LOCUS       NM_020693               6855 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DS cell adhesion molecule like 1 (DSCAML1), transcript
            variant 1, mRNA.
ACCESSION   NM_020693
VERSION     NM_020693.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6855)
  AUTHORS   Ogata,S., Hashizume,K., Hayase,Y., Kanno,Y., Hori,K., Balan,S.,
            Yoshikawa,T., Takahashi,H., Taya,S. and Hoshino,M.
  TITLE     Potential involvement of DSCAML1 mutations in neurodevelopmental
            disorders
  JOURNAL   Genes Cells 26 (3), 136-151 (2021)
   PUBMED   33501714
  REMARK    GeneRIF: Potential involvement of DSCAML1 mutations in
            neurodevelopmental disorders.
REFERENCE   2  (bases 1 to 6855)
  AUTHORS   Kosova,G., Hotaling,J.M., Ohlander,S., Niederberger,C., Prins,G.S.
            and Ober,C.
  TITLE     Variants in DPF3 and DSCAML1 are associated with sperm morphology
  JOURNAL   J Assist Reprod Genet 31 (2), 131-137 (2014)
   PUBMED   24271036
  REMARK    GeneRIF: DSCAML1 protein rs680730 SNP is associated with poor sperm
            morphology.
REFERENCE   3  (bases 1 to 6855)
  AUTHORS   Huang,J., Wang,Y., Raghavan,S., Feng,S., Kiesewetter,K. and Wang,J.
  TITLE     Human down syndrome cell adhesion molecules (DSCAMs) are
            functionally conserved with Drosophila Dscam[TM1] isoforms in
            controlling neurodevelopment
  JOURNAL   Insect Biochem Mol Biol 41 (10), 778-787 (2011)
   PUBMED   21645617
REFERENCE   4  (bases 1 to 6855)
  AUTHORS   Fuerst,P.G., Bruce,F., Tian,M., Wei,W., Elstrott,J., Feller,M.B.,
            Erskine,L., Singer,J.H. and Burgess,R.W.
  TITLE     DSCAM and DSCAML1 function in self-avoidance in multiple cell types
            in the developing mouse retina
  JOURNAL   Neuron 64 (4), 484-497 (2009)
   PUBMED   19945391
  REMARK    GeneRIF: in all transgenic retinal cell types examined, both DSCAM
            and DSCAM-LIKE1 genes are functioning similarly in self-avoidance,
            whereas the stratification of neurites and synaptic specificity are
            intact in their absence.
REFERENCE   5  (bases 1 to 6855)
  AUTHORS   Pollin,T.I., Damcott,C.M., Shen,H., Ott,S.H., Shelton,J.,
            Horenstein,R.B., Post,W., McLenithan,J.C., Bielak,L.F.,
            Peyser,P.A., Mitchell,B.D., Miller,M., O'Connell,J.R. and
            Shuldiner,A.R.
  TITLE     A null mutation in human APOC3 confers a favorable plasma lipid
            profile and apparent cardioprotection
  JOURNAL   Science 322 (5908), 1702-1705 (2008)
   PUBMED   19074352
REFERENCE   6  (bases 1 to 6855)
  AUTHORS   Barlow,G.M., Micales,B., Chen,X.N., Lyons,G.E. and Korenberg,J.R.
  TITLE     Mammalian DSCAMs: roles in the development of the spinal cord,
            cortex, and cerebellum?
  JOURNAL   Biochem Biophys Res Commun 293 (3), 881-891 (2002)
   PUBMED   12051741
REFERENCE   7  (bases 1 to 6855)
  AUTHORS   Agarwala,K.L., Ganesh,S., Tsutsumi,Y., Suzuki,T., Amano,K. and
            Yamakawa,K.
  TITLE     Cloning and functional characterization of DSCAML1, a novel
            DSCAM-like cell adhesion molecule that mediates homophilic
            intercellular adhesion
  JOURNAL   Biochem Biophys Res Commun 285 (3), 760-772 (2001)
   PUBMED   11453658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000757.4 and AP002342.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 27, 2018 this sequence version replaced NM_020693.3.
