LOCUS       NM_000794               4031 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens dopamine receptor D1 (DRD1), mRNA.
ACCESSION   NM_000794
VERSION     NM_000794.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4031)
  AUTHORS   Grant,C.E., Flis,A.L., Toulabi,L., Zingone,A., Rossi,E., Aploks,K.,
            Sheppard,H. and Ryan,B.M.
  TITLE     DRD1 suppresses cell proliferation and reduces EGFR activation and
            PD-L1 expression in NSCLC
  JOURNAL   Mol Oncol 18 (6), 1631-1648 (2024)
   PUBMED   38572507
  REMARK    GeneRIF: DRD1 suppresses cell proliferation and reduces EGFR
            activation and PD-L1 expression in NSCLC.
REFERENCE   2  (bases 1 to 4031)
  AUTHORS   Pedersen,R., Johansson,J., Nordin,K., Rieckmann,A., Wahlin,A.,
            Nyberg,L., Backman,L. and Salami,A.
  TITLE     Dopamine D1-Receptor Organization Contributes to Functional Brain
            Architecture
  JOURNAL   J Neurosci 44 (11), e0621232024 (2024)
   PUBMED   38302439
  REMARK    GeneRIF: Dopamine D1-Receptor Organization Contributes to
            Functional Brain Architecture.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4031)
  AUTHORS   Gao,A.Y., Diaz Espinosa,A.M., Nguyen,B.B.N., Link,P.A., Meridew,J.,
            Jones,D.L., Gibbard,D.F., Tschumperlin,D.J. and Haak,A.J.
  TITLE     Dopamine Receptor D1 Is Exempt from Transforming Growth Factor
            beta-Mediated Antifibrotic G Protein-Coupled Receptor Landscape
            Tampering in Lung Fibroblasts
  JOURNAL   J Pharmacol Exp Ther 386 (3), 277-287 (2023)
   PUBMED   37024146
  REMARK    GeneRIF: Dopamine Receptor D1 Is Exempt from Transforming Growth
            Factor beta-Mediated Antifibrotic G Protein-Coupled Receptor
            Landscape Tampering in Lung Fibroblasts.
REFERENCE   4  (bases 1 to 4031)
  AUTHORS   Andreska,T., Luningschror,P., Wolf,D., McFleder,R.L.,
            Ayon-Olivas,M., Rattka,M., Drechsler,C., Perschin,V., Blum,R.,
            Aufmkolk,S., Granado,N., Moratalla,R., Sauer,M., Monoranu,C.,
            Volkmann,J., Ip,C.W., Stigloher,C. and Sendtner,M.
  TITLE     DRD1 signaling modulates TrkB turnover and BDNF sensitivity in
            direct pathway striatal medium spiny neurons
  JOURNAL   Cell Rep 42 (6), 112575 (2023)
   PUBMED   37252844
  REMARK    GeneRIF: DRD1 signaling modulates TrkB turnover and BDNF
            sensitivity in direct pathway striatal medium spiny neurons.
REFERENCE   5  (bases 1 to 4031)
  AUTHORS   Zhao,Y., Li,Y., Li,H. and Shi,S.
  TITLE     Dopamine D1 receptor activation ameliorates ox-LDL-induced
            endothelial cell senescence via CREB/Nrf2 pathway
  JOURNAL   Exp Cell Res 425 (2), 113542 (2023)
   PUBMED   36894051
  REMARK    GeneRIF: Dopamine D1 receptor activation ameliorates ox-LDL-induced
            endothelial cell senescence via CREB/Nrf2 pathway.
REFERENCE   6  (bases 1 to 4031)
  AUTHORS   Liu,Y.F., Civelli,O., Zhou,Q.Y. and Albert,P.R.
