LOCUS       NM_001941               7583 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3a, mRNA.
ACCESSION   NM_001941
VERSION     NM_001941.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7583)
  AUTHORS   Saleh,M.A., Said,R.M., Ahmed Rashed,L.A. and El-Kalioby,M.
  TITLE     Upregulation of Anti-Desmocollin 3 Antibodies in Pemphigus
            Diseases: A Case-control Study
  JOURNAL   Acta Dermatovenerol Croat 31 (4), 178-183 (2023)
   PUBMED   38651843
  REMARK    GeneRIF: Upregulation of Anti-Desmocollin 3 Antibodies in Pemphigus
            Diseases: A Case-control Study.
REFERENCE   2  (bases 1 to 7583)
  AUTHORS   Kawamura,T., Muramatsu,K., Orita,A., Mai,Y., Sugai,T., Haga,N.,
            Fujimura,Y., Miyauchi,T., Izumi,K., Koga,H., Ishii,N. and Ujiie,H.
  TITLE     Two cases of Hallopeau-type pemphigus vegetans with anti-desmoglein
            1 and anti-desmocollin 3 antibodies without mucosal involvement
  JOURNAL   J Eur Acad Dermatol Venereol 37 (4), e508-e510 (2023)
   PUBMED   36305887
  REMARK    GeneRIF: Two cases of Hallopeau-type pemphigus vegetans with
            anti-desmoglein 1 and anti-desmocollin 3 antibodies without mucosal
            involvement.
REFERENCE   3  (bases 1 to 7583)
  AUTHORS   Koga,H., Teye,K., Otsuji,Y., Ishii,N., Hashimoto,T. and Nakama,T.
  TITLE     Autoantibodies to DSC3 in Pemphigus Exclusively Recognize
            Calcium-Dependent Epitope in Extracellular Domain 2
  JOURNAL   J Invest Dermatol 141 (9), 2123-2131 (2021)
   PUBMED   33766509
  REMARK    GeneRIF: Autoantibodies to DSC3 in Pemphigus Exclusively Recognize
            Calcium-Dependent Epitope in Extracellular Domain 2.
REFERENCE   4  (bases 1 to 7583)
  AUTHORS   Cui,T., Yang,L., Ma,Y., Petersen,I. and Chen,Y.
  TITLE     Desmocollin 3 has a tumor suppressive activity through inhibition
            of AKT pathway in colorectal cancer
  JOURNAL   Exp Cell Res 378 (2), 124-130 (2019)
   PUBMED   30857973
  REMARK    GeneRIF: DSC3 suppresses colorectal cancer cell growth through
            inhibition of AKT pathway and regulation of E-cadherin
REFERENCE   5  (bases 1 to 7583)
  AUTHORS   Gadhavi,P.L., Greenwood,M.D., Strom,M., King,I.A. and Buxton,R.S.
  TITLE     The regulatory region of the human desmocollin 3 promoter forms a
            DNA four-way junction
  JOURNAL   Biochem Biophys Res Commun 281 (2), 520-528 (2001)
   PUBMED   11181078
REFERENCE   6  (bases 1 to 7583)
  AUTHORS   Whittock,N.V., Hunt,D.M., Rickman,L., Malhi,S., Vogazianou,A.P.,
            Dawson,L.F., Eady,R.A., Buxton,R.S. and McGrath,J.A.
  TITLE     Genomic organization and amplification of the human desmosomal
            cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3
  JOURNAL   Biochem Biophys Res Commun 276 (2), 454-460 (2000)
   PUBMED   11027496
REFERENCE   7  (bases 1 to 7583)
  AUTHORS   King,I.A., Sullivan,K.H., Bennett,R. Jr. and Buxton,R.S.
  TITLE     The desmocollins of human foreskin epidermis: identification and
            chromosomal assignment of a third gene and expression patterns of
            the three isoforms
  JOURNAL   J Invest Dermatol 105 (3), 314-321 (1995)
   PUBMED   7665906
REFERENCE   8  (bases 1 to 7583)
  AUTHORS   Amagai,M., Wang,Y., Minoshima,S., Kawamura,K., Green,K.J.,
            Nishikawa,T. and Shimizu,N.
  TITLE     Assignment of the human genes for desmocollin 3 (DSC3) and
            desmocollin 4 (DSC4) to chromosome 18q12
  JOURNAL   Genomics 25 (1), 330-332 (1995)
   PUBMED   7774948
REFERENCE   9  (bases 1 to 7583)
  AUTHORS   Kawamura,K., Watanabe,K., Suzuki,T., Yamakawa,T., Kamiyama,T.,
            Nakagawa,H. and Tsurufuji,S.
