LOCUS       NM_020134               5178 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens dihydropyrimidinase like 5 (DPYSL5), transcript
            variant 1, mRNA.
ACCESSION   NM_020134
VERSION     NM_020134.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5178)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5178)
  AUTHORS   Jeanne,M., Demory,H., Moutal,A., Vuillaume,M.L., Blesson,S.,
            Thepault,R.A., Marouillat,S., Halewa,J., Maas,S.M.,
            Motazacker,M.M., Mancini,G.M.S., van Slegtenhorst,M.A., Andreou,A.,
            Cox,H., Vogt,J., Laufman,J., Kostandyan,N., Babikyan,D.,
            Hancarova,M., Bendova,S., Sedlacek,Z., Aldinger,K.A., Sherr,E.H.,
            Argilli,E., England,E.M., Audebert-Bellanger,S., Bonneau,D.,
            Colin,E., Denomme-Pichon,A.S., Gilbert-Dussardier,B., Isidor,B.,
            Kury,S., Odent,S., Redon,R., Khanna,R., Dobyns,W.B., Bezieau,S.,
            Honnorat,J., Lohkamp,B., Toutain,A. and Laumonnier,F.
  TITLE     Missense variants in DPYSL5 cause a neurodevelopmental disorder
            with corpus callosum agenesis and cerebellar abnormalities
  JOURNAL   Am J Hum Genet 108 (5), 951-961 (2021)
   PUBMED   33894126
  REMARK    GeneRIF: Missense variants in DPYSL5 cause a neurodevelopmental
            disorder with corpus callosum agenesis and cerebellar
            abnormalities.
REFERENCE   3  (bases 1 to 5178)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 5178)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5178)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5178)
  AUTHORS   Ricard,D., Rogemond,V., Charrier,E., Aguera,M., Bagnard,D.,
            Belin,M.F., Thomasset,N. and Honnorat,J.
  TITLE     Isolation and expression pattern of human Unc-33-like
            phosphoprotein 6/collapsin response mediator protein 5
            (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive
            oligodendrocytes
  JOURNAL   J Neurosci 21 (18), 7203-7214 (2001)
   PUBMED   11549731
REFERENCE   7  (bases 1 to 5178)
  AUTHORS   Yu,Z., Kryzer,T.J., Griesmann,G.E., Kim,K., Benarroch,E.E. and
            Lennon,V.A.
  TITLE     CRMP-5 neuronal autoantibody: marker of lung cancer and
            thymoma-related autoimmunity
  JOURNAL   Ann Neurol 49 (2), 146-154 (2001)
   PUBMED   11220734
REFERENCE   8  (bases 1 to 5178)
  AUTHORS   Fukada,M., Watakabe,I., Yuasa-Kawada,J., Kawachi,H., Kuroiwa,A.,
            Matsuda,Y. and Noda,M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   9  (bases 1 to 5178)
  AUTHORS   Horiuchi,M., El Far,O. and Betz,H.
  TITLE     Ulip6, a novel unc-33 and dihydropyrimidinase related protein
            highly expressed in developing rat brain
  JOURNAL   FEBS Lett 480 (2-3), 283-286 (2000)
   PUBMED   11034345
REFERENCE   10 (bases 1 to 5178)
  AUTHORS   Inatome,R., Tsujimura,T., Hitomi,T., Mitsui,N., Hermann,P.,
            Kuroda,S., Yamamura,H. and Yanagi,S.
  TITLE     Identification of CRAM, a novel unc-33 gene family protein that
            associates with CRMP3 and protein-tyrosine kinase(s) in the
            developing rat brain
  JOURNAL   J Biol Chem 275 (35), 27291-27302 (2000)
   PUBMED   10851247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF264015.1, AC013472.8 and AW139156.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020134.3.
            
            Summary: This gene encodes a member of the CRMP (collapsing
            response mediator protein) family thought to be involved in neural
            development. Antibodies to the encoded protein were found in some
            patients with neurologic symptoms who had paraneoplastic syndrome.
