LOCUS       NM_001938              10124 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens down-regulator of transcription 1 (DR1), mRNA.
ACCESSION   NM_001938
VERSION     NM_001938.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10124)
  AUTHORS   An,H., Yu,X., Liu,Y., Fang,L., Shu,M., Zhai,Q. and Chen,J.
  TITLE     Downregulation of transcription 1 hinders the replication of Dabie
            bandavirus by promoting the expression of TLR7, TLR8, and TLR9
            signaling pathway
  JOURNAL   Ticks Tick Borne Dis 15 (2), 102307 (2024)
   PUBMED   38194758
  REMARK    GeneRIF: Downregulation of transcription 1 hinders the replication
            of Dabie bandavirus by promoting the expression of TLR7, TLR8, and
            TLR9 signaling pathway.
REFERENCE   2  (bases 1 to 10124)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10124)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   4  (bases 1 to 10124)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 10124)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 10124)
  AUTHORS   Cowell,I.G. and Hurst,H.C.
  TITLE     Protein-protein interaction between the transcriptional repressor
            E4BP4 and the TBP-binding protein Dr1
  JOURNAL   Nucleic Acids Res 24 (18), 3607-3613 (1996)
   PUBMED   8836190
REFERENCE   7  (bases 1 to 10124)
  AUTHORS   Kashanchi,F., Khleif,S.N., Duvall,J.F., Sadaie,M.R.,
            Radonovich,M.F., Cho,M., Martin,M.A., Chen,S.Y., Weinmann,R. and
            Brady,J.N.
  TITLE     Interaction of human immunodeficiency virus type 1 Tat with a
            unique site of TFIID inhibits negative cofactor Dr1 and stabilizes
            the TFIID-TFIIA complex
  JOURNAL   J Virol 70 (8), 5503-5510 (1996)
   PUBMED   8764062
REFERENCE   8  (bases 1 to 10124)
  AUTHORS   Goppelt,A., Stelzer,G., Lottspeich,F. and Meisterernst,M.
  TITLE     A mechanism for repression of class II gene transcription through
            specific binding of NC2 to TBP-promoter complexes via heterodimeric
            histone fold domains
  JOURNAL   EMBO J 15 (12), 3105-3116 (1996)
   PUBMED   8670811
REFERENCE   9  (bases 1 to 10124)
  AUTHORS   Mermelstein,F., Yeung,K., Cao,J., Inostroza,J.A.,
            Erdjument-Bromage,H., Eagelson,K., Landsman,D., Levitt,P.,
            Tempst,P. and Reinberg,D.
  TITLE     Requirement of a corepressor for Dr1-mediated repression of
            transcription
  JOURNAL   Genes Dev 10 (8), 1033-1048 (1996)
   PUBMED   8608938
REFERENCE   10 (bases 1 to 10124)
  AUTHORS   Inostroza,J.A., Mermelstein,F.H., Ha,I., Lane,W.S. and Reinberg,D.
  TITLE     Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor
            of class II gene transcription
  JOURNAL   Cell 70 (3), 477-489 (1992)
   PUBMED   1339312
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137159.7, BC035507.2 and
            AL833729.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001938.2.
            
            Summary: This gene encodes a TBP- (TATA box-binding protein)
            associated phosphoprotein that represses both basal and activated
            levels of transcription. The encoded protein is phosphorylated in
            vivo and this phosphorylation affects its interaction with TBP.
