LOCUS       NM_000798               2376 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dopamine receptor D5 (DRD5), mRNA.
ACCESSION   NM_000798
VERSION     NM_000798.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   O'Higgins,M., Benito,A., Real-Lopez,M., Gil-Miravet,I., Ochoa,E.
            and Haro,G.
  TITLE     Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and
            antisocial personality disorders in polydrug users
  JOURNAL   Personal Ment Health 17 (1), 77-86 (2023)
   PUBMED   35961947
  REMARK    GeneRIF: Relationship of DRD5 and MAO-B VNTR polymorphisms with
            paranoid and antisocial personality disorders in polydrug users.
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Bai,R., Mei,J. and Hu,W.
  TITLE     Hypermethylation of DRD5 Promoter Is a Biomarker Across 12 Cancer
            Types
  JOURNAL   DNA Cell Biol 39 (11), 2052-2058 (2020)
   PUBMED   32907377
  REMARK    GeneRIF: Hypermethylation of DRD5 Promoter Is a Biomarker Across 12
            Cancer Types.
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Lee,C.G., Moon,H. and Park,S.
  TITLE     The effects of dopamine receptor genes on the trajectories of sport
            participation from adolescence through young adulthood
  JOURNAL   Ann Hum Biol 47 (3), 256-262 (2020)
   PUBMED   32183536
  REMARK    GeneRIF: The effects of dopamine receptor genes on the trajectories
            of sport participation from adolescence through young adulthood.
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2376)
  AUTHORS   Wang,S., Tan,X., Chen,P., Zheng,S., Ren,H., Cai,J., Zhou,L.,
            Jose,P.A., Yang,J. and Zeng,C.
  TITLE     Role of Thioredoxin 1 in Impaired Renal Sodium Excretion of hD 5 R
            F173L Transgenic Mice
  JOURNAL   J Am Heart Assoc 8 (8), e012192 (2019)
   PUBMED   30957627
  REMARK    GeneRIF: These suggest that hD5R(F173L) increases blood pressure,
            in part, by decreasing renal thioredoxin 1 expression and
            increasing reactive oxygen species production. Hyperphosphorylation
            of hD5R(F173L), with its dissociation from Galphas and Galphaq, is
            the key factor in impaired D5R function of hD5R(F173L)-TG mice.
REFERENCE   6  (bases 1 to 2376)
  AUTHORS   Grandy,D.K., Allen,L.J., Zhang,Y., Magenis,R.E. and Civelli,O.
  TITLE     Chromosomal localization of three human D5 dopamine receptor genes
  JOURNAL   Genomics 13 (4), 968-973 (1992)
   PUBMED   1387108
REFERENCE   7  (bases 1 to 2376)
  AUTHORS   Eubanks,J.H., Altherr,M., Wagner-McPherson,C., McPherson,J.D.,
            Wasmuth,J.J. and Evans,G.A.
  TITLE     Localization of the D5 dopamine receptor gene to human chromosome
            4p15.1-p15.3, centromeric to the Huntington's disease locus
  JOURNAL   Genomics 12 (3), 510-516 (1992)
   PUBMED   1532789
REFERENCE   8  (bases 1 to 2376)
  AUTHORS   Polymeropoulos,M.H., Xiao,H. and Merril,C.R.
  TITLE     The human D5 dopamine receptor (DRD5) maps on chromosome 4
  JOURNAL   Genomics 11 (3), 777-778 (1991)
   PUBMED   1774076
REFERENCE   9  (bases 1 to 2376)
  AUTHORS   Tiberi,M., Jarvie,K.R., Silvia,C., Falardeau,P., Gingrich,J.A.,
            Godinot,N., Bertrand,L., Yang-Feng,T.L., Fremeau,R.T. Jr. and
            Caron,M.G.
  TITLE     Cloning, molecular characterization, and chromosomal assignment of
            a gene encoding a second D1 dopamine receptor subtype: differential
            expression pattern in rat brain compared with the D1A receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7491-7495 (1991)
   PUBMED   1831904
REFERENCE   10 (bases 1 to 2376)
  AUTHORS   Sunahara,R.K., Guan,H.C., O'Dowd,B.F., Seeman,P., Laurier,L.G.,
            Ng,G., George,S.R., Torchia,J., Van Tol,H.H. and Niznik,H.B.
  TITLE     Cloning of the gene for a human dopamine D5 receptor with higher
            affinity for dopamine than D1
  JOURNAL   Nature 350 (6319), 614-619 (1991)
   PUBMED   1826762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098976.2 and BC009748.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000798.4.
            
            Summary: This gene encodes the D5 subtype of the dopamine receptor.
