LOCUS       NM_001939               7282 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dystrophin related protein 2 (DRP2), transcript
            variant 1, mRNA.
ACCESSION   NM_001939
VERSION     NM_001939.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7282)
  AUTHORS   Sivera,R., Pelayo-Negro,A.L., Jerico,I., Dominguez-Gonzalez,C.,
            Horga,A., Rodriguez De Rivera,F.J., Gallardo,E., Tembl,J.I.,
            Bermejo-Guerrero,L., Pagola Lorz,M.I., Azorin,I., Cordoba,M.,
            Fenollar-Cortes,M.D.M., Millet,E., Vilchez,J.J., Espinos,C.,
            Apellaniz-Ruiz,M. and Sevilla,T.
  TITLE     Expanding the Clinical Spectrum of DRP2-Associated
            Charcot-Marie-Tooth Disease
  JOURNAL   Neurology 102 (7), e209174 (2024)
   PUBMED   38513194
  REMARK    GeneRIF: Expanding the Clinical Spectrum of DRP2-Associated
            Charcot-Marie-Tooth Disease.
REFERENCE   2  (bases 1 to 7282)
  AUTHORS   Toma,C., Torrico,B., Hervas,A., Valdes-Mas,R., Tristan-Noguero,A.,
            Padillo,V., Maristany,M., Salgado,M., Arenas,C., Puente,X.S.,
            Bayes,M. and Cormand,B.
  TITLE     Exome sequencing in multiplex autism families suggests a major role
            for heterozygous truncating mutations
  JOURNAL   Mol Psychiatry 19 (7), 784-790 (2014)
   PUBMED   23999528
  REMARK    GeneRIF: Among the genes found disrupted in this study, there is
            evidence suggesting that YWHAZ and also the X-linked DRP2 may be
            considered as novel autism candidate genes.
REFERENCE   3  (bases 1 to 7282)
  AUTHORS   Sediva,A., Smith,C.I., Asplund,A.C., Hadac,J., Janda,A., Zeman,J.,
            Hansikova,H., Dvorakova,L., Mrazova,L., Velbri,S., Koehler,C.,
            Roesch,K., Sullivan,K.E., Futatani,T. and Ochs,H.D.
  TITLE     Contiguous X-chromosome deletion syndrome encompassing the BTK,
            TIMM8A, TAF7L, and DRP2 genes
  JOURNAL   J Clin Immunol 27 (6), 640-646 (2007)
   PUBMED   17851739
REFERENCE   4  (bases 1 to 7282)
  AUTHORS   Sherman,D.L., Fabrizi,C., Gillespie,C.S. and Brophy,P.J.
  TITLE     Specific disruption of a schwann cell dystrophin-related protein
            complex in a demyelinating neuropathy
  JOURNAL   Neuron 30 (3), 677-687 (2001)
   PUBMED   11430802
REFERENCE   5  (bases 1 to 7282)
  AUTHORS   Tommasi di Vignano,A., Di Zenzo,G., Sudol,M., Cesareni,G. and
            Dente,L.
  TITLE     Contribution of the different modules in the utrophin
            carboxy-terminal region to the formation and regulation of the DAP
            complex
  JOURNAL   FEBS Lett 471 (2-3), 229-234 (2000)
   PUBMED   10767429
REFERENCE   6  (bases 1 to 7282)
  AUTHORS   Roberts,R.G., Freeman,T.C., Kendall,E., Vetrie,D.L., Dixon,A.K.,
            Shaw-Smith,C., Bone,Q. and Bobrow,M.
  TITLE     Characterization of DRP2, a novel human dystrophin homologue
  JOURNAL   Nat Genet 13 (2), 223-226 (1996)
   PUBMED   8640231
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z70280.1, BC111695.1 and
            Z68331.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_001939.2.
