LOCUS       NM_018370               3279 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens DNA damage regulated autophagy modulator 1 (DRAM1),
            mRNA.
ACCESSION   NM_018370
VERSION     NM_018370.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3279)
  AUTHORS   Zhang,H., Luan,L., Li,X., Sun,X. and Yang,K.
  TITLE     DNA damage-regulated autophagy modulator 1 prevents glioblastoma
            cells proliferation by regulating lysosomal function and autophagic
            flux stability
  JOURNAL   Exp Cell Res 437 (2), 114016 (2024)
   PUBMED   38537746
  REMARK    GeneRIF: DNA damage-regulated autophagy modulator 1 prevents
            glioblastoma cells proliferation by regulating lysosomal function
            and autophagic flux stability.
REFERENCE   2  (bases 1 to 3279)
  AUTHORS   Qi,Y., Hu,M., Han,C., Wang,J., Chen,F., Guo,H., She,Y., Zhang,M.,
            Zhang,J., Zhao,Z., Xie,H., Wang,S., Chen,M., Wang,J. and Zeng,D.
  TITLE     ARHGAP4 promotes leukemogenesis in acute myeloid leukemia by
            inhibiting DRAM1 signaling
  JOURNAL   Oncogene 42 (34), 2547-2557 (2023)
   PUBMED   37443303
  REMARK    GeneRIF: ARHGAP4 promotes leukemogenesis in acute myeloid leukemia
            by inhibiting DRAM1 signaling.
REFERENCE   3  (bases 1 to 3279)
  AUTHORS   Feng,Q., Cheng,M., Jin,J., Zhang,S., Bai,Y. and Xu,J.
  TITLE     DRAM1 plays a tumor suppressor role in clear cell renal cell
            carcinoma through modulating Akt signaling
  JOURNAL   Acta Histochem 124 (3), 151874 (2022)
   PUBMED   35299128
  REMARK    GeneRIF: DRAM1 plays a tumor suppressor role in clear cell renal
            cell carcinoma through modulating Akt signaling.
REFERENCE   4  (bases 1 to 3279)
  AUTHORS   Zhang,Y., Li,X., Li,Y., Li,Y., Wang,Y., Zhu,L., Chen,P., Tian,Z.,
            Qiu,Y., Feng,R., Zeng,Z., He,Y., Chen,B., Zhang,S., Mao,R. and
            Chen,M.
  TITLE     DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates
            Autophagy and Apoptosis of Intestinal Epithelial Cells in
            Inflammatory Bowel Disease
  JOURNAL   Dig Dis Sci 66 (10), 3375-3390 (2021)
   PUBMED   33184797
  REMARK    GeneRIF: DNA Damage-Regulated Autophagy Modulator 1 (DRAM1)
            Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in
            Inflammatory Bowel Disease.
REFERENCE   5  (bases 1 to 3279)
  AUTHORS   Geng,J., Zhang,R., Yuan,X., Xu,H., Zhu,Z., Wang,X., Wang,Y., Xu,G.,
            Guo,W., Wu,J. and Qin,Z.H.
  TITLE     DRAM1 plays a tumor suppressor role in NSCLC cells by promoting
            lysosomal degradation of EGFR
  JOURNAL   Cell Death Dis 11 (9), 768 (2020)
   PUBMED   32943616
  REMARK    GeneRIF: DRAM1 plays a tumor suppressor role in NSCLC cells by
            promoting lysosomal degradation of EGFR.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3279)
  AUTHORS   O'Prey,J., Skommer,J., Wilkinson,S. and Ryan,K.M.
  TITLE     Analysis of DRAM-related proteins reveals evolutionarily conserved
            and divergent roles in the control of autophagy
  JOURNAL   Cell Cycle 8 (14), 2260-2265 (2009)
   PUBMED   19556885
  REMARK    GeneRIF: DRAM is activated by p53 which is required for the ability
            of p53 to induce autophagy and is also critical for the ability of
            p53 to induce programmed cell death.
REFERENCE   7  (bases 1 to 3279)
  AUTHORS   Kerley-Hamilton,J.S., Pike,A.M., Hutchinson,J.A., Freemantle,S.J.
            and Spinella,M.J.
  TITLE     The direct p53 target gene, FLJ11259/DRAM, is a member of a novel
            family of transmembrane proteins
  JOURNAL   Biochim Biophys Acta 1769 (4), 209-219 (2007)
   PUBMED   17397945
  REMARK    GeneRIF: identified FLJ11259/DRAM as a p53-inducible member of a
            novel family of transmembrane proteins. FLJ11259/DRAM may be an
            important modulator of p53 responses in diverse tumor types.
REFERENCE   8  (bases 1 to 3279)
  AUTHORS   Crighton,D., Wilkinson,S. and Ryan,K.M.