  TITLE     cDNA cloning and expression of a novel human desmocollin
  JOURNAL   J Biol Chem 269 (42), 26295-26302 (1994)
   PUBMED   7929347
REFERENCE   10 (bases 1 to 7583)
  AUTHORS   Arnemann,J., Spurr,N.K., Wheeler,G.N., Parker,A.E. and Buxton,R.S.
  TITLE     Chromosomal assignment of the human genes coding for the major
            proteins of the desmosome junction, desmoglein DGI (DSG),
            desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and
            plakoglobin DPIII (JUP)
  JOURNAL   Genomics 10 (3), 640-645 (1991)
   PUBMED   1889810
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA860471.1, D17427.1,
            AC025212.5 and AI123917.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001941.4.
            
            Summary: The protein encoded by this gene is a calcium-dependent
            glycoprotein that is a member of the desmocollin subfamily of the
            cadherin superfamily. These desmosomal family members, along with
            the desmogleins, are found primarily in epithelial cells where they
            constitute the adhesive proteins of the desmosome cell-cell
            junction and are required for cell adhesion and desmosome
            formation. The desmosomal family members are arranged in two
            clusters on chromosome 18, occupying less than 650 kb combined.
            Mutations in this gene are a cause of hypotrichosis and recurrent
            skin vesicles disorder. The protein can act as an autoantigen in
            pemphigus diseases, and it is also considered to be a biomarker for
            some cancers. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (Dsc3a) represents the shorter
            transcript but encodes the longer isoform (Dsc3a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17427.1, X83929.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360428.9/ ENSP00000353608.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA860471.1         74-104
            32-3035             D17427.1           17-3020
            3036-7088           AC025212.5         127767-131819       c
            7089-7583           AI123917.1         1-495               c
FEATURES             Location/Qualifiers
     source          1..7583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7583
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="desmocollin 3"
                     /db_xref="GeneID:1825"
                     /db_xref="HGNC:HGNC:3037"
                     /db_xref="MIM:600271"
     exon            1..151
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2773
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="isoform Dsc3a preproprotein is encoded by
                     transcript variant Dsc3a; desmocollin-4; cadherin family
                     member 3"
                     /codon_start=1
                     /product="desmocollin-3 isoform Dsc3a preproprotein"
                     /protein_id="NP_001932.2"
                     /db_xref="CCDS:CCDS32810.1"
                     /db_xref="GeneID:1825"
                     /db_xref="HGNC:HGNC:3037"
                     /db_xref="MIM:600271"
                     /translation="MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLE
                     ADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKR
                     KQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVE
                     SDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTA
                     DGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTM
                     HTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFG
                     LIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVN
                     FTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRV
                     TALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRY
                     KKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVN
