LOCUS       NM_006426               2664 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens dihydropyrimidinase like 4 (DPYSL4), mRNA.
ACCESSION   NM_006426
VERSION     NM_006426.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2664)
  AUTHORS   Qiu,L., Sheng,P. and Wang,X.
  TITLE     Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory
            Networks and Key Genes Based on Bioinformatics Analysis
  JOURNAL   Biochem Genet 61 (1), 428-447 (2023)
   PUBMED   35877019
  REMARK    GeneRIF: Identification of Metabolic Syndrome-Related miRNA-mRNA
            Regulatory Networks and Key Genes Based on Bioinformatics Analysis.
REFERENCE   2  (bases 1 to 2664)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2664)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2664)
  AUTHORS   Nagano,H., Hashimoto,N., Nakayama,A., Suzuki,S., Miyabayashi,Y.,
            Yamato,A., Higuchi,S., Fujimoto,M., Sakuma,I., Beppu,M.,
            Yokoyama,M., Suzuki,Y., Sugano,S., Ikeda,K., Tatsuno,I., Manabe,I.,
            Yokote,K., Inoue,S. and Tanaka,T.
  TITLE     p53-inducible DPYSL4 associates with mitochondrial supercomplexes
            and regulates energy metabolism in adipocytes and cancer cells
  JOURNAL   Proc Natl Acad Sci U S A 115 (33), 8370-8375 (2018)
   PUBMED   30061407
  REMARK    GeneRIF: DPYSL4 plays a key role in the tumor-suppressor function
            of p53 by regulating oxidative phosphorylation and the cellular
            energy supply via its association with mitochondrial
            supercomplexes, possibly linking to the pathophysiology of both
            cancer and obesity.
REFERENCE   5  (bases 1 to 2664)
  AUTHORS   Nakamura,F., Kumeta,K., Hida,T., Isono,T., Nakayama,Y.,
            Kuramata-Matsuoka,E., Yamashita,N., Uchida,Y., Ogura,K.,
            Gengyo-Ando,K., Mitani,S., Ogino,T. and Goshima,Y.
  TITLE     Amino- and carboxyl-terminal domains of Filamin-A interact with
            CRMP1 to mediate Sema3A signalling
  JOURNAL   Nat Commun 5, 5325 (2014)
   PUBMED   25358863
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2664)
  AUTHORS   Fukada,M., Watakabe,I., Yuasa-Kawada,J., Kawachi,H., Kuroiwa,A.,
            Matsuda,Y. and Noda,M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   7  (bases 1 to 2664)
  AUTHORS   Inatome,R., Tsujimura,T., Hitomi,T., Mitsui,N., Hermann,P.,
            Kuroda,S., Yamamura,H. and Yanagi,S.
  TITLE     Identification of CRAM, a novel unc-33 gene family protein that
            associates with CRMP3 and protein-tyrosine kinase(s) in the
            developing rat brain
  JOURNAL   J Biol Chem 275 (35), 27291-27302 (2000)
   PUBMED   10851247
REFERENCE   8  (bases 1 to 2664)
  AUTHORS   Honnorat,J., Byk,T., Kusters,I., Aguera,M., Ricard,D., Rogemond,V.,
            Quach,T., Aunis,D., Sobel,A., Mattei,M.G., Kolattukudy,P.,
            Belin,M.F. and Antoine,J.C.
  TITLE     Ulip/CRMP proteins are recognized by autoantibodies in
            paraneoplastic neurological syndromes
  JOURNAL   Eur J Neurosci 11 (12), 4226-4232 (1999)
   PUBMED   10594648
REFERENCE   9  (bases 1 to 2664)
  AUTHORS   Byk,T., Ozon,S. and Sobel,A.
  TITLE     The Ulip family phosphoproteins--common and specific properties
  JOURNAL   Eur J Biochem 254 (1), 14-24 (1998)
   PUBMED   9652388
REFERENCE   10 (bases 1 to 2664)
  AUTHORS   Hamajima,N., Matsuda,K., Sakata,S., Tamaki,N., Sasaki,M. and
            Nonaka,M.
