LOCUS       NM_001289162            3387 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dynein regulatory complex subunit 7 (DRC7), transcript
            variant 1, mRNA.
ACCESSION   NM_001289162 XM_005256202
VERSION     NM_001289162.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3387)
  AUTHORS   Dowling,J.K., Becker,C.E., Bourke,N.M., Corr,S.C., Connolly,D.J.,
            Quinn,S.R., Pandolfi,P.P., Mansell,A. and O'Neill,L.A.J.
  TITLE     Promyelocytic leukemia protein interacts with the
            apoptosis-associated speck-like protein to limit inflammasome
            activation
  JOURNAL   J Biol Chem 289 (10), 6429-6437 (2014)
   PUBMED   24407287
REFERENCE   4  (bases 1 to 3387)
  AUTHORS   Zhang,D. and Aravind,L.
  TITLE     Novel transglutaminase-like peptidase and C2 domains elucidate the
            structure, biogenesis and evolution of the ciliary compartment
  JOURNAL   Cell Cycle 11 (20), 3861-3875 (2012)
   PUBMED   22983010
REFERENCE   5  (bases 1 to 3387)
  AUTHORS   Yang,Y., Cochran,D.A., Gargano,M.D., King,I., Samhat,N.K.,
            Burger,B.P., Sabourin,K.R., Hou,Y., Awata,J., Parry,D.A.,
            Marshall,W.F., Witman,G.B. and Lu,X.
  TITLE     Regulation of flagellar motility by the conserved flagellar protein
            CG34110/Ccdc135/FAP50
  JOURNAL   Mol Biol Cell 22 (7), 976-987 (2011)
   PUBMED   21289096
REFERENCE   6  (bases 1 to 3387)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB093780.1, BC030661.1, AK292558.1, AK093035.1, BC036667.1 and
            AC018552.6.
            
            On May 17, 2019 this sequence version replaced NM_001289162.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Both variants 1 and
            2 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360716.8/ ENSP00000353942.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DB093780.1         6-11
            7-544               BC030661.1         6-543
            545-2482            AK292558.1         414-2351
            2483-3036           AK093035.1         2127-2680
            3037-3037           BC036667.1         2901-2901
            3038-3387           AC018552.6         8305-8654           c
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..3387
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /note="dynein regulatory complex subunit 7"
                     /db_xref="GeneID:84229"
                     /db_xref="HGNC:HGNC:25289"
                     /db_xref="MIM:618769"
     exon            1..47
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            48..178
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            179..418
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..2840
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /note="isoform a is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 135; coiled-coil
                     domain-containing protein lobo homolog; coiled-coil domain
                     containing 135"
                     /codon_start=1
                     /product="dynein regulatory complex subunit 7 isoform a"
                     /protein_id="NP_001276091.1"
                     /db_xref="CCDS:CCDS10787.1"
                     /db_xref="GeneID:84229"
                     /db_xref="HGNC:HGNC:25289"
                     /db_xref="MIM:618769"
                     /translation="MEVLREKVEEEEEAEREEAAEWAEWARMEKMMRPVEVRKEEITL
