LOCUS       NM_000796               2770 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens dopamine receptor D3 (DRD3), transcript variant a,
            mRNA.
ACCESSION   NM_000796
VERSION     NM_000796.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2770)
  AUTHORS   Qu,K., He,Y., Zhang,Z., Cao,Y., Qin,Q., Zhou,Z. and Zhen,L.
  TITLE     Association Study Between DRD2, DRD3 Genetic Polymorphisms and
            Adverse Reactions in Chinese Patients on Amisulpride Treatment
  JOURNAL   Pharmacopsychiatry 57 (6), 283-289 (2024)
   PUBMED   39187246
  REMARK    GeneRIF: Association Study Between DRD2, DRD3 Genetic Polymorphisms
            and Adverse Reactions in Chinese Patients on Amisulpride Treatment.
REFERENCE   2  (bases 1 to 2770)
  AUTHORS   Ricard,J.A., Labache,L., Segal,A., Dhamala,E., Cocuzza,C.V.,
            Jones,G., Yip,S.W., Chopra,S. and Holmes,A.J.
  TITLE     A shared spatial topography links the functional connectome
            correlates of cocaine use disorder and dopamine D2/3 receptor
            densities
  JOURNAL   Commun Biol 7 (1), 1178 (2024)
   PUBMED   39300138
  REMARK    GeneRIF: A shared spatial topography links the functional
            connectome correlates of cocaine use disorder and dopamine D2/3
            receptor densities.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2770)
  AUTHORS   Ferrari,M., Vecchio,D., D'Alfonso,S., Gemma,A., Marino,F., Comi,C.
            and Cosentino,M.
  TITLE     Polymorphisms in the Dopaminergic Receptor D3 Gene Correlate with
            Disease Progression Rate in Relapsing-Remitting Multiple Sclerosis
            Patients
  JOURNAL   Genes (Basel) 15 (6), 736 (2024)
   PUBMED   38927672
  REMARK    GeneRIF: Polymorphisms in the Dopaminergic Receptor D3 Gene
            Correlate with Disease Progression Rate in Relapsing-Remitting
            Multiple Sclerosis Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2770)
  AUTHORS   Sarkar,S., Biswas,A., Ansari,S., Choudhury,S., Banerjee,R.,
            Chatterjee,S., Dey,S. and Kumar,H.
  TITLE     Association of dopamine receptor D3 polymorphism with
            Levodopa-induced Dyskinesia: A study on Parkinson's disease
            patients from India
  JOURNAL   Neurosci Lett 825, 137706 (2024)
   PUBMED   38431040
  REMARK    GeneRIF: Association of dopamine receptor D3 polymorphism with
            Levodopa-induced Dyskinesia: A study on Parkinson's disease
            patients from India.
REFERENCE   5  (bases 1 to 2770)
  AUTHORS   Goncalves,A., Mendes,A., Damasio,J., Vila-Cha,N., Boleixa,D.,
            Leal,B. and Cavaco,S.
  TITLE     DRD3 Predicts Cognitive Impairment and Anxiety in Parkinson's
            Disease: Susceptibility and Protective Effects
  JOURNAL   J Parkinsons Dis 14 (2), 313-324 (2024)
   PUBMED   38363619
  REMARK    GeneRIF: DRD3 Predicts Cognitive Impairment and Anxiety in
            Parkinson's Disease: Susceptibility and Protective Effects.
REFERENCE   6  (bases 1 to 2770)
  AUTHORS   Potenza,M.N., Graminski,G.F., Schmauss,C. and Lerner,M.R.
  TITLE     Functional expression and characterization of human D2 and D3
            dopamine receptors
  JOURNAL   J Neurosci 14 (3 Pt 2), 1463-1476 (1994)
   PUBMED   7907363
REFERENCE   7  (bases 1 to 2770)
  AUTHORS   Le Coniat,M., Sokoloff,P., Hillion,J., Martres,M.P., Giros,B.,
            Pilon,C., Schwartz,J.C. and Berger,R.
  TITLE     Chromosomal localization of the human D3 dopamine receptor gene
  JOURNAL   Hum Genet 87 (5), 618-620 (1991)
   PUBMED   1916765
REFERENCE   8  (bases 1 to 2770)
  AUTHORS   Sokoloff,P., Giros,B., Martres,M.P., Bouthenet,M.L. and
            Schwartz,J.C.