  TITLE     A novel gene family defined by human dihydropyrimidinase and three
            related proteins with differential tissue distribution
  JOURNAL   Gene 180 (1-2), 157-163 (1996)
   PUBMED   8973361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512622.9, BC029280.1, BC136329.1 and BC142974.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006426.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.112042.1, BC142974.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338492.9/ ENSP00000339850.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AL512622.9         73984-74061
            79-1811             BC029280.1         1-1733
            1812-2364           BC136329.1         1719-2271
            2365-2664           BC142974.1         2350-2649
FEATURES             Location/Qualifiers
     source          1..2664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..2664
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /note="dihydropyrimidinase like 4"
                     /db_xref="GeneID:10570"
                     /db_xref="HGNC:HGNC:3016"
                     /db_xref="MIM:608407"
     exon            1..155
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1835
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /note="CRMP-3; ULIP-4; UNC33-like phosphoprotein 4;
                     collapsin response mediator protein 3"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 4"
                     /protein_id="NP_006417.2"
                     /db_xref="CCDS:CCDS7665.1"
                     /db_xref="GeneID:10570"
                     /db_xref="HGNC:HGNC:3016"
                     /db_xref="MIM:608407"
                     /translation="MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQ
                     IGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTT
                     MILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKG
                     VNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGIT
                     GPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFG
                     EPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHC
                     TFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIF
                     NFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQG
                     RVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVMV
                     PAKPGSGAPARASCPGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPGGRS
                     NITSLS"
     exon            156..244
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            245..429
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            430..594
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            595..656
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            657..737
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            738..806
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            807..927
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1084
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1226
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1397
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1577
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1743
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..2664
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2643..2648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /note="hexamer: ATTAAA"
     polyA_site      2664
                     /gene="DPYSL4"
                     /gene_synonym="CRMP3; DRP-4; ULIP4"
                     /note="major polyA site"
ORIGIN      
        1 gcagtctgtc tcccgccgtc cccacgcacg cgtcccggct cacgcgtccc cccgcccgcc
       61 cgcccgcccg cccgcccccg cttgtgccgc ccctaccaga gacccccagg agcaggatgt
      121 ccttccaggg caagaaaagc atcccccgga tcacgagtga ccgccttctg atcagaggtg
      181 ggaggatcgt gaatgacgac cagtcctttt acgctgatgt gcacgtggaa gatggcttga
      241 taaaacaaat cggagaaaac ctcatcgtcc ctgggggcat caagaccatt gacgcccacg
      301 gcctgatggt ccttcctggt ggcgttgacg tccacacaag gctgcagatg cctgtcctgg
      361 gcatgacacc ggctgacgac ttctgtcagg gcaccaaggc agcgctagca ggaggaacca
      421 ccatgatctt ggaccacgtc ttccccgaca cgggtgtgag cctgctggcg gcctacgagc
      481 agtggcggga gcgggcggac agcgcggcct gctgcgacta ctccctgcac gtggacatca
      541 cccgatggca tgagagcatc aaggaggagc tggaggccct ggtcaaggag aagggtgtga
      601 actccttcct ggtcttcatg gcatacaagg accggtgcca gtgcagcgac agccagatgt
      661 acgagatctt cagcatcatc cgggacctgg gggccttggc ccaggtgcac gctgagaacg
      721 gggacatcgt ggaggaggag cagaagcggt tgctggagct cggcatcact ggccccgagg
      781 gccacgtgct cagccacccc gaggaggtgg aggctgaggc ggtgtaccga gctgtcacca
      841 tcgccaagca ggcaaactgc ccgctgtacg tcaccaaggt gatgagcaag ggggcggccg
      901 acgccatcgc tcaggccaag cgcagagggg tggtcgtgtt tggggagccc atcaccgcca
      961 gcctgggcac cgacggttca cactactgga gcaagaactg ggccaaggcc gcagccttcg
     1021 tcacatcacc ccctgtcaac ccagacccca ccacggcgga ccacctcacc tgcttgctgt
     1081 ccagcgggga cctccaggtg acaggcagcg cccactgcac cttcaccact gcccagaagg
     1141 ctgtgggcaa ggacaacttc gcgctgatcc ccgagggcac caacggcatt gaggagcgca
     1201 tgtcgatggt ctgggagaaa tgtgtggcct ctgggaagat ggacgagaat gagttcgtcg
     1261 cggtgaccag tacaaatgct gccaaaatct tcaattttta cccaaggaag gggcgagtgg
     1321 ctgtgggctc tgacgctgac ctggtcatat ggaaccccaa ggccaccaag atcatctctg
     1381 ccaagaccca caatctgaac gtggagtaca acatcttcga gggagtggag tgccggggag
     1441 cgcctgccgt ggtcataagt cagggccgag tggcgctgga ggacgggaag atgtttgtca
     1501 ccccgggggc gggccgcttc gtccctcgga aaacattccc ggactttgtc tacaagagga
     1561 tcaaagctcg caacaggctg gcggagatcc acggtgtgcc ccgtggactg tatgacgggc
     1621 ccgtccacga ggtgatggtg cctgccaagc cagggagtgg cgctccggcc cgcgcgtcct
     1681 gcccaggcaa gatctccgtc cctcctgtgc gcaacctaca tcagtcgggg ttcagcctat
     1741 ctgggtctca ggctgatgac cacatcgccc gacgcacagc acagaagatc atggcaccac
     1801 ctggcggccg ctccaacatc acctctctct cctagacgcc caggaccggc cctgtgagcc
     1861 gtgctggccc cacccgaggc cgcgggggcc ccagggcact cgcccccctc cttagcattt
     1921 tcttttgtag aagtttctcg aaggtgcttg gcggtcttgc cttccccctc cccacaggct
     1981 ctccttgtgg ggtcccaggt cctgctgcca agagcccctc aagagaaggg ctgaacctgg
     2041 ggagatgtca ctgccagggt gaggtggagc cacatggcag ggacaatgcc ggcagcctga
     2101 gcccaggcac cccagtgccc gctgggccca gcctggggac agggaacctg ccgggctcac
     2161 agtgtgggag cagctggaca ccaggcttct tggtgaaccg gcgaggggcc gagtcccgcc
     2221 tggtgggcat ttgccgccgc ctccccacca ccagtcactg cctcgcagag ccctacactc
     2281 ccgcagccgc tcctcagagg cctgtgccca tcgcaggcct gggaggaaag tgggcgcaga
     2341 gccctcctgc tcacacagct gctgagactt cagggaccca tcagaacttg gtgcagcaca
     2401 gccccgcccg tggagggtcc cttttacgca ccccaaggcc cacacctaag cttccatgta
     2461 gccctcatcc agggaagttt tgcgatcctt taggaagaca ctgtcctctt attacagatt
     2521 gtgtatttcc gtaggcttct tagtagcagc tttgtacact gaggacactg tagccaggaa
     2581 cctgtgcatg ccacccaccg cctggacagg cagtcatcct gcctctgatg tgaatcaggc
     2641 ccattaaaga cgtctgggtt tgaa
//
