LOCUS       NM_133637               2584 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DEAQ-box RNA dependent ATPase 1 (DQX1), mRNA.
ACCESSION   NM_133637
VERSION     NM_133637.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2584)
  AUTHORS   Li,R., Yin,Y.H., Jin,J., Liu,X., Zhang,M.Y., Yang,Y.E. and Qu,Y.Q.
  TITLE     Integrative analysis of DNA methylation-driven genes for the
            prognosis of lung squamous cell carcinoma using MethylMix
  JOURNAL   Int J Med Sci 17 (6), 773-786 (2020)
   PUBMED   32218699
  REMARK    GeneRIF: Integrative analysis of DNA methylation-driven genes for
            the prognosis of lung squamous cell carcinoma using MethylMix.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA852016.1, BC075018.2, BC033238.1, AA515987.1 and BM987933.1.
            
            On Nov 23, 2018 this sequence version replaced NM_133637.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404568.4/ ENSP00000384621.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               DA852016.1         52-474
            424-1956            BC075018.2         1-1533
            1957-2455           BC033238.1         1061-1559
            2456-2580           AA515987.1         1-125               c
            2581-2584           BM987933.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..2584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..2584
                     /gene="DQX1"
                     /note="DEAQ-box RNA dependent ATPase 1"
                     /db_xref="GeneID:165545"
                     /db_xref="HGNC:HGNC:20410"
                     /db_xref="MIM:620580"
     exon            1..96
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     exon            97..352
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2269
                     /gene="DQX1"
                     /EC_number="3.6.4.12"
                     /note="DEAQ box polypeptide 1 (RNA-dependent ATPase); DEAQ
                     RNA-dependent ATPase DQX1"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DQX1"
                     /protein_id="NP_598376.2"
                     /db_xref="CCDS:CCDS1949.2"
                     /db_xref="GeneID:165545"
                     /db_xref="HGNC:HGNC:20410"
                     /db_xref="MIM:620580"
                     /translation="MTSQPLRLAEEYGPSPGESELAVNPFDGLPFSSRYYELLKQRQA
                     LPIWAARFTFLEQLESNPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQKGQVTVTQ
                     PYPLAARSLALRVADEMDLTLGHEVGYSIPQEDCTGPNTLLRFCWDRLLLQEVASTRG
                     TGAWGVLVLDEAQERSVASDSLQGLLQDARLEKLPGDLRVVVVTDPALEPKLRAFWGN
                     PPIVHIPREPGERPSPIYWDTIPPDRVEAACQAVLELCRKELPGDVLVFLPSEEEISL
                     CCESLSREVESLLLQGLPPRVLPLHPDCGRAVQAVYEDMDARKVVVTHWLADFSFSLP
                     SIQHVIDSGLELRSVYNPRIRAEFQVLRPISKCQAEARRLRARGFPPGSCLCLYPKSF
                     LELEAPPLPQPRVCEENLSSLVLLLKRRQIAEPGECHFLDQPAPEALMQALEDLDYLA
                     ALDDDGDLSDLGVILSEFPLAPELAKALLASCEFDCVDEMLTLAAMLTAAPGFTRPPL
                     SAEEAALRRALEHTDGDHSSLIQVYEAFIQSGADEAWCQARGLNWAALCQAHKLRGEL
                     LELMQRIELPLSLPAFGSEQNRRDLQKALVSGYFLKVARDTDGTGNYLLLTHKHVAQL
                     SSYCCYRSRRAPARPPPWVLYHNFTISKDNCLSIVSEIQPQMLVELAPPYFLSNLPPS
                     ESRDLLNQLREGMADSTAGSKSSSAQEFRDPCVLQ"
     exon            353..546
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..931
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1159
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1259
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1418
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1610
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1730