            This protein contains a histone fold motif at the amino terminus, a
            TBP-binding domain, and a glutamine- and alanine-rich region. The
            binding of DR1 repressor complexes to TBP-promoter complexes may
            establish a mechanism in which an altered DNA conformation,
            together with the formation of higher order complexes, inhibits the
            assembly of the preinitiation complex and controls the rate of RNA
            polymerase II transcription. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.16018.1,
                                           SRR3476690.1028365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370272.9/ ENSP00000359295.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL137159.7         50972-50985
            15-3069             BC035507.2         1-3055
            3070-3219           AL833729.1         3039-3188
            3220-3223           BC035507.2         3204-3207
            3224-10124          AL137159.7         67658-74558
FEATURES             Location/Qualifiers
     source          1..10124
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..10124
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /note="down-regulator of transcription 1"
                     /db_xref="GeneID:1810"
                     /db_xref="HGNC:HGNC:3017"
                     /db_xref="MIM:601482"
     exon            1..959
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             740..1270
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /note="negative cofactor 2-beta; TATA-binding
                     protein-associated phosphoprotein"
                     /codon_start=1
                     /product="protein Dr1"
                     /protein_id="NP_001929.1"
                     /db_xref="CCDS:CCDS744.1"
                     /db_xref="GeneID:1810"
                     /db_xref="HGNC:HGNC:3017"
                     /db_xref="MIM:601482"
                     /translation="MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCT
                     EFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRR
                     KASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASA
                     SNQAGSSQDEEDDDDI"
     exon            960..1123
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..10124
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1546..1551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /note="hexamer: AATAAA"
     polyA_site      1566
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
     regulatory      3198..3203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /note="hexamer: AATAAA"
     polyA_site      3223
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /note="major polyA site"
     regulatory      7087..7092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /note="hexamer: TATAAA"
     polyA_site      7109
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
     regulatory      9268..9273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /note="hexamer: AATAAA"
     polyA_site      9286
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
     regulatory      9902..9907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /note="hexamer: AATAAA"
     polyA_site      9937
