LOCUS       NM_001197293            4798 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens dihydropyrimidinase like 2 (DPYSL2), transcript
            variant 1, mRNA.
ACCESSION   NM_001197293
VERSION     NM_001197293.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4798)
  AUTHORS   Li,S., Guo,Y., Takahashi,M., Suzuki,H., Kosaki,K. and Ohshima,T.
  TITLE     Forebrain commissure formation in zebrafish embryo requires the
            binding of KLC1 to CRMP2
  JOURNAL   Dev Neurobiol 84 (3), 203-216 (2024)
   PUBMED   38830696
  REMARK    GeneRIF: Forebrain commissure formation in zebrafish embryo
            requires the binding of KLC1 to CRMP2.
REFERENCE   2  (bases 1 to 4798)
  AUTHORS   Kurita,H., Ueda,M., Kimura,M., Okuda,A., Ohuchi,K., Hozumi,I. and
            Inden,M.
  TITLE     Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal
            Pathway
  JOURNAL   Biol Pharm Bull 47 (4), 796-800 (2024)
   PUBMED   38583951
  REMARK    GeneRIF: Zinc Deficiency Decreases Neurite Extension via CRMP2
            Signal Pathway.
REFERENCE   3  (bases 1 to 4798)
  AUTHORS   Feuer,K.L., Peng,X., Yovo,C.K. and Avramopoulos,D.
  TITLE     DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic
            neurons confirms its role in mTOR signaling and neurodevelopmental
            disorders
  JOURNAL   Mol Psychiatry 28 (10), 4353-4362 (2023)
   PUBMED   37479784
  REMARK    GeneRIF: DPYSL2/CRMP2 isoform B knockout in human iPSC-derived
            glutamatergic neurons confirms its role in mTOR signaling and
            neurodevelopmental disorders.
REFERENCE   4  (bases 1 to 4798)
  AUTHORS   Brustovetsky,T., Khanna,R. and Brustovetsky,N.
  TITLE     CRMP2 Participates in Regulating Mitochondrial Morphology and
            Motility in Alzheimer's Disease
  JOURNAL   Cells 12 (9), 1287 (2023)
   PUBMED   37174687
  REMARK    GeneRIF: CRMP2 Participates in Regulating Mitochondrial Morphology
            and Motility in Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4798)
  AUTHORS   Soutar,M.P., Thornhill,P., Cole,A.R. and Sutherland,C.
  TITLE     Increased CRMP2 phosphorylation is observed in Alzheimer's disease;
            does this tell us anything about disease development?
  JOURNAL   Curr Alzheimer Res 6 (3), 269-278 (2009)
   PUBMED   19519308
  REMARK    Review article
REFERENCE   6  (bases 1 to 4798)
  AUTHORS   Gu,Y. and Ihara,Y.
  TITLE     Evidence that collapsin response mediator protein-2 is involved in
            the dynamics of microtubules
  JOURNAL   J Biol Chem 275 (24), 17917-17920 (2000)
   PUBMED   10770920
REFERENCE   7  (bases 1 to 4798)
  AUTHORS   Gu,Y., Hamajima,N. and Ihara,Y.
  TITLE     Neurofibrillary tangle-associated collapsin response mediator
            protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518,
            and Ser-522
  JOURNAL   Biochemistry 39 (15), 4267-4275 (2000)
   PUBMED   10757975
REFERENCE   8  (bases 1 to 4798)
  AUTHORS   Kitamura,K., Takayama,M., Hamajima,N., Nakanishi,M., Sasaki,M.,
            Endo,Y., Takemoto,T., Kimura,H., Iwaki,M. and Nonaka,M.
  TITLE     Characterization of the human dihydropyrimidinase-related protein 2
            (DRP-2) gene
  JOURNAL   DNA Res 6 (5), 291-297 (1999)
   PUBMED   10574455
REFERENCE   9  (bases 1 to 4798)
  AUTHORS   Hamajima,N., Matsuda,K., Sakata,S., Tamaki,N., Sasaki,M. and
            Nonaka,M.