  TITLE     Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and
            calcium signals of the human dopamine-D1 receptor: selective
            potentiation by protein kinase A
  JOURNAL   Mol Endocrinol 6 (11), 1815-1824 (1992)
   PUBMED   1282671
REFERENCE   7  (bases 1 to 4031)
  AUTHORS   Minowa,M.T., Minowa,T., Monsma,F.J. Jr., Sibley,D.R. and
            Mouradian,M.M.
  TITLE     Characterization of the 5' flanking region of the human D1A
            dopamine receptor gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 3045-3049 (1992)
   PUBMED   1557411
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1992 May 1;89(9):4220]
REFERENCE   8  (bases 1 to 4031)
  AUTHORS   Tiberi,M., Jarvie,K.R., Silvia,C., Falardeau,P., Gingrich,J.A.,
            Godinot,N., Bertrand,L., Yang-Feng,T.L., Fremeau,R.T. Jr. and
            Caron,M.G.
  TITLE     Cloning, molecular characterization, and chromosomal assignment of
            a gene encoding a second D1 dopamine receptor subtype: differential
            expression pattern in rat brain compared with the D1A receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7491-7495 (1991)
   PUBMED   1831904
REFERENCE   9  (bases 1 to 4031)
  AUTHORS   Grandy,D.K., Zhou,Q.Y., Allen,L., Litt,R., Magenis,R.E., Civelli,O.
            and Litt,M.
  TITLE     A human D1 dopamine receptor gene is located on chromosome 5 at
            q35.1 and identifies an EcoRI RFLP
  JOURNAL   Am J Hum Genet 47 (5), 828-834 (1990)
   PUBMED   1977312
REFERENCE   10 (bases 1 to 4031)
  AUTHORS   Sunahara,R.K., Niznik,H.B., Weiner,D.M., Stormann,T.M., Brann,M.R.,
            Kennedy,J.L., Gelernter,J.E., Rozmahel,R., Yang,Y.L., Israel,Y. et
            al.
  TITLE     Human dopamine D1 receptor encoded by an intronless gene on
            chromosome 5
  JOURNAL   Nature 347 (6288), 80-83 (1990)
   PUBMED   1975640
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091393.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000794.4.
            
            Summary: This gene encodes the D1 subtype of the dopamine receptor.
            The D1 subtype is the most abundant dopamine receptor in the
            central nervous system. This G-protein coupled receptor stimulates
            adenylyl cyclase and activates cyclic AMP-dependent protein
            kinases. D1 receptors regulate neuronal growth and development,
            mediate some behavioral responses, and modulate dopamine receptor
            D2-mediated events. Alternate transcription initiation sites result
            in two transcript variants of this gene. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA249160.1, SRR1803611.17628.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393752.3/ ENSP00000377353.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-484               AC091393.3         111870-112353
            485-4031            AC091393.3         112470-116016
FEATURES             Location/Qualifiers
     source          1..4031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..4031
                     /gene="DRD1"
                     /gene_synonym="D1R; DADR; DRD1A"
                     /note="dopamine receptor D1"
                     /db_xref="GeneID:1812"
                     /db_xref="HGNC:HGNC:3020"
                     /db_xref="MIM:126449"
     exon            1..484
                     /gene="DRD1"