            
            Summary: Members of the dystrophin family of proteins perform a
            critical role in the maintenance of membrane-associated complexes
            at points of intercellular contact in vertebrate cells. The protein
            encoded by this gene is predicted to resemble certain short
            C-terminal isoforms of dystrophin and dystrophin-related protein 1
            (DRP1 or utrophin). DRP2 is expressed principally in the brain and
            spinal cord. Two transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genome sequence data because no single transcript was available for
            the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289825.1, BC111695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395209.8/ ENSP00000378635.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               Z70280.1           3141-3298           c
            159-325             Z70280.1           2974-3140           c
            326-3512            BC111695.1         5-3191
            3513-7276           Z68331.3           14942-18705
            7277-7282           Z68331.3           18706-18711
FEATURES             Location/Qualifiers
     source          1..7282
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..7282
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /note="dystrophin related protein 2"
                     /db_xref="GeneID:1821"
                     /db_xref="HGNC:HGNC:3032"
                     /db_xref="MIM:300052"
     exon            1..361
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..464
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..644
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             528..3401
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="dystrophin-related protein 2 isoform 1"
                     /protein_id="NP_001930.2"
                     /db_xref="CCDS:CCDS14480.2"
                     /db_xref="GeneID:1821"
                     /db_xref="HGNC:HGNC:3032"
                     /db_xref="MIM:300052"
                     /translation="MQPMVMQGCPYTLPRCHDWQAADQFHHSSSLRSTCPHPQVRAAV
                     TSPAPPQDGAGVPCLSLKLLNGSVGASGPLEPPAMNLCWNEIKKKSHNLRARLEAFSD
                     HSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIY
                     SVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNLSRFVWKQATVASELWEKLTAR
                     CVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWEPIGDLFIDSLPEHIQAIK
                     LFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMENSQALEQINVRWKQLQASVSERLKQ
                     LQDAHRDFGPGSQHFLSSSVQVPWERAISPNKVPYYINHQAQTTCWDHPKMTELYQTL
                     ADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQASEHVMDVVEVIHC
                     LTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKTGIACLCGTEV
                     KEKLQYLFSQVANSGSQCDQRHLGVLLHEAIQVPRQLGEVAAFGGSNVEPSVRSCFRF
                     STGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQCPIKGFRYR
                     SLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFRSKHY
                     FSKHPQRGYLPVQSVLEADYSETPASSPMWPHADTHSRIEHFASRLAEMESQNCSFFN
                     DSLSPDDSIDEDQYLLRHSSPITDREPAFGQQAPCSVATESKGELQKILAHLEDENRI
                     LQGELRRLKWQHEEAAEAPSLADGSTEAATDHRNEELLAEARILRQHKSRLETRMQIL
                     EDHNKQLESQLQRLRELLLQPPTESDGSGSAGSSLASSPQQSEGSHPREKGQTTPDTE
                     AADDVGSKSQDVSLCLEDIMEKLRHAFPSVRSSDVTANTLLAS"
     exon            645..808
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..965