                     KQETLRDLEKKLSEIQITVSAELPAFTKDTIDISKLPISYKTNTPKEEHLLQVADNFS
                     RQYSHLCPDRVPLFLHPLNECEVPKFVSTTLRPTLMPYPELYNWDSCAQFVSDFLTMV
                     PLPDPLKPPSHLYSSTTVLKYQKGNCFDFSTLLCSMLIGSGYDAYCVNGYGSLDLCHM
                     DLTREVCPLTVKPKETIKKEEKVLPKKYTIKPPRDLCSRFEQEQEVKKQQEIRAQEKK
                     RLREEEERLMEAEKAKPDALHGLRVHSWVLVLSGKREVPENFFIDPFTGHSYSTQDEH
                     FLGIESLWNHKNYWINMQDCWNCCKDLIFDLGDPVRWEYMLLGTDKSQLSLTEEDDSG
                     INDEDDVENLGKEDEDKSFDMPHSWVEQIEISPEAFETRCPNGKKVIQYKRAKLEKWA
                     PYLNSNGLVSRLTTYEDLQCTNILEIKEWYQNREDMLELKHINKTTDLKTDYFKPGHP
                     QALRVHSYKSMQPEMDRVIEFYETARVDGLMKREETPRTMTEYYQGRPDFLSYRHASF
                     GPRVKKLTLSSAESNPRPIVKITERFFRNPAKPAEEDVAERVFLVAEERIQLRYHCRE
                     DHITASKREFLRRTEVDSKGNKIIMTPDMCISFEVEPMEHTKKLLYQYEAMMHLKREE
                     KLSRHQVWESELEVLEILKLREEEEAAHTLTISIYDTKRNEKSKEYREAMERMMHEEH
                     LRQVETQLDYLAPFLAQLPPGEKLTCWQAVRLKDECLSDFKQRLINKANLIQARFEKE
                     TQELQKKQQWYQENQVTLTPEDEDLYLSYCSQAMFRIRILEQRLNRHKELAPLKYLAL
                     EEKLYKDPRLGELQKIFA"
     exon            419..593
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            594..719
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            720..914
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1073
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1292
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1421
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1494
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1623
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1752
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1973
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2189
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2300
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2411
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2606
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2746
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..3387
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3014..3019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /note="hexamer: AATAAA"
     polyA_site      3035
                     /gene="DRC7"
                     /gene_synonym="C16orf50; CCDC135; CFAP50; FAP50"
                     /note="major polyA site"
ORIGIN      
        1 gttaccatgg agatggctaa cagctagagc aggctgtcct cggagggaac cgggtcacat
       61 cgcagggcca cctctagctg caagagaatc tgggaagctg agcaattcaa accaggcaca
      121 ctgctgcccc ccacacaact ggggttctgc cgtatagaag aggagactgg atctttggag
      181 acattccatc tccagacacc cagagacgct ccagaatgga ggtcctgagg gagaaggtgg
      241 aggaggagga ggaggccgag cgggaggagg cggccgagtg ggctgaatgg gcgaggatgg
      301 agaaaatgat gaggccagtt gaggtgcgga aggaggaaat caccttaaag caggagacgc
      361 tcagagacct ggagaagaag ctgtcagaga tccagatcac tgtctcagcg gagctcccgg
      421 cctttaccaa ggacactatt gacatctcca agctgcccat ttcctacaaa accaacacac
      481 ccaaggagga acacctgctg caggtggcag acaacttctc ccgccagtac agccatctgt
      541 gcccggaccg cgtgcccctc ttcctgcacc ccctgaacga gtgtgaagtg cccaagttcg
      601 tgagcacaac cctccggccc acactgatgc cctaccccga gctctacaac tgggacagct
      661 gtgcccagtt tgtctccgac ttcctcacca tggtgcccct gcctgaccct ctcaagccgc