  TITLE     DRAM links autophagy to p53 and programmed cell death
  JOURNAL   Autophagy 3 (1), 72-74 (2007)
   PUBMED   17102582
  REMARK    GeneRIF: DRAM links autophagy to p53 and programmed cell death.
            Review article
REFERENCE   9  (bases 1 to 3279)
  AUTHORS   Crighton,D., Wilkinson,S., O'Prey,J., Syed,N., Smith,P.,
            Harrison,P.R., Gasco,M., Garrone,O., Crook,T. and Ryan,K.M.
  TITLE     DRAM, a p53-induced modulator of autophagy, is critical for
            apoptosis
  JOURNAL   Cell 126 (1), 121-134 (2006)
   PUBMED   16839881
  REMARK    GeneRIF: Collectively therefore, these studies not only report a
            stress-induced regulator of autophagy but also highlight the
            relationship of DRAM and autophagy to p53 function and
            damage-induced programmed cell death.
REFERENCE   10 (bases 1 to 3279)
  AUTHORS   Green,D.R. and Chipuk,J.E.
  TITLE     p53 and metabolism: Inside the TIGAR
  JOURNAL   Cell 126 (1), 30-32 (2006)
   PUBMED   16839873
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC018435.1, AC084398.25 and
            AI079438.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018370.2.
            
            Summary: This gene is regulated as part of the p53 tumor suppressor
            pathway. The gene encodes a lysosomal membrane protein that is
            required for the induction of autophagy by the pathway. Decreased
            transcriptional expression of this gene is associated with various
            tumors. This gene has a pseudogene on chromosome 4. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.41122.1,
                                           SRR1803612.215939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258534.13/ ENSP00000258534.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1209              BC018435.1         230-1438
            1210-2848           AC084398.25        14768-16406         c
            2849-3279           AI079438.1         22-452              c
FEATURES             Location/Qualifiers
     source          1..3279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..3279
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /note="DNA damage regulated autophagy modulator 1"
                     /db_xref="GeneID:55332"
                     /db_xref="HGNC:HGNC:25645"
                     /db_xref="MIM:610776"
     exon            1..341
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..927
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /note="damage-regulated autophagy modulator"
                     /codon_start=1
                     /product="DNA damage-regulated autophagy modulator protein
                     1"
                     /protein_id="NP_060840.2"
                     /db_xref="CCDS:CCDS41823.1"
                     /db_xref="GeneID:55332"
                     /db_xref="HGNC:HGNC:25645"
                     /db_xref="MIM:610776"
                     /translation="MLCFLRGMAFVPFLLVTWSSAAFIISYVVAVLSGHVNPFLPYIS
                     DTGTTPPESGIFGFMINFSAFLGAATMYTRYKIVQKQNQTCYFSTPVFNLVSLVLGLV
                     GCFGMGIVANFQELAVPVVHDGGALLAFVCGVVYTLLQSIISYKSCPQWNSLSTCHIR
                     MVISAVSCAAVIPMIVCASLISITKLEWNPREKDYVYHVVSAICEWTVAFGFIFYFLT
                     FIQDFQSVTLRISTEINGDI"
     exon            342..409
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /inference="alignment:Splign:2.1.0"
     exon            410..552
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /inference="alignment:Splign:2.1.0"
     exon            553..730
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /inference="alignment:Splign:2.1.0"
     exon            731..789
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /inference="alignment:Splign:2.1.0"
     exon            790..882
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /inference="alignment:Splign:2.1.0"
     exon            883..3279
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3261..3266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /note="hexamer: AATAAA"
     polyA_site      3279
                     /gene="DRAM1"
                     /gene_synonym="DRAM"
                     /note="major polyA site"