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1086
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1355
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1502
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1581
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1642
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1704
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1779
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1981
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2067
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2225
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2392
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2504
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2641
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2707
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2773
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2917
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3155
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3276
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..7282
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4834..4839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /note="hexamer: ATTAAA"
     polyA_site      4856
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /note="major polyA site"
     regulatory      7258..7263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /note="hexamer: AATAAA"
     polyA_site      7282
                     /gene="DRP2"
                     /gene_synonym="DRP-2"
                     /note="major polyA site"
ORIGIN      
        1 cgctttcctc ctctgcttct aatgaattga catctccaag agccgccaca tctctggtag
       61 ttttacaaaa ctgtccttgc tcttcctgcg tttgcccagt caagggtatt tttgcctgag
      121 gtcggaatga tgctgttagt cctggtgata tgattgcata gcaacacaga gcagctctga
      181 gaggggagga ggaggagaag aaggaagaca gggaagtggg agagacagag ggagagtgtg
      241 catacagcag ctgtcggcat ccctgtctca gggacttctt tgctgattca cagaggcagc
      301 ccagccccgg cctcccagct tacagctgcc gcctgcttct cagacctgac ggaatcagaa
      361 gctacataat attcgccgtg tgagtggcta tcgtaataga taacatttga atatctacta
      421 aatgccagaa actatgaatt aactcctctc aacaaagcta agaggtgctt aatgatcaat
      481 agttggtgca ctgcctatcc tcatcccccc catgagcctt ggtttttatg caacctatgg
      541 tcatgcaggg atgcccttac accctcccac gatgtcatga ctggcaggca gctgaccagt
      601 tccatcatag cagcagcctc cgaagcacct gcccccaccc tcaggttaga gctgctgtca
      661 ccagccctgc acctcctcaa gatggtgctg gggttccctg cctaagccta aagctgttga
      721 acgggtctgt tggtgcctct ggacccctgg aaccaccagc catgaatctg tgttggaatg
      781 aaataaaaaa gaagtctcac aacctccgcg ctcgcctaga ggccttctca gaccacagtg
      841 gaaagcttca gctccctctt caagagatta ttgactggct cagccaaaag gatgaggagt
      901 tgtcagctca gctgccccta cagggggatg tggccctggt gcaacaggag aaggagacac
      961 atgcggcctt tatggaagaa gtcaagtctc ggggccccta catctattct gtgctggagt
     1021 cagctcaggc cttcctgtcc cagcacccat ttgaggagtt agaggagcct cattctgaga
     1081 gcaaagatac ctccccgaaa cagcggatcc agaatctcag ccgctttgta tggaagcagg
     1141 cgacggtggc cagtgaactg tgggagaagt tgacagcccg ctgtgtggac cagcaccgtc
     1201 acattgagcg gactctggag cagctcttgg agattcaagg ggcaatggag gaactaagca
     1261 ctactctgag ccaagctgag ggagtccgag ccacttggga gcccattggg gatctcttca
     1321 ttgattcact cccagagcac atccaggcta ttaagctgtt caaagaagaa ttctccccca
     1381 tgaaagatgg agtaaagttg gtgaatgatc tggcccacca acttgccatt tctgatgtgc
     1441 acttgtcaat ggagaattcc caggccctgg aacagatcaa cgtccgatgg aaacaactac
     1501 aggcgtcagt tagtgagagg cttaagcagc tccaggatgc ccaccgggac tttgggcctg