      721 cctcgcacct gtactcctcg accactgtgc tcaagtacca gaaggggaac tgctttgact
      781 tcagtacgct gctctgctcc atgcttatcg gctctggcta tgatgcttac tgcgtcaacg
      841 gctacggctc gctggacctg tgccacatgg acctgacgcg ggaggtgtgc ccactcactg
      901 tgaagcccaa ggagaccatc aagaaggagg aaaaggtgct gcctaagaag tataccatca
      961 aaccccccag ggacctgtgc agcaggtttg agcaggagca agaggtgaag aagcagcagg
     1021 agatcagagc ccaggagaag aagcggctga gggaggagga ggagcgcctc atggaagcgg
     1081 agaaggcaaa gccggatgcc ctgcacggcc tgcgggtgca ctcctgggtc cttgtgctat
     1141 cggggaagcg cgaggtgcct gagaacttct tcatcgaccc attcacagga catagctaca
     1201 gcacccagga tgagcacttc ctgggcatcg aaagcctgtg gaaccacaag aactactgga
     1261 tcaacatgca ggattgctgg aactgctgca aggacttgat ctttgacctg ggtgaccctg
     1321 tgagatggga gtacatgctc ctggggactg ataagtctca gctgtccttg actgaagaag
     1381 acgacagtgg gataaacgat gaggatgatg tggaaaatct gggcaaggag gatgaggata
     1441 agagcttcga catgccccac tcgtgggtgg agcagattga gatctccccg gaagcatttg
     1501 agacccgctg cccgaacggg aagaaggtga ttcagtacaa gagggcaaag ctggagaagt
     1561 gggccccgta cctcaatagc aatggccttg tgagccgcct caccacctat gaggacttgc
     1621 agtgtaccaa tattttggag ataaaggagt ggtaccagaa ccgggaagac atgctggagc
     1681 tgaaacacat aaacaagacc acagacctga agacagacta cttcaagcct ggccaccccc
     1741 aggctctgcg cgtgcactcg tacaagtcca tgcaacctga gatggaccgt gtcattgagt
     1801 tttatgaaac ggcccgtgtg gatggcctga tgaagcggga ggagacaccc aggacaatga
     1861 cagagtacta tcaaggacgc ccagacttcc tctcctaccg ccatgccagc ttcggacccc
     1921 gagtcaagaa gctcactctg agcagtgcag agtcaaaccc ccggcccatt gtgaaaatca
     1981 cagagcggtt cttccgcaac ccagcgaagc ccgcggagga ggacgtggca gagcgcgtgt
     2041 ttctggtcgc ggaggagcgc atccagctgc gctaccactg ccgtgaggac cacatcacgg
     2101 cctccaagcg cgagttcctg cggcgcaccg aggtggacag caaaggcaac aagatcatca
     2161 tgacgcccga catgtgcatc agcttcgagg tggagcccat ggagcacacc aagaagctgc
     2221 tctaccagta cgaggccatg atgcacctga agagggagga gaagctgtcc agacatcagg
     2281 tctgggagtc agagctggag gtgctggaga ttctgaagct tcgagaggaa gaggaggcgg
     2341 cgcacacact gaccatctcc atctatgaca ccaagcggaa tgagaagagc aaggaatatc
     2401 gggaggccat ggagcgcatg atgcacgaag agcacctgcg gcaggtggag acccagctgg
     2461 actacctggc cccattcctg gcccagctcc cgccaggaga gaaactaaca tgctggcagg
     2521 cggtgcgcct caaggatgag tgcctcagcg acttcaagca gcggctcatc aacaaggcca
     2581 acctcatcca ggcccgcttt gagaaggaga cccaggagct gcaaaagaag cagcagtggt
     2641 accaggagaa ccaggtgacg ctgacacccg aggatgaaga cctgtacctg agttactgct
     2701 ctcaggccat gttccgcatc cgcatcctgg agcagcgcct caatcgacac aaggaactgg
     2761 ccccactgaa gtacctggct ctggaggaaa agctctacaa ggacccacgc ctgggggagc
     2821 tccagaaaat attcgcttga tgtccctcct ggggcctcag ccagagctgc cagagaaagg
     2881 aaacctcttc ccgcagcctg gctcctgtgt tccctctatc cagccaatgc ctgtttacac
     2941 agacacctgg cctcactgcc agcccacctc ccctacagcc ctgtttgttc ctgcttctca
     3001 tgattttcct gtaaataaac acactcttaa tttgccattt gtgccttgcg cttcacaagc
     3061 tccagcagca gcctttctct tcttctgtta tctatagcct gggaccaccc ccttcctccc
     3121 cttggcctgt cgtttgcttc ctgtccttct ctccgttgga atgtcaggtc ttcacagcac
     3181 ctctgcagat ggtcccacag ccatctgcaa acaactggtt atatctcaat gtgactaggg
     3241 tggcccacct caccaagtgg gatggggaag gctaagatgc atgccccaga atttgaggac
     3301 tgaatcccag ctcctcctct taccagatac cacttaccca tctgtggaat ggggtagcat
     3361 tgttgcatta aataagactt atggcca
//