ORIGIN      
        1 actctggccc ggcagcctcg ccgcccgcag cctcgctccg ctcctcgcgc ttcccctccc
       61 tccggggctg ggcctgcccc ggccgtcgcg gagcctcccc tcccaccgtc cgtgagtgta
      121 cgcgcccggc cgccgcctcc aggcagcccg gagcaacccg gcgcccggcc ccgctgggcg
      181 cagcactccg tcggcggcgg cggcggcgcg atgctgtgct tcctgagggg aatggctttc
      241 gtccccttcc tcttggtgac ctggtcgtca gccgccttca ttatctccta cgtggtcgcc
      301 gtgctctccg ggcacgtcaa ccccttcctc ccgtatatca gtgatacggg aacaacacct
      361 ccagagagtg gtatttttgg atttatgata aacttctctg catttcttgg tgcagccacg
      421 atgtatacaa gatacaaaat agtacagaag caaaatcaaa cctgctattt cagcactcct
      481 gtttttaact tggtgtcttt agtgcttgga ttggtgggat gtttcggaat gggcattgtc
      541 gccaattttc aggagttagc tgtgccagtg gttcatgacg ggggcgctct tttggccttt
      601 gtctgtggtg tcgtgtacac gctcctacag tccatcatct cttacaaatc atgtccccag
      661 tggaacagtc tctcgacatg ccacatacgg atggtcatct ctgccgtttc ttgcgcagct
      721 gtcatcccca tgattgtctg tgcttcacta atttccataa ccaagctgga gtggaatcca
      781 agagaaaagg attatgtata tcacgtagtg agtgcgatct gtgaatggac agtggccttt
      841 ggttttattt tctacttcct aactttcatc caagatttcc agagtgtcac cctaaggata
      901 tccacagaaa tcaatggtga tatttgaaga aagaagaatt cagtctcact cagtgaatgt
      961 cgcaggccat ttctaaaagt gctacagagg acagacaggg ttttgaggcc accctgatta
     1021 ttgggatgca tctgcagcac atccaggact tgaatttcat tacgagttcc taatagttgt
     1081 atttctaaag atgtgtttcc tagagaatgt acagccttat gacactgtag tgatgttttt
     1141 ataattttct aagtagattt ttttatatta acaaattcat atacagaaaa aataaggtgt
     1201 tacaaaaaat ggagagctct tatttttgta cagattctgt cgtttttgtt ttatttgtgt
     1261 gagatttatg gaaatacact aaatgagtaa ttcaggttca gtacatttat tacaaagtga
     1321 aatcagggga tattcatttg taaattttat tcttagtgaa tgaactgtat aatttttttt
     1381 atcaggagag cacttataaa attcaattta taaagatcat atacccaaat cataaagatt
     1441 tagttgatac attaacacta agatactctg atttttagcc gaactaaaca aagtgcttct
     1501 actgagaggc ctttatacca ccatgtacag taactctaag tgaatacgga agaccttggt
     1561 tttgaaattc tgccaccttg tttctccctg ctcatgaggt cgcacctttt gctcttgctg
     1621 ctaattgccc attcgtagtg ggtgtaatgc caggtggaat ggtttcaaca agtcaggtga
     1681 aaaccatcct ttattgttgc tggcacaact tgatatatag tctgactcag aactgaagct
     1741 cacatctcaa attcatttca tgccagtaaa tgtggcaaag agaagaaagg cccaagagcg
     1801 agacaagaag aatggagaag ggggcagcca agaagaactt ctgggttcag ggtactgttt
     1861 atttgctcct tctcttcatg cctgtggctg gatgtcccac aacactataa gaaatataag
     1921 tcaagccctt tgtgttaagc aagaactaca gactccatct tttcacccaa atcatgaatg
     1981 accaataaaa agcaagttat tccagaggaa gaagcagccc ttgaaatgtt aaggcttagg
     2041 cttgaaaggt gaagagcagg aattctctct ttcaaatcct agagcataaa cccatgtgtg
     2101 gccaagtgag atcagccctc aagggcacat gccaagggca gagcagccca tgtagacagc
     2161 ttcggagggc atgggggtgt agggagttcg gggtagctcc tcattaacta tttgttgggt
     2221 gagtaaaggg gtgaggctca gtggcaggta cctctgcaat gacaagctgc ctcccctcta
     2281 tgtgtttagc atatgttatt agaacatgtc cgacacccct accgctgcca tttgggccct
     2341 ttaataaagc caagtagaga aatctggcaa taaaaggcaa atgtaagcat gctttcttta
     2401 agacgcatca taaatggttt tctttaagtg aatggaagag tttgacagag atacaccttt
     2461 gtaagaaaac attaagaatg ctggctggct gtggtggctc acacctgtat tcccagcact
     2521 ttgggaggcc taggcaggag gattgcttga gcctgggact tcgagaccag actgggaaac
     2581 atggcaaaat cccatctcta caacaaaaat acaaaaatta gccaagtgcg gtggtgtgcc
     2641 tgtagtccta gttacttggg aggctgaggt gggagaatca cctgagccca ggaggtggag
     2701 gctgcagtga gccatgccaa tgcactccag tctgggcaac agagtgagac cctgtctcaa
     2761 aaataaataa ataaataaat gaataaagag aatgctaatc atttctgggt tcactgcgac
     2821 tcactgtagt gctggggatc ccccttgtaa cactggaact gaaagacagt gatgaaagct
     2881 atgtcaagca ttcattattc tgaagaggag gagaaatgcc acataccttt cccatgggac
     2941 ctgtggtgga atgaatccat acttctgcct cacttcgagc agacttttgt tctcggcgct
     3001 cctcacgatg gagtttcatg cttcattttc acatctctct gcacaattag attgggagct
     3061 ccttgagggc agagtacgtg ccttaatctt tatctttgta atgccacaat gaacagagtg
     3121 cctcctggta cactgtagga gcttaagaaa tactcactga atgcatgaat gaatgaatga
     3181 acaaatgaag gaatgactaa ggatgtttgt agtgctataa tatagaatgg gatttactct
     3241 gctttaccag ttagtttcat aataaacaaa tagtctgta
//
