LOCUS       NM_001276451            3078 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens dorsal root ganglia homeobox (DRGX), mRNA.
ACCESSION   NM_001276451
VERSION     NM_001276451.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3078)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 3078)
  AUTHORS   Kim,B.Y., Jin,H.J. and Kim,J.Y.
  TITLE     Genome-wide association analysis of Sasang constitution in the
            Korean population
  JOURNAL   J Altern Complement Med 18 (3), 262-269 (2012)
   PUBMED   22394158
REFERENCE   3  (bases 1 to 3078)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 3078)
  AUTHORS   Saito,T., Greenwood,A., Sun,Q. and Anderson,D.J.
  TITLE     Identification by differential RT-PCR of a novel paired homeodomain
            protein specifically expressed in sensory neurons and a subset of
            their CNS targets
  JOURNAL   Mol Cell Neurosci 6 (3), 280-292 (1995)
   PUBMED   7496632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027674.10.
            
            On Apr 26, 2019 this sequence version replaced NM_001276451.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1803613.475607.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA2145544,
                                    SAMEA2146411 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374139.8/ ENSP00000363254.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AC027674.10        130454-130608       c
            156-270             AC027674.10        129926-130040       c
            271-368             AC027674.10        125683-125780       c
            369-470             AC027674.10        124652-124753       c
            471-649             AC027674.10        121199-121377       c
            650-762             AC027674.10        120997-121109       c
            763-3078            AC027674.10        98584-100899        c
FEATURES             Location/Qualifiers
     source          1..3078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..3078
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /note="dorsal root ganglia homeobox"
                     /db_xref="GeneID:644168"
                     /db_xref="HGNC:HGNC:21536"
                     /db_xref="MIM:606701"
     exon            1..155
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            156..270
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1028
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /note="paired-like homeodomain trancription factor DRG11;
                     paired related homeobox-like 1"
                     /codon_start=1
                     /product="dorsal root ganglia homeobox protein"
                     /protein_id="NP_001263380.1"
                     /db_xref="CCDS:CCDS44388.2"
                     /db_xref="GeneID:644168"
                     /db_xref="HGNC:HGNC:21536"
                     /db_xref="MIM:606701"
                     /translation="MFYFHCPPQLEGTATFGNHSSGDFDDGFLRRKQRRNRTTFTLQQ
                     LEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGASDQEPGA
                     KEPMAEVTPPPVRNINSPPPGDQARSKKEALEAQQSLGRTVGPAGPFFPSCLPGTLLN
                     TATYAQALSHVASLKGGPLCSCCVPDPMGLSFLPTYGCQSNRTASVATLRMKAREHSE
                     AVLQSANLLPSTSSSPGPVAKPAPPDGSQEKTSPTKEQSEAEKSV"
     exon            271..368
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..470
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..649
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..762
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..3078
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3053..3058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /note="hexamer: AATAAA"
     polyA_site      3078
                     /gene="DRGX"
                     /gene_synonym="DRG11; PRRXL1"
                     /note="major polyA site"
ORIGIN      
