LOCUS       NM_001197294            5492 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dihydropyrimidinase like 3 (DPYSL3), transcript
            variant 1, mRNA.
ACCESSION   NM_001197294
VERSION     NM_001197294.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5492)
  AUTHORS   Liang,P.I., Lai,H.Y., Chan,T.C., Li,W.M., Hsing,C.H., Huang,S.K.,
            Hsieh,K.L., Tseng,W.H., Chen,T.J., Li,W.S., Chen,H.D., Kuo,Y.H. and
            Li,C.F.
  TITLE     Upregulation of dihydropyrimidinase-like 3 (DPYSL3) protein
            predicts poor prognosis in urothelial carcinoma
  JOURNAL   BMC Cancer 23 (1), 599 (2023)
   PUBMED   37380971
  REMARK    GeneRIF: Upregulation of dihydropyrimidinase-like 3 (DPYSL3)
            protein predicts poor prognosis in urothelial carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5492)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5492)
  AUTHORS   Park,S.Y., Kim,J.T., Park,E.S., Hwang,Y.S., Yoon,H.R., Baek,K.E.,
            Jung,H., Yoon,S.R., Kim,B.Y., Cho,H.J. and Lee,H.G.
  TITLE     Collapsin response mediator protein 4 enhances the radiosensitivity
            of colon cancer cells through calcium-mediated cell signaling
  JOURNAL   Oncol Rep 45 (4) (2021)
   PUBMED   33655336
  REMARK    GeneRIF: Collapsin response mediator protein 4 enhances the
            radiosensitivity of colon cancer cells through calciummediated cell
            signaling.
REFERENCE   4  (bases 1 to 5492)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5492)
  AUTHORS   Tsai,Y.M., Wu,K.L., Chang,Y.Y., Hung,J.Y., Chang,W.A., Chang,C.Y.,
            Jian,S.F., Tsai,P.H., Huang,Y.C., Chong,I.W. and Hsu,Y.L.
  TITLE     Upregulation of Thr/Tyr kinase Increases the Cancer Progression by
            Neurotensin and Dihydropyrimidinase-Like 3 in Lung Cancer
  JOURNAL   Int J Mol Sci 21 (5), 1640 (2020)
   PUBMED   32121246
  REMARK    GeneRIF: Upregulation of Thr/Tyr kinase Increases the Cancer
            Progression by Neurotensin and Dihydropyrimidinase-Like 3 in Lung
            Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5492)
  AUTHORS   Matsuo,T., Stauffer,J.K., Walker,R.L., Meltzer,P. and Thiele,C.J.
  TITLE     Structure and promoter analysis of the human unc-33-like
            phosphoprotein gene. E-box required for maximal expression in
            neuroblastoma and myoblasts
  JOURNAL   J Biol Chem 275 (22), 16560-16568 (2000)
   PUBMED   10748015
  REMARK    Erratum:[J Biol Chem 2000 Aug 11;275(32):25052-3]
REFERENCE   7  (bases 1 to 5492)
  AUTHORS   Inagaki,H., Kato,Y., Hamajima,N., Nonaka,M., Sasaki,M. and
            Eimoto,T.
  TITLE     Differential expression of dihydropyrimidinase-related protein
            genes in developing and adult enteric nervous system
  JOURNAL   Histochem Cell Biol 113 (1), 37-41 (2000)
   PUBMED   10664068
REFERENCE   8  (bases 1 to 5492)
  AUTHORS   Gaetano,C., Matsuo,T. and Thiele,C.J.
  TITLE     Identification and characterization of a retinoic acid-regulated
            human homologue of the unc-33-like phosphoprotein gene (hUlip) from
            neuroblastoma cells
  JOURNAL   J Biol Chem 272 (18), 12195-12201 (1997)
   PUBMED   9115293
REFERENCE   9  (bases 1 to 5492)
  AUTHORS   Hamajima,N., Matsuda,K., Sakata,S., Tamaki,N., Sasaki,M. and
            Nonaka,M.