  TITLE     A novel gene family defined by human dihydropyrimidinase and three
            related proteins with differential tissue distribution
  JOURNAL   Gene 180 (1-2), 157-163 (1996)
   PUBMED   8973361
REFERENCE   10 (bases 1 to 4798)
  AUTHORS   Goshima,Y., Nakamura,F., Strittmatter,P. and Strittmatter,S.M.
  TITLE     Collapsin-induced growth cone collapse mediated by an intracellular
            protein related to UNC-33
  JOURNAL   Nature 376 (6540), 509-514 (1995)
   PUBMED   7637782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015743.9, DA649686.1,
            AB209195.1, BX463316.2, BC056408.1 and AC015564.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001197293.2.
            
            Summary: This gene encodes a member of the collapsin response
            mediator protein family. Collapsin response mediator proteins form
            homo- and hetero-tetramers and facilitate neuron guidance, growth
            and polarity. The encoded protein promotes microtubule assembly and
            is required for Sema3A-mediated growth cone collapse, and also
            plays a role in synaptic signaling through interactions with
            calcium channels. This gene has been implicated in multiple
            neurological disorders, and hyperphosphorylation of the encoded
            protein may play a key role in the development of Alzheimer's
            disease. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.100680.1,
                                           SRR1660803.227283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521913.7/ ENSP00000427985.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC015743.9         65920-66081
            163-441             DA649686.1         1-279
            442-1035            AB209195.1         1-594
            1036-1036           BX463316.2         699-699
            1037-2115           AB209195.1         596-1674
            2116-2811           BC056408.1         1791-2486
            2812-4565           AC015564.13        93218-94971
            4566-4798           BC056408.1         4239-4471
FEATURES             Location/Qualifiers
     source          1..4798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..4798
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /note="dihydropyrimidinase like 2"
                     /db_xref="GeneID:1808"
                     /db_xref="HGNC:HGNC:3014"
                     /db_xref="MIM:602463"
     exon            1..649
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..2329
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dihydropyrimidinase-related protein 2; collapsin response
                     mediator protein hCRMP-2; unc-33-like phosphoprotein 2"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 2 isoform 1"
                     /protein_id="NP_001184222.1"
                     /db_xref="CCDS:CCDS83268.1"
                     /db_xref="GeneID:1808"
                     /db_xref="HGNC:HGNC:3014"
                     /db_xref="MIM:602463"
                     /translation="MAERKQSGKAAEDEEVPAFFKNLGSGSPKPRQKFCGMFCPVEGS
                     SENKTIDFDSLSVGRGSGQVVAQQRDVAHLGPDPQPPYSRQGRRAGGEPSVESGRKVE
                     IRRASGKEALQNINDQSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGV
                     KTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPG
                     TSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFK
                     DRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPE
                     EVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDG
                     SHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGK
                     DNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAV
