LOCUS       XM_005250818            2230 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens dihydropyrimidinase (DPYS), transcript
            variant X1, mRNA.
ACCESSION   XM_005250818
VERSION     XM_005250818.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005250818.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2230
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..2230
                     /gene="DPYS"
                     /gene_synonym="DHP; DHPase"
                     /note="dihydropyrimidinase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 43
                     ESTs, 5 long SRA reads, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 11 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:1807"
                     /db_xref="HGNC:HGNC:3013"
                     /db_xref="MIM:613326"
     CDS             136..1803
                     /gene="DPYS"
                     /gene_synonym="DHP; DHPase"
                     /codon_start=1
                     /product="dihydropyrimidinase isoform X1"
                     /protein_id="XP_005250875.1"
                     /db_xref="GeneID:1807"
                     /db_xref="HGNC:HGNC:3013"
                     /db_xref="MIM:613326"
                     /translation="MAAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGG
                     APAGLRVLDAAGKLVLPGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFA
                     IPQKGGSLIEAFETWRSWADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKM
                     FMAYKDLYMVTDLELYEAFSRCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHE
                     LCRPEAVEAEATLRAITIASAVNCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAAS
                     LGTDGTHYWNKEWHHAAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQ
                     KALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRK
                     GRIAVGSDADIVIWDPKGTRGCRSCVAFSDNGSVYKTNMNLPLQCLANARVHMEERTI
                     SAKTHHQAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYI
                     YKRIKQRDRTCTPTPVERAPYKGEVATLKSRVTKEDATAGTRKQAHP"
ORIGIN      
        1 ggatttgcag cctgaggcag agctcggggg ctgtcggtgg ggaccttgca ggagggcacc
       61 ccaagcccgc ccggcccgcc caacccagcc cctgcgcgca gcccgggccg agtaggaccc
      121 cgcgcgcccc tcgctatggc ggcgccctcg cggctcctga tccgcggggg tcgcgtggtc
      181 aacgatgact tctcggaggt ggccgacgtg ctggtggagg acggcgtggt gcgggcactc
      241 gggcacgacc tgctgcctcc cgggggcgct cctgcggggc tgcgggtcct cgacgccgcc
      301 ggcaagctcg tcctgcccgg aggcatcgac acacacacgc acatgcagtt ccccttcatg
      361 ggctcgcggt ccatcgacga cttccaccag ggcaccaagg ctgctctctc aggaggcacc
      421 accatgatta ttgatttcgc cattcctcag aaaggtggct ccctcattga ggccttcgag
      481 acctggcgaa gctgggctga tcccaaagtt tgctgcgact acagccttca tgtggcagtg
      541 acgtggtgga gtgaccaggt taaagaagaa atgaaaatcc ttgtgcaaga taaaggtgtt
      601 aactctttca agatgtttat ggcctataaa gatctgtaca tggtgacaga cctggagctg
      661 tacgaagcct tctctcggtg caaggaaatt ggagcaattg cccaggtcca tgcggaaaat
      721 ggagacttaa ttgcagaggg agcaaagaag atgttggctc tggggataac aggccctgag
      781 ggccacgagc tgtgccgccc agaggcagtg gaggcagagg ccacgctgag agccatcacc
      841 atagccagcg ctgtgaactg tcctctctac attgtgcatg tgatgagcaa gtctgcagct
      901 aaggtgatag cggatgcaag gagagatggg aaggtggtct atggtgaacc catagcagcc
      961 agtcttggca cagatggcac tcactactgg aataaagaat ggcaccatgc agcccaccat
     1021 gtcatgggtc cacctttgcg accagacccc tcaacacccg acttcctcat gaatctgttg
     1081 gctaatgatg atctaaccac aacagggact gataactgca ctttcaacac ctgccagaaa
     1141 gctcttggga aggatgattt taccaagatc cccaatgggg tgaatggtgt tgaagatcgg
     1201 atgtccgtaa tatgggaaaa aggcgtgcat agtggtaaaa tggatgaaaa cagatttgtg
     1261 gcagttacca gcacaaatgc agccaaaatt tttaatctct atccaagaaa aggaagaata
     1321 gctgtaggat cagatgctga cattgttatt tgggacccaa aaggcacaag aggatgtaga
     1381 agttgtgttg cattctctga caatggatct gtatataaaa ccaatatgaa tttaccactt
     1441 cagtgcctgg caaatgcccg agttcacatg gaagaaagga ctatctcagc aaaaactcat
     1501 catcaggctg ttaacttcaa cattttcgag ggcatggttt gccacggggt gccccttgtg
     1561 actatttcaa gaggcaaagt ggtatatgaa gccggagtgt tcagtgtcac ggcaggagat
     1621 gggaagttta ttcctcgaaa accatttgct gaatatattt acaaacgaat aaagcagcga
     1681 gaccggactt gcacacctac ccctgtggag cgtgcaccct ataagggaga agtcgccaca
     1741 ctgaaatcca gagtgacaaa agaagatgcc acagcaggga ccaggaaaca ggcccacccc
     1801 tgaagtgtgt gccatcggta aaaaaatcag aggaaaggag gctgccattc ccttcacagc
     1861 caaacattgt caacccatgg agaagcaggc cttattcaac tccctaggat cctttagaaa
     1921 aaattcacca ctataggctt ctttgatttt ctttcagaag caattgctgt ctttctcact
     1981 gtgtttttgt tgctgcataa gattgaaggt ataaatttat attattgtga tggaaaggct
     2041 gtgtggaaat tcattgatga tactttaaaa tgtcatcttt gcttgtacta gatttcttac
     2101 ttagaatttt taaaaatcat tttcttgttt aaatagtttc tttttttaaa aaaatggtta
     2161 cattagtttt aaaatagctc tgtgatttta ctttttattg taattaataa acattgagat
     2221 cttcatttta
//