  TITLE     A novel gene family defined by human dihydropyrimidinase and three
            related proteins with differential tissue distribution
  JOURNAL   Gene 180 (1-2), 157-163 (1996)
   PUBMED   8973361
REFERENCE   10 (bases 1 to 5492)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011373.4, BC077077.1, D78014.1 and CA424493.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001197294.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC077077.1, SRR1803612.105721.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343218.10/ ENSP00000343690.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC011373.4         136183-136194       c
            13-1191             BC077077.1         1-1179
            1192-2225           D78014.1           750-1783
            2226-5488           BC077077.1         2214-5476
            5489-5492           CA424493.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..5492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..5492
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /note="dihydropyrimidinase like 3"
                     /db_xref="GeneID:1809"
                     /db_xref="HGNC:HGNC:3015"
                     /db_xref="MIM:601168"
     exon            1..591
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..2265
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dihydropyrimidinase-related protein 3; collapsin response
                     mediator protein 4 long; unc-33-like phosphoprotein 1;
                     testicular secretory protein Li 7"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 3 isoform 1"
                     /protein_id="NP_001184223.1"
                     /db_xref="CCDS:CCDS56387.1"
                     /db_xref="GeneID:1809"
                     /db_xref="HGNC:HGNC:3015"
                     /db_xref="MIM:601168"
                     /translation="MASGRRGWDSSHEDDLPVYLARPGTTDQVPRQKYGGMFCNVEGA
                     FESKTLDFDALSVGQRGAKTPRSGQGSDRGSGSRPGIEGDTPRRGQGREESREPAPAS
                     PAPAGVEIRSATGKEVLQNLGPKDKSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIG
                     DNLIVPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMI
                     IDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVN
                     SFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGP
                     EGHVLSRPEELEAEAVFRAITIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEP
                     ITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTF
                     STAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNL
                     YPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEYNIFEGMELRGAPLVVICQGKI
                     MLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTP
                     KGGTPAGSARGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITS
                     LS"
     exon            592..680
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..865
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1030
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1092
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1173
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1242
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1363
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1520
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1662
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1833
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2013
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2176
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..5492
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2909..2914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2928
