LOCUS       NM_016449               1300 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens aspartate rich 1 (DRICH1), mRNA.
ACCESSION   NM_016449
VERSION     NM_016449.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1300)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1300)
  AUTHORS   Mair,B., Tomic,J., Masud,S.N., Tonge,P., Weiss,A., Usaj,M.,
            Tong,A.H.Y., Kwan,J.J., Brown,K.R., Titus,E., Atkins,M.,
            Chan,K.S.K., Munsie,L., Habsid,A., Han,H., Kennedy,M., Cohen,B.,
            Keller,G. and Moffat,J.
  TITLE     Essential Gene Profiles for Human Pluripotent Stem Cells Identify
            Uncharacterized Genes and Substrate Dependencies
  JOURNAL   Cell Rep 27 (2), 599-615 (2019)
   PUBMED   30970261
REFERENCE   3  (bases 1 to 1300)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1300)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB052993.1 and BC056888.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016449.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056888.1, SRR5189667.34953.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317749.9/ ENSP00000316137.5
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DB052993.1         1-21
            22-269              BC056888.1         1-248
            270-560             DB052993.1         270-560
            561-1300            BC056888.1         540-1279
FEATURES             Location/Qualifiers
     source          1..1300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..1300
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /note="aspartate rich 1"
                     /db_xref="GeneID:51233"
                     /db_xref="HGNC:HGNC:28031"
     exon            1..506
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..988
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /codon_start=1
                     /product="aspartate-rich protein 1"
                     /protein_id="NP_057533.2"
                     /db_xref="CCDS:CCDS42985.1"
                     /db_xref="GeneID:51233"
                     /db_xref="HGNC:HGNC:28031"
                     /translation="MGNILTCCINSHCGWPRGKDAPCYESDTDIYETVAAATSESTTV
                     EPGKLDVGATEGQDLQHISNQKMPTGPPEDRLSLKFLPSSEEDNDDAKILPSPVQGSS
                     EDNLSLVCLPRSEDDDCDDDDDDDAQILPSRVQGGCYRFDSSSCSSEDNLSLVCLPRS
                     EDDDCDDDDDDAQILPSPVQACSEDSLFLRCSLRHKDEEEEDDDDIHITARIESDLTL
                     ESLSDEEIHPG"
     exon            507..574
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..596
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..682
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..704
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..734
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..817
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..839
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..919
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..941
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..983
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1300
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1278..1283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /note="hexamer: AATAAA"
     polyA_site      1300
                     /gene="DRICH1"
                     /gene_synonym="C22orf43; KB-208E9.1"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtagc tcgcagtgga gggaggagga gctccaactg tgctctttga tggcagtttt
       61 tgcacctttg ggtgcttgtc atgttcgttt atttttcaaa gaagacagca ggtccctgac
      121 ctcatagacc agctagtttg ggaggtggcg gcagaataag ggctgaggac ccagatctgc
      181 ctggggtcag gctgcttcta aaagtgcagg gccaccctca gtagtgtggc tgctagggca
      241 gcacagttac aatttcgctg aaggctgagg caggagtgga gaggcatgga gaggccccat
      301 ggggaatata ctgacctgtt gtatcaactc ccactgtggc tggcccaggg ggaaggacgc
      361 accctgttat gaatctgata ctgatattta tgagactgtg gctgctgcaa catcagaatc
      421 cactactgta gagcctggca agctggatgt gggagccacg gagggccaag acctgcagca
      481 catcagcaac caaaagatgc ccacaggtcc ccctgaggac cgcctgagtt taaaatttct
      541 gccatcaagt gaggaagaca atgatgatgc caagatttta ccatcacctg tccagggttc
      601 ttctgaggac aacctgagtt tagtatgcct accacgaagt gaagatgatg actgtgatga
      661 tgatgatgat gatgatgccc agattttacc gtcacgtgtc cagggtggct gttaccggtt
      721 tgatagcagt tcttgttctt ctgaggacaa cctgagttta gtatgcctac cacgaagtga
      781 agatgatgac tgtgatgatg atgatgatga tgcccagatt ttaccgtcac ctgtccaggc
      841 ttgttctgaa gatagcctgt ttttaagatg ctcactgaga cacaaagatg aagaagaaga
      901 agatgatgat gacatccaca taacagctcg gatagaaagt gacttgacgc tggagagtct
      961 aagtgatgaa gagattcatc cagggtgaag cccttctgtg gagctgacca gggtgctgac
     1021 ccaaagggca ggccagcgcg tgctgcaggg tccccagctt tgcccctgga ggtctcaatc
     1081 ctctctacat tctgaggaaa actcttggtc ccagcagaga gaaaaagtcc aaggctgctt
     1141 cccacccacc gccagcacta ggtttggcct gtaccatcca ggacccagtg cttctgggcc
     1201 tggcatttct cctttggcaa gagagtgaga agagacgtga ctgtgctcca cgagcagaaa
     1261 gtgccattcc cacttgaaat aaagagactg agtgcattta
//