     1561 ggtcacagca ctttctctcc tcctctgtcc aggttccctg ggaaagagca atttcaccca
     1621 ataaagttcc ctactacatc aaccaccagg ctcagaccac atgctgggac catcccaaga
     1681 tgacagagtt ataccaaacc ctagctgatc tgaacaacat taagttctca gcttatcgca
     1741 ctgccatgaa actccgcaga gtccagaaag ccctgcgctt ggacctggta actttaacca
     1801 cagccctgga aatcttcaat gagcatgatc tgcaggccag tgagcacgtg atggatgtgg
     1861 tagaggtcat tcactgcctg actgccttat atgaacgttt ggaggaggaa agaggcatcc
     1921 tggtcaacgt gccactctgt gtggacatga gcctcaattg gctcctcaat gtttttgata
     1981 gtggtcgcag cggaaagatg cgggcattgt cttttaagac tggcattgca tgcttgtgtg
     2041 gcacggaagt gaaggaaaaa cttcagtacc tcttcagcca agtggccaac tcaggcagcc
     2101 agtgtgacca gcgccacctt ggtgtcctgc ttcatgaggc cattcaggtg ccccgtcagc
     2161 tgggtgaagt ggcagccttt gggggcagca atgtggagcc cagtgtccgt agttgcttcc
     2221 gttttagcac cgggaagcca gtcattgaag catcccagtt cctggagtgg gtcaacctgg
     2281 agccccagtc catggtgtgg ctggctgttc tgcatcgggt caccattgct gagcaagtga
     2341 agcatcagac caagtgctct atctgtaggc agtgccccat caaggggttc aggtaccgga
     2401 gtctgaagca attcaacgtt gacatctgcc agacctgctt cttgacaggc agggccagca
     2461 aaggcaataa gctgcactac cccatcatgg agtattacac accgaccaca tccagtgaga
     2521 acatgaggga ctttgccaca accttaaaga acaaattccg ctccaagcat tatttcagca
     2581 aacaccctca gcgaggttat ctgcctgtgc aatcagtgct ggaggctgac tacagtgaga
     2641 cgccggcttc ttccccgatg tggccacacg ccgacacaca ctcccgaatt gagcattttg
     2701 ccagcaggct tgctgagatg gaaagtcaaa attgctcctt ctttaatgac agcttgtccc
     2761 cagatgacag catagacgag gaccagtacc tgctgcggca ctccagcccc atcacagacc
     2821 gggagccagc ctttggacag caggctccat gcagtgtggc cacagaaagc aaaggggagc
     2881 tacagaagat cctggcccac ttggaagatg agaaccggat tctccaggga gagctgaggc
     2941 gcctgaagtg gcagcatgag gaggcagctg aggcacccag tctggctgac ggctccactg
     3001 aggcagcaac agaccaccgc aatgaggagc ttctggccga ggcccgtatc cttcggcaac
     3061 ataagagccg cctggagacg cgcatgcaga tcctcgaaga tcacaacaag cagctagagt
     3121 cccagctgca gcgtctgagg gagcttctcc tgcagccacc caccgaatca gatggcagtg
     3181 gctctgcagg ctcgtcccta gcttcctctc cacagcagtc agaaggcagt cacccccggg
     3241 agaagggaca gactactcca gataccgagg ctgcagatga tgtggggtca aagagccagg
     3301 atgtcagcct gtgcttggag gacatcatgg agaaactccg tcatgccttc cccagtgtgc
     3361 gaagttctga tgtgactgcc aacaccctgc tggcctcttg atggagccag atccccatcc
     3421 tatagttcat agtcctctcc tggttccggt caaagccttt cctcagcctt cacccaacct
     3481 ttccagtttc cactggcccc acattcctca actagtatta tttgggctct gggcagcagc
     3541 agggatctgg tggtatgtga ggtgcatgcg ggcagtgatg ggagaagggg aggcatgatt
     3601 cttctgaccc tagaaatgtt ccctttaatc ttcaagttcg agatcagccc tttaagtacc
     3661 tttctgttgc agcccaggca aatatcactt ggccattcag atggggagca gagaagctgc
     3721 cttgcagagc taagcggtac atgttggccc ctcttccttc tccgtggaat tatggaaaga
     3781 gagaagccta attaccccaa ggttccatcc agcattatga atccacaggg tttaccccta
     3841 ctctctggcg caactcaggg aggcaaaagg gtatccccga gacaccttcc ccaccccaag
     3901 tgcccctgaa aaagtctggg cagtgtgtgt tctattactt cagctccagg acagattgct
     3961 agccatccta atgctaccta ggtattggtt tctcctcaaa tatcttcatt ttctttagcc
     4021 tcagtccctg acagaccttc cttaagggga gaacagttca ttctggttct tctacgttat
     4081 atttggaagc attaaatcca tacttatggg tttagatttt ttttttgccc cacatcttcc
     4141 tatttcttaa agtcctcagc attttgagag acccactgag ttgcgagttg ctctggaaac
     4201 ctggctgaag ccaccctttg ctcctctgag tctgtcctca cagacctgag gacacagtgg
     4261 cagcttgctg agcaagggag tgttgctttc cttgggtaag gaagaggaag cccacctcaa
     4321 gtctggagta gtatgactgc catccaacac ccttccaggc tgtgaccctt ctagctctca
     4381 ggctgaatca ggtgaggtgg ctgattgtcc ccagctaatc ataaggcatt tgcaactggc
