggagcctggc ccgccgtgca gagcagtttt ctggaactct
      301 ccacctccgt ctcccttggg gcccagtgcg gcgccgagcc cccgtcggga tctgcctgag
      361 aaaagtgtca tgaaaaaaga gcagaagaga gacctcactg ttgctgaaag gggaattttc
      421 tttccccgtt ggcggttact tcatgatcgg acgagaagta tctaggtgac tgaagatatt
      481 ccatttttat gtttgtacac atgaagctga taaaagaaga tgtgaacatg atttctcttt
      541 gtcataatag gctgatgagt aagtaagcct gaaaaatatt tgaaatgaag gcaagaattt
      601 tgaattttta aaaaccaact aagactttga tcacttgttg aggatgtttc tctctcataa
      661 atgaaagaaa aacgtattca caagacaaga agtataaaaa gttgagagga atgacaactg
      721 agtccactca ctcgaagaat gtcagtactt catcatcttc tttgggcaaa catacacaaa
      781 tgcatcatac atgtgtggtg agcttatcac cagtgatggt tttctgtgct agaaatgact
      841 cttaatttga attttggagt gctttttctc tttttttaca atgtgtgttc caactctttg
      901 tgttaaatag atttaagtaa aggaggtaaa tgctaaattc atagtgtttt ttacctgtat
      961 cacttccctg tgtattatgg aaaaattaga gattttaacg ttattcaaag ttttactgga
     1021 agcaaaactg tgccagggac agagatatac aatttaagtt ttctcttttt ggcaactgca
     1081 cttgcttaaa atgtactgaa tgtcagctgg atttcacagc atatcagatt tacagtcttt
     1141 gtcttatcaa ggcctttact gtatgtttta tactaaccag atgggaaaca cattgagcat
     1201 catatctgac atgtatgcct aagggaggag ctcccccatg gatcatggcg ttaatgttta
     1261 caggacattt actattctta gcattattga tgtttgcttt ctctactttt gaggaatctg
     1321 tgagcaatta ttccgaatgg gcagttttca cagatgatat agatcagttt aaaacacaga
     1381 aagtgcaaga tttcagaccc aaccaaaagc tgaagaaaag tatgcttcat ccaagtttat
     1441 attttgatgc tggagaaatc caagcaatga gacaaaagtc tcgtgcaagc catttgcatc
     1501 tttttagagc tatcagaagt gcagtgacag ttatgctgtc caacccaaca tactacctac
     1561 ctccaccaaa gcatgctgat tttgctgcca agtggaatga aatttatggt aacaatctgc
     1621 ctcctttagc attgtactgt ttgttatgcc cagaagacaa agttgccttt gaatttgtct
     1681 tggaatatat ggacaggatg gttggctaca aagactggct agtagagaat gcaccaggag
     1741 atgaggttcc aattggccat tccttaacag gttttgccac tgcctttgac tttttatata
     1801 acttattaga taatcatcga agacaaaaat acctggaaaa aatatgggtt attactgagg
     1861 aaatgtacga gtattccaag gtccgctcat ggggcaaaca gcttctccat aaccaccaag
     1921 ccactaatat gatagcatta ctcacagggg ccttggtgac tggagtagat aaaggatcta
     1981 aagcaaatat atggaaacag gctgtagtgg atgtcatgga aaagacaatg tttctattga
     2041 atcatattgt tgatggttct ttggatgaag gtgtggccta tggaagctac acagctaaat
     2101 ccgtcacaca gtatgttttt ctggcccagc gccattttaa tatcaacaac ttggataata
     2161 actggttaaa gatgcacttt tggttctatt atgccaccct tttacctggc ttccaaagaa
     2221 ctgtgggtat agcagattcc aattataatt ggttttatgg tccagaaagc cagctagttt
     2281 tcttggataa gttcatctta aagaatggag ctggaaattg gttagctcag caaattagaa
     2341 agcaccgacc taaagatgga ccgatggttc cttcaactgc ccaaaggtgg agtactcttc
     2401 acactgaata catctggtat gatccccagc tcacaccaca gccacctgct gattatggta
     2461 ctgcaaaaat acacacattc cctaactggg gtgtggttac ttatggggct gggttgccaa
