LOCUS       NM_004147               1665 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens developmentally regulated GTP binding protein 1
            (DRG1), mRNA.
ACCESSION   NM_004147 XM_003403741
VERSION     NM_004147.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1665)
  AUTHORS   Westrip,C.A.E., Paul,F., Al-Murshedi,F., Qaitoon,H., Cham,B.,
            Fletcher,S.C., Hendrix,E., Boora,U., Ng,A.Y.J., Bonnard,C.,
            Najafi,M., Alawbathani,S., Lambert,I., Fox,G., Venkatesh,B.,
            Bertoli-Avella,A., Tan,E.S., Al-Maawali,A., Reversade,B. and
            Coleman,M.L.
  TITLE     Inactivation of DRG1, encoding a translation factor GTPase, causes
            a recessive neurodevelopmental disorder
  JOURNAL   Genet Med 25 (9), 100893 (2023)
   PUBMED   37179472
  REMARK    GeneRIF: Inactivation of DRG1, encoding a translation factor
            GTPase, causes a recessive neurodevelopmental disorder.
REFERENCE   2  (bases 1 to 1665)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1665)
  AUTHORS   Beljan,S., Dominko,K., Talajic,A., Hlousek-Kasun,A., Skrobot
            Vidacek,N., Herak Bosnar,M., Vlahovicek,K. and Cetkovic,H.
  TITLE     Structure and function of cancer-related developmentally regulated
            GTP-binding protein 1 (DRG1) is conserved between sponges and
            humans
  JOURNAL   Sci Rep 12 (1), 11379 (2022)
   PUBMED   35790840
  REMARK    GeneRIF: Structure and function of cancer-related developmentally
            regulated GTP-binding protein 1 (DRG1) is conserved between sponges
            and humans.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1665)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1665)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   6  (bases 1 to 1665)
  AUTHORS   Zhao,X.F. and Aplan,P.D.
  TITLE     SCL binds the human homologue of DRG in vivo
  JOURNAL   Biochim Biophys Acta 1448 (1), 109-114 (1998)
   PUBMED   9824680
REFERENCE   7  (bases 1 to 1665)
  AUTHORS   Mahajan,M.A., Park,S.T. and Sun,X.H.
  TITLE     Association of a novel GTP binding protein, DRG, with TAL oncogenic
            proteins
  JOURNAL   Oncogene 12 (11), 2343-2350 (1996)
   PUBMED   8649774
REFERENCE   8  (bases 1 to 1665)
  AUTHORS   Schenker,T., Lach,C., Kessler,B., Calderara,S. and Trueb,B.
  TITLE     A novel GTP-binding protein which is selectively repressed in SV40
            transformed fibroblasts
  JOURNAL   J Biol Chem 269 (41), 25447-25453 (1994)
   PUBMED   7929244
REFERENCE   9  (bases 1 to 1665)
  AUTHORS   Sazuka,T., Tomooka,Y., Ikawa,Y., Noda,M. and Kumar,S.
  TITLE     DRG: a novel developmentally regulated GTP-binding protein
  JOURNAL   Biochem Biophys Res Commun 189 (1), 363-370 (1992)
   PUBMED   1449490
REFERENCE   10 (bases 1 to 1665)
  AUTHORS   Sazuka,T., Kinoshita,M., Tomooka,Y., Ikawa,Y., Noda,M. and Kumar,S.
  TITLE     Expression of DRG during murine embryonic development
  JOURNAL   Biochem Biophys Res Commun 189 (1), 371-377 (1992)
   PUBMED   1280421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU584654.1, BC019285.1 and AL096701.14.
