LOCUS       NM_001388               1900 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens developmentally regulated GTP binding protein 2
            (DRG2), transcript variant 1, mRNA.
ACCESSION   NM_001388
VERSION     NM_001388.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Westrip,C.A.E., Zhuang,Q., Hall,C., Eaton,C.D. and Coleman,M.L.
  TITLE     Developmentally regulated GTPases: structure, function and roles in
            disease
  JOURNAL   Cell Mol Life Sci 78 (23), 7219-7235 (2021)
   PUBMED   34664086
  REMARK    GeneRIF: Developmentally regulated GTPases: structure, function and
            roles in disease.
            Review article
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Park,B.S., Im,H.L., Yoon,N.A., Tu,T.H., Park,J.W., Kim,J.G. and
            Lee,B.J.
  TITLE     Developmentally regulated GTP-binding protein-2 regulates adipocyte
            differentiation
  JOURNAL   Biochem Biophys Res Commun 578, 1-6 (2021)
   PUBMED   34520979
  REMARK    GeneRIF: Developmentally regulated GTP-binding protein-2 regulates
            adipocyte differentiation.
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Kim,S.C., Lee,W.H., Kim,S.H., Abdulkhayevich,A.A., Park,J.W.,
            Kim,Y.M., Moon,K.H., Lee,S.H. and Park,S.
  TITLE     Developmentally regulated GTP-binding protein 2 levels in prostate
            cancer cell lines impact docetaxel-induced apoptosis
  JOURNAL   Investig Clin Urol 62 (4), 485-495 (2021)
   PUBMED   34190439
  REMARK    GeneRIF: Developmentally regulated GTP-binding protein 2 levels in
            prostate cancer cell lines impact docetaxel-induced apoptosis.
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Li,B. and Trueb,B.
  TITLE     DRG represents a family of two closely related GTP-binding proteins
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 196-204 (2000)
   PUBMED   10760581
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Vlangos,C.N., Das,P., Patel,P.I. and Elsea,S.H.
  TITLE     Assignment of developmentally regulated GTP-binding protein (DRG2)
            to human chromosome band 17p11.2 with somatic cell hybrids and
            localization to the Smith-Magenis syndrome critical interval
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 283-285 (2000)
   PUBMED   10828610
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Sprang,S.R.
  TITLE     G proteins, effectors and GAPs: structure and mechanism
  JOURNAL   Curr Opin Struct Biol 7 (6), 849-856 (1997)
   PUBMED   9434906
  REMARK    Review article
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Schenker,T. and Trueb,B.
  TITLE     Assignment of the gene for a developmentally regulated GTP-binding
            protein (DRG2) to human chromosome bands 17p13-->p12 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 274-275 (1997)
   PUBMED   9605870
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Schenker,T., Lach,C., Kessler,B., Calderara,S. and Trueb,B.
  TITLE     A novel GTP-binding protein which is selectively repressed in SV40
            transformed fibroblasts
  JOURNAL   J Biol Chem 269 (41), 25447-25453 (1994)
   PUBMED   7929244
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA602486.1, BC000493.2 and
            X80754.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001388.4.
            
            Summary: This gene encodes a GTP-binding protein known to function
            in the regulation of cell growth and differentiation. Read-through
            transcripts containing this gene and a downstream gene have been
            identified, but they are not thought to encode a fusion protein.