            A pseudogene of this gene is found on chromosome 11. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.269431.1,
                                           SRR1803612.190135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288699.11/ ENSP00000288699.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2435              AF264015.1         36-2470
            2436-5131           AC013472.8         35790-38485
            5132-5178           AW139156.1         17-63               c
FEATURES             Location/Qualifiers
     source          1..5178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..5178
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /note="dihydropyrimidinase like 5"
                     /db_xref="GeneID:56896"
                     /db_xref="HGNC:HGNC:20637"
                     /db_xref="MIM:608383"
     exon            1..123
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            124..388
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1822
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /note="CRMP3-associated molecule; collapsin response
                     mediator protein-5; DRP-5; ULIP-6; UNC33-like
                     phosphoprotein 6"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 5"
                     /protein_id="NP_064519.2"
                     /db_xref="CCDS:CCDS1730.1"
                     /db_xref="GeneID:56896"
                     /db_xref="HGNC:HGNC:20637"
                     /db_xref="MIM:608383"
                     /translation="MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMI
                     PGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVL
                     PDKETSLVDAYEKCRGLADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMF
                     MTYKDLYMLRDSELYQVLHACKDIGAIARVHAENGELVAEGAKEALDLGITGPEGIEI
                     SRPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHA
                     TLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQK
                     AMGKEDFTKIPHGVSGVQDRMSVIWERGVVGGKMDENRFVAVTSSNAAKLLNLYPRKG
                     RIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENG
                     VFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRGVDRTPYLGDVAVVVHPGKKEMG
                     TPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW"
     exon            389..547
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            548..727
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            728..796
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            797..841
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            842..917
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1074
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1216
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1359
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1567
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1736
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..5178
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4752..4757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /note="hexamer: AATAAA"
     polyA_site      4776
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
     regulatory      5157..5162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /note="hexamer: ATTAAA"