            
            On May 17, 2019 this sequence version replaced NM_004147.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.305923.1, AF078103.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331457.9/ ENSP00000329715.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BU584654.1         92-101
            11-1399             BC019285.1         1-1389
            1400-1665           AL096701.14        33165-33430
FEATURES             Location/Qualifiers
     source          1..1665
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..1665
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /note="developmentally regulated GTP binding protein 1"
                     /db_xref="GeneID:4733"
                     /db_xref="HGNC:HGNC:3029"
                     /db_xref="MIM:603952"
     exon            1..122
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1184
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated 3; DRG-1; NEDD-3; neural precursor cell
                     expressed developmentally down-regulated protein 3; TRAFAC
                     GTPase DRG1; translation factor GTPase DRG1"
                     /codon_start=1
                     /product="developmentally-regulated GTP-binding protein 1"
                     /protein_id="NP_004138.1"
                     /db_xref="CCDS:CCDS13897.1"
                     /db_xref="GeneID:4733"
                     /db_xref="HGNC:HGNC:3029"
                     /db_xref="MIM:603952"
                     /translation="MSSTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELIT
                     PKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTV
                     PGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKI
                     IENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNAD
                     VTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRW
                     NFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFK
                     YALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK"
     exon            123..246
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /inference="alignment:Splign:2.1.0"
     exon            247..422
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /inference="alignment:Splign:2.1.0"
     exon            423..492
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /inference="alignment:Splign:2.1.0"
     exon            493..662
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /inference="alignment:Splign:2.1.0"
     exon            663..793
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /inference="alignment:Splign:2.1.0"
     exon            794..961
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1084
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1665
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1365..1370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /note="hexamer: CATAAA"
     polyA_site      1399
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /note="major polyA site"
     regulatory      1512..1517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
                     /note="hexamer: GATAAA"
     polyA_site      1533
                     /gene="DRG1"
                     /gene_synonym="NEDD3; TANALS"
ORIGIN      
        1 agtagcgcct ggtggcggtg gcagtttgcc cgcgggtgtg tgaagggaga cagtgtggag
       61 gccacagggt actcgccacg atgagcagca ccttagctaa gatcgcggag atagaagcag
      121 agatggctcg gactcaaaag aacaaggcca cagcacacca cttagggctg cttaaggctc
      181 gtcttgctaa gcttcgtcga gaactcatta ctccaaaggg tggtggtggt ggaggtccag
      241 gagaaggttt tgatgtggcc aagacaggtg atgctcgaat tggatttgtt ggttttccat
      301 ctgtggggaa gtcaacactg cttagtaacc tggcaggggt atattctgag gtggcagcct
      361 atgaattcac tactctgacc actgtgcctg gtgtcatcag atacaaaggt gccaagatcc
      421 agctcctgga tctcccaggt atcattgaag gtgccaagga tgggaaaggt agaggtcgtc
      481 aagtcattgc agtggcccga acctgtaact tgatcttgat tgttctggat gtcctgaaac
      541 ctttgggaca taagaagata attgaaaatg agctggaagg ctttggcatt cgcttgaaca
      601 gcaaaccccc caacattggc tttaagaaga aggacaaggg aggcattaat ctcacagcca
      661 cttgccccca gagtgagctg gatgctgaaa ctgtgaagag cattctggct gaatacaaga
      721 ttcataatgc cgatgtgact ctacgtagtg atgctacagc tgatgacctc attgatgtgg
      781 tggaaggaaa cagagtttat atcccctgta tctatgtgtt aaataagatt gaccaaatct
      841 ccattgagga attggatatc atctataagg tgcctcactg tgtacccatc tctgcccatc
      901 accgctggaa ttttgatgac ctattggaaa agatctggga ctatctgaaa ctagtgagaa
      961 tttacaccaa acccaaaggc cagttaccag attacacatc cccagtggtg cttccttact
     1021 ccaggaccac agtggaggat ttctgcatga agattcacaa aaatcttatc aaagaattta
     1081 aatatgctct ggtctggggt ctctctgtga aacacaatcc tcagaaagtg ggtaaagacc
     1141 atacgttgga ggatgaggat gtcattcaaa ttgtgaagaa gtgaaacctt tcccttttcc
     1201 catctgccgg acgaaccaca acagcgttcc ccatgatcaa gcaccctacc ccagttcttt
     1261 ctggttttgg cagtcactgg atcaggatcc aggggaggga gatggaggca cccaaactgg
     1321 aacttcattt gtcttacctt ggtgtcacct tgtatgtcga actgcataaa agatctggta
     1381 ggctggtcag ctacatgcag ctcatgtgtc attgtcagaa tttgttttgg gatgggctga
     1441 atgaggaagg gtatatacgg tgaagcagct acagaaggga tccttgggaa cttcatcttg
     1501 agtgtgaaat ggataaaaat atgacatgct gcatcttact tgatgtttac ttatgggaac
     1561 cccttccaaa ctagatatgg ctttcagtcc tttcaagtag tctttcccac atgatactgg
     1621 agagaggaag gactttatgt aagttaattg atcactcccc gcaag
//