            This gene is located within the Smith-Magenis syndrome region on
            chromosome 17. [provided by RefSeq, Jan 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.932256.1,
                                           SRR3476690.882587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225729.8/ ENSP00000225729.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA602486.1         64-84
            22-656              BC000493.2         1-635
            657-1900            X80754.1           628-1871
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1900
                     /gene="DRG2"
                     /note="developmentally regulated GTP binding protein 2"
                     /db_xref="GeneID:1819"
                     /db_xref="HGNC:HGNC:3030"
                     /db_xref="MIM:602986"
     exon            1..140
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1171
                     /gene="DRG2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TRAFAC GTPase DRG2; translation factor GTPase DRG2"
                     /codon_start=1
                     /product="developmentally-regulated GTP-binding protein 2
                     isoform 1"
                     /protein_id="NP_001379.1"
                     /db_xref="CCDS:CCDS11191.1"
                     /db_xref="GeneID:1819"
                     /db_xref="HGNC:HGNC:3030"
                     /db_xref="MIM:602986"
                     /translation="MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEP
                     SKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPG
                     VIEYKGANIQLLDLPGIIEGAAQGKGRGRQVIAVARTADVIIMMLDATKGEVQRSLLE
                     KELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVL
                     FREDCSPDEFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVISCGMKLNL
                     DYLLEMLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKYAL
                     VWGTSTKYSPQRVGLTHTMEHEDVIQIVKK"
     exon            141..301
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            302..391
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..452
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            453..543
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..616
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..707
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..805
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..882
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..971
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1030
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1084
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1900
                     /gene="DRG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1262..1267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRG2"
                     /note="hexamer: AATACA"
     polyA_site      1292
                     /gene="DRG2"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRG2"
                     /note="hexamer: AATAAA"
     polyA_site      1900
                     /gene="DRG2"
                     /note="major polyA site"
ORIGIN      
        1 actctgtcgc cgccgtcaga ccggaattgc cggtgccgcc gccaccgctg tctgtgcgcc
       61 cacctctgct gctaccatgg ggatcttaga gaagatctcg gagatcgaga aggagatcgc
      121 tcggacacag aagaacaagg ccactgagta tcatctgggc ctgctgaaag ctaagctcgc
      181 caagtatcgg gcccagctcc tggaaccgtc caaatcggcc tcgtccaaag gagagggctt
      241 tgatgtcatg aagtcgggtg atgcccgtgt ggcgctgatt ggatttccct ctgtgggtaa
      301 gtccacattc ttgagtctga tgacctccac ggccagcgag gcagcgtcct atgagttcac
      361 cactctgacg tgtattcctg gggtcattga atacaaaggt gccaacatcc agctcctgga
      421 ccttcctgga atcattgaag gcgcagccca aggaaaaggc cgtggccggc aggtgatcgc
      481 tgtggcgcgc acggctgacg tcatcatcat gatgctggat gccaccaagg gagaggtgca
      541 gaggtctctg ctggagaagg agctggagtc tgtgggcatc cgcctcaaca agcacaagcc
      601 taacatctac ttcaagccca agaaaggtgg tggcatctcc tttaactcga cagtcacgct
      661 gacccagtgc tcggaaaagc tggtgcagct catcctgcac gaatacaaga tcttcaatgc
      721 agaagtgctt ttccgagaag actgctcccc ggacgagttc atcgatgtga tcgtgggcaa
      781 ccgggtgtac atgccctgcc tgtatgttta taacaaaatc gaccagatct ccatggaaga
      841 ggtggaccgc ctggcccgaa aacccaacag tgtggtcatc agctgcggca tgaagctgaa
      901 cctggactat ctgctggaga tgctttggga gtacttggcc ctgacctgca tctacaccaa
      961 gaagagagga cagaggccag acttcacaga cgccatcatt ctccggaaag gggcctcagt
     1021 ggagcacgtg tgccaccgca tccaccggtc actcgccagc cagttcaagt acgccctggt
     1081 gtggggcacc agcaccaagt acagtccgca gcgggtgggc ctgacccaca ccatggagca
     1141 tgaggacgtc atccagatcg tgaagaagta acggcgcctg ccgggcctcc cgcccacctg
     1201 cctcgtctcc ctggggaggt ggtcccactg ggacacacaa acacccaaac agaaaaatac
     1261 aaatacacgt accccaggaa ggggtccctc aagtctctgc tatttacaga agtttcttca
     1321 gtaggcagac gaagagtgtg ttggggcaaa ggggctcggt tggaggcatt tcccataaga
     1381 ctgagccctc tcatgggggt tttgagtttg tagtgctgag cctgcatctg tgcctcccag
     1441 ccccctgcac tgagggagca agttgcccac atgcccgcca gccagggcct aaagcagatg
     1501 gcatgctcag tgccaggctg gtagctgggc ctgtttgggt ccctggaggc tgtggctgct
     1561 gtcatggcac ctcactccct cagctcttgc cagcttctct gacacttggg ttgggggccc
     1621 ttccaggagg aaaccccctt gggtgcccca cacagggctc tccatgatgg gaaccagtgg
     1681 ttagtggctt caaaggccca gctgacaccc tccacagcct aaggggtgtc ctaaagtgcc
     1741 tccccctgta ttccccctcc cagggcagcc cctgcccagc acaaaacccc aggaccctgg
     1801 ctctgcacgc ctggggcagg gacttttgag tttaggatct gtattttcta agtccccagt
     1861 tctcctggct ctcctttctg aaataaagga ttgaaaacgg
//