                     IEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWS
                     LTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSR
                     STGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAP
                     GDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHH
                     HTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEG
                     RGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR"
     exon            152..236
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            237..436
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            437..556
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            557..712
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            713..857
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1024
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1159
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1345
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1602
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1745
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1970
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2195
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2317
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2575
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..7583
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5863..5868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="hexamer: AATAAA"
     polyA_site      5883
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="major polyA site"
     regulatory      6122..6127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="hexamer: AATAAA"
     polyA_site      6149
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="major polyA site"
     regulatory      6552..6557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="hexamer: AGTAAA"
     polyA_site      6574
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="major polyA site"
     regulatory      6728..6733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="hexamer: ATTAAA"
     polyA_site      6750
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="major polyA site"
     regulatory      7568..7573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="hexamer: AATGAA"
     polyA_site      7583
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
ORIGIN      
        1 ctcccgcgcc ctgcacctcg gcaggtctcg ctctcggcac cctcccggcg cccgcgttct
       61 cctggccctg cccggcatcc cgatggccgc cgctgggccc cggcgctccg tgcgcggagc
      121 cgtctgcctg catctgctgc tgaccctcgt gatcttcagt cgtgctggtg aagcctgcaa
      181 aaaggtgata cttaatgtac cttctaaact agaggcagac aaaataattg gcagagttaa
      241 tttggaagag tgcttcaggt ctgcagacct catccggtca agtgatcctg atttcagagt
      301 tctaaatgat gggtcagtgt acacagccag ggctgttgcg ctgtctgata agaaaagatc
      361 atttaccata tggctttctg acaaaaggaa acagacacag aaagaggtta ctgtgctgct
      421 agaacatcag aagaaggtat cgaagacaag acacactaga gaaactgttc tcaggcgtgc
      481 caagaggaga tgggcaccta ttccttgctc tatgcaagag aattccttgg gccctttccc
      541 attgtttctt caacaagttg aatctgatgc agcacagaac tatactgtct tctactcaat
      601 aagtggacgt ggagttgata aagaaccttt aaatttgttt tatatagaaa gagacactgg
      661 aaatctattt tgcactcggc ctgtggatcg tgaagaatat gatgtttttg atttgattgc
      721 ttatgcgtca actgcagatg gatattcagc agatctgccc ctcccactac ccatcagggt
      781 agaggatgaa aatgacaacc accctgtttt cacagaagca atttataatt ttgaagtttt
      841 ggaaagtagt agacctggta ctacagtggg ggtggtttgt gccacagaca gagatgaacc
      901 ggacacaatg catacgcgcc tgaaatacag cattttgcag cagacaccaa ggtcacctgg
      961 gctcttttct gtgcatccca gcacaggcgt aatcaccaca gtctctcatt atttggacag
     1021 agaggttgta gacaagtact cattgataat gaaagtacaa gacatggatg gccagttttt
     1081 tggattgata ggcacatcaa cttgtatcat aacagtaaca gattcaaatg ataatgcacc
     1141 cactttcaga caaaatgctt atgaagcatt tgtagaggaa aatgcattca atgtggaaat
     1201 cttacgaata cctatagaag ataaggattt aattaacact gccaattgga gagtcaattt