                     /gene_synonym="D1R; DADR; DRD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            485..4031
                     /gene="DRD1"
                     /gene_synonym="D1R; DADR; DRD1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             968..2308
                     /gene="DRD1"
                     /gene_synonym="D1R; DADR; DRD1A"
                     /note="dopamine D1 receptor"
                     /codon_start=1
                     /product="D(1A) dopamine receptor"
                     /protein_id="NP_000785.1"
                     /db_xref="CCDS:CCDS4393.1"
                     /db_xref="GeneID:1812"
                     /db_xref="HGNC:HGNC:3020"
                     /db_xref="MIM:126449"
                     /translation="MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLV
                     CAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAF
                     DIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQ
                     LSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIY
                     RIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSV
                     IMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFN
                     ADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIP
                     HAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT"
     regulatory      4007..4012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRD1"
                     /gene_synonym="D1R; DADR; DRD1A"
                     /note="hexamer: AATAAA"
     polyA_site      4031
                     /gene="DRD1"
                     /gene_synonym="D1R; DADR; DRD1A"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcttgc tggtgccagc tcggctcgct gcctcgcatt gccacaggct cctgagaggt
       61 cgcgggcagt gcctgcgggg aggcgcgggg ccctgctctg tagggctgaa ggccgcccga
      121 ggttcgccaa ggctctgggc tctcgaaagg aagccaagaa aagaagctgc ccaggtgacc
      181 agtcctggga gtgctctctc ccaaggaagc tccgagcgcc caggagccct tagccggggt
      241 ctagtgccct ttgaacaatc tccagctctt caaggaagtg ggctgccgcc gcctctcttg
      301 ggacctggcc tgggatcctt tccccaaacg caccccggcg atttttgcgc accgggagcc
      361 gaacccctgc tgcgcgcagc tggctgggct caggcgcgct tcctcaacgt ttcggagccg
      421 ctgcccccag cgaagtccac attccaagct ccaggggctt tgagagagac gaccccaagg
      481 caaggcgttt ggagagctgc tgaggagcca ggggcttgga ggagcgagaa gacatgtatt
      541 ttcagctgag tctcagaagg ggagaatctc ctgtcaccac cagaaaagca acagccccga
      601 aatgtgattg caactgacta gcagagcaga ggcccaggag tcactggatt gatgatttag
      661 aatatgctaa aaagccagtg ctttatttgg ggaattcagg ggctttctgg tgcccaagac
      721 agtgacctgc agcaagggag tcagaagaca gatgtagaaa tcaagagtga ccatccacgg
      781 gattgacttg gattgccact caagcggtcc tctcatggaa tgttggtgag gccctctgcc
      841 agggaagcaa tctggctgtg caaagtgctg cctggtgggg aggactcctg gaaatctgac
      901 tgacccctat tccctgcttg ggaacttgag gggtgtcaga gcccctgatg tgctttctct
      961 taggaagatg aggactctga acacctctgc catggacggg actgggctgg tggtggagag
     1021 ggacttctct gttcgtatcc tcactgcctg tttcctgtcg ctgctcatcc tgtccacgct
     1081 cctggggaac acgctggtct gtgctgccgt tatcaggttc cgacacctgc ggtccaaggt
     1141 gaccaacttc tttgtcatct ccttggctgt gtcagatctc ttggtggccg tcctggtcat
     1201 gccctggaag gcagtggctg agattgctgg cttctggccc tttgggtcct tctgtaacat
     1261 ctgggtggcc tttgacatca tgtgctccac tgcatccatc ctcaacctct gtgtgatcag