     polyA_site      5178
                     /gene="DPYSL5"
                     /gene_synonym="CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggccc ccgagcgagc gcgcgtgcag ccgccgccgc cccgagcacc cgcagctccg
       61 gcgccgcggc gagacggaga cggaccgagc cacgggcccc cgcggccgca gcatctcgga
      121 ggagaacatg cttgccaact cagccagcgt gaggatcctc atcaagggag gcaaggtggt
      181 gaacgatgac tgcacccacg aggctgacgt ctacatcgag aatggcatca tccagcaggt
      241 gggccgcgag ctcatgatcc ctggcggggc caaggtgatt gatgccacag gaaaactggt
      301 gatccctggt ggcatcgaca ccagcaccca cttccaccag accttcatga atgccacgtg
      361 cgtggacgac ttctaccatg ggaccaaggc agcactcgtc ggaggcacca ccatgatcat
      421 cggccacgtc ctgcccgaca aggagacctc ccttgtggac gcttatgaga agtgccgagg
      481 tctggccgac cccaaggtct gctgtgatta cgccctccac gtggggatca cctggtgggc
      541 acccaaggtg aaagcagaaa tggagacact ggtgagggag aagggtgtca actcgttcca
      601 gatgttcatg acctacaagg acctgtacat gcttcgagac agtgagctgt accaagtgtt
      661 gcacgcttgc aaggacattg gggcaatcgc ccgcgtccat gctgaaaatg gggagcttgt
      721 ggccgagggt gctaaggagg cactggattt ggggatcaca ggcccagaag gaatcgagat
      781 cagccgtcca gaggagctgg aagctgaagc cactcatcgt gttatcacca ttgcaaacag
      841 gactcactgt ccaatctacc tggtcaacgt gtccagtatc tcggctggtg acgttatcgc
      901 agctgctaag atgcaaggga aggttgtgct ggcggagacc accactgcac atgccacgct
      961 gacaggctta cactactacc accaggactg gtcccacgcg gctgcctatg tcacggtgcc
     1021 tcccctgaga ctggacacca acacctcaac ctacctcatg agcctgctgg ccaatgacac
     1081 tctgaacatc gtggcatcag atcaccggcc tttcaccaca aagcagaaag ctatgggcaa
     1141 ggaagacttc accaagatcc cacatggagt gagtggcgtg caggaccgca tgagcgtcat
     1201 ctgggagaga ggagtggttg gaggaaagat ggatgagaac cgttttgtgg ccgttaccag
     1261 ttccaacgca gctaagcttc tgaacctgta tccccgcaag ggccgcatta ttcccggagc
     1321 cgatgctgat gtggtggtgt gggacccaga agccacaaag accatctcag ccagcacgca
     1381 ggtccaggga ggagacttca acctgtatga gaacatgcgc tgccacggcg tgccactggt
     1441 caccatcagc cgggggcgcg tcgtgtatga gaacggcgtc ttcatgtgcg ccgagggcac
     1501 cggcaagttc tgtcccctga ggtccttccc agacactgtc tacaagaagc tggtccagag
     1561 agagaagact ttaaaggtta gaggagtgga ccgcactccc tacctggggg atgtcgctgt
     1621 tgtcgtgcac cctgggaaaa aagagatggg aaccccactc gcagacactc ctacccggcc
     1681 cgtcacccgg catgggggca tgagggacct tcacgaatcc agcttcagcc tctctggctc
     1741 tcagatcgat gaccatgttc caaagcgagc ttcagctcgg atcctcgctc ctcccggagg
     1801 caggtcgagt ggcatttggt aaaggcattg ccaagccccc cgagtgagga cgcaccgccg
     1861 ccaccagccc gcaactctcc agccgaagct gcaggggcag gagaggctgg gctgggtggc
     1921 acaccacccg aggggggccc cgggacccac ggagccctcc ctatgtctgc aaagtgattc
     1981 actgtgcttc gagccaactc taacaggcac tttgagatgt gttcctcctg ctgtagtcct
     2041 ttctgccttg gcctcggcgg gcttttctgg ggcccaggaa gcccacacta tgcacagagc
     2101 ccaatgcata gagccctggc cagcccttcc tctcactcct gcctccgctg gctttgggaa
     2161 agcccagact ttagtgccct gccccctggc tgactggcca gttgcccaga gcactttagc
     2221 agatgtggtt tcaaagtaaa ggcctcctcc cccacccctt aggccccgtg gtgacatttc
     2281 ccaagtcaga cagatgtcag cttcccagcc atgcccagga cgtcctatct cccccaaccc
     2341 acctctggcc ctgtgtaggg gcagggatgg gggtggctgg gactcctggt gcccctcgcc
     2401 agcttctcct gcgccccgcc cacaccctcg gggggtcaca ggcccagaag ggtagctggg
     2461 cggggctcga ggctggtgcc aggcgcgtgt aaatggtttt gttttgcacg tttggtttgc