        1 gctgcagaca gacagcaaga catctggcca cttcccgagt cacttctttg gtcctgcggg
       61 cgccagccgc gccgagcccc gcccgccgcc agccgagcag ggcttgcgga tcggaggcgg
      121 tcacgctccg acctcctcga ccgccgcccg ccgagccagg caggagcaac gcgcgcgggt
      181 ccgttctgct gccaccctcc caggtctcgg ccgtccagcc gatctgacag ccggcgatgt
      241 tttatttcca ctgcccgcca cagctagagg gcactgcaac ctttggcaat cactcttcgg
      301 gggattttga tgacgggttt ctgcgtagaa aacagcgccg gaaccggacg acgttcactc
      361 ttcagcagct ggaagctctc gaggccgttt ttgcccaaac acactatcca gatgtcttca
      421 ccagagaaga gctcgccatg aaaataaacc tcacagaagc cagagtgcag gtttggttcc
      481 agaacagaag ggccaaatgg aggaagacag agagaggggc ctcagaccag gagccaggag
      541 ccaaggagcc catggcagag gtgacacctc ctccagtgag aaacatcaac tccccgcccc
      601 ctggggacca agcccggagt aagaaggagg cgctggaggc ccagcagagc ctggggcgaa
      661 cggtaggtcc tgcagggcct ttcttcccct cctgcttgcc ggggactctc ctgaacacgg
      721 ccacctacgc ccaggccttg tcccatgtgg cttccctcaa agggggccca ctgtgctctt
      781 gctgcgtccc agaccccatg ggactctcct tccttcccac ctatggctgc cagagtaacc
      841 gcacggccag cgtggccacc ctgcgcatga aggcccgcga gcactcagaa gctgtcctgc
      901 agtcagccaa cctcctgcct tccaccagca gcagccccgg ccctgtcgcc aagccggcgc
      961 ccccagatgg cagccaggaa aagacctctc ccaccaagga acagagcgag gcagagaaga
     1021 gtgtatgagg gtccacagtg ccccgcccgg cctgccctcc cccgcccctc cttctcccag
     1081 cctcagcccc tacagaaaac tctccaaata gcaaggagaa gcctgcggcc ccagggcctc
     1141 tgcatggacc caggacgggc aagtgagacc cacagctccc ttggcacctg gagcgtccct
     1201 ctggagtccc accagtgcgg cagtgttgtc ctggcttctt tggcaacaga tcccgatggc
     1261 acttggtggc agcagagccc tctctgtgag gagcctccct gggatttcca tccaggccca
     1321 gagtctcgga gggaggtaga ttcctcatcc gtctcccttc ctatttcctc cctgggctgc
     1381 ctttgaaggt cttgtcaacc ccaggaactg tggcatgggc tgaagtttca tgaaaagaaa
     1441 agggcctgtc ccgcttacag tgtttaagaa ctggggaact ggtggaaccc caagcgactc
     1501 ttgctcccct ggaccaagat gagcagtaat gccctttctc ttgttggaga atattggttg
     1561 tgggcttcat tacaaagtga gaagatgcag ggtagggagg ggccaacagg acacagcctg
     1621 tcccagagga ccacggtggc tctgacccag gagatctcac tggcacatct ggccgggggg
     1681 ctgggctaat cacccaggcc acctgctcca tgaactgggg gctgctgtct tgacactgtg
     1741 ggtgtggaac tagtgtggcc cctgtacctg aagcactcac ctgcaagccc ttcctctctc
     1801 ccagatagac ctgtggattg gtgggaagtt aagcaactga aaagcagctc tctggtccag
     1861 gagggcctga gggcccttgg agagggaaga agcccttcag gaatgcctct gaagtaatta
     1921 tgcatacaga tgaactacct ttccccacat gcctggcacg tagagggggc tcttcagtgg
     1981 tggtggtttt ttactgggga aaaaaaagta ggaaaggaga caggaacggc gtatgtgcag
     2041 atatggagca tggggaagac agctttctca tggtgtggag agcattaatt ccaaagggcc
     2101 aaatttcaca gagatttctg ttttggtcta gtgtggctgt tttctctggt gaggatggtg
     2161 acctagagga gatccaaggg gaacgtgcaa tagcataagc tctgccgctt tctggcaggg
     2221 gcgcccggca tgggaaaggt tgcagtcttt ggtggctttt gctgatggtg tttccatgcg
     2281 gatggttatt gccttcatga tggttatttt ggtttcagtt attatcgtca aaatgtttta
     2341 ctttcacatt tcctgtcccc tttttacctt cccccactcc atgaccccca aataatactc
     2401 ctgagtgtat catgccttgt ctatgatcac tacgaagcat ttgataaaac ccactgtctc
     2461 ctttaaagaa aaaaatcaaa tccttcttcc tgctgtattt tgcttgttga gtataaagat
     2521 gaaacgattt gccaaaaagc ggcaaagttg cttccgtttc cctgtaatta cgaatgtttg
     2581 gttgaaggat gtaagctcaa gcccttatgt acactaactc ttcaatctaa ttgtttgatt
     2641 aaactcgtat ttcctccaga aaggtacata aataagtgaa ctgttgagca aattaagaat
     2701 acttaacagc attgcatctg aaaagtagtt atgctgatta aattttgtgt ccttgaggac
     2761 tttcaggaaa ttacttttga tcgtcaataa cacaattaag taaactacac acacattagc
     2821 atgaataatt gataagaaat tatgtattac cacgaagcac tgatttaata attcatgatg
     2881 cgacactcta gtgactgtgc aaaactggat catatcgaaa agtctgcctg atgttactga
     2941 aaggaaagaa aatgagcacc aaacctctgc agagatattg agtactttgt tttgttgtac
     3001 aaaggcaaaa agtaatgatg catgatgtag tttctgtttg tttaaatacc caaataaatt
     3061 tagaggagtt aaaacaaa
//