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1921
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2112
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2584
                     /gene="DQX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2559..2564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DQX1"
                     /note="hexamer: TATAAA"
     polyA_site      2584
                     /gene="DQX1"
                     /note="major polyA site"
ORIGIN      
        1 ggaatttacc tttgtacttc acacggtcag ggttggtggt gactacgtgg gtctggagct
       61 gactgccgtc ctgacacgtc ctagagctgc aagcaggtcc tgccagagag ccaccatgac
      121 ctctcagcct ctcaggctag cagaagagta tggcccaagt cctggggagt ctgaactggc
      181 tgtgaacccc tttgatgggc ttcccttctc ttcccgctac tatgagctgc tgaagcagcg
      241 ccaagccttg cccatctggg ctgctcgctt taccttcttg gagcagttgg agagtaaccc
      301 cactggagtg gtgctggtgt ctggggagcc tggttctggc aagagcaccc agatccctca
      361 gtggtgtgca gagtttgcgc tggccagagg gttccagaaa ggacaggtta ctgttactca
      421 gccctaccct cttgcagccc ggagcctggc tctgcgggtt gctgatgaga tggacctgac
      481 cctgggtcat gaggttggat acagcatccc ccaggaggac tgcacggggc ccaacaccct
      541 gctcaggttc tgctgggaca ggctgcttct gcaggaggtg gcctcgaccc gaggcactgg
      601 agcctggggc gtgctggtac tagatgaggc tcaggagcgg tcggtggcat cagattcact
      661 ccaggggcta ctgcaagatg ccaggctgga aaaacttccg ggggacctca gagtggttgt
      721 ggttactgac ccagcccttg aacctaagct ccgagctttc tggggcaatc ctcctattgt
      781 gcatataccc agagagcctg gtgagagacc ttcccccatc tactgggaca ccatcccacc
      841 tgatcgggtg gaagctgcct gccaagcagt gcttgaattg tgtcggaagg agcttccagg
      901 agatgtgcta gtgttcctgc ccagtgagga ggaaatttcc ctgtgctgtg aatccttgtc
      961 cagggaggta gagtccttgc ttctccaagg gcttccacca cgagtactgc cccttcaccc
     1021 agactgtgga cgagccgttc aggctgtgta tgaggacatg gatgcccgaa aggttgtggt
     1081 cactcactgg ctggctgact tctccttctc cctcccttcc atccaacatg tcatcgactc
     1141 aggactggag ctccgaagtg tttacaatcc taggatccga gcagaattcc aagtgttgag
     1201 gccaatcagc aagtgtcagg cagaggcaag acgattgcga gcaagagggt tcccaccagg
     1261 atcctgcctc tgcctgtatc ctaagtcctt cttagaacta gaagctccac cattgccaca
     1321 acccagggtg tgtgaggaga atctgagctc cctggtgtta ctactaaaaa ggagacagat
     1381 tgcagagcca ggggagtgtc acttcctgga ccagcctgct ccagaagcac tgatgcaagc
     1441 cctggaagat ttagactatc tggcagccct ggatgatgat ggggacctgt cagatctggg
     1501 tgtcatacta tcagaattcc ctctggcccc tgagctggcc aaagccctgc tggcctcatg
     1561 cgagtttgac tgtgtggacg agatgctcac cctggctgcc atgctcacag ctgcccctgg
     1621 gtttacccgt cctccactca gtgcagaaga agctgccctg cgtcgggccc tggaacacac
     1681 ggatggtgac cacagttctc tgatccaggt gtatgaagcc tttatacaaa gtggagcaga
     1741 tgaggcttgg tgccaggctc gaggtctgaa ttgggcagca ttgtgccaag cccataaact
     1801 tcggggagaa ctcctagaac tcatgcaacg aattgaactt cccttgtccc taccagcctt
     1861 tggctctgag cagaatcgca gagaccttca gaaagcactg gtgtcaggat actttctcaa
     1921 ggtggccaga gacacagacg ggactggaaa ttaccttctc ctaacccata agcatgtggc
     1981 ccagctctcc tcatactgct gctaccgaag ccgcagagct cctgccagac ccccaccatg
     2041 ggtgctctac cacaatttca ccatatccaa agacaactgc ctttccattg tttctgagat
     2101 tcaaccacag atgctggtgg aattggcccc tccatacttc ctgagtaact tgcctcccag
     2161 tgagagcaga gaccttctga accagctaag ggaaggaatg gcagattcta cagcagggag
     2221 caaatcatcc tcagcccagg agttcagaga tccctgtgtc ctgcagtgac ctgcctgcct
     2281 atggaatgga gctgggttca tctcatcaca ttagattatc cctcagggtg acaccaaagc
     2341 acccagacag atttagaagc ccaaagttta gggtcaaatg taaaccctgg aacctgagtc
     2401 ccaagaaatg gtagactggg aatggaaaga atggggtaaa ccacagtcta catagggaag
     2461 gactctttcc ttagccttct cttattgatt ggagagggac tgacatgctc ctcattctct
     2521 taactttgcc aaacccattc ttgtactccc ttgtgatcta taaaagattt ttctatgatg
     2581 ccaa
//
