LOCUS       XM_047421416            3087 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens dihydropyrimidinase (DPYS), transcript
            variant X5, mRNA.
ACCESSION   XM_047421416
VERSION     XM_047421416.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..3087
                     /gene="DPYS"
                     /gene_synonym="DHP; DHPase"
                     /note="dihydropyrimidinase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 10
                     ESTs, 8 long SRA reads, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 8 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:1807"
                     /db_xref="HGNC:HGNC:3013"
                     /db_xref="MIM:613326"
     CDS             136..1581
                     /gene="DPYS"
                     /gene_synonym="DHP; DHPase"
                     /codon_start=1
                     /product="dihydropyrimidinase isoform X4"
                     /protein_id="XP_047277372.1"
                     /db_xref="GeneID:1807"
                     /db_xref="HGNC:HGNC:3013"
                     /db_xref="MIM:613326"
                     /translation="MAAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGG
                     APAGLRVLDAAGKLVLPGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFA
                     IPQKGGSLIEAFETWRSWADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKM
                     FMAYKDLYMVTDLELYEAFSRCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHE
                     LCRPEAVEAEATLRAITIASAVNCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAAS
                     LGTDGTHYWNKEWHHAAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQ
                     KALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRK
                     GRIAVGSDADIVIWDPKGTRTISAKTHHQAVNFNIFEGMVCHGVPLVTISRGKVVYEA
                     GVFSVTAGDGKFIPRKPFAEYIYKRIKQRDR"
ORIGIN      
        1 ggatttgcag cctgaggcag agctcggggg ctgtcggtgg ggaccttgca ggagggcacc
       61 ccaagcccgc ccggcccgcc caacccagcc cctgcgcgca gcccgggccg agtaggaccc
      121 cgcgcgcccc tcgctatggc ggcgccctcg cggctcctga tccgcggggg tcgcgtggtc
      181 aacgatgact tctcggaggt ggccgacgtg ctggtggagg acggcgtggt gcgggcactc
      241 gggcacgacc tgctgcctcc cgggggcgct cctgcggggc tgcgggtcct cgacgccgcc
      301 ggcaagctcg tcctgcccgg aggcatcgac acacacacgc acatgcagtt ccccttcatg
      361 ggctcgcggt ccatcgacga cttccaccag ggcaccaagg ctgctctctc aggaggcacc
      421 accatgatta ttgatttcgc cattcctcag aaaggtggct ccctcattga ggccttcgag
      481 acctggcgaa gctgggctga tcccaaagtt tgctgcgact acagccttca tgtggcagtg
      541 acgtggtgga gtgaccaggt taaagaagaa atgaaaatcc ttgtgcaaga taaaggtgtt
      601 aactctttca agatgtttat ggcctataaa gatctgtaca tggtgacaga cctggagctg
      661 tacgaagcct tctctcggtg caaggaaatt ggagcaattg cccaggtcca tgcggaaaat
      721 ggagacttaa ttgcagaggg agcaaagaag atgttggctc tggggataac aggccctgag
      781 ggccacgagc tgtgccgccc agaggcagtg gaggcagagg ccacgctgag agccatcacc
      841 atagccagcg ctgtgaactg tcctctctac attgtgcatg tgatgagcaa gtctgcagct
      901 aaggtgatag cggatgcaag gagagatggg aaggtggtct atggtgaacc catagcagcc
      961 agtcttggca cagatggcac tcactactgg aataaagaat ggcaccatgc agcccaccat
     1021 gtcatgggtc cacctttgcg accagacccc tcaacacccg acttcctcat gaatctgttg
     1081 gctaatgatg atctaaccac aacagggact gataactgca ctttcaacac ctgccagaaa
     1141 gctcttggga aggatgattt taccaagatc cccaatgggg tgaatggtgt tgaagatcgg
     1201 atgtccgtaa tatgggaaaa aggcgtgcat agtggtaaaa tggatgaaaa cagatttgtg
     1261 gcagttacca gcacaaatgc agccaaaatt tttaatctct atccaagaaa aggaagaata
     1321 gctgtaggat cagatgctga cattgttatt tgggacccaa aaggcacaag gactatctca
     1381 gcaaaaactc atcatcaggc tgttaacttc aacattttcg agggcatggt ttgccacggg
     1441 gtgccccttg tgactatttc aagaggcaaa gtggtatatg aagccggagt gttcagtgtc
     1501 acggcaggag atgggaagtt tattcctcga aaaccatttg ctgaatatat ttacaaacga
     1561 ataaagcagc gagaccggta atagggaacc ccaacctttt ctggaaaatc aggatcacat
     1621 tgcattttat agagaaacag gaatagcttc atggagtgat gtatggtttc agaatactgc
     1681 tgccaaagct tttaaactgg gttgtatctt tgcaatgata agcataattt gccttgtaga
     1741 taagataaaa ttgagtggat ggctgctttg gtccttgaga tgggtattct ccatttctga
     1801 aataaccatt tgtcaatgtc tttctcaagg tggtagctca gagaaaataa tttaagacat
     1861 atcacttgcc atataatcct aatttcttca ggttaatcac taccaataca aggtaataca
     1921 catgctggag ttggctcatt ttggctcaca agagacatat gtacgcatct gtgcccaact
     1981 cttcattcag tggtgtcagt ttggtagctt gaaaacagcc agagaaggag tatttacacc
     2041 acagaaatag gcaggtgctt taagttaggg ctttaaggat ggtgaggaaa aaggaaggta
     2101 gagatagttg ttaatattta ccaacacatc actacacaca ggacactttc taagtactct
     2161 ttttcatgct ttatctaatc aatcaacatc cgttcagtaa atatttattg atcaccagtt
     2221 atgttccaag cacactttaa ttctttcaac aacccttgga ggtaagtagt gatattccta
     2281 tttcatatat taagaaatag aggctcaggg agctcacata gttaccaagt ggcagtgttg
     2341 ggactcaaac ccaggtttgt ctacctccaa agccaatccc tttaacttgt atcactgcag
     2401 tatcctaacc ataaacttta atccctactc aaacaaatag ccacccattc ccccatcctt
     2461 atgatatcgc tccctcagtc tcccctctgc acagagggtt cacttcctct cggactggca
     2521 aatttaccag aggagccagc cctgaaatga gacagcccag ctttgtagct cacagcattt
     2581 tgtttgtttg tttgtttatt tatttattta ttgcttcaaa atctttccct ctcccactcc
     2641 agccaggata ttttaaggat taaattgaga tatttggtaa attgtaaaca tcatcaaaat
     2701 gccaatcttc attgttatag atcacctctg ttgcacctag ggctttctca tgtacaagtg
     2761 attcacagag ccctgggtag ctcagttcaa tgtgtgctga gtgccctcta cattcaccag
     2821 gccaggcgtg gatttcattc tcagggagtc actgttcatt tggtctgctt gctgttgacc
     2881 cagcatctgc tgtttggtat ttggaagttc tgttgtcttt attgatattt tagtatctta
     2941 gcctccatga acagcattca atcattaata cctttgggat tcttctctgt tgatcttgct
     3001 aatttcagaa aatctagcat ccagccaggc gtggtggctc acacctgtaa tcccagcact
     3061 ttgggatgct gaagcgggtg gatcacc
//