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
     regulatory      10105..10110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
                     /note="hexamer: TATAAA"
     polyA_site      10124
                     /gene="DR1"
                     /gene_synonym="NC2; NC2-BETA; NC2B; NCB2"
ORIGIN      
        1 gcaaagggtg tcgggagcgg cttcctgcaa accttccctg gcatctggag ggaccaccgt
       61 tgccgcgtct tcggcttcca cgatctgcgt tcgggctacg cggccacggc ggcagccact
      121 gcgactccca ctgtgcctgg ctctgtccat attagttccc aggcggccgt cgccgttcca
      181 gcagcggcag cggcagcggc agcggcggac atgttgtgag gcggcggcgc gggtgtctga
      241 aggatggttt ggccgaggcg gcggcaacgg ctgctggcgg cggcggcagc ggcagcgggg
      301 cctcgggctc tatagagccg agcccgctgg gtacccgccc ggtaccgcgg cgaggccagt
      361 gcccctggat cttgcctctg ctccgacgcc gttggggacc agttaggcga cagcgcccgc
      421 ccctctgagg agacacgaag gtggttcccc agccgctcaa atttccggac caccgcgctt
      481 tcccctcctc agcctgggct gtgctctctc tagaatcctc gggcccccac tttcttccca
      541 aactcatcct aaatctctca cacacgcgag tgttcccagc cctcaagcca gctgctcctc
      601 cgttcatttt ctgcaccctc ttcgcaaagc accccccggg atcactctcc gagggcgact
      661 ttttgagaaa tctcggtgga gtagtggacc agagctgggg agtttttaaa agccggggcg
      721 cgagaaacag gaaggtacta tggcttcctc gtctggcaac gatgatgatc tcactatccc
      781 cagagctgct atcaataaaa tgatcaaaga gactcttcct aatgtccggg tggccaacga
      841 tgctcgagag ctggtggtga actgctgcac tgaattcatt caccttatat cttctgaagc
      901 caatgagatt tgtaacaaat cggaaaagaa gaccatctca ccagagcatg tcatacaagc
      961 actagaaagt ttgggatttg gctcttacat cagtgaagta aaagaagtct tgcaagagtg
     1021 taaaacagta gcattaaaaa gaagaaaggc cagttctcgt ttggaaaacc ttggcattcc
     1081 tgaagaagag ttattgagac agcaacaaga attatttgca aaagctagac agcaacaagc
     1141 agaattggcc caacaggaat ggcttcaaat gcagcaagct gcccaacaag cccagcttgc
     1201 tgctgcctca gccagtgcat ctaatcaggc gggatcttct caggatgaag aagatgatga
     1261 tgatatctga aattcaccag ctgagtttct atttcttcta taaatgtttt tccctgcaca
     1321 acaaaaacag tgaaagaaat gcttatctgt aattttgtat gcatcttggt ggacttgtca
     1381 ttggtattct agggatgtct gctattaagt ttcatctatt gtgtgctata catgtaaaaa
     1441 ctgtctcttt gaactattga aaatttaagg ttcagtataa tatcaatttt gaatttttaa
     1501 tggtgtttat gaaattttag atagcagcga gtccttcgtt tgatcaataa acagtgttac
     1561 agataacttc aagtttataa aaatacagtg aaatttctac aaagctctaa atctgcattt
     1621 gcatttcctc tgccctttta actaaactaa aacttgtgaa ttttaaatta ttaagggggg
     1681 ggtgctgtgt gaatcagtag acattggatt gggttggtga aagagttcag ttctgtagta
     1741 tctgaatttg tcttttaaaa tgagtacata tataggcaat aaatatatat gctcagatca
     1801 atatacttgt ttagaaaaac ttcaagacat tcaaaaacta ggaaggagta tgtttaatag
     1861 tatttgtata aatttggtgg ttatgttttt ttattttgtt tctgttttgt gtagaggtaa
     1921 aaactatagt tttattacag cataattcat tttgagctcc actatgacat ttcaaagact
     1981 gcccagtttg gaagtctgtc atgattttta ctctttcact ccaattcagt aattgttgat
     2041 agtattactt acctagtcca tccatactca tattattcaa atatataggt ggtacttttg
     2101 aaacaattac attggttctc ttggtttaac tgaggtttat gaatattcaa acctttgctg
     2161 ggggaaagaa atgaaagtta atgagcatgc ttgctatgag agagggattt ttaatttaac
     2221 ttgtagttat agtttactta ttgtttttag aattactttt acattttccc aactagatgg
     2281 cctagagtcc aacattacct tttgagatga cattattgtc tccataattg agtgatagct