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /note="major polyA site"
     regulatory      5468..5473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      5492
                     /gene="DPYSL3"
                     /gene_synonym="CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP;
                     ULIP-1"
                     /note="major polyA site"
ORIGIN      
        1 actctgggcc cctgctccgc gcgctagctg gctgtgtggc tcgctggctc gctagggaca
       61 agcaggaatc ggagcagcac tgccgcctct ggcgcgaagg ctcaggcgcc tcctcccgcc
      121 acagtcactg tggctcggcg cacgctgccg gcggctgccc tttccgcctc tggggaagaa
      181 aaacccgcgg gccgctttcg tgcttgaacc atggcctcgg gccggagggg ctgggacagc
      241 tcccacgaag acgatctgcc cgtgtacctg gccaggccgg gcaccacgga ccaggtcccg
      301 cggcagaaat acggcggcat gttctgcaac gtggagggcg ccttcgagag caagacgctg
      361 gatttcgatg ccctcagcgt ggggcagcgg ggcgcgaaga ctcctcggag cggccagggc
      421 agcgaccgag gatcggggag tcggcccggg atcgaggggg acaccccgcg caggggccaa
      481 ggccgggaag agagcaggga gcccgcgccc gcctcccccg cccccgccgg ggtagagatc
      541 cggagcgcca ccggcaaaga ggtgttgcag aacctcggcc ccaaggacaa gagtgaccgt
      601 ctccttatca agggaggcag aatcgtcaat gatgatcagt ccttttatgc tgatatttac
      661 atggaagatg gcttaataaa acaaattgga gacaatctga ttgttcctgg aggagtgaag
      721 accattgaag ccaatgggaa gatggtgatc cctggaggca tcgatgtcca tactcacttc
      781 cagatgccat ataagggaat gaccacagta gatgacttct tccaagggac aaaggcggcc
      841 ttagcaggtg gcaccaccat gatcattgac catgtggtgc ctgagcctga gtccagcctg
      901 actgaggcct atgagaaatg gagagagtgg gctgatggga agagttgctg tgactatgcc
      961 ctgcatgtgg acatcaccca ctggaatgac agcgtcaagc aggaagtgca gaacctcatc
     1021 aaggacaaag gggttaactc cttcatggtt tatatggctt ataaggattt gtatcaagta
     1081 tctaacacag agctctatga gatcttcacc tgcctgggag agctgggggc cattgctcaa
     1141 gttcatgctg agaatgggga tatcattgcc caggagcaaa cccgcatgtt ggaaatgggg
     1201 ataactggcc cagaaggcca tgtactgagc aggccagaag agctggaagc tgaggctgtg
     1261 ttccgtgcca tcaccattgc cagccaaacc aattgccctc tctacgtcac aaaggtcatg
     1321 agcaagagtg cagctgacct catctcacaa gccaggaaaa aaggaaatgt agtctttggt
     1381 gagcccatca ctgccagcct cggcatagat ggaacccatt attggagcaa gaactgggcc
     1441 aaggcggctg catttgtgac atccccaccc ctgagccctg acccaactac tccggactac
     1501 atcaactcct tgctggccag cggggatctg cagctatctg ggagtgccca ctgcaccttc
     1561 agcactgccc agaaagcaat tgggaaggac aacttcacag ccattcctga gggcaccaat
     1621 ggtgtggagg agcggatgtc tgtcatctgg gacaaggctg tggccacagg gaaaatggac
     1681 gaaaaccagt tcgtggctgt gacaagcaca aacgctgcca agatcttcaa cctgtatccc
     1741 cgcaagggaa gaatatctgt gggttctgac agcgacctcg tcatctggga tccagatgct
     1801 gtgaagatcg tctctgccaa gaaccaccag tctgcggcag agtacaacat ctttgaaggg
     1861 atggagctgc gcggggctcc tctggttgtc atctgccagg gcaagatcat gctggaagat
     1921 ggcaacctgc acgtgaccca gggggctggc cgcttcatac cctgcagccc gttctccgac
     1981 tatgtctaca agcgcattaa agcacggagg aagatggcag acctgcatgc cgtcccaagg
     2041 ggcatgtacg atgggcctgt gtttgacctg accaccaccc ccaaaggtgg cacccccgca
     2101 ggctctgctc ggggctctcc tactcggccg aacccacctg tgaggaatct tcatcagtcg
     2161 ggatttagcc tgtcaggcac ccaagtggat gagggggttc gctcagccag caagcgcatc
     2221 gtggcgcccc caggcggccg ttctaatatc acatctctga gttaagcaag ccttcctcaa
     2281 agagaggggc agaagcaaga agagattgtt ttgaagccaa aatggtacac cgatatttaa
     2341 gaaggaaagc gaatccaaac ggttgtgatc taaagaatca ataagcctca agccttatgt
     2401 ttctccaatg ttacgctcgc ttgcctagct ttacgaatat tgctttgttt tctgtttatg
     2461 catagccttg atttgtttga ctcccctccc cccatttaca tgcatgcaat cagacaggcc
     2521 actaaggtaa aagagtctgc tctatcatag tgttgagagc gtgtgtagtg ctgcatctta
