LOCUS       NM_000795               2808 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1,
            mRNA.
ACCESSION   NM_000795
VERSION     NM_000795.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2808)
  AUTHORS   Lambert,J., Petrovitch,D., Himes,K.P., Freiermuth,C.E., Braun,R.S.,
            Brown,J.L., Bischof,J.J., Lyons,M.S., Punches,B.E.,
            Littlefield,A.K., Kisor,D.F. and Sprague,J.E.
  TITLE     Association of genetic variants in CYP3A5, DRD2 and NK1R with
            opioid overdose
  JOURNAL   Chem Biol Interact 403, 111242 (2024)
   PUBMED   39265714
  REMARK    GeneRIF: Association of genetic variants in CYP3A5, DRD2 and NK1R
            with opioid overdose.
REFERENCE   2  (bases 1 to 2808)
  AUTHORS   Qu,K., He,Y., Zhang,Z., Cao,Y., Qin,Q., Zhou,Z. and Zhen,L.
  TITLE     Association Study Between DRD2, DRD3 Genetic Polymorphisms and
            Adverse Reactions in Chinese Patients on Amisulpride Treatment
  JOURNAL   Pharmacopsychiatry 57 (6), 283-289 (2024)
   PUBMED   39187246
  REMARK    GeneRIF: Association Study Between DRD2, DRD3 Genetic Polymorphisms
            and Adverse Reactions in Chinese Patients on Amisulpride Treatment.
REFERENCE   3  (bases 1 to 2808)
  AUTHORS   Yang,Q., Zhang,X., Zhang,L., Cheng,C. and Zhao,J.
  TITLE     Exploring the influence of the DRD2 gene on mathematical ability:
            perspectives of gene association and gene-environment interaction
  JOURNAL   BMC Psychol 12 (1), 572 (2024)
   PUBMED   39425204
  REMARK    GeneRIF: Exploring the influence of the DRD2 gene on mathematical
            ability: perspectives of gene association and gene-environment
            interaction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2808)
  AUTHORS   Ricard,J.A., Labache,L., Segal,A., Dhamala,E., Cocuzza,C.V.,
            Jones,G., Yip,S.W., Chopra,S. and Holmes,A.J.
  TITLE     A shared spatial topography links the functional connectome
            correlates of cocaine use disorder and dopamine D2/3 receptor
            densities
  JOURNAL   Commun Biol 7 (1), 1178 (2024)
   PUBMED   39300138
  REMARK    GeneRIF: A shared spatial topography links the functional
            connectome correlates of cocaine use disorder and dopamine D2/3
            receptor densities.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2808)
  AUTHORS   Mathis,T., Baudin,F., Mariet,A.S., Augustin,S., Bricout,M.,
            Przegralek,L., Roubeix,C., Benzenine,E., Blot,G., Nous,C.,
            Kodjikian,L., Mauget-Faysse,M., Sahel,J.A., Plevin,R., Zeitz,C.,
            Delarasse,C., Guillonneau,X., Creuzot-Garcher,C., Quantin,C.,
            Hunot,S. and Sennlaub,F.
  TITLE     DRD2 activation inhibits choroidal neovascularization in patients
            with Parkinson's disease and age-related macular degeneration
  JOURNAL   J Clin Invest 134 (17), e174199 (2024)
   PUBMED   39012703
  REMARK    GeneRIF: DRD2 activation inhibits choroidal neovascularization in
            patients with Parkinson's disease and age-related macular
            degeneration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2808)
  AUTHORS   Raymond,D., Saunders-Pullman,R. and Ozelius,L.
  TITLE     SGCE Myoclonus-Dystonia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301587
REFERENCE   7  (bases 1 to 2808)
  AUTHORS   Eubanks,J.H., Djabali,M., Selleri,L., Grandy,D.K., Civelli,O.,
            McElligott,D.L. and Evans,G.A.
  TITLE     Structure and linkage of the D2 dopamine receptor and neural cell
            adhesion molecule genes on human chromosome 11q23
  JOURNAL   Genomics 14 (4), 1010-1018 (1992)
   PUBMED   1478642
REFERENCE   8  (bases 1 to 2808)
  AUTHORS   Liu,Y.F., Civelli,O., Grandy,D.K. and Albert,P.R.