     1321 cgtggacagg tattgggcta tctccagccc tttccggtat gagagaaaga tgacccccaa
     1381 ggcagccttc atcctgatca gtgtggcatg gaccttgtct gtactcatct ccttcatccc
     1441 agtgcagctc agctggcaca aggcaaaacc cacaagcccc tctgatggaa atgccacttc
     1501 cctggctgag accatagaca actgtgactc cagcctcagc aggacatatg ccatctcatc
     1561 ctctgtaata agcttttaca tccctgtggc catcatgatt gtcacctaca ccaggatcta
     1621 caggattgct cagaaacaaa tacggcgcat tgcggccttg gagagggcag cagtccacgc
     1681 caagaattgc cagaccacca caggtaatgg aaagcctgtc gaatgttctc aaccggaaag
     1741 ttcttttaag atgtccttca aaagagaaac taaagtcctg aagactctgt cggtgatcat
     1801 gggtgtgttt gtgtgctgtt ggctaccttt cttcatcttg aactgcattt tgcccttctg
     1861 tgggtctggg gagacgcagc ccttctgcat tgattccaac acctttgacg tgtttgtgtg
     1921 gtttgggtgg gctaattcat ccttgaaccc catcatttat gcctttaatg ctgattttcg
     1981 gaaggcattt tcaaccctct taggatgcta cagactttgc cctgcgacga ataatgccat
     2041 agagacggtg agtatcaata acaatggggc cgcgatgttt tccagccatc atgagccacg
     2101 aggctccatc tccaaggagt gcaatctggt ttacctgatc ccacatgctg tgggctcctc
     2161 tgaggacctg aaaaaggagg aggcagctgg catcgccaga cccttggaga agctgtcccc
     2221 agccctatca gtcatattgg actatgacac tgacgtctct ctggagaaga tccaacccat
     2281 cacacaaaac ggtcagcacc caacctgaac tcgcagatga atcctgccac acatgctcat
     2341 cccaaaagct agaggagatt gctctggggc ttgctattaa gaaactaagg tacggtgaga
     2401 ctctgaggtg tcaggagagc cctctgctgc tttccaacac acaattaact ccgtttccaa
     2461 atacattcca gtgtattttc tgtgttgttc atagtcaatc aaacagggac actacaaaca
     2521 tggggagcca taagggacat gtctttggct tcagaattgt ttttagaaat ttattcttat
     2581 cttaggattt accaaatagg gcaaagaatc aacagtgaac agcttcactt aaaatcaaat
     2641 ttttctggga agaaaatgag atgggttgag tttgctgtat acaaacaggt gctaacactg
     2701 ttcccagcaa agttttcaga ttgtaaaggt aggtgcatgc cttcataaat tatttctaaa
     2761 acattaattg aggcttacag taggagtgag aaattttttt ccagaattga gagatgtttt
     2821 gttgatattg gttctattta tttattgtat atatggatat ttttaattta tgatataata
     2881 aatatatatt tatcatattt aataggataa attaatgagt tttatccaag accttacaac
     2941 cacatttctg gccatttaac tagcacttta taagccaatg aagcaaacac acagactctg
     3001 tgagattcta aatgttcatg tgtaacttct agaaacacag cagaaactga tagataaggg
     3061 aataaagttg aaatgattcc ttaaaattca tggacacaga taaatgcaag gtgagaattg
     3121 acaaatgcta taaatgcttt ctttttctga aaagattttg aaaaatttaa aaaagtatag
     3181 ctactactgt gttcaaaacg ttttaaatga caaatgactt tcccagggga atttgcagtt
     3241 ctgtaaatat cttaaataaa agccaactta agaagagccc agcattaaat ttacgatctt
     3301 aggtggtaat gaaaagtata tgctgctttg tatttatgta aaataattgg ccctctccat
     3361 cttttctcat ttcatgtgtc aggtagtttt tctgaaccac acaaatggct ttcctggaga
     3421 gagatctgta gcacagacag tgggttacag cagccccact gagggaccaa actcaaaccc
     3481 tgcatttcca tcttaccagg tcaaaccaaa ccagtcagtg gggctacttt ttatagtgct
     3541 ttaatctgaa tttagagctg atttttaaag gagtctttaa atgttaatgg tatactaact
     3601 aacgaatagt gcctcattat cattcttgag tcagatactt ctgttgatgg gagaaacaga
     3661 agaatccttc cctttgggtg tgttgagctc ccccaaagcc atcagcatct cttttgacaa
     3721 atgctagtcc tttctctgtg ctttggaatc aggttcctgc atcatcaccc ggactgtaaa
     3781 aagtatcata agcctccctt gccagatgcc aactcgtggg gcatttcaac agagtttctt
     3841 tgaaatgttt acaacgtatt cttcttgata agcaatgaac ttaacattta gatgcaatcc
     3901 gtgaaaagaa aaaaaaatct gaaaaatatc tcctgcatca ggtctgtgtt atttatgtat
     3961 tgtgaatgtt ttcttaattt tattggctgt atgctttctt acacataata aaaatatttt
     4021 gtgaactcaa a
//