                     GSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHV
                     TEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSA
                     KTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG"
     exon            650..738
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..923
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1088
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1150
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1231
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1300
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1421
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1578
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1720
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1891
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2071
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2237
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..4798
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4774..4779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /note="hexamer: AATAAA"
     polyA_site      4798
                     /gene="DPYSL2"
                     /gene_synonym="CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3;
                     ULIP-2; ULIP2"
                     /note="major polyA site"
ORIGIN      
        1 ctttcggctc ccgcagccgc agcggacgcc ctcccagatc caactttgcc gcttccccga
       61 gctcgcgctg tagccgcggg gggcgtgggc agggagggga gaagcggggt cagggggagg
      121 gaccgggagg gtgggtcgcc ggctcgccag ccctccttcc tttctgtgca ccttgcggtg
      181 ggcggcgaac ggcagccgcg gcagcagcta gggggcttgt gcacacagcg agggagactt
      241 agggactggc agacggacgg acggacggcg aggaccctac ccgagccccc gagccatggc
      301 cgagagaaag caatccggga aggcggcaga ggacgaagag gtccctgctt tttttaaaaa
      361 cctgggctcc ggcagcccca agccccggca gaaattctgt ggcatgttct gcccggtgga
      421 agggtcctcg gagaacaaga ccatcgactt cgactcgctg tcggtgggcc ggggctcggg
      481 gcaggtggtg gctcagcagc gggacgtcgc ccacttgggc ccggacccgc agccgccgta
      541 ctcgcggcag ggccggcgcg ccggcggaga gccatctgtt gaatcgggcc ggaaggtgga
      601 gatccggagg gcctcgggca aagaagccct gcagaacatc aacgaccaga gcgatcgtct
      661 tctgatcaaa ggaggtaaaa ttgttaatga tgaccagtcg ttctatgcag acatatacat
      721 ggaagatggg ttgatcaagc aaataggaga aaatctgatt gtgccaggag gagtgaagac
      781 catcgaggcc cactcccgga tggtgatccc cggaggaatt gacgtccaca ctcgtttcca
      841 gatgcctgat cagggaatga cgtctgctga tgatttcttc caaggaacca aggcggccct
      901 ggctggggga accactatga tcattgacca cgttgttcct gagcctggga caagcctgct
      961 cgctgccttt gaccagtgga gggaatgggc cgacagcaag tcctgctgtg actactctct
     1021 gcatgtggac atcagtgagt ggcataaggg catccaggag gagatggaag cgcttgtgaa
     1081 ggatcacggg gtaaattcct tcctcgtgta catggctttc aaagatcgct tccagctaac
     1141 ggattgccag atttatgaag tactgagtgt gatccgggat attggcgcca tagcccaagt
     1201 ccacgcagaa aatggcgaca tcattgcaga ggagcagcag aggatcctgg atctgggcat
     1261 cacgggcccc gagggacatg tgctgagccg acctgaggag gtcgaggccg aagccgtgaa
     1321 tcgtgccatc accatcgcca accagaccaa ctgcccgctg tatatcacca aggtgatgag
     1381 caaaagctct gctgaggtca tcgcccaggc acggaagaag ggaactgtgg tgtatggcga
     1441 gcccatcact gccagcttgg gaacggacgg ctcccattac tggagcaaga actgggccaa
     1501 ggctgctgcc tttgtcacct ccccaccctt gagccctgat ccaaccactc cagactttct
     1561 caactccttg ctgtcctgtg gagacctcca ggtcacgggc agtgcccatt gcacgtttaa
     1621 cactgcccag aaggctgtag gaaaggacaa cttcaccctg attccggagg gcaccaatgg
     1681 cactgaggag cggatgtccg tcatctggga caaggctgtg gtcactggga agatggatga
     1741 gaaccagttt gtggctgtga ccagcaccaa tgcagccaaa gtcttcaacc tttacccccg
     1801 gaaaggccgc attgctgtgg gatccgatgc cgacctggtc atctgggacc ccgacagcgt