     2521 gcagtagttt ggtttgactt gtttgtgcat cctgtgaaaa ataacggtgc ttgtgtcact
     2581 agcatagaat agcgacagga atagatgtgg tccttaggag acgctgcact tgacaccaac
     2641 cagacagcac agggcagggg tggtggaggg ggctgggctc acaggcctct cttttccccg
     2701 cctgcagtct tctgggctgc gggaggccct ggccctttcc ccttcccctc ccctccttgt
     2761 ctagtttccc acattccaaa agggggcctg ggatgctagc cccagagatg ccagcccttc
     2821 aggaagcagg tgtcctttcc cctctctgcc cctgatcact cccagcactc cccttgcctt
     2881 cccctgtctt cacctgccac cacacacaca cacacacaca cacacacaca cacacacgca
     2941 cggcttccta taacttcttc ctgctggaca gagactcagc gctcctcctg tgtgactggc
     3001 aagaggcctc atgcctgctg agagaggagg agtgggagag gggcttgcca gacaccagag
     3061 agggagaccc caggcccaca ggacctggct gtcgaacccg cattgctgct caggtgccgt
     3121 gatctcccgt ggtcggcacc aggcccttgc cagctcatgg cctcatcttc tcccctgtcc
     3181 atccaggtgg gccctccctg cttctaaagc cccacagaag ttcccatgga aacactagag
     3241 gccgggtgtc tccttccacc tccagtgatc tgggaagtga cccagccgcc tgcccttgtt
     3301 aagcctggtc tgccccgtgg gaagtgactt catgttgcac atgtgatttc agcccccgag
     3361 gcttgcgcga ggcttctgga ccctcggtta aaggtcagcc cctggccggg tgcggtggct
     3421 cacgcctgta atcccagcac tttgggaggc caaggcgggt ggatcatgga gtcaggagat
     3481 cgagaccatc ctggctaaca cggtgaaacc ccgtctctac taaaaataca aaaattaccc
     3541 aggcgtggtg gcgggcgcct gtagtcccag ctactgagga ggctgaggca ggagaatagc
     3601 gtgaacccgg gaggcggagc ttgcagtgag ccaagatcac gccactgcac ttcagcctgg
     3661 acgacagagt gagactccat ctcaaaaaac agacaaacaa aaaagtcagc ccctgcacat
     3721 ctctgtagtg cttttcatgt attcaaacca cttccgtata tgacctctca cttagtcctc
     3781 atgacaatgg agcacttatt attcttccca ttttacagat gaggaaacta agacccagaa
     3841 agttcaggtc ctctgacccc agaagtgtct gtgatgaccc tcccaacctt ggctatctac
     3901 cccacctgtg gagaggaggt ctggggtgac atctattgta gatcccacct gagagtttaa
     3961 ccaatgagaa gacttacttt cctggtaggc agcctgcttt gttttgcaca ggaagataga
     4021 ttttttttct catctttctt ataaacaacc tcatgcacat tctgtgtttg agccaagact
     4081 agtcacccat tgggggctaa ccgtgcagtg tgagctgcgt ccacaccctc acttctccct
     4141 tcactccccc tttcctcact caggggctga gaggacagag gtggtcagcc ggggagcaga
     4201 ggtggcgaag gggctcatgg caagtggcag ccattggaac aggggtgagg acccaggcct
     4261 gggaaagcca ccagggatgg gggaaaccat gacgccgcct cctggtgcag tgcacaccat
     4321 ctctatccct gtcagccctc actgggtcat gggccttggg cagatgtcaa agagcccagc
     4381 agcagcggtg gtggccagct gggcagagca tccttgcttg ggctaggaaa gctttacctt
     4441 ctctgagtgc ctccgcctga gagatgtgtg acccgtggca ccagggaacc acgtcttgga
     4501 gtggtccact gtaggccatg cgcttcatcc acccccagtc cctacatagg ccctaccctt
     4561 gcccgggagc ttctagatag aaatcagaaa gagattcaag gagccaaatg agcggtcagc
     4621 ccccaccatg cactccttgc cccgtgcaga gctccagcca gcttcgtcac cagccccact
     4681 ggctcctggt tggaacgaaa gggtctctgg ttgcactgaa tgcagctctc aaactggtct
     4741 tgtacttgct gaataaatac tgttgttctt gccttagctg ctctctaggt ttgtggggtt
     4801 aagttgccag aaaattgtgc tactgtgtgt gcgtgtgcgt gcgtgtgtgt agtgctagga
     4861 gtccacagta ggtctctgtc aagccgatgt cgtgatgagg gcttttctga tactgaccca
     4921 gaagccacag aaccacaagg aaacccaaac cccctccagc tgctgaggcg caggcacagc
     4981 ctggggtcgg atggagcctc cagcacccca gcacccaggt gacttcccca ctcccctgta
     5041 aatgtcatgg tgctaagact gtgtcaaccc caagacgaca catggtcctg tgctttggcc
     5101 accgtttgag gcaaaaacta aacagcccga cacgttgtgt tctggtgcag gtttgtatta
     5161 aactgtagct acttctca
//