            
            Summary: The protein encoded by this gene is a member of the Ig
            superfamily of cell adhesion molecules and is involved in neuronal
            differentiation. The encoded membrane-bound protein localizes to
            the cell surface, where it forms aggregates that repel neuronal
            processes of the same cell type. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF491813.1, AB032958.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651296.2/ ENSP00000498769.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AP000757.4         41464-41646         c
            184-501             AP000757.4         24923-25240         c
            502-648             AP000757.4         21221-21367         c
            649-795             AP002342.3         104878-105024       c
            796-1074            AP002342.3         97307-97585         c
            1075-1350           AP002342.3         93632-93907         c
            1351-1647           AP002342.3         90968-91264         c
            1648-1920           AP002342.3         88969-89241         c
            1921-2199           AP002342.3         77956-78234         c
            2200-2319           AP002342.3         77426-77545         c
            2320-2496           AP002342.3         76347-76523         c
            2497-2696           AP002342.3         54465-54664         c
            2697-2793           AP002342.3         53676-53772         c
            2794-2922           AP002342.3         52945-53073         c
            2923-3090           AP002342.3         44371-44538         c
            3091-3161           AP002342.3         42413-42483         c
            3162-3402           AP002342.3         37445-37685         c
            3403-3549           AP002342.3         33953-34099         c
            3550-3705           AP002342.3         31257-31412         c
            3706-3845           AP002342.3         23052-23191         c
            3846-3999           AP002342.3         16389-16542         c
            4000-4117           AP002342.3         12322-12439         c
            4118-4281           AP002342.3         11769-11932         c
            4282-4380           AP002342.3         11388-11486         c
            4381-4569           AP002342.3         10398-10586         c
            4570-4857           AP002342.3         9625-9912           c
            4858-5013           AP002342.3         8147-8302           c
            5014-5044           AP002342.3         5944-5974           c
            5045-5163           AP002342.3         5641-5759           c
            5164-5316           AP002342.3         4855-5007           c
            5317-5511           AP002342.3         4037-4231           c
            5512-5823           AP002342.3         3225-3536           c
            5824-6855           AP002342.3         275-1306            c
FEATURES             Location/Qualifiers
     source          1..6855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..6855
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /note="DS cell adhesion molecule like 1"
                     /db_xref="GeneID:57453"
                     /db_xref="HGNC:HGNC:14656"
                     /db_xref="MIM:611782"
     exon            1..183
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..6299
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Downs syndrome cell adhesion molecule like 1;
                     down syndrome cell adhesion molecule-like protein 1; down
                     syndrome cell adhesion molecule 2; DSCAM-like 1; cell
                     adhesion molecule DSCAML1"
                     /codon_start=1
                     /product="cell adhesion molecule DSCAML1 isoform 1
                     precursor"
                     /protein_id="NP_065744.3"
                     /db_xref="CCDS:CCDS8384.2"
                     /db_xref="GeneID:57453"
                     /db_xref="HGNC:HGNC:14656"
                     /db_xref="MIM:611782"
                     /translation="MWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVV
                     VPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF
                     CTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS
                     WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV
                     TDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI
                     TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVIL
                     SCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA
                     QTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVR
                     DGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI
                     RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQK
                     GMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDM
                     PIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER
                     QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPL
                     TGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTT
                     IAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKP
                     ADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGN
                     SIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSE
                     PSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENS
                     PGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLED
                     VPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNIT
                     TTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSA
                     SSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYL
                     LWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA
                     VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNL
                     LVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSS
                     ERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINST
                     HARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELRMR
                     ACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLF
                     IVRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIED
                     KEGIKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGT
                     NPVSRKNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYS
                     ASLSQDTDKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSD
                     QMTTGTNENADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCN
                     LPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHP
                     GAPAAASTATLPQRTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGP
                     HTKMGGSRDSLLEMSTSGVGRSQKQGAGAYSKSYTLV"
     exon            184..501
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            502..648
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..795
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1074
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1350
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1647
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1920
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2199
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2319
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2496
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2696
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2793
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2922
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3090
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3161
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3402
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3549
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3705
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3706..3845
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3999
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4117
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4118..4281
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4380
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4381..4569
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4570..4857
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4858..5013
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5014..5044
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5045..5163
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5164..5316
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5317..5511
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5512..5823
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            5824..6855
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6837..6842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /note="hexamer: AATAAA"
     polyA_site      6855
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /note="major polyA site"
ORIGIN      
        1 agccgagcgc tgggctgagg agcagagaga gcggggcgcc gagtgcgggc ggctgggagc
       61 gcgctgagcg ggggagaggc gctgccgcac ggccggccac aggaccacct ccccggagaa
      121 tagggcctct ttatggcatg tggctggtaa ctttcctcct gctcctggac tctttacaca
      181 aagcccgccc tgaagatgtt ggcaccagcc tctactttgt aaatgactcc ttgcagcagg
      241 tgaccttttc cagctccgtg ggggtggtgg tgccctgccc ggccgcgggc tcccccagcg
      301 cggcccttcg atggtacctg gccacagggg acgacatcta cgacgtgccg cacatccggc
      361 acgtccacgc caacgggacg ctgcagctct accccttctc cccctccgcc ttcaatagct
      421 ttatccacga caatgactac ttctgcaccg cggagaacgc tgccggcaag atccggagcc
      481 ccaacatccg cgtcaaagca gttttcaggg aaccctacac cgtccgggtg gaggatcaaa
      541 ggtcaatgcg tggcaacgtg gccgtcttca agtgcctcat cccctcttca gtgcaggaat
      601 atgttagcgt tgtatcttgg gagaaagaca cagtctccat catcccagaa cacaggtttt
      661 ttattaccta ccacggcggg ctgtacatct ctgacgtaca gaaggaggac gccctctcca
      721 cctatcgctg catcaccaag cacaagtata gcggggagac ccggcagagc aatggggcac
      781 gcctctctgt gacagaccct gctgagtcga tccccaccat cctggatggc ttccactccc
      841 aggaagtgtg ggccggccac accgtggagc tgccctgcac cgcctcgggc taccctatcc
      901 ccgccatccg ctggctcaag gatggccggc ccctcccggc tgacagccgc tggaccaagc
      961 gcatcacagg gctgaccatc agcgacttgc ggaccgagga cagcggcacc tacatttgtg
     1021 aggtcaccaa caccttcggt tcggcagagg ccacaggcat cctcatggtc attgatcccc
     1081 ttcatgtgac cctgacacca aagaagctga agaccggcat tggcagcacg gtcatcctct
     1141 cctgtgccct gacgggctcc ccagagttca ccatccgctg gtatcgcaac acggagctgg
     1201 tgctgcctga cgaggccatc tccatccgcg ggctcagcaa cgagacgctg ctcatcacct
     1261 cggcccagaa gagccattcc ggggcctacc agtgcttcgc tacccgcaag gcccagaccg
     1321 cccaggactt tgccatcatt gcacttgagg atggcacgcc ccgcatcgtc tcgtccttca
     1381 gcgagaaggt ggtcaacccc ggggagcagt tctcactgat gtgtgcggcc aagggcgccc
     1441 cgccccccac ggtcacctgg gccctcgacg atgagcccat cgtgcgggat ggcagccacc
     1501 gcaccaacca gtacaccatg tcggacggca ccaccatcag ccacatgaac gtcacaggcc
     1561 cccagatccg cgacgggggc gtgtaccggt gcacagcgcg gaacttggtg ggcagtgctg
     1621 aatatcaggc gcgaataaac gtaagaggcc cacccagcat ccgggctatg cggaacatca
     1681 cagcagtcgc cgggcgggac acccttatca actgcagggt catcggctat ccctactact
     1741 ccatcaagtg gtacaaggat gccctgctgc tgccagacaa ccaccgccag gtggtgtttg
     1801 agaatgggac cctcaagctg actgacgtgc agaagggcat ggatgagggg gagtacctgt
     1861 gcagtgtcct catccagccc cagctctcca tcagccagag cgttcacgta gccgtcaaag
     1921 tgccccctct gatccagccc ttcgaattcc cacccgcctc catcggccag ctgctctaca
     1981 ttccctgtgt ggtgtcctcg ggggacatgc ccatccgtat cacctggagg aaggacggac
     2041 aggtgatcat ctcaggctcg ggcgtgacca tcgagagcaa ggaattcatg agctccctgc
     2101 agatctctag cgtctccctc aagcacaacg gcaactatac atgcatcgcc agcaacgcag
     2161 ccgccaccgt gagccgggag cgccagctca tcgtgcgtgt gccccctcga tttgtggtgc
     2221 aacccaacaa ccaggatggc atctacggca aagctggtgt gctcaactgc tcggtggacg
     2281 gctacccccc acccaaggtc atgtggaagc atgccaaggg gagcgggaac ccccagcagt
     2341 accaccctgt gcccctcact ggccgcatcc agatcctgcc caacagctcg ctgctgatcc
     2401 gccacgtcct agaagaggac atcggctact acctctgcca ggccagcaac ggcgtaggca
     2461 ccgacatcag caagtccatg ttcctcacag tcaagatccc ggccatgatc acttcccacc
     2521 ccaacaccac catcgccatc aagggccatg cgaaggagct aaactgcacg gcacggggtg
     2581 agcggcccat catcatccgc tgggagaagg gggacacagt catcgaccct gaccgcgtca
     2641 tgcggtatgc catcgccacc aaggacaacg gcgacgaggt cgtctccaca ctgaagctca
     2701 agcccgctga ccgtggggac tctgtgttct tcagctgcca tgccatcaac tcgtatgggg
     2761 aggaccgggg cttgatccaa ctcactgtgc aagagccccc cgacccccca gagctggaga
     2821 tccgggaggt gaaggcccgg agcatgaacc tgcgctggac ccagcgattc gacgggaaca
     2881 gcatcatcac gggcttcgac attgaataca agaacaaatc agattcctgg gacttcaagc
     2941 agtccacacg caacatctcc cccaccatca accaggccaa cattgtggac ttgcacccgg
     3001 catctgtgta cagcatccgc atgtactctt tcaacaagat tggccgcagt gaaccaagca
     3061 aggagctcac catcagcact gaggaggccg ctcccgatgg gccccccatg gatgttacct
     3121 tgcagccagt gacctcacag agcatccagg tgacctggaa ggcacccaag aaggagctgc
     3181 agaacggtgt catccggggc taccagattg gctacagaga gaacagcccc ggcagcaacg
     3241 ggcagtacag catcgtggag atgaaggcca cgggggacag cgaggtctac accctggaca
     3301 acctcaagaa gttcgcccag tatggggtgg tggtccaagc cttcaatcgg gctggcacgg