     4441 taccgtgtgt agtggcccct ccataggagc cacaggccac aaatcaggaa gctggccact
     4501 ttccacccag acaacaacag caaggccttc ctgtgcctaa aattgttatt tctaactctg
     4561 gaaggtgaat ccaatcctca aactgaacta gctcttccta ggcgacatat accatgatct
     4621 ctttatccag aaactgttca gaatagatag taggggtggg ggagtgggct tgggaatgtt
     4681 gaatagattc agagcccact taggcagctt tctcccaaga ggagctttat aacctagagc
     4741 cctgcagttg acttcatttg cctaagttta tatacataca tatctattct acatatctac
     4801 tgtacatcag tgctctcctg gcctcactca cacattaaat tctaatacct cttgaagtat
     4861 taatgttctg ccttgctctt tgttagcccc agcctctggt tggaaagata gatgtatcct
     4921 ggctgttccc ctaggatatc tctctccatt gatgtttggg gtgggctgtc ctcaagacca
     4981 aagcaacaga aacctgtggt cacagagaat ctaacaggaa gagtcactgt tctcttcact
     5041 cattccaaat cttgttccct tgagacctgg gccttgggtg aattttcctg ggctccccta
     5101 aatggttcag gtgccaaaat agagcaaacc caagctctgc ccaccccatg cagaaaagga
     5161 caaacaggcc tttattagcc tttgccagct aagacacaga gaacattctc tggtcccttc
     5221 cagctcttat ggtctcactc agggctaaag aaagcaacag ttgccaccac aatcaggagg
     5281 gagtgacggt tggggtgttg tattataatc cagcagtggg ccagtgggta gaactgctag
     5341 gaacctagtt tgatctgctg caggggaggc agggcagtgg cttgggtcca gaagcttagg
     5401 gttgcctcct ccaccactaa gtcacaggtc cagggtgtca gacttcacag cataacatct
     5461 gccttagtgt tcatgaggtc tctgggcagg agaactgggt atctggatag atggttgagc
     5521 aggtggtagg cgggcatcaa tcatagaacc tgggcatcag tcagagtggg agcatatttg
     5581 tagaagccta gattgtgggc gggaatgtgg gacggagggc tcaaggactt tggaggcata
     5641 tgcctgccta agccttaggc gggtacatgt tatggagcaa ttttttacca ggaaagtcct
     5701 ggaaaatctt ttctgttatc cccaccccac ctgagagctc ttgggctgct gagggcctgt
     5761 ggcaactgca gtgggccagg catggtagaa aagatgtaga tcttgttatg taggatttgc
     5821 gttgtaggtg gactgaagca gcaggtcaag agttgaattc tcactaaggg gtcactgaca
     5881 ttttgtggtc ctgtgtttac cttaatgcct aaggtgagtg tattgttcaa gggtccaggg
     5941 acagtcactg cagtatgtgt ggggaatttt cccacagtaa ggtaaatgga tccttgggta
     6001 ctatgaatcc aacttggggt tggatttacc aaaatgtgtt gtatgttgtt agacatcttg
     6061 ttgtgtatta gtcttctaag gatattgtgc atggcactgt gtagtttata gccctacact
     6121 ggaaggatgg tgaagggagt tgctagattg atagcctaaa gaaaaccttc tgactgtggg
     6181 attagcatca atgataagga atgtgagcat ttgctggggt tgttgtcaaa tagtatcaga
     6241 gaacagttag gactgagagg tgatttcttc ttgacagaat ttgatagagg ccaaaaagcc
     6301 attacgagga tacctctgct tccagtgaca gcagagtgga ttcacattga ttgggcattg
     6361 tcacggaagg ctgactagct ggaggacatc aggctgtgct atgcttccct agggaggaca
     6421 tgtgcccttc cctccagatt agaaaggcta gaatcaagag tttcaagtgc tcattttctt
     6481 caaggtccaa ggttgggaac tatttcccta cagagaaatc tgtttgagtt tctggtgctc
     6541 caggaaatgg gttggcagga cacagaaatg agaaaccctg aggccaggaa gaggccaatc
     6601 ctaggagatg ttttccctcc agattcattt taaggaatat ctgtgcttcc tgatgtgtgt
     6661 gcttgagatt tgggctctat atccagcatt tgaactcaca ttctcagtgg cagagtcatg
     6721 gtctgtggca ccatttcaag gccaaaaatc ccatccaatt tcccttcaca tagatgacag
     6781 aaaagcaaga aagtagctgc cttaactcga acagttctgg gaaaaaaact gggggccttg
     6841 tcctgaggct gtggagactt aattcttcag ctgggtggtt cccgtaggaa caaggaacac
     6901 tttagctact tcttactctt ttaacaccaa tggctgtggg agaaggaaag gctcaaggcc
     6961 agggctcagc tcgcagagtc catcttctcc cacagttgcc acatttgaga gggggcctgc
     7021 tgaatgccct tgctgtcccc tatggcagta ttgaggcctg accgaagtct ggtatgctgc
     7081 ttgctggcta caagaactgg tcacaggatg aaaattgggg aaaggatttg ggggaggtga
     7141 caagggtggc atggaagtct aggggacaaa gggacagggt tgggaacaaa ttggttaact
     7201 ttgattgcca ctcactgtgg tgctttcccc ctttcccttg aattctgctt tgaaaagaat
     7261 aaatttgtac ttgtttactt tg
//
