LOCUS       NM_000797               1399 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens dopamine receptor D4 (DRD4), mRNA.
ACCESSION   NM_000797
VERSION     NM_000797.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1399)
  AUTHORS   Alachkar,A., Phan,A., Dabbous,T., Alhassen,S., Alhassen,W.,
            Reynolds,B., Rubinstein,M., Ferre,S. and Civelli,O.
  TITLE     Humanized dopamine D4.7 receptor male mice display risk-taking
            behavior and deficits of social recognition and working memory in
            light/dark-dependent manner
  JOURNAL   J Neurosci Res 102 (2), e25299 (2024)
   PUBMED   38361407
  REMARK    GeneRIF: Humanized dopamine D4.7 receptor male mice display
            risk-taking behavior and deficits of social recognition and working
            memory in light/dark-dependent manner.
            Review article
REFERENCE   2  (bases 1 to 1399)
  AUTHORS   Yang,H.M., Lung,H., Yang,M.C. and Lung,F.W.
  TITLE     DRD4 VNTR 4/4 homozygosity as a genetic biomarker for treatment
            selection in patients with schizophrenia
  JOURNAL   Asian J Psychiatr 91, 103831 (2024)
   PUBMED   37988928
  REMARK    GeneRIF: DRD4 VNTR 4/4 homozygosity as a genetic biomarker for
            treatment selection in patients with schizophrenia.
REFERENCE   3  (bases 1 to 1399)
  AUTHORS   Taheri,N., Pirboveiri,R., Sayyah,M., Bijanzadeh,M. and Ghandil,P.
  TITLE     Association of DRD2, DRD4 and COMT genes variants and their
            gene-gene interactions with antipsychotic treatment response in
            patients with schizophrenia
  JOURNAL   BMC Psychiatry 23 (1), 781 (2023)
   PUBMED   37880658
  REMARK    GeneRIF: Association of DRD2, DRD4 and COMT genes variants and
            their gene-gene interactions with antipsychotic treatment response
            in patients with schizophrenia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1399)
  AUTHORS   Slominski,B., Skrzypkowska,M., Mysliwiec,M. and Trzonkowski,P.
  TITLE     Variation in the Dopamine-4-Receptor Gene in Patients with Type 1
            Diabetes
  JOURNAL   Neuroendocrinology 113 (8), 875-884 (2023)
   PUBMED   37080173
  REMARK    GeneRIF: Variation in the Dopamine-4-Receptor Gene in Patients with
            Type 1 Diabetes.
REFERENCE   5  (bases 1 to 1399)
  AUTHORS   Chio,C.L., Drong,R.F., Riley,D.T., Gill,G.S., Slightom,J.L. and
            Huff,R.M.
  TITLE     D4 dopamine receptor-mediated signaling events determined in
            transfected Chinese hamster ovary cells
  JOURNAL   J Biol Chem 269 (16), 11813-11819 (1994)
   PUBMED   7512953
REFERENCE   6  (bases 1 to 1399)
  AUTHORS   Livingstone,C.D., Strange,P.G. and Naylor,L.H.
  TITLE     Molecular modelling of D2-like dopamine receptors
  JOURNAL   Biochem J 287 (Pt 1) (Pt 1), 277-282 (1992)
   PUBMED   1358063
REFERENCE   7  (bases 1 to 1399)
  AUTHORS   Van Tol,H.H., Wu,C.M., Guan,H.C., Ohara,K., Bunzow,J.R.,
            Civelli,O., Kennedy,J., Seeman,P., Niznik,H.B. and Jovanovic,V.
  TITLE     Multiple dopamine D4 receptor variants in the human population
  JOURNAL   Nature 358 (6382), 149-152 (1992)
   PUBMED   1319557
REFERENCE   8  (bases 1 to 1399)
  AUTHORS   Gelernter,J., Kennedy,J.L., van Tol,H.H., Civelli,O. and Kidd,K.K.
  TITLE     The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS
  JOURNAL   Genomics 13 (1), 208-210 (1992)
   PUBMED   1349574
REFERENCE   9  (bases 1 to 1399)
  AUTHORS   Van Tol,H.H., Bunzow,J.R., Guan,H.C., Sunahara,R.K., Seeman,P.,
            Niznik,H.B. and Civelli,O.
  TITLE     Cloning of the gene for a human dopamine D4 receptor with high
            affinity for the antipsychotic clozapine
  JOURNAL   Nature 350 (6319), 610-614 (1991)
   PUBMED   1840645
REFERENCE   10 (bases 1 to 1399)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP006284.2, EU432112.1,
            L12398.1 and BM674709.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000797.3.
            
            Summary: This gene encodes the D4 subtype of the dopamine receptor.