     2341 ttaaaaaaaa gattagtttt gcttaagaag ttatgttaca actgatcagc cctatatgaa
     2401 ttaactgatc agccctatat gaaacataag ttgtgttata acttatcagc cgtatatgga
     2461 acataaatag tttctacctg cttgttagag aagctttaat ttggttctaa taaatacagt
     2521 atggtagtgt ttataggaat ccaggatgtt gaagaaatgg cataatgtct atattttgga
     2581 aacagaaagg aaaagtcact taagatagta ttaagtaatt aaattcctat gtcagttgcc
     2641 aaatctttta aacttatgta ttcaccaagc ccaaaaatag attgtggctc ccaggattcc
     2701 aattttaatt ggagagctaa gtaagtaaag ttttataact gttaggtttc ttaatgatca
     2761 tattttgcag ttttagtaaa agggaaatat tgttatacat ttattaaata tacttccccc
     2821 atgaagtgaa aaggttaatt ttgctgaatg ttttaagttg aagttacttc atggatgtca
     2881 tacccatgaa gtgcatttgg atgagataga agaaattgtt ttttaaaaag tttaagtacc
     2941 aaaggtagtc tagtctagaa cgataagtta atacgtgttg gcttttctaa tttgtactgt
     3001 aacatcctta tactttctat tttaagtata tctgtttctt aagtaaacaa cttagatatt
     3061 ttccacacct tttttttttt ttctgatgca gagttcaggt taatatttta ctgcatctga
     3121 taatgtatta tacgtttgaa gcctagtgac ttttcatttt gacattcttg tgatttcata
     3181 tgctgtattc ttcaagcaat aaaattgtga tgtgttttat aaatggtttt tatatttaat
     3241 gttctataga gagatttcta ttattaccat ttttactatt ttcaagaatc ttaggcccaa
     3301 aagacatttt ggtcatttgg tatgtagtac ctgccttttg tttttgttta ctgttatttc
     3361 aaaaaatgtg gttttacttg tatttttata atttacagtc ctaagatcga ggcataacaa
     3421 agcttactta tgcaatattt tatttttagg ttttttcttt tttttttttt tttttttttt
     3481 tttttagcat ttaagagtca ctattatgtt ttgccagtta aaatttttta aatcttttga
     3541 agagagaaac aaaatcttca gcgttcttga gaaataaaat tattgttcag taagtatttt
     3601 tccatcccct tgaatatatg ttatatattc tttttcggca gattatcaga ttagtaagtg
     3661 tttaaaaggc atcagttttt aaaactgcat ataccacaca cacacaaaac agtacacaaa
     3721 taaaggtttt cacaaattaa acaaactcac atactagtct tcagatcaaa acacagagca
     3781 ttatgtgtac cccagaagcc ctcctctttc cccatcttaa cactgtcttc tttcttgctg
     3841 aaagttacta tcctgacttc taaaatcata gattagtttt gcctgttttt tattttatgt
     3901 aaatgtaatc atacataata cacttttttt cattcatcat ttttgtgaat attttagttt
     3961 cttgttgcca ctgtaacaaa ctaccacaaa cttagtgact taaaacaaca cagatttatt
     4021 cttttatagt cctggagatc agaagtccaa aaatcagttt cattaggcct aaatcaaagt
     4081 atcagcaggg ttggctcttt attgaggttg tgagggagaa tgttttcttc ccttttttgg
     4141 cttccagtga cggcctgtat ttatgggctt gtgacccctt cctctctatg atcaaagctt
     4201 gcttttgtca ttatatcatc ttctcttctg tagtcagatc tttccctgcc tctaagttta
     4261 gggctcacct gcataaagca gggataatcc ccctatctca agatccttaa tttaatcaca
     4321 tctgcagaat ctcttttgcc atataagtga cattcacagg ttccagggat tcatacgctg
     4381 gctatctttg gaggccgtta ttcaacctgc caaagtgaga tccattctta ttgttgcatg
     4441 tatttgtagt tcattcattc tcattgctgt atagtcttcc gtttgtttat ccatttttca
     4501 ttacatccaa aagttattca ttctcccatt aatagtcttt tgagaatttt tcaattctga
     4561 gctattatga atagtactgt gtagaacatt cttatacatg tcttttggtg agtgtataca
     4621 tttccattga gtataaacct aagaatggaa ttgccaggtt gtagggtgtg tatattttca
     4681 gttttagtat ttactgtcaa acagttttcc aaagtgactg taagaaggca ccattttaat
     4741 gtgtagcata aaaatgaatt acgctaatga tcttagtggg ttgaatttct cgaaacacct
     4801 aaattgtacc aaatgagtta tattgcagca ggtatgttgt taatttcata taacaggaaa
     4861 ataagagcaa aagtaattgc ccttattaac tgacacatta gtattacata ctcattaggt