     1261 taccatttta aagggaaatg aaaatggaca tttcaaaatc agcacagaca aagaaactaa
     1321 tgaaggtgtt ctttctgttg taaagccact gaattatgaa gaaaaccgtc aagtgaacct
     1381 ggaaattgga gtaaacaatg aagcgccatt tgctagagat attcccagag tgacagcctt
     1441 gaacagagcc ttggttacag ttcatgtgag ggatctggat gaggggcctg aatgcactcc
     1501 tgcagcccaa tatgtgcgga ttaaagaaaa cttagcagtg gggtcaaaga tcaacggcta
     1561 taaggcatat gaccccgaaa atagaaatgg caatggttta aggtacaaaa aattgcatga
     1621 tcctaaaggt tggatcacca ttgatgaaat ttcagggtca atcataactt ccaaaatcct
     1681 ggatagggag gttgaaactc ccaaaaatga gttgtataat attacagtcc tggcaataga
     1741 caaagatgat agatcatgta ctggaacact tgctgtgaac attgaagatg taaatgataa
     1801 tccaccagaa atacttcaag aatatgtagt catttgcaaa ccaaaaatgg ggtataccga
     1861 cattttagct gttgatcctg atgaacctgt ccatggagct ccattttatt tcagtttgcc
     1921 caatacttct ccagaaatca gtagactgtg gagcctcacc aaagttaatg atacagctgc
     1981 ccgtctttca tatcagaaaa atgctggatt tcaagaatat accattccta ttactgtaaa
     2041 agacagggcc ggccaagctg caacaaaatt attgagagtt aatctgtgtg aatgtactca
     2101 tccaactcag tgtcgtgcga cttcaaggag tacaggagta atacttggaa aatgggcaat
     2161 ccttgcaata ttactgggta tagcactgct cttttctgta ttgctaactt tagtatgtgg
     2221 agtttttggt gcaactaaag ggaaacgttt tcctgaagat ttagcacagc aaaacttaat
     2281 tatatcaaac acagaagcac ctggagacga tagagtgtgc tctgccaatg gatttatgac
     2341 ccaaactacc aacaactcta gccaaggttt ttgtggtact atgggatcag gaatgaaaaa
     2401 tggagggcag gaaaccattg aaatgatgaa aggaggaaac cagaccttgg aatcctgccg
     2461 gggggctggg catcatcata ccctggactc ctgcagggga ggacacacgg aggtggacaa
     2521 ctgcagatac acttactcgg agtggcacag ttttactcaa ccccgtctcg gtgaaaaatt
     2581 gcatcgatgt aatcagaatg aagaccgcat gccatcccaa gattatgtcc tcacttataa
     2641 ctatgaggga agaggatctc cagctggttc tgtgggctgc tgcagtgaaa agcaggaaga
     2701 agatggcctt gactttttaa ataatttgga acccaaattt attacattag cagaagcatg
     2761 cacaaagaga taatgtcaca gtgctacaat taggtctttg tcagacattc tggaggtttc
     2821 caaaaataat attgtaaagt tcaatttcaa catgtatgta tatgatgatt tttttctcaa
     2881 ttttgaatta tgctactcac caatttatat ttttaaagca agttgttgct tatcttttcc
     2941 aaaaagtgaa aaatgttaaa acagacaact ggtaaatctc aaactccagc actggaatta
     3001 aggtctctaa agcatctgct cttttttttt tttacggata ttttagtaat aaatatgctg
     3061 gataaatatt agtccaacaa tagctaagtt atgctaatat cacattatta tgtattcact
     3121 ttaagtgata gtttaaaaaa taaacaagaa atattgagta tcactatgtg aagaaagttt
     3181 tggaaaagaa acaatgaaga ctgaattaaa ttaaaaatgt tgcagctcat aaagaattgg
     3241 gactcacccc tactgcacta ccaaattcat ttgactttgg aggcaaaatg tgttgaagtg
     3301 ccctatgaag tagcaatttt ctataggaat atagttggaa ataaatgtgt gtgtgtatat
     3361 tattattaat caatgcaata tttaaaatga aatgagaaca aagaggaaaa tggtaaaaac
     3421 ttgaaatgag gctggggtat agtttgtcct acaatagaaa aaagagagag cttcctaggc
     3481 ctgggctctt aaatgctgca ttataactga gtctatgagg aaatagttcc tgtccaattt
     3541 gtgtaatttg tttaaaattg taaataaatt aaacttttct ggtttctgtg ggaaggaaat
     3601 agggaatcca atggaacagt agctttgctt tgcagtctgt ttcaagattt ctgcatccac
     3661 aagttagtag caaactgggg aatactcgct gcagctgggg ttccctgctt tttggtagca
     3721 agggtccaga gatgaggtgt ttttttcggg gagctaataa caaaaacatt ttaaaactta
     3781 cctttactga agttaaatcc tctattgctg tttctattct ctcttatagt gaccaacatc
     3841 tttttaattt agatccaaat aaccatgtcc tcctagagtt tagaggctag agggagctga
     3901 ggggaggatc ttactgaaag caccctgggg agattgattg tccttaaacc taagccccac
     3961 aaacttgaca cctgatcagg tctgggagct acaaaatttc atttttctcc tcactgccct
     4021 tcttctgagt ggcattggcc tgaatcaagg aaagccaggc cttgtgggcc cccttctttc
     4081 ggctttctgc taaagcaaca cctccagcag agattccctt aagtgactcc aggttttcca
     4141 ccatccttca gcgtgaatta atttttaatc agtttgcttt ctccagagaa attttaaaat
     4201 aatagaagaa atagaaattt tgaatgtata aaagaaaaag atcaagttgt cattttagaa
     4261 cagagggaac tttgggagaa agcagcccaa gtaggttatt tgtacagtca gagggcaaca
     4321 ggaagatgca ggccttcaag ggcaaggaga ggccacaagg aatatgggtg ggagtaaaag
     4381 caacatcgtc tgcttcatac tttttcctag gcttggcact gccttttcct ttctcaggcc