     2521 acacacagac caacaccttt gtgtctttta aatctgggaa gctgggggga cgagctgtgt
     2581 atgacatagt tcattttcag ccatattcct ggattgatgg gtggagaagt tttaacccag
     2641 gacatgagca tccagatcag aactcattta cttttgcccc caatggacaa gtatttgttt
     2701 ctgaagctct ctatggaccc aagttgagcc accttaacaa tgtattggtg tttgctccat
     2761 caccctcaag ccagtgtaat aagccctggg aaggtcaact gggagaatgt gcgcagtggc
     2821 ttaagtggac tggcgaggag gttggtgatg cagctgggga aataatcact gcctctcaac
     2881 atggggaaat ggtatttgtg agtggggaag ccgtgtctgc ttattcttca gcaatgagac
     2941 tgaaaagtgt atatcgtgct ttgcttctct taaattccca aactctgcta gttgttgatc
     3001 atattgagag gcaagaagat tccccaataa attctgtcag tgccttcttt cataatttgg
     3061 atattgattt taaatatatc ccatataagt ttatgaatag gtataatggt gccatgatgg
     3121 atgtgtggga tgcacattac aaaatgtttt ggtttgatca tcatggcaat agtcccatgg
     3181 ccagtataca ggaagcagag caagctgctg aatttaaaaa acgatggact caatttgtta
     3241 atgttacttt tcagatggaa cccacaatca caagaattgc atatgtcttt tatgggccat
     3301 atatcaatgt ctccagctgc agatttattg atagttccaa tcctggactt cagatttctc
     3361 tcaatgtcaa taatactgaa catgttgttt ctattgtaac tgattaccat aacctgaaga
     3421 caagattcaa ttatctggga ttcggtggct ttgccagtgt ggctgatcaa ggccaaataa
     3481 cccgatttgg tttgggcact caagcaatag taaagcctgt aagacatgat aggattattt
     3541 tcccctttgg atttaaattt aatatagcag ttggattaat tttgtgcatt agcttggtga
     3601 ttttaacttt ccaatggcgt ttttaccttt cttttagaaa actaatgcga tggatattaa
     3661 tacttgttat tgccttgtgg tttattgagc ttttggatgt gtggagcact tgtagtcagc
     3721 ccatttgtgc aaaatggaca aggacagagg ctgagggaag caagaagtct ttgtcttctg
     3781 aagggcacca catggatctt cctgatgttg tcattacctc acttcctggt tcaggagctg
     3841 aaattctcaa acaacttttt ttcaacagta gtgattttct ctacatcagg gttcctacag
     3901 cctacattga tattcctgaa actgagttgg aaatcgactc atttgtagat gcttgtgaat
     3961 ggaaggtgtc agatatccgc agtgggcatt ttcgtttact ccgaggctgg ttgcagtctt
     4021 tagtccagga cacaaaatta catttgcaaa acatccatct gcatgaaccc aataggggta
     4081 aactggccca atattttgca atgaataagg acaaaaaaag aaaatttaaa aggagagagt
     4141 ctttgccaga acaaagaagt caaatgaaag gcgcctttga tagagatgct gaatatatta
     4201 gggctttgag gagacacctg gtttactatc caagtgcacg tcctgtgctc agtttaagca
     4261 gtggaagctg gacgttaaag cttcattttt ttcaggaagt tttaggagct tcgatgaggg
     4321 cattgtacat agtaagagac cctcgggcat ggatttattc aatgttgtac aatagtaaac
     4381 caagtcttta ttctttgaag aatgtaccag agcatttagc aaaattgttt aaaatagagg
     4441 gaggtaaagg caaatgtaac ttaaattcgg gttatgcttt cgagtatgaa ccattgagga
     4501 aagaattatc aaaatccaaa tcaaatgcag tgtccctctt gtctcacttg tggctagcaa
     4561 atacagcagc agccttgaga ataaatacag atttgctgcc tactagctac cagctggtca
     4621 agtttgaaga tattgtgcat tttcctcaga aaactactga aaggattttt gcctttcttg
     4681 gaattccttt gtctcctgct agtttaaacc aaatattgtt tgccacctct acaaaccttt