     1861 taaaaccatc tctgccaaga cacacaacag ctctctcgag tacaacatct ttgaaggcat
     1921 ggagtgccgc ggctccccac tggtggtcat cagccagggg aagattgtcc tggaggacgg
     1981 caccctgcat gtcaccgaag gctctggacg ctacattccc cggaagccct tccctgattt
     2041 tgtttacaag cgtatcaagg caaggagcag gctggctgag ctgagagggg ttcctcgtgg
     2101 cctgtatgac ggacctgtgt gtgaagtgtc tgtgacgccc aagacagtca ctccagcctc
     2161 ctcggccaag acgtctcctg ccaagcagca ggccccacct gtccggaacc tgcaccagtc
     2221 tggattcagt ttgtctggtg ctcagattga tgacaacatt ccccgccgca ccacccagcg
     2281 tatcgtggcg ccccccggtg gccgtgccaa catcaccagc ctgggctaga gctcctgggc
     2341 tgtgccgtcc actggggact ggggatggga cacctgagga cattctgaga cttctttctt
     2401 ccttcctttt tttttttttg tttttttttt taagagcctg tgatagttac tgtggagcag
     2461 ccagttcatg gggtccccct tggggcccca caccccgtct ctcaccaaga gttactgatt
     2521 ttgctcatcc acttccctac acatctatgg gtatcacacc caagactacc caccaagctc
     2581 atacagggaa ccacacccaa cacttagaca tgcgaacaag cagcccccag cgagggtctc
     2641 cttcgccttc aacctcctag tgtctgttag catcttcctt ttcatggggg gagggaagat
     2701 aaagtgaatt gcccagagct gcctttttct tttcttttta aaaattttaa gaagttttct
     2761 ttgtggggct ggggaggggc cggggtcagg gagagtcttt tttttttttt tttttaaata
     2821 ctaaattgga acatttaatt ccatattaat acaaggggtt tgaactggac atcctaatga
     2881 tgcaattacg tcatcaccca gctgattccg ggtggttggc aaactcatcg tgtctgtcct
     2941 gagaggctcc acaatgccca cccgcatcgc cattctgtag tcttcagggt cagctgttga
     3001 taaaggggca ggcttgcgtt attggcctag attttgctgc agattaaatc ctttgaggat
     3061 tctcttctct tttaccattt ttctgcgtgc tctcactctc tctttctctc tctagctttt
     3121 taattcatga atattttcgt gtctgtctct ctctctctct gtgtttcctc cagcccttgt
     3181 ctcggagacg gtgttttcct cccttgcccc attatctttt cacctcccag gtctaccatt
     3241 tcatggtggt cgttgggtcc gcctaaagga tttgagcgtt tgccattgca agcatagtgc
     3301 tgtgtcatcc tggtccatgt aggactggtg ctaaccacct gccatcatga ggatgtgtgc
     3361 tagagtgtgg gaccctggcc aagtgcagga atgggccatg ccgtctcacc cacagtatca
     3421 cacgtggaac cgcagacagg gcccagaagc tttagaggta tgaggctgca gaaccggaga
     3481 gattttcctc tgtgcagtgc tctctggcta aagtcacggt caaacctaaa caccgagcct
     3541 cattaaccca agtgaaccaa ccaaagtcac cagttcagaa gtgctaagct aataggagtc
     3601 tgacccgagg gcctgctgct tcctggttaa gtatcttttg agattctaga acacatggga
     3661 gctttttatt ttcggggaaa aaccgtattt ttttcttgtc caattatttc taaagacaca
     3721 ctacatagaa agaggcccta taaactcaaa aagtcattgg gaaacttaaa gtctattcta
     3781 ctttgcaaga ggagaaatgt gttttatgaa cgatagatca catcagaact cctgtgggga
     3841 ggaaacctta taaattaaac acatggcccc cttagagacc acaggtgatg tctgtctcca
     3901 tccttccctc tccttttctg tcacctttcc ccctagctgg ctcctttgga cctacccctg
     3961 tccttgctga cttgtgttgc attgtattcc aaacgtgttt acaggttctc ttaagcaatg
     4021 ttgtatttgc aggcttttct gaataccaaa tctgcttttt gtaaagcgta aaaacatcac
     4081 aaagtaggtc attccatcac cacccttgtc tctctacaca ttttgccttt ggggatctgg
     4141 ttggggtttt gggttttttg ttgttgttgt ttatttgtta ttttaaaggt aaattgcact
     4201 tttaaaaaaa taattggttg acttaatata tttgcttttt ttctcacctg cacttagagg
     4261 aaatttgaac aagttggaaa aaaacaattt ttgtttcaat tctaagaaac acttgcagct
     4321 ctagtattca cttgagtctt cctgtttttc ctgtaccggg tcatggtaat ttttggttgt
     4381 tttggttgtt ttcttaaaaa acaagttaaa acctgacgat ttctgcaggc tgtgtaagca
     4441 tgtttacctg ttggcttgct ttgtgtgtct gttaaatgaa tgtcatatgt aaatgctaaa
     4501 ataaatcgac agtgtctcag aactgaataa ctgcagtgac ttgatgctct aaaacagtgt
     4561 aggatttaag aatagatggt ttttaatcct ggaaattgtg attgtgaccc atgagtggag
     4621 gaactttcag ttctaaagct gataaagtgt gtagccagaa gagtactttt ttttttgtaa
     4681 ccactgtctt gatggcaaaa taattatggt aaaaaacaag tctcgtgttt attattcctt
     4741 aagaactctg tgttatatta ccatggaacg cctaataaag caaaatgtgg ttgtttca
//