            The D5 subtype is a G-protein coupled receptor which stimulates
            adenylyl cyclase. This receptor is expressed in neurons in the
            limbic regions of the brain. It has a 10-fold higher affinity for
            dopamine than the D1 subtype. Pseudogenes related to this gene
            reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC009748.2, SRR1803615.117444.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304374.4/ ENSP00000306129.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2008              AC098976.2         61537-63544
            2009-2376           BC009748.2         1664-2031
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..2376
                     /gene="DRD5"
                     /gene_synonym="DBDR; DRD1B; DRD1L2"
                     /note="dopamine receptor D5"
                     /db_xref="GeneID:1816"
                     /db_xref="HGNC:HGNC:3026"
                     /db_xref="MIM:126453"
     exon            1..2376
                     /gene="DRD5"
                     /gene_synonym="DBDR; DRD1B; DRD1L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..1830
                     /gene="DRD5"
                     /gene_synonym="DBDR; DRD1B; DRD1L2"
                     /note="D1beta dopamine receptor; dopamine receptor D1B;
                     dopamine D5 receptor; d(5) dopamine receptor"
                     /codon_start=1
                     /product="D(1B) dopamine receptor"
                     /protein_id="NP_000789.1"
                     /db_xref="CCDS:CCDS3405.1"
                     /db_xref="GeneID:1816"
                     /db_xref="HGNC:HGNC:3026"
                     /db_xref="MIM:126453"
                     /translation="MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTA
                     CLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAE
                     VAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVM
                     VGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCD
                     SSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSA
                     ACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFP
                     CVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNE
                     LISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPV
                     AESVWELDCEGEISLDKITPFTPNGFH"
     regulatory      2356..2361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRD5"
                     /gene_synonym="DBDR; DRD1B; DRD1L2"
                     /note="hexamer: AATAAA"
     polyA_site      2376
                     /gene="DRD5"
                     /gene_synonym="DBDR; DRD1B; DRD1L2"
                     /note="major polyA site"
ORIGIN      
        1 agtgccagcc tggcgcccgc gactgcctgc cccagcccct cagtggcggc ttgctctctt
       61 ctctcgctcc gaaccagaca cagccgctgc cgctgccgtc cggcgcgcta cagactcccg
      121 agaacagccc tggctgtcag cgagcaccag ccgcttcctg tccccatcgc ggagactgga
      181 ggggcgcacc acggccatgg agccagaggc gcttcaggag gcaagagaag tccccgcgcg
      241 ctccgcagcc cggcgcagct catggtgagc gccctctggg gctcgagggt cccttggctg
      301 agggggcgca tcctcggggt gcccgatggg gctgcctggg ggtcgcaggg ctgaagttgg
      361 gaccgcgcac agaccgcccc tgcagtccag cccgaaatgc tgccgccagg cagcaacggc
      421 accgcgtacc cggggcagtt cgctctatac cagcagctgg cgcaggggaa cgccgtgggg
      481 ggctcggcgg gggcaccgcc actggggccc tcacaggtgg tcaccgcctg cctgctgacc
      541 ctactcatca tctggaccct gctgggcaac gtgctggtgt gcgcagccat cgtgcggagc
      601 cgccacctgc gcgccaacat gaccaacgtc ttcatcgtgt ctctggccgt gtcagacctt
      661 ttcgtggcgc tgctggtcat gccctggaag gcagtcgccg aggtggccgg ttactggccc
      721 tttggagcgt tctgcgacgt ctgggtggcc ttcgacatca tgtgctccac tgcctccatc
      781 ctgaacctgt gcgtcatcag cgtggaccgc tactgggcca tctccaggcc cttccgctac
      841 aagcgcaaga tgactcagcg catggccttg gtcatggtcg gcctggcatg gaccttgtcc
      901 atcctcatct ccttcattcc ggtccagctc aactggcaca gggaccaggc ggcctcttgg
      961 ggcgggctgg acctgccaaa caacctggcc aactggacgc cctgggagga ggacttttgg
     1021 gagcccgacg tgaatgcaga gaactgtgac tccagcctga atcgaaccta cgccatctct
     1081 tcctcgctca tcagcttcta catccccgtt gccatcatga tcgtgaccta cacgcgcatc
     1141 taccgcatcg cccaggtgca gatccgcagg atttcctccc tggagagggc cgcagagcac
     1201 gcgcagagct gccggagcag cgcagcctgc gcgcccgaca ccagcctgcg cgcttccatc
     1261 aagaaggaga ccaaggttct caagaccctg tcggtgatca tgggggtctt cgtgtgttgc
     1321 tggctgccct tcttcatcct taactgcatg gtccctttct gcagtggaca ccccgaaggc
     1381 cctccggccg gcttcccctg cgtcagtgag accaccttcg acgtcttcgt ctggttcggc
     1441 tgggctaact cctcactcaa ccccgtcatc tatgccttca acgccgactt tcagaaggtg
     1501 tttgcccagc tgctggggtg cagccacttc tgctcccgca cgccggtgga gacggtgaac
     1561 atcagcaatg agctcatctc ctacaaccaa gacatcgtct tccacaagga aatcgcagct
     1621 gcctacatcc acatgatgcc caacgccgtt acccccggca accgggaggt ggacaacgac
     1681 gaggaggagg gtcctttcga tcgcatgttc cagatctatc agacgtcccc agatggtgac
     1741 cctgttgctg agtctgtctg ggagctggac tgcgaggggg agatttcttt agacaaaata
     1801 acacctttca ccccgaatgg attccattaa actgcattaa gaaaccccct catggatctg
     1861 cataaccgca cagacattga caagcacgca cacacacgca aatacatgcc tttccagtgc
     1921 tgctcccttt atcatgtgtt tctgtgtagt agctcgtgtg cttagaaacc tcaccccatt
     1981 gattggtagt tcgaagaatt ggcagaagca gttgcaataa actcagtcaa atgtacccag
     2041 cctaccagag atggaccaac gatcctatga gagaagagag tatggtgctg ggtccttaaa
     2101 aaaaaaaatg atacttggtc cttaaaaaat atgctctccc ctcccttttt aaacaaatgg
     2161 cttgttcagt cacttgtttg tgtttgaatt gatttttaaa cagcaggttg tgtgtgtgtg
     2221 cagtgatgtg gtgggagcac agctttcctg ggtctggatt cccgtggctt tgtgcttatg
     2281 tcatttcttc tctctgtgct ggtgggggcc tctttaccat agcttaagaa gtatccctga
     2341 tttattctgg tgtctaataa acacagatta tttgta
//