  TITLE     Molecular cloning and characterization of a novel dopamine receptor
            (D3) as a target for neuroleptics
  JOURNAL   Nature 347 (6289), 146-151 (1990)
   PUBMED   1975644
REFERENCE   9  (bases 1 to 2770)
  AUTHORS   Giros,B., Martres,M.P., Sokoloff,P. and Schwartz,J.C.
  TITLE     [Gene cloning of human dopaminergic D3 receptor and identification
            of its chromosome]
  JOURNAL   C R Acad Sci III 311 (13), 501-508 (1990)
   PUBMED   2129115
REFERENCE   10 (bases 1 to 2770)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY228458.1, AK292309.1,
            BC095510.1 and AC092896.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 16, 2019 this sequence version replaced NM_000796.5.
            
            Summary: This gene encodes the D3 subtype of the five (D1-D5)
            dopamine receptors. The activity of the D3 subtype receptor is
            mediated by G proteins which inhibit adenylyl cyclase. This
            receptor is localized to the limbic areas of the brain, which are
            associated with cognitive, emotional, and endocrine functions.
            Genetic variation in this gene may be associated with
            susceptibility to hereditary essential tremor 1. Alternative
            splicing of this gene results in transcript variants encoding
            different isoforms, although some variants may be subject to
            nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (a) represents the predominant
            transcript and encodes the longer isoform (a). Variants a, f and g
            encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128123.1, SRR1803614.151435.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383673.5/ ENSP00000373169.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AY228458.1         1-293
            294-455             AK292309.1         153-314
            456-1150            BC095510.1         26-720
            1151-1151           AC092896.9         134944-134944       c
            1152-1616           BC095510.1         722-1186
            1617-1698           AK292309.1         1476-1557
            1699-2770           AC092896.9         123021-124092       c
FEATURES             Location/Qualifiers
     source          1..2770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.31"
     gene            1..2770
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /note="dopamine receptor D3"
                     /db_xref="GeneID:1814"
                     /db_xref="HGNC:HGNC:3024"
                     /db_xref="MIM:126451"
     exon            1..396
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..701
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..1634
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /note="isoform a is encoded by transcript variant a;
                     essential tremor 1"
                     /codon_start=1
                     /product="D(3) dopamine receptor isoform a"
                     /protein_id="NP_000787.2"
                     /db_xref="CCDS:CCDS2978.1"
                     /db_xref="GeneID:1814"
                     /db_xref="HGNC:HGNC:3024"
                     /db_xref="MIM:126451"
                     /translation="MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIV
                     FGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRIC
                     CDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVL
                     AFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQR
                     RRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGEL
                     KREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIV
                     LGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRK
                     AFLKILSC"
     exon            702..814
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..957
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1154