     3361 ggccctcttc cagcgagatc aatgccacca ctctggagga tgtgcccagc cagccccctg
     3421 agaacgtccg ggccctgtcc atcacttctg acgtggccgt catctcctgg tcagagcccc
     3481 cgcgcagcac cctcaatggc gtcctcaaag gctatcgggt catcttctgg tccctctatg
     3541 ttgatgggga gtggggcgag atgcagaaca tcaccaccac gcgggagcgg gtggagctgc
     3601 ggggcatgga gaagttcacc aactacagcg tccaggtgct ggcctacacc caggctgggg
     3661 acggcgtacg cagcagtgtg ctctacatcc agaccaagga ggacgttcca ggtccccctg
     3721 ctggcatcaa agctgtccct tcatcagcta gcagtgtggt tgtgtcttgg ctccccccta
     3781 ccaagcccaa cggggtgatc cgcaagtaca ccatcttctg ttccagcccc gggtctggcc
     3841 agccggctcc cagcgagtac gagacgagtc cagagcagct cttctaccgg atcgcccacc
     3901 taaaccgcgg tcagcagtat ctgctgtggg tggccgccgt cacctctgcc ggccggggca
     3961 acagcagcga gaaggtgacc atcgagcctg ctggcaaggc cccagcaaag atcatctcct
     4021 ttgggggcac cgtgacaaca ccttggatga aagatgttcg gctgccttgc aattcagtgg
     4081 gagatccagc ccctgctgtg aagtggacca aggacagtga agactcggcc attccagtgt
     4141 ccatggatgg gcaccggctc atccacacca atggcacact gctgctgcgt gcagtgaagg
     4201 ctgaggactc tggctactac acgtgcacgg ccaccaacac tggtggcttt gacaccatca
     4261 tcgtcaacct tctggtgcaa gttcccccgg accagccccg cctcactgtc tccaaaacct
     4321 cagcttcgtc catcaccctg acctggattc caggtgacaa tgggggcagc tccatccgag
     4381 gcttcgtgct acagtactcg gtggacaaca gcgaggagtg gaaggatgtg ttcatcagct
     4441 ccagcgagcg ctccttcaag ctggacagcc tcaagtgtgg cacgtggtac aaggtgaagc
     4501 tggcagccaa gaacagcgtg ggctctgggc gcatcagcga gatcatcgag gccaagaccc
     4561 acgggcggga gccctccttc agcaaagacc aacacctctt cacccacatc aactccacgc
     4621 atgctcggct taacctgcag ggctggaaca atgggggctg ccctatcaca gccatcgttc
     4681 tggagtaccg gcccaagggg acctgggcct ggcagggcct ccgggccaac agctccgggg
     4741 aggtgtttct gacggaactg cgagaggcca cgtggtacga gctgcgcatg agggcttgca
     4801 acagtgcggg ctgcggcaat gaaacagccc agttcgccac cctggactac gatggcagca
     4861 ccattccacc catcaagtct gctcaaggtg aaggggatga tgtgaagaag ctgttcacca
     4921 tcggctgccc tgtcatcctg gccacactgg gggtggcact gctcttcatc gtacgcaaga
     4981 agaggaagga gaaacggctg aagcgactcc gagatgcaaa gagtttggca gaaatgttga
     5041 taagcaagaa caatagaagc tttgacaccc ctgtgaaagg gccaccccag ggcccacggc
     5101 tacacattga catccccagg gtccagctgc tcatcgagga caaagaaggc atcaagcaac
     5161 tgggagatga caaggccacc atccctgtga cagatgctga gttcagccaa gctgtcaacc
     5221 cacagagctt ctgtactggc gtctccttgc accacccaac cctcatccag agcacaggac
     5281 ccctcatcga catgtctgac atccggccag gaaccaatcc agtgtccagg aagaatgtga
     5341 agtcagccca cagcacccgg aaccggtact caagccagtg gaccctgacc aagtgccagg
     5401 cctccacacc tgcccgcacc ctcacctccg actggcgcac cgtgggctcc cagcatggtg
     5461 tcacggtcac tgagagtgac agctacagtg ccagcctgtc ccaggacaca gacaaaggaa
     5521 ggaacagcat ggtgtccact gagagtgcct cttccaccta cgaggagctg gcccgggcct
     5581 atgagcatgc caagctggag gagcagctgc agcacgccaa gtttgagatc accgagtgct
     5641 tcatctctga cagttcctct gaccagatga ccacaggcac caacgagaac gccgacagca
     5701 tgacatccat gagcacaccc tcagagcctg gcatctgccg ctttaccgcc tcaccaccca
     5761 agccccagga tgcggaccgg ggcaaaaacg tggctgtgcc catccctcac cgggccaaca
     5821 agagtgacta ctgcaacctg cccctgtatg ccaagtcaga ggccttcttt cgaaaggcag
     5881 atggacgtga gccctgcccc gtggtcccac cccgtgaggc ctccatccgg aacctggctc
     5941 gaacctacca cacccaggct cgccacctga ccctggaccc tgccagcaag tccttgggcc
     6001 ttccccaccc aggggccccc gctgccgcct ccacagccac cttacctcag aggactctgg
     6061 ccatgccagc ccccccagcc ggcacagccc ccccagcccc cggccccacc cctgctgagc
     6121 cacccaccgc ccccagcgct gcccctccgg cccccagcac cgagcctcca cgagccgggg
     6181 gcccacacac caaaatgggg ggctccaggg actcgcttct cgagatgagc acatcggggg
     6241 tagggaggtc tcagaagcag ggggccgggg cctactccaa atcctacacc ctggtgtagg
     6301 gcccgcagga agagcagcca cgcctggacc gcgccgcgcc gcagccccac acgccagctc
     6361 ggctgttttt ctgcattatt tatattcaac tgacagacaa aaaccaacca acgacaaaac
     6421 aaaaaccccc aatcatgaac gcctgtacat agaactcttt tgtacaaatg aaactatttt
     6481 cttcttctcc atgaagccag ggcacaaaga atttgacagt acaagtcaaa tcccccaccc
     6541 cacaaaatat gtgtggagat atatatacat atatagacag acaggaacgc gtccacgagc
     6601 tatatatcta tatatttctc tcaccctatt ttgagacaga ggcacaaaga ctcagcaatt
     6661 tttttccctc ctcctcacct tccccccagt ctaggtggtt ttgacaaaga ccaaaatccc
     6721 aactcagaga cactgcatgc gattttactg ttccaagaaa accaggagtt gcttcaattt
     6781 gcagatgctt atgtgttaat acctttttct atgaaaaaag acccagcgcc gtgtgcaata
     6841 aaggttatgt ttcta
//