     4741 tttaccttcc ctatgaaggg gaaatatcac caactaatac taatgtttgg aaacagaact
     4801 tgcctagaga tgaaattaaa ctaattgaaa acatctgctg gactctgatg gatcgcctag
     4861 gatatccaaa gtttatggac taaatgctgc aggtcagcag aaatttgcac taataatact
     4921 taccaaccca ctttgtggat atgaatcaga agagtttgtt tattctttag tgtgtgtgtg
     4981 tgtgtgcacg cgtgtatgtg ttcagtgttg tttgcacaga gagattgttt taaaaaatgg
     5041 caccatattt ggcctagcag gatttatttt tatgtcatca cctcccttgc ctttgtttct
     5101 gaaaattttg tctgctaaaa agtttctgct acagagtggt agatgaagtt atatcatggg
     5161 gtcaggggag atgggaaaat tttaagtttt tgtctaactc cccttcatct gtaactgtgc
     5221 taatctatct agagacctca aacactgcta aaggccttgc aattgctgct ttacccacgc
     5281 atctcttgct ttcaagatgg actacaaaag ttccttatcc ttttgaaaag gtcttctgac
     5341 acacttatct tgcacaaaga aaaagaaaat ttcttttact gtgtttaatg ttcagtgata
     5401 tcactgagga aatggtgaaa gctcctatca gaactatagg atttcttctg ggaaatacag
     5461 atggaaatac agaatgaata tgtttttttg aggtcggaaa ctgactttaa aagcctcctt
     5521 gaagtttttt acttagaaat ataaggaata agtctttgaa caatctgggt ggcaagggct
     5581 ggtagattat tttagacatg attgtctgtt taaaactctc ctttcacttt ttatcctccc
     5641 tggagctaca gctgttcgcc atcacatcac tcccatccta tcctttctgt cactgtcaag
     5701 caaaacaatc agtagttact aatcgctgaa ctctcaatat tgtggggcat tttcccccca
     5761 gttgattaat tttgcgttaa agactgacac agacttagaa tcaaatttat ttttctggaa
     5821 ttaacactct gtgactcaaa gtagtgccac tgcagtgtct ttttaaactg gaaacagaat
     5881 tggaaaactg cctgacttat cttgcatccc tttgaatgag tttacagact gccagtgtct
     5941 gcaaaagttg aaagcaaatg ggagatgatg tcagaggcat ctgtttcctt taccatctgc
     6001 atcttattat aaatgtagtc gtcataaagt gtggtttatt ttattttggt aggctctgaa
     6061 atcaaaatgc tacgccatta taagccagtg gagtaattac aatgtattgg atgaaaacat
     6121 aaggcagtgt ggagacttga tgaaaatctc tgtacagatt gcagtcttct tcctgatgtt
     6181 tcaaactgtg gttcccccaa gctctctaac acttggaagt ctgtcattct gacctagata
     6241 aaagtggttc tttctcagta gttattatta tgtcaaaatg tgcctccaga gtgataaagc
     6301 tctgtatatg ttagattcca gctaaaccta acttggctgt catttttctt ccattatagt
     6361 gtgagtggag actgcccccc ctccccaaca tattccttcc catatctctc atgattgtcc
     6421 ctctgtaatt tcaaaatgaa tgaaattcat gtgaatgtag gttgagaggg cactgaagac
     6481 ctgaatctac actagtaatc tcaagaaaga ttattcattc tatctcagag ttaccggcaa
     6541 gcatataaaa tgctacttgg ataatatcta catgaatatt gcatgctaca tggttgataa
     6601 cactatttcc attattgggc agaatctcag tgtttacttt caattcctag gatatgtgat
     6661 cgtgaatcag atcacatata aaaagtctgg attgtcagta gtattagatc tgatcaaggt
     6721 aggaattaca attgcatgca ggtagcaagc aagaaagcag aaactactgt tccctttatt
     6781 ttaacattgt acagacaata cagaaatgta cctgttggcg gccgggtgca gtggctcacg
     6841 cctgtaatcc cagcacttcg ggaggccgag gcgggtggat cacgaggtca ggagatcaag
     6901 accatcctgg ctaacacggt gaaaccccgt ctctactaaa aaaaaaagta caaaaaatta
     6961 gccgggcgtg gtggcgggca cctgtagtcc cagctacacg ggaggctgag gcaggagaat