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1437
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..2770
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2742..2747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /note="hexamer: AATAAA"
     polyA_site      2770
                     /gene="DRD3"
                     /gene_synonym="D3DR; ETM1; FET1"
                     /note="major polyA site"
ORIGIN      
        1 gatagagaga caaagaggaa aagagagcga ggtagaaaac ggatactgcc tatgcctact
       61 ccatccctct ttcagcacca aggacagaac ctctgagcgg ctgacccaag caacgctcag
      121 tttagggtcc ctcccaaatc ctctaaagaa aacggataca ttcgaaagca gctatgaaac
      181 atgcactaag gtctaatagg gaagctggaa aagcagcact caagtaattt caccttagag
      241 gcaaaaatgg gtgatttctt tctgttcatt tcatagtttc tgagtcctga gaaaggcaaa
      301 gtttgctttg cttgggtatg tctgctgtca gtaaatggct gcaggagccg aagtggtaaa
      361 ctcctcggtc tccagaaatc agaagaaaat tttagggaag ccccttggca tcacgcacct
      421 ccctctgggc tatggcatct ctgagccagc tgagtggcca cctgaactac acctgtgggg
      481 cagagaactc cacaggtgcc agccaggccc gcccacatgc ctactatgcc ctctcctact
      541 gcgcgctcat cctggccatc gtcttcggca atggcctggt gtgcatggct gtgctgaagg
      601 agcgggccct gcagactacc accaactact tagtagtgag cctggctgtg gcagacttgc
      661 tggtggccac cttggtgatg ccctgggtgg tatacctgga ggtgacaggt ggagtctgga
      721 atttcagccg catttgctgt gatgtttttg tcaccctgga tgtcatgatg tgtacagcca
      781 gcatccttaa tctctgtgcc atcagcatag acaggtacac tgcagtggtc atgcccgttc
      841 actaccagca tggcacggga cagagctcct gtcggcgcgt ggccctcatg atcacggccg
      901 tctgggtact ggcctttgct gtgtcctgcc ctcttctgtt tggctttaat accacagggg
      961 accccactgt ctgctccatc tccaaccctg attttgtcat ctactcttca gtggtgtcct
     1021 tctacctgcc ctttggagtg actgtccttg tctatgccag aatctatgtg gtgctgaaac
     1081 aaaggagacg gaaaaggatc ctcactcgac agaacagtca gtgcaacagt gtcaggcctg
     1141 gcttccccca gcaaaccctc tctcctgacc cggcacatct ggagctgaag cgttactaca
     1201 gcatctgcca ggacactgcc ttgggtggac caggcttcca agaaagagga ggagagttga
     1261 aaagagagga gaagactcgg aattccctga gtcccaccat agcgcccaag ctcagcttag
     1321 aagttcgaaa actcagcaat ggcagattat cgacatcttt gaagctgggg cccctgcaac
     1381 ctcggggagt gccacttcgg gagaagaagg caacccaaat ggtggccatt gtgcttgggg
     1441 ccttcattgt ctgctggctg cccttcttct tgacccatgt tctcaatacc cactgccaga
     1501 catgccacgt gtccccagag ctttacagtg ccacgacatg gctgggctac gtgaatagcg
     1561 ccctcaaccc tgtgatctat accaccttca atatcgagtt ccggaaagcc ttcctcaaga
     1621 tcctgtcttg ctgagggagc agaagaggga acactctttg tacccatttc tagctgccag
     1681 gctgttggcc cactcagaaa gactgtgcag tgtcctccgg catgcagtag gaagaagatt
     1741 cctggagcca ggatgtccct gcttgtcagg tataaccaga tgtgtcctcc aaaacagaat
     1801 attctacctc cccagctaaa atctgacttc attctgacaa tcttcaaatg actggggagc
     1861 ttccaagtga taagcaataa ttcagaaaga agctgataaa acatgactca cacaaaattg
     1921 tcatcagagg catgattcat tacactgaag gaaaatgaac agatctcatc attctcaact
     1981 tgcaggggtc cttgaaatca gccagtaaac caccttctag aacagccagt ctgtcttcct
     2041 tcaaacctct aattaactgt caggctaacc ttgtactttt acgggcccat tcctcttggt
     2101 catttctttc cttcactgta tctggaactg tgaatggcaa ggccagtgct tctacctctc
     2161 tgtagaatcc gatgggctac atttggtgag gtgaatttct cacaccaaga gaaacactgt
     2221 cccacattgg gatgggggct tcatttcaaa ctttgctacc cttgtatttt agctttagct
     2281 aagaaggctt tctgattcca ttcctttact ctctagagga aatctcagag tctcaacttc
     2341 cagaatcatt caagatgggg atattttctg aagacggaat gacacatccc attgtagttt
     2401 cactgttgaa acttatggtt cagaacatac cttagatatg cttttcataa cactaccaaa
     2461 ttttcctacc cagggcatct ccatttctgc ttaacaggga cccaatatag tggaccacat
     2521 catgacattt tgggcaacag tggaccacat atacaacggt ggtctcataa gataataatg
     2581 gagctgaaga atttctatca cttaatgatg tcatagctgt tgcaacatca tagctcaatg
     2641 cattatttac atgtctgtgg tgatgctggt ataaacaaaa tgatgctgcc agtcgtgtaa
     2701 aagtatacaa ttgtgtacag tacgtaatac ttaatattga taataaatga ctatgttact
     2761 ggtttatgta
//