     4921 tattgctcct tagaaaaaat gcaaatttta agtaatcgta agtagtatgt tgaattagta
     4981 tgttgtggga aaatctgtga tttaattttt taattgaatt ttaaattttg ggttataacc
     5041 tcattaaaat gcatgatatt tccttatata ggtttctaaa ttatgtctgt ccaactcatc
     5101 tatatccaaa tggccattag gaagaattat ccaattcaga tggcataggc actgccttcc
     5161 aatttcttca tttgtatttt tttgttgctg ttttcttttt tgcctctgtc cccaacaatt
     5221 tgaccacaag tcctacccca cctcctctgt ttttcaccat cccccaggat ataaagtgtc
     5281 atggttagga tcggccaggg tgaagagaat gataacataa gtagcctcct ttcacctaaa
     5341 gtattaccac tggttcttat cctatttcct caaaataaat gagaagagaa agtaaggaat
     5401 aagaggaaga aacttttttt ttttttttaa agaaacaggg tctcactatg tttccttttt
     5461 cttttttctt ttcttttctt tctttttttt tttttttttt ttgagacaga gtcttgctct
     5521 gtcacccagg ctggaatgca gtggcgcgat ctcggctcac tgcaagctcc gcctcccggg
     5581 ttcacgccat tctcctgcct cagcctcctg agtagctggg actacaggtg cccgctagca
     5641 cgcccagcta attttttttg ttttttttta gtagagacag ggtttcaccg tgttagccag
     5701 gatggtctcg atctcctgac ctcgtgatcc acccgccttg gcctcccaaa gtgctgggat
     5761 tacaggcgtg agccactgcg cccggcctat gtttcttaat atagattgca gtggctagat
     5821 tacagtgact attcacaggc ataatcataa tgcaccatag cctcaaactc ctgggctcaa
     5881 gcaatccaaa aggaggaaac ttttaactta tgatcagttt ctaccataaa tcaagcaact
     5941 tagaaaaacc ttagaacagg gtttctcaaa ccaagcattg ttagtatttg gggttggtta
     6001 agtctttgtt tgtgggagcc tatcctgtgc attgtaggat ttctagcagc ataattggct
     6061 tatgcccact tgatgtcatt agcaccactc cccaccctac ttccagttgt gacaacccaa
     6121 aaatgtctcc agacatagcc aactgtccct gggtgttgcg agtataggag gcaaaattgc
     6181 accctgttga aaaccaccac cttagatcat ctaggtttta cttttaggat aagacacttg
     6241 agggaaaggc tgtgaaactg aacctctgtt agaagcaaca cacagtatca ctgcaaaaag
     6301 actaaaagaa ataggtgatt tggaaagagg aggcccagga ttaaaatatg tttccaagaa
     6361 agtcaaatct tacaggagac tcttgacttc acatctgctg atccctttac ccgataggac
     6421 ctagagcagc cattataaat ctctgtacct gcttgctgct tttctacctc attgttagcc
     6481 acacccagtt tgaaacagat gaggtatgct atttcataac tagtacatct tttaataagc
     6541 attttttatt gtgattaaat atgcatatcg taaaattcac cactttaacc agttttaagt
     6601 gttcaattct gtggcattaa gtatattcat actattgtgc aaccaccacc accatccgtc
     6661 tacagaactc ttcatcttcc caaactgaaa ttatgtattc attaaacaat aaccacccat
     6721 tacctcctct ctcctcagcc tctggtaacc agcattcagt ctctatgaat tgactactct
     6781 ggatatctaa atggattcat tcttatttca tttaccataa tgtcttcaaa gttcattcat
     6841 gttgtagcat gtattagaat ttctttcctc ttaaaggcca aatatgccgt agtatgtaaa
     6901 taccgtattt tgtttatcag ttcatccatt aatggacact gggttgcttc tgctttttgg
     6961 ctattgtgaa taatgcttct gtgaacgtgg gtatacaaat aactgtttga gtcctaatag
     7021 gcttgttatt tttgagtgca cagatctgta tattcgcaat tgaaataggg aaagtcttta
     7081 tattcatata aagataattt ataatacaat aagtcctcaa tgttgttgat aggttctggg
     7141 aaactgcgag tttaagaaaa acaacatata atgaaatcaa ttttaccata ggtgaactga
     7201 tataaataag agttaagtcc ctatggcata tatttctggt tacaaaaaca ctaccaaatt
     7261 tctaataaag acccaaaaca cttctaaaat taaacattga gattaatatg agctttatat
     7321 acatttaaaa aggataaaaa caagtaagaa ttggctggac atggtggctt acgcctgtaa
     7381 tctcaacact gggaagtcga ggtgggcaga tggcttgacc tcaggagttc ggaaccagcc
     7441 tgggtaatat ggtgaaaccc gtctctacag aaaaattcaa aaattagcca gaggtggtgg
     7501 cttgcacctg tagtcccagc tactcgggag cctgatgtgg gaggatccct tgagcctggg