     7021 ggcatgaacc tgggaggcag agcttgcagt gagtggagat gcgccactgc actccagcct
     7081 gggcgacaga gcgagactcc gcctcaaaaa aaaaaaaaaa agaaaaaaag aaatgtacct
     7141 gttggcagga gaaggccaga tggagtatgt ggagtaatag ggaaagaaga gttacagaaa
     7201 atgaaaaaga aaatgagtta cactgagaat gaatatggga acacgtcatt gatagcaaaa
     7261 gaaaggtaca ggcttacgaa aatgatcttt acaatgtatc ccagctttca cccccacatg
     7321 gcaatgcaga gttgtattta cttgtttctg tactcaccta ctcccacccc aagggaaaat
     7381 tttagacatg aaccctacta tttagttatt ctaaaataga aagtttgctg gagaaagcgt
     7441 ccactcacag attgttctgt aaggaatgtt atgtatgggt gagcgggtga cacatccatt
     7501 gggtatgtat gcatgtgatg gtgcctgaga cccctgcctt agaaacagaa ttcctaaggg
     7561 gattgactct cccagcatgt tcccaggtcc tgcaccctta gggtgatcta ggaaaatttt
     7621 aaatagcttc tactcttatt tttgttcttt gaaataatta aaagagggat tatcactatc
     7681 tgatacttct gaaagaaaca cttacaaaat ttcttatctg taaaatccgt ctttttctac
     7741 attaacttcc ccaaacatag gcctaattga gataattgct tttattataa taataggatt
     7801 gaaattttaa aattttgaaa ggacttatta attttgctga caaaagtgaa gtaacaaata
     7861 taatgataat tggcttttta aattttcaaa caacatagat ttactcaaga tgaaataaaa
     7921 aggccatatt cagagttgaa tttaatgaaa actcagagga aataggaaaa tctgctcagg
     7981 agaaagaagc taaatctgca tagatttagt ttgtagaatt taatttaaaa tttaaatttt
     8041 aacaaagtga tgacacaaca atatgtacgt ttaggtgtgg acaccaaaat attagacatt
     8101 tgattgtcct tttacataga gaataactaa taaatgcctg acaagaatgg gacaatcctt
     8161 ccttgtatca aaattcccag gtcttgctac attgccctct gcaaatgtat tcaaagaaga
     8221 acctcctcca ccacttactt ttggttggca taattgttca gcaacgattt ctgtacatca
     8281 ccaagtatct ttggcattct tggtatacaa agtatatcac aattttaagt gagtaaatat
     8341 taatgataat ttttgaattg ctttgtttgg cttgattaac tttgatcaga aatagaaacg
     8401 ttttcatttg ttgatttagg aaaaagcata aatagaatgc agtataacac cacttccaaa
     8461 ggtaaggata cctaacattc tttttttttt tttttttttt ttttttggga tggagtctca
     8521 ctttgttgcc caggctggag tgcagtggtc tgatctcggc tcactgcaac ctccgcctac
     8581 cgggttcaag tgattctcct acgtcagcct cctgaatagc tgggattaca ggtgcacgcc
     8641 accatgcttg gctcattttt gtatttttag tagtgacagc gtttcaccac attggtcagg
     8701 ctggtctcaa tctcttgacc tggtgatctg cccacctggg cctcccaaaa tgctgggatt
     8761 acaggcatga gccaccacac ctggcaaggg tacctgacat tctaagatat caagacactt
     8821 aatatgtggg ctattagctg cttatttaaa tgttgaccaa attgtctgat atatctgatt
     8881 aatcatgatt tcacttcatt tcggaagaaa aattatccat atcattttta aagacgcaaa
     8941 tgactttgga tttttgcata gagtacaata gacacttcaa acaatagatt ctaacattct
     9001 ctgaaacact tgagatgttt gagctaccat ttatatgggt tatttatatt tagtctaagt
     9061 aacacataca tgtttaattg attctgtttt catggataga ttcaactaag tcttccaagc
     9121 aattaatttt ttgttcgtcg tcgtttttcc ttcatacgtt atctagttat gcagcactgg
     9181 aaacagactg aagatcataa accagtttta tcagacctat gtgtaataag actcctgtta
     9241 atacaaaaat aaaaagctaa aagcaa
//