            The D4 subtype is a G-protein coupled receptor which inhibits
            adenylyl cyclase. It is a target for drugs which treat
            schizophrenia and Parkinson disease. Mutations in this gene have
            been associated with various behavioral phenotypes, including
            autonomic nervous system dysfunction, attention
            deficit/hyperactivity disorder, and the personality trait of
            novelty seeking. This gene contains a polymorphic number (2-10
            copies) of tandem 48 nt repeats; the sequence shown contains four
            repeats. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU432112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152568, SAMEA2159931
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000176183.6/ ENSP00000176183.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AP006284.2         95986-96021
            37-905              EU432112.1         1-869
            906-906             AP006284.2         98836-98836
            907-1296            EU432112.1         871-1260
            1297-1396           L12398.1           1405-1504
            1397-1399           BM674709.1         16-18               c
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1399
                     /gene="DRD4"
                     /gene_synonym="D4DR"
                     /note="dopamine receptor D4"
                     /db_xref="GeneID:1815"
                     /db_xref="HGNC:HGNC:3025"
                     /db_xref="MIM:126452"
     exon            1..321
                     /gene="DRD4"
                     /gene_synonym="D4DR"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1296
                     /gene="DRD4"
                     /gene_synonym="D4DR"
                     /note="D(2C) dopamine receptor; seven transmembrane helix
                     receptor; dopamine D4 receptor"
                     /codon_start=1
                     /product="D(4) dopamine receptor"
                     /protein_id="NP_000788.2"
                     /db_xref="CCDS:CCDS7710.1"
                     /db_xref="GeneID:1815"
                     /db_xref="HGNC:HGNC:3025"
                     /db_xref="MIM:126452"
                     /translation="MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLL
                     IGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWL
                     LSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATW
                     LLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRG
                     LQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGP
                     DCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRR
                     AKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVN
                     SALNPVIYTVFNAEFRNVFRKALRACC"
     exon            322..434
                     /gene="DRD4"
                     /gene_synonym="D4DR"
                     /inference="alignment:Splign:2.1.0"
     exon            435..1093
                     /gene="DRD4"
                     /gene_synonym="D4DR"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1399
                     /gene="DRD4"
                     /gene_synonym="D4DR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1382..1387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRD4"
                     /gene_synonym="D4DR"
                     /note="hexamer: AACAAA"
     polyA_site      1399
                     /gene="DRD4"
                     /gene_synonym="D4DR"
                     /note="major polyA site"
ORIGIN      
        1 gttgtccgcg gtgctcagcg cccgcccggg cgcgccatgg ggaaccgcag caccgcggac
       61 gcggacgggc tgctggctgg gcgcgggccg gccgcggggg catctgcggg ggcatctgcg
      121 gggctggctg ggcagggcgc ggcggcgctg gtggggggcg tgctgctcat cggcgcggtg
      181 ctcgcgggga actcgctcgt gtgcgtgagc gtggccaccg agcgcgccct gcagacgccc
      241 accaactcct tcatcgtgag cctggcggcc gccgacctcc tcctcgctct cctggtgctg
      301 ccgctcttcg tctactccga ggtccagggt ggcgcgtggc tgctgagccc ccgcctgtgc
      361 gacgccctca tggccatgga cgtcatgctg tgcaccgcct ccatcttcaa cctgtgcgcc
      421 atcagcgtgg acaggttcgt ggccgtggcc gtgccgctgc gctacaaccg gcagggtggg
      481 agccgccggc agctgctgct catcggcgcc acgtggctgc tgtccgcggc ggtggcggcg
      541 cccgtactgt gcggcctcaa cgacgtgcgc ggccgcgacc ccgccgtgtg ccgcctggag
      601 gaccgcgact acgtggtcta ctcgtccgtg tgctccttct tcctaccctg cccgctcatg
      661 ctgctgctct actgggccac gttccgcggc ctgcagcgct gggaggtggc acgtcgcgcc
      721 aagctgcacg gccgcgcgcc ccgccgaccc agcggccctg gcccgccttc ccccacgcca
      781 cccgcgcccc gcctccccca ggacccctgc ggccccgact gtgcgccccc cgcgcccggc
      841 cttccccggg gtccctgcgg ccccgactgt gcgcccgccg cgcccagcct cccccaggac
      901 ccctgcggcc ccgactgtgc gccccccgcg cccggcctcc ccccggaccc ctgcggctcc
      961 aactgtgctc cccccgacgc cgtcagagcc gccgcgctcc caccccagac tccaccgcag
     1021 acccgcagga ggcggcgtgc caagatcacc ggccgggagc gcaaggccat gagggtcctg
     1081 ccggtggtgg tcggggcctt cctgctgtgc tggacgccct tcttcgtggt gcacatcacg
     1141 caggcgctgt gtcctgcctg ctccgtgccc ccgcggctgg tcagcgccgt cacctggctg
     1201 ggctacgtca acagcgccct caaccccgtc atctacactg tcttcaacgc cgagttccgc
     1261 aacgtcttcc gcaaggccct gcgtgcctgc tgctgagccg ggcacccccg gacgcccccc
     1321 ggcctgatgg ccaggcctca gggaccaagg agatggggag ggcgcttttg tacgttaatt
     1381 aaacaaattc cttcccaaa
//