     2581 tgacaagggg acagacaagc tgggacgtca gggaaatgaa caaaagggac gcaggttatt
     2641 tggggtgagt gggtggtggg agcctggagc aaggtggagg gtgcagaggg gctggggtag
     2701 ggcatgtagg agggaggtgg gtgggtcagg tgagtggaag gggtgttgta tattgtgttg
     2761 atgacgtacg ttatttccat ggaagatagc cgctgtggca gctgtcacat caccacagct
     2821 ccctagggtc tgccgagaag gcaggcagtc tttgggttct gttctttgtc acgtccccta
     2881 caagtaaatt ttgtttcttt gaacgtttat taaaatgcca agacccaacc atttcttcca
     2941 cctgcttgat tgtgccagtg tttgctcagg cctctttctt agtgttgctt tcaaatcctt
     3001 ctctttcctg ggttgggaag gccaggcagg gacagagcaa atgacacttc tcttcctctt
     3061 gccctccctg cctctttggt gctcttaaaa gccagcagct gagaacatag cacaggccca
     3121 cgtggtgagg gcacccacag cttaaagacg cttccttcta aacacggcga ggtcacctct
     3181 cactcttctg tctttgcaaa ccgagaagag tggcatgctt ctggcatccc aagtcaggat
     3241 tttagctcag atgaggcaga atgaagggcc tctcttacag gcagtttgtg tttgattctc
     3301 tcgatcctgg cacatccatg ataaatagga gtttttgaaa gttggtttta ttaggtgttc
     3361 cctaattttt accgtaatag gtcatctcag cttatatgaa agtcaagtgg ggaactggga
     3421 aagccaaagt cagtcttgag cagagggagc acattttgtg gacctggttc cacctttcca
     3481 ttccaaacca cctgtttccc cttccattag cagaaactct gggggaactt tgtgtctcag
     3541 tcctagaatc tccccaagtg agtggaagtg acatgatgca gtcttcctca tggggcacct
     3601 gaaagaaatt agtgtgggtg cttcgatcta ccttgtctgt cagagttgaa tatctctttc
     3661 cctatcatgc tgcttctgaa aattcagttt tggagcaagt cctgtgagca agataagaat
     3721 ctatagaacc aagatgctca ttttcagaag aaatatgttc aacctgggat cagacttcca
     3781 tgctctgggg aatccaagtg gtagcacctg taaccctgtg tactaagtgc tttgaagaga
     3841 agagcaggcc tcagacacct tttaattgct taggagaaac cattgtctct gactgcaggt
     3901 ttgaataagt tgaagaccag agaaaagtac acactgggct acaaaggaat ttggagatag
     3961 ccaaggaaca ggatttcccc tagcaagcta ccttctgttc aaatcatgaa aaaagactat
     4021 ttccccttag aatagggaag cttgctattt taaagctctt gtagtgcttt tcttttaagg
     4081 gagatgtagt aaaagggaaa atgtagctct tagtttacac ttcaaagatg tgggggtctt
     4141 tcagagaact aagaataaca gttttatgtg cagagagagt ttgccagatc tgaagcatat
     4201 acctcattga ctaggctgtt actttgggat aggttgcagt accagccaca gccagcagat
     4261 agaggaaaag acacacataa actcgcttct gagcgtccac ttctgcactc tctgctctgc
     4321 tgttactcag cccctgagtc tgactcatct ctgcacaacc tctctgtgcc atgaagataa
     4381 gtcttccatg gccaaatcgg tcatccgcac tgcccttggg acttccgaag tgaaccattc
     4441 caccagaacc tttgattctg cacaagattt ccttgctctg ggaacaaccc ccaaatgccc
     4501 ttgggaggaa caacatgagc tcaggaagcc tctctttctt cacttaccat tactaactct
     4561 ccaagcatag aaatccctgg gaattgcgag aataactccc actattttaa aatttatatt
     4621 cagatttgtt tcgtttcata agacacatca aacaggccta tacaaaaggt ttaggaaaag
     4681 aaaacaatgg tgagtcccgg ccctcttcga attcactggc acctcatgca agtgtaggaa
     4741 ggcacgctgg atcgtctatc tgattccaaa gctgtccttt gccatctcat cccttggcct
     4801 gccccccaac cctgaggatg cccctgccat ccccccaacc tcctcatatt gcctctgaac
     4861 ccagatggca atccatcccg gttctctctg agggccacgg gcttgggtag tggaaagggt
     4921 gtttgggaaa ttgttaaatc agttacccgt agtagagcta tttcttgtac ttctaagttt
     4981 tctagaagtg gaaggattgt agtcatcctg aaaatgggtt tacttcaaaa tccctcagcc
     5041 ttgttcttca cgactgtcta tactgagagt gtcatgtttc cacaaagggc tgacacctga
     5101 gcctggattt tcactcatcc ctgagaagcc ctttccagta gggtgggcaa ttcccaactt
     5161 ccttgccaca agcttcccag gctttctccc ctggaaaact ccagcttgag tcccagatac
     5221 actcatgggc tgccctgggc agccagcatt cattgtaagt tccctctttg aaaactggtg
     5281 tgtgggtgtt cagttctgtg tctggtgggt atggacagac agtaatctcc tgtgatctgt
     5341 gctagctgtg aggcagctct ggaacgtgaa gagctgtttg gtttgaaccg tgaacaaaac
     5401 tgtgttttga gtttagctga cattaaagaa aaaagttcat cacgtgactg ttaatgtaaa
     5461 cctggttatt aaaataacta tgaaattacc aa
//