  TITLE     Differential sensitivity of the short and long human dopamine D2
            receptor subtypes to protein kinase C
  JOURNAL   J Neurochem 59 (6), 2311-2317 (1992)
   PUBMED   1331329
REFERENCE   9  (bases 1 to 2808)
  AUTHORS   Araki,K., Kuwano,R., Morii,K., Hayashi,S., Minoshima,S.,
            Shimizu,N., Katagiri,T., Usui,H., Kumanishi,T. and Takahashi,Y.
  TITLE     Structure and expression of human and rat D2 dopamine receptor
            genes
  JOURNAL   Neurochem Int 21 (1), 91-98 (1992)
   PUBMED   1363862
  REMARK    Erratum:[Neurochem Int 1992 Oct;21(3):465]
REFERENCE   10 (bases 1 to 2808)
  AUTHORS   Dearry,A., Falardeau,P., Shores,C. and Caron,M.G.
  TITLE     D2 dopamine receptors in the human retina: cloning of cDNA and
            localization of mRNA
  JOURNAL   Cell Mol Neurobiol 11 (5), 437-453 (1991)
   PUBMED   1835903
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002840.3, DA693976.1,
            BF437994.1, X51362.1 and BC021195.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000795.3.
            
            Summary: This gene encodes the D2 subtype of the dopamine receptor.
            This G-protein coupled receptor inhibits adenylyl cyclase activity.
            A missense mutation in this gene causes myoclonus dystonia; other
            mutations have been associated with schizophrenia. Alternative
            splicing of this gene results in two transcript variants encoding
            different isoforms. A third variant has been described, but it has
            not been determined whether this form is normal or due to aberrant
            splicing. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (long).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.202143.1, X51362.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362072.8/ ENSP00000354859.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AP002840.3         111571-111689       c
            120-302             DA693976.1         1-183
            303-796             BF437994.1         16-509
            797-1292            X51362.1           608-1103
            1293-2798           BC021195.2         1034-2539
            2799-2808           X51362.1           2592-2601
FEATURES             Location/Qualifiers
     source          1..2808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     gene            1..2808
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /note="dopamine receptor D2"
                     /db_xref="GeneID:1813"
                     /db_xref="HGNC:HGNC:3023"
                     /db_xref="MIM:126450"
     exon            1..323
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /inference="alignment:Splign:2.1.0"
     exon            324..639
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1686
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /note="isoform long is encoded by transcript variant 1;
                     d(2) dopamine receptor; seven transmembrane helix
                     receptor; dopamine D2 receptor"
                     /codon_start=1
                     /product="D(2) dopamine receptor isoform long"
                     /protein_id="NP_000786.1"
                     /db_xref="CCDS:CCDS8361.1"
                     /db_xref="GeneID:1813"
                     /db_xref="HGNC:HGNC:3023"
                     /db_xref="MIM:126450"
                     /translation="MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLL
                     IAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF
                     SRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVW
                     VLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRR
                     RRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRA
                     QELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDH
                     PKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFIT
                     HILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC"
     exon            640..749
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /inference="alignment:Splign:2.1.0"