     7561 aggtcgaggc tgcagtgagc catgatcacg ctactgcact ccagtctggg caacagagca
     7621 aaatcctatc tcaaaaaaaa tatatatatt atccagcccc aaatgtttat ggggttgtta
     7681 ttgataaacc ctgcattaaa caatcccaca gtcggtgctg cggtgagccg tgatggtacc
     7741 actgcattcc agcctgggtg acagaatgag accctgtctc aaaaaaaaaa aaaaaaagta
     7801 aaaattattt acccaatatt tggcgaatca gtgagtgaca gcagttgtag tgctagtggg
     7861 ttaaatcaag gaataactgt tgggaagtga aaattttaag gagcacctcc taccaccatg
     7921 cagttcaaaa acaaaaaata agaaataaag tgggcttgct gagtgctttc atactgcatc
     7981 atttattgtg catttgtatg attattatat actttacaaa ttttcgtttt acagtaattt
     8041 gtattcattc gtttttcaac ctgcttattt cagttcagtg tcttgggtag ctggagccta
     8101 tcccagcagc tcagggagca aagtgggagc caaccctgga caggatgcct tttcatcaca
     8161 gggcgcactc acacggcaca cacacgcata ctgggaccat ttagctgtac caattcacct
     8221 aacgtgcatc tttgggaatt gagaagaaac cagaataccc agagaaaact catgcagata
     8281 tgtggaggac atgcaaaatt cacacagaca gtggccctgg ttgtaaataa ttgtttttca
     8341 tcaatgttat aatgaaatta caggccgggt gtggtggctt acgcctgtaa tcccagcact
     8401 ttgggaggcc gaggcgggtg gatcacgagg tcaggagata gagaccatcc cggccaacat
     8461 agtgaaacct catctgtgct aaaatacaaa aaattagcca ggcttggtgg tgtgcacctg
     8521 tagtcccagc tacttgggag gctgaggcag gggatttctt gaacccagaa ggcggaggtt
     8581 gcagtgagtt gagatcgcga cactgcactc cagcctgaca acagagcaag acttcgtctc
     8641 aaaaaaacaa acaaaaaaag aaattacatt agttgaggac ctgctgtatg tgatatgaac
     8701 aatgaggatc aactcttttt gtaatagttt ttttacatat gttatttcat ttgtttattt
     8761 cctctgtgag ggtaagtatt gatagtccag tcatagactg gtaacacagg cacaccatta
     8821 aaaataatag acatacagta tgcagtattt tgttttactt atgaaactcc gtattttatg
     8881 tatgatgtat tgagtatgaa gaatagtaca tactgtttcc ttttaacttt atgtttcttg
     8941 cctttgtata ttttatatga atagcacttg tcactaacat agaaagcagt agaggtggaa
     9001 gagggagact tgccagaata agtttttaat gtgaatcaga gatttttatt aggaattggg
     9061 agtggaagga gagagatagt attagaaagt atgtatgcag caaaggatgg agaaactgtc
     9121 cttgttgtta aggcatctaa ggatgctcca attactgggg aaaacatacc aggctcaaaa
     9181 tggtctgatt atgcaaatac cttctaatac gtttgtttct tttgttgtgc ctataaaaga
     9241 tgccattaac ttcatattta tgtcactaat aaacttctag aatccatgta gtagggtgta
     9301 gtagtgtggt taagctatga agaacaatgg tatttatttc caaaacactt atttggtata
     9361 ttacatagga tagagtatgt tttctaagcc aaatagtgtt aggttttcat gtgcagttgc
     9421 cttacacata tactagtagc ccttacaaaa tttcgtctgt ctttattata aacatgttgt
     9481 aagtgaggaa actaagattc caagaaatta agtactgttg gccctctgtg tctgggggtt
     9541 ccacatctat agatcgacca accatggact gatggattga aaacatttgg ggaaaaaaca
     9601 aaaaataacc caacaatgaa atagtataaa ttttaaaaat aatataacaa tatttatata
     9661 tcatttacat tatgttagat attataatct agagatgatt agcatccttg gattttggat
     9721 tttggtatcc ttggggtatc ctggaaccaa tccctggcgg ataccaaggg atgactgtaa
     9781 tataataaca tctaacaagt gaaggatttg aaccccaatg taagtaatta tgaaaactat
     9841 ttttcttcca ctagaacttt tttccccaaa aatactctgg aaatactgga acaaatacta
     9901 aaataaatga cctttatttg aagatctttt aaaaaaatta taagcctgcc tgaggatagc
     9961 aaaattgtgt gcttttgcaa ggtaattgta gaactcattc taaggaagca gaggtaatgt
    10021 ctgttactat tttcagctcc ctttttctgt ccactgttgt ctaaatgatt cactcagtgt
    10081 tatgcagaat atgagaagtt attttataaa gttgatttgt ggta
//