     4441 aatggcaact gccatttgag tccggtgagg gatcagccaa cctcttctct atggctcacc
     4501 ttatttggag tgagaaatca aggagacaga gctgactgca tgatgagtct gaaggcattt
     4561 gcaggatgag cctgaactgg ttgtgcagaa caaacaaggc attcatggga attgttgtat
     4621 tccttctgca gccctccttc tgggcactaa gaaggtctat gaattaaatg cctatctaaa
     4681 attctgattt attcctacat tttctgtttt ctaatttgac cctaaaatct atgtgtttta
     4741 gacttagact ttttattgcc cccccccccc cctttttttt ttgagacgga gtctcgctct
     4801 gacgcacagg ctggagtgca gtggctccga tctctgctca ctgaaagctc cgcctcccgg
     4861 gttcacgcca ttctcctgcc tcagcctcct gagtagctgg gactacaggc gcccaccacc
     4921 acgcccggct aattttttgt atttttaata gagacggggt ttcactgtgt tagccaggat
     4981 ggtctcgatc tcctgacctc gtgatccgcc tgcctcggcc tcccaaagtg ctgggattac
     5041 aggcatgacc caccgctccc ggccttgttt tccgtttaaa gtcgtcttct tttaatgtaa
     5101 tcattttgaa catgtgtgaa agttgatcat acgaattgga tcaatcttga aatactcaac
     5161 caaaagacag tcgagaagcc agggggagaa agaactcagg gcacaaaata ttggtctgag
     5221 aatggaattc tctgtaagcc tagttgctga aatttcctgc tgtatccaga agccagtttt
     5281 atctaacggc tactgaaaca cccactgtgt tttgctcact ccctcactca ccgatcaaaa
     5341 cctgctacct ccccaagact ttactagtgc cgataaactt tctcaaagag caaccagtat
     5401 cacttccctg tttataaaac ctctaaccat ctctttgttc tttgaacatg ctgaaaacca
     5461 cctggtctgc atgtatgccc gaatttgtaa ttcttttctc tcaaatgaaa atttaatttt
     5521 agggattcat ttctatattt tcacatatgt agtattatta tttccttata tgtgtaaggt
     5581 gaaatttatg gtatttgagt gtgcaagaaa atatattttt aaagctttca tttttccccc
     5641 agtgaatgat ttagaatttt ttatgtaaat atacagaatg ttttttctta cttttataag
     5701 gaagcagctg tctaaaatgc agtggggttt gttttgcaat gttttaaaca gagttttagt
     5761 attgctatta aaagaagtta ctttgctttt aaagaaactt ggctgcttaa aataagcaaa
     5821 aattggatgc gtaaagtaat atttacagat gtggggagat gtaataaaac aatattaact
     5881 tggtttcttg tttttgctgt atttagagat taaataattc taagatgatc actttgcaaa
     5941 attatgctta tggctggcat ggaaatagaa ataattatgt ctttgttgta ttaatgggga
     6001 atattttgga caatgtttca ttatcaaatt gtcgacatca ttaatatata ttgtaatgtt
     6061 gggaagagat cactattttg aagcacagct ttacagatga gtatctatga tacatatgta
     6121 taataaattt tgattgggta ttaaaagtat tagaaggtgg ttataattgc agagtattcc
     6181 atgaatagta cactgacaca ggggttttac tttgaggacc agtgtagtca agggaaaaca
     6241 tgagttaaaa agaaaagcag gcgatattgc agtcttgatt ctgccactta caggatagat
     6301 aacgcctgaa ctttaatgac aagatgatcc aaccataaag gtgctctgtg cttcacagtg
     6361 aatcttttcc ccatgcagga gtgtgctccc ctacaaacgt taagactgat catttcaaaa
     6421 atctattagc tatatcaaaa gccttacatt ttaatatagg ttgaaccaaa atttcaattc
     6481 cagtaacttc tattgtaacc attatttttg tgtatgtctt caagaatgtt cattggattt
     6541 ttgtttgtaa tagtaaaata ccggatacat ttcacgtgtc cttcagtatt gatttggttg
     6601 aatattgggt cataatggtt gagaagcatg gacactagag ccagaatgct tggatatgaa
     6661 tcctggatct gtcacttact tctgtgtgac ctttgaaagg ctacttattt cctctcttag
     6721 ctttctcatt aaaatcaatg aacaatgcca gcctcatggg gttgttgaat gattaaatga
     6781 gttactatac ctaaagtaca tagaacactg cctgcacata gtaaaagaat tataagtgtg
     6841 aggtagttgg taaaattatg tagttggata tactaccgaa caatatctca tctcttttta
     6901 gggaaataaa gtttgtgcat atatataatc ccgaaacatg atttccagac aatggaattg
     6961 ataatttatt ctttctgtgt tgattttttc acaatgaaca ttgataacac ttattttatt
     7021 ttaagttcca ggatacacgt gcaggatgtg caggtttgtt acataggtaa acgtgtccca
     7081 tggtggtttg ctgcacctat caacctgata acatttttaa tttaagaaaa aggttaatac
     7141 cagcttagac agtttatttt ggctcttata ttatttagaa ttaggcttgg tttcatgggc
     7201 agaaaaatta aatagtattc agaacatgtt tacgggcttc tgtattcgac agtttatttt
     7261 gattgcaaag gtttgaatct cagaaccttc ttttcccttt acttaaaaaa tggtaaaatt
     7321 cataaaacat ggctatgaat ggttaaaatt catcattttc accattttaa agtgtataat
     7381 tcagtgactt tagtacattt aaaatgttgt gaaactgtta ccactatcta gttctggaac
     7441 attttcatca ccccaagagg aaacctttta agcagtcatt ctcctcttcc cctccctgca
     7501 ttatcccctg gcaaccactg atatcttttc tgtctctatg gatttgccta ctctggacat
     7561 tcatataaat gaaatcgtac ata
//