     exon            750..886
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1077
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1164
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1492
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..2808
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2779..2784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /note="hexamer: AATAAA"
     polyA_site      2808
                     /gene="DRD2"
                     /gene_synonym="D2DR; D2R"
                     /note="major polyA site"
ORIGIN      
        1 agtgccgaac cggcagcctc acgcgcgcac cgcgccgcct ccgccccgtc cccgcgctcc
       61 ctcctgcccg cccgccccgc gcccggcccc gccccgcccc gccccgccgc ggcccgtcca
      121 ctgctccccg cgggccagag ccggccgagc tgctgcccgc cggggctctg aacggcgcgg
      181 cggggccggg agccagggac cggccgagga gagtggcggc cccggacggc tgccggaggg
      241 gcggccgcgc gtggatgcgg cgggagctgg aagcctcaag cagccggcgc cgtctctgcc
      301 cccgggcgcc ctatggcttg aagagcctgg ccacccagtg gctccaccgc cctgatggat
      361 ccactgaatc tgtcctggta tgatgatgat ctggagaggc agaactggag ccggcccttc
      421 aacgggtcag acgggaaggc ggacagaccc cactacaact actatgccac actgctcacc
      481 ctgctcatcg ctgtcatcgt cttcggcaac gtgctggtgt gcatggctgt gtcccgcgag
      541 aaggcgctgc agaccaccac caactacctg atcgtcagcc tcgcagtggc cgacctcctc
      601 gtcgccacac tggtcatgcc ctgggttgtc tacctggagg tggtaggtga gtggaaattc
      661 agcaggattc actgtgacat cttcgtcact ctggacgtca tgatgtgcac ggcgagcatc
      721 ctgaacttgt gtgccatcag catcgacagg tacacagctg tggccatgcc catgctgtac
      781 aatacgcgct acagctccaa gcgccgggtc accgtcatga tctccatcgt ctgggtcctg
      841 tccttcacca tctcctgccc actcctcttc ggactcaata acgcagacca gaacgagtgc
      901 atcattgcca acccggcctt cgtggtctac tcctccatcg tctccttcta cgtgcccttc
      961 attgtcaccc tgctggtcta catcaagatc tacattgtcc tccgcagacg ccgcaagcga
     1021 gtcaacacca aacgcagcag ccgagctttc agggcccacc tgagggctcc actaaagggc
     1081 aactgtactc accccgagga catgaaactc tgcaccgtta tcatgaagtc taatgggagt
     1141 ttcccagtga acaggcggag agtggaggct gcccggcgag cccaggagct ggagatggag
     1201 atgctctcca gcaccagccc acccgagagg acccggtaca gccccatccc acccagccac
     1261 caccagctga ctctccccga cccgtcccac catggtctcc acagcactcc cgacagcccc
     1321 gccaaaccag agaagaatgg gcatgccaaa gaccacccca agattgccaa gatctttgag
     1381 atccagacca tgcccaatgg caaaacccgg acctccctca agaccatgag ccgtaggaag
     1441 ctctcccagc agaaggagaa gaaagccact cagatgctcg ccattgttct cggcgtgttc
     1501 atcatctgct ggctgccctt cttcatcaca cacatcctga acatacactg tgactgcaac
     1561 atcccgcctg tcctgtacag cgccttcacg tggctgggct atgtcaacag cgccgtgaac
     1621 cccatcatct acaccacctt caacattgag ttccgcaagg ccttcctgaa gatcctccac
     1681 tgctgactct gctgcctgcc cgcacagcag cctgcttccc acctccctgc ccaggccggc
     1741 cagcctcacc cttgcgaacc gtgagcagga aggcctgggt ggatcggcct cctcttcacc
     1801 ccggcaggcc ctgcagtgtt cgcttggctc catgctcctc actgcccgca caccctcact
     1861 ctgccagggc agtgctagtg agctgggcat ggtaccagcc ctggggctgg gccccccagc
     1921 tcaggggcag ctcatagagt cccccctccc acctccagtc cccctatcct tggcaccaaa
     1981 gatgcagccg ccttccttga ccttcctctg gggctctagg gttgctggag cctgagtcag
     2041 ggcccagagg ctgagttttc tctttgtggg gcttggcgtg gagcaggcgg tggggagaga
     2101 tggacagttc acaccctgca aggcccacag gaggcaagca agctctcttg ccgaggagcc
     2161 aggcaacttc agtcctggga gacccatgta aataccagac tgcaggttgg accccagaga
     2221 ttcccaagcc aaaaacctta gctccctccc gcaccccgat gtggacctct actttccagg
     2281 ctagtccgga cccacctcac cccgttacag ctccccaagt ggtttccaca tgctctgaga
     2341 agaggagccc tcatcttgaa gggcccagga gggtctatgg ggagaggaac tccttggcct
     2401 agcccaccct gctgccttct gacggccctg caatgtatcc cttctcacag cacatgctgg
     2461 ccagcctggg gcctggcagg gaggtcaggc cctggaactc tatctgggcc tgggctaggg
     2521 gacatcagag gttctttgag ggactgcctc tgccacactc tgacgcaaaa ccactttcct
     2581 tttctattcc ttctggcctt tcctctctcc tgtttccctt cccttccact gcctctgcct
     2641 tagaggagcc cacggctaag aggctgctga aaaccatctg gcctggcctg gccctgccct
     2701 gaggaaggag gggaagctgc agcttgggag agcccctggg gcctagactc tgtaacatca
     2761 ctatccatgc accaaactaa taaaactttg acgagtcacc ttccagga
//
